Incidental Mutation 'R1848:Celsr2'
| ID |
207857 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Celsr2
|
| Ensembl Gene |
ENSMUSG00000068740 |
| Gene Name |
cadherin, EGF LAG seven-pass G-type receptor 2 |
| Synonyms |
EGFL2, Adgrc2, flamingo, mfmi1 |
| MMRRC Submission |
039873-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1848 (G1)
|
| Quality Score |
212 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
108298167-108323383 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 108308626 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 1767
(V1767E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000088046
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000090558]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000090558
AA Change: V1767E
PolyPhen 2
Score 0.348 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000088046
Gene: ENSMUSG00000068740
AA Change: V1767E
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
31 |
N/A |
INTRINSIC |
|
low complexity region
|
35 |
53 |
N/A |
INTRINSIC |
|
CA
|
203 |
287 |
1.36e-26 |
SMART |
|
CA
|
311 |
397 |
1.33e-29 |
SMART |
|
CA
|
421 |
503 |
2.59e-27 |
SMART |
|
CA
|
527 |
608 |
3.33e-30 |
SMART |
|
CA
|
632 |
710 |
5.18e-18 |
SMART |
|
CA
|
734 |
813 |
1.08e-29 |
SMART |
|
CA
|
837 |
919 |
8.08e-29 |
SMART |
|
low complexity region
|
920 |
932 |
N/A |
INTRINSIC |
|
CA
|
943 |
1021 |
4.3e-24 |
SMART |
|
CA
|
1049 |
1125 |
1.87e-1 |
SMART |
|
low complexity region
|
1188 |
1198 |
N/A |
INTRINSIC |
|
EGF
|
1231 |
1286 |
1.81e-3 |
SMART |
|
EGF_CA
|
1288 |
1324 |
2.24e-8 |
SMART |
|
EGF
|
1331 |
1366 |
6.65e-2 |
SMART |
|
LamG
|
1387 |
1554 |
8.4e-30 |
SMART |
|
EGF
|
1577 |
1610 |
8e-5 |
SMART |
|
LamG
|
1636 |
1770 |
1.56e-24 |
SMART |
|
EGF
|
1796 |
1829 |
2.35e-2 |
SMART |
|
EGF
|
1831 |
1867 |
3.88e-3 |
SMART |
|
TNFR
|
1908 |
1943 |
1.35e-1 |
SMART |
|
EGF_Lam
|
1924 |
1969 |
9.54e-12 |
SMART |
|
HormR
|
1972 |
2034 |
1.57e-20 |
SMART |
|
Pfam:GAIN
|
2046 |
2289 |
3e-62 |
PFAM |
|
GPS
|
2315 |
2368 |
1.86e-25 |
SMART |
|
Pfam:7tm_2
|
2373 |
2605 |
1.1e-48 |
PFAM |
|
low complexity region
|
2715 |
2733 |
N/A |
INTRINSIC |
|
low complexity region
|
2857 |
2873 |
N/A |
INTRINSIC |
|
low complexity region
|
2874 |
2881 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126349
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147251
|
| SMART Domains |
Protein: ENSMUSP00000122329
Gene: ENSMUSG00000068740
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:GAIN
|
35 |
278 |
5.1e-63 |
PFAM |
|
GPS
|
304 |
357 |
1.86e-25 |
SMART |
|
Pfam:7tm_2
|
362 |
594 |
2e-49 |
PFAM |
|
low complexity region
|
704 |
722 |
N/A |
INTRINSIC |
|
low complexity region
|
846 |
862 |
N/A |
INTRINSIC |
|
low complexity region
|
863 |
870 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147565
|
| SMART Domains |
Protein: ENSMUSP00000122516
Gene: ENSMUSG00000068740
| Domain | Start | End | E-Value | Type |
|---|
|
EGF
|
13 |
46 |
8e-5 |
SMART |
|
LamG
|
72 |
206 |
1.56e-24 |
SMART |
|
| Meta Mutation Damage Score |
0.3039 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.2%
- 20x: 92.2%
|
| Validation Efficiency |
98% (120/123) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this allele have mild to moderately dilated lateral ventricles in the brain but are otherwise normal. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(4) : Targeted, knock-out(1) Targeted, other(3)
|
| Other mutations in this stock |
Total: 120 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933402J07Rik |
C |
A |
8: 88,295,121 (GRCm39) |
Y86* |
probably null |
Het |
| Aadac |
A |
G |
3: 59,947,118 (GRCm39) |
E272G |
probably damaging |
Het |
| Abcc8 |
A |
T |
7: 45,816,326 (GRCm39) |
D271E |
probably benign |
Het |
| Acan |
T |
C |
7: 78,748,783 (GRCm39) |
F1185L |
probably benign |
Het |
| Adam1a |
A |
T |
5: 121,657,683 (GRCm39) |
C537S |
probably damaging |
Het |
| Ago2 |
A |
G |
15: 72,995,814 (GRCm39) |
V395A |
probably benign |
Het |
| Alox15 |
A |
G |
11: 70,241,578 (GRCm39) |
V101A |
probably damaging |
Het |
| Ankra2 |
T |
C |
13: 98,407,632 (GRCm39) |
I194T |
probably damaging |
Het |
| Apobec4 |
C |
A |
1: 152,631,981 (GRCm39) |
P3H |
probably damaging |
Het |
| Arid3b |
G |
T |
9: 57,703,960 (GRCm39) |
Y329* |
probably null |
Het |
| Atm |
A |
T |
9: 53,379,312 (GRCm39) |
S1993T |
probably benign |
Het |
| Bpgm |
T |
G |
6: 34,464,669 (GRCm39) |
S129A |
probably benign |
Het |
| Brat1 |
A |
G |
5: 140,704,264 (GRCm39) |
D839G |
possibly damaging |
Het |
| Ccdc15 |
A |
T |
9: 37,253,866 (GRCm39) |
S128T |
probably benign |
Het |
| Cd300lg |
A |
T |
11: 101,937,032 (GRCm39) |
|
probably benign |
Het |
| Cdc34b |
C |
A |
11: 94,633,303 (GRCm39) |
Q168K |
probably damaging |
Het |
| Cep350 |
T |
C |
1: 155,829,397 (GRCm39) |
D169G |
probably benign |
Het |
| Col7a1 |
A |
T |
9: 108,798,633 (GRCm39) |
D1762V |
possibly damaging |
Het |
| Coro7 |
A |
G |
16: 4,448,298 (GRCm39) |
L724P |
probably damaging |
Het |
| Crb1 |
T |
A |
1: 139,164,750 (GRCm39) |
I1125F |
probably damaging |
Het |
| Ctif |
T |
A |
18: 75,653,012 (GRCm39) |
D415V |
probably damaging |
Het |
| Dab1 |
C |
T |
4: 104,588,948 (GRCm39) |
A524V |
probably benign |
Het |
| Dhrs2 |
A |
G |
14: 55,478,298 (GRCm39) |
D237G |
probably benign |
Het |
| Dhx9 |
T |
C |
1: 153,341,499 (GRCm39) |
Q582R |
probably damaging |
Het |
| Dnajc1 |
C |
T |
2: 18,224,524 (GRCm39) |
R443Q |
probably damaging |
Het |
| Dnm2 |
C |
T |
9: 21,416,977 (GRCm39) |
R837W |
possibly damaging |
Het |
| Dpf2 |
C |
A |
19: 5,956,643 (GRCm39) |
Q70H |
probably damaging |
Het |
| Dqx1 |
T |
A |
6: 83,043,088 (GRCm39) |
D608E |
probably damaging |
Het |
| Dync2h1 |
T |
A |
9: 7,049,166 (GRCm39) |
T3245S |
probably benign |
Het |
| Ect2l |
A |
G |
10: 18,075,781 (GRCm39) |
L35P |
probably damaging |
Het |
| Efcab5 |
A |
T |
11: 76,994,132 (GRCm39) |
L1285Q |
probably damaging |
Het |
| Eif4g1 |
G |
C |
16: 20,500,617 (GRCm39) |
R697P |
probably damaging |
Het |
| Emsy |
T |
A |
7: 98,250,028 (GRCm39) |
E753V |
probably damaging |
Het |
| Entpd3 |
A |
G |
9: 120,387,485 (GRCm39) |
I227M |
probably damaging |
Het |
| Epn1 |
T |
A |
7: 5,092,997 (GRCm39) |
V103E |
probably damaging |
Het |
| Esrra |
T |
C |
19: 6,889,378 (GRCm39) |
D337G |
probably benign |
Het |
| Fam83e |
A |
T |
7: 45,378,193 (GRCm39) |
K406* |
probably null |
Het |
| Fam83e |
A |
T |
7: 45,378,194 (GRCm39) |
K406M |
possibly damaging |
Het |
| Fat2 |
A |
G |
11: 55,202,384 (GRCm39) |
I230T |
probably damaging |
Het |
| Fbxl16 |
A |
G |
17: 26,035,420 (GRCm39) |
I6V |
probably benign |
Het |
| Fgf23 |
T |
C |
6: 127,050,156 (GRCm39) |
I55T |
probably damaging |
Het |
| Fibcd1 |
T |
A |
2: 31,711,561 (GRCm39) |
D288V |
probably damaging |
Het |
| Flnb |
T |
C |
14: 7,892,113 (GRCm38) |
I594T |
probably damaging |
Het |
| Gabbr2 |
T |
C |
4: 46,739,823 (GRCm39) |
E449G |
probably benign |
Het |
| Gbf1 |
T |
G |
19: 46,260,476 (GRCm39) |
S1130A |
possibly damaging |
Het |
| Gipc3 |
T |
C |
10: 81,177,099 (GRCm39) |
E157G |
probably damaging |
Het |
| Glra3 |
G |
T |
8: 56,393,942 (GRCm39) |
A18S |
probably benign |
Het |
| Gm6625 |
A |
C |
8: 89,873,462 (GRCm39) |
|
noncoding transcript |
Het |
| Gpx4 |
A |
G |
10: 79,891,870 (GRCm39) |
|
probably benign |
Het |
| Grb10 |
A |
G |
11: 11,896,029 (GRCm39) |
F264L |
possibly damaging |
Het |
| Grik3 |
T |
C |
4: 125,587,931 (GRCm39) |
Y684H |
probably damaging |
Het |
| Gstp1 |
C |
T |
19: 4,086,795 (GRCm39) |
|
probably benign |
Het |
| H2bc27 |
A |
T |
11: 58,839,928 (GRCm39) |
I55F |
possibly damaging |
Het |
| Haus8 |
G |
A |
8: 71,708,767 (GRCm39) |
|
probably benign |
Het |
| Hip1 |
G |
A |
5: 135,463,995 (GRCm39) |
|
probably null |
Het |
| Hspbap1 |
T |
A |
16: 35,639,134 (GRCm39) |
|
probably null |
Het |
| Htr2b |
T |
A |
1: 86,027,151 (GRCm39) |
I452F |
possibly damaging |
Het |
| Hydin |
T |
A |
8: 111,296,440 (GRCm39) |
H3656Q |
probably benign |
Het |
| Klb |
T |
A |
5: 65,506,180 (GRCm39) |
D142E |
probably benign |
Het |
| Lamb3 |
A |
T |
1: 193,016,924 (GRCm39) |
T777S |
possibly damaging |
Het |
| Lins1 |
C |
A |
7: 66,364,070 (GRCm39) |
T650K |
probably damaging |
Het |
| Loxhd1 |
A |
G |
18: 77,369,667 (GRCm39) |
K5R |
possibly damaging |
Het |
| Lpp |
G |
A |
16: 24,580,405 (GRCm39) |
M40I |
probably damaging |
Het |
| Mia2 |
A |
T |
12: 59,217,037 (GRCm39) |
|
probably benign |
Het |
| Miip |
A |
C |
4: 147,947,549 (GRCm39) |
F204V |
probably damaging |
Het |
| Mmp21 |
T |
C |
7: 133,278,882 (GRCm39) |
R323G |
probably benign |
Het |
| Mta3 |
T |
A |
17: 84,062,980 (GRCm39) |
|
probably benign |
Het |
| Myh1 |
A |
G |
11: 67,104,456 (GRCm39) |
K1004R |
probably benign |
Het |
| Myh14 |
T |
A |
7: 44,281,853 (GRCm39) |
I810F |
probably damaging |
Het |
| Nbas |
A |
C |
12: 13,463,598 (GRCm39) |
D1295A |
probably damaging |
Het |
| Niban3 |
T |
C |
8: 72,056,413 (GRCm39) |
M371T |
possibly damaging |
Het |
| Npr2 |
T |
G |
4: 43,632,384 (GRCm39) |
V67G |
probably benign |
Het |
| Oas1f |
C |
A |
5: 120,993,492 (GRCm39) |
Q235K |
probably damaging |
Het |
| Or12d17 |
T |
A |
17: 37,777,938 (GRCm39) |
S280R |
probably damaging |
Het |
| Or13a27 |
T |
A |
7: 139,925,900 (GRCm39) |
M1L |
probably benign |
Het |
| Or1p1 |
G |
T |
11: 74,180,039 (GRCm39) |
C189F |
probably damaging |
Het |
| Or52ae9 |
T |
C |
7: 103,390,381 (GRCm39) |
N22S |
probably benign |
Het |
| Or7e166 |
C |
T |
9: 19,624,386 (GRCm39) |
H88Y |
probably benign |
Het |
| Pafah2 |
GCCCC |
GCCCCC |
4: 134,152,852 (GRCm39) |
|
probably null |
Het |
| Pde1b |
A |
G |
15: 103,433,767 (GRCm39) |
|
probably null |
Het |
| Pdilt |
T |
C |
7: 119,088,607 (GRCm39) |
T465A |
probably benign |
Het |
| Plxnd1 |
T |
C |
6: 115,943,507 (GRCm39) |
H1233R |
probably damaging |
Het |
| Ppm1b |
T |
A |
17: 85,301,552 (GRCm39) |
M144K |
probably benign |
Het |
| Prkdc |
T |
C |
16: 15,625,922 (GRCm39) |
L3316S |
probably benign |
Het |
| Prm2 |
T |
A |
16: 10,609,455 (GRCm39) |
|
probably benign |
Het |
| Prmt7 |
T |
C |
8: 106,963,640 (GRCm39) |
V240A |
probably benign |
Het |
| Prx |
C |
A |
7: 27,218,313 (GRCm39) |
A938E |
possibly damaging |
Het |
| Rbm7 |
A |
G |
9: 48,402,194 (GRCm39) |
V131A |
probably benign |
Het |
| Ric1 |
T |
A |
19: 29,578,213 (GRCm39) |
|
probably null |
Het |
| Rnf150 |
A |
T |
8: 83,590,639 (GRCm39) |
M1L |
possibly damaging |
Het |
| Rnf20 |
C |
T |
4: 49,644,628 (GRCm39) |
R298W |
probably damaging |
Het |
| Rp1 |
T |
A |
1: 4,417,455 (GRCm39) |
Y1219F |
possibly damaging |
Het |
| Scn7a |
A |
G |
2: 66,514,357 (GRCm39) |
|
probably null |
Het |
| Sdad1 |
A |
G |
5: 92,440,510 (GRCm39) |
|
probably null |
Het |
| Septin9 |
T |
C |
11: 117,243,909 (GRCm39) |
|
probably benign |
Het |
| Serinc3 |
T |
C |
2: 163,487,409 (GRCm39) |
|
probably benign |
Het |
| Shc3 |
C |
T |
13: 51,615,424 (GRCm39) |
G178R |
probably damaging |
Het |
| Slc4a10 |
A |
T |
2: 62,146,950 (GRCm39) |
K1090M |
probably damaging |
Het |
| Slco1a1 |
T |
C |
6: 141,868,837 (GRCm39) |
I376V |
probably benign |
Het |
| Slmap |
A |
T |
14: 26,143,729 (GRCm39) |
F719L |
probably benign |
Het |
| Smgc |
A |
G |
15: 91,743,956 (GRCm39) |
N573D |
possibly damaging |
Het |
| Spx |
G |
A |
6: 142,359,805 (GRCm39) |
|
probably null |
Het |
| Srrt |
C |
G |
5: 137,295,207 (GRCm39) |
E308Q |
probably damaging |
Het |
| Tas2r130 |
T |
A |
6: 131,607,560 (GRCm39) |
R78S |
probably benign |
Het |
| Tchhl1 |
A |
G |
3: 93,378,408 (GRCm39) |
R371G |
probably damaging |
Het |
| Teddm2 |
C |
T |
1: 153,726,194 (GRCm39) |
A174T |
probably benign |
Het |
| Tktl2 |
G |
A |
8: 66,964,999 (GRCm39) |
V186M |
probably damaging |
Het |
| Trim33 |
T |
C |
3: 103,231,956 (GRCm39) |
|
probably benign |
Het |
| Tspan31 |
A |
G |
10: 126,905,327 (GRCm39) |
V40A |
probably damaging |
Het |
| Uevld |
A |
G |
7: 46,594,975 (GRCm39) |
|
probably benign |
Het |
| Vcl |
G |
T |
14: 21,059,063 (GRCm39) |
A560S |
probably benign |
Het |
| Vmn2r24 |
T |
A |
6: 123,793,183 (GRCm39) |
C837S |
probably damaging |
Het |
| Vmn2r57 |
C |
T |
7: 41,077,531 (GRCm39) |
V212M |
probably damaging |
Het |
| Vps13c |
A |
G |
9: 67,843,622 (GRCm39) |
T1968A |
probably benign |
Het |
| Vtn |
A |
G |
11: 78,391,393 (GRCm39) |
R269G |
probably damaging |
Het |
| Wdcp |
G |
A |
12: 4,900,245 (GRCm39) |
V34I |
possibly damaging |
Het |
| Zc3h14 |
A |
G |
12: 98,719,091 (GRCm39) |
D152G |
possibly damaging |
Het |
| Zfp189 |
C |
T |
4: 49,529,266 (GRCm39) |
P123L |
probably benign |
Het |
| Zfp318 |
T |
C |
17: 46,716,981 (GRCm39) |
S1038P |
possibly damaging |
Het |
| Zfp873 |
A |
G |
10: 81,896,406 (GRCm39) |
D416G |
probably benign |
Het |
|
| Other mutations in Celsr2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00898:Celsr2
|
APN |
3 |
108,321,195 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01020:Celsr2
|
APN |
3 |
108,310,586 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01420:Celsr2
|
APN |
3 |
108,301,079 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL01448:Celsr2
|
APN |
3 |
108,300,555 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01559:Celsr2
|
APN |
3 |
108,314,183 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL01674:Celsr2
|
APN |
3 |
108,322,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01863:Celsr2
|
APN |
3 |
108,301,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02309:Celsr2
|
APN |
3 |
108,303,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02325:Celsr2
|
APN |
3 |
108,320,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02409:Celsr2
|
APN |
3 |
108,321,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02514:Celsr2
|
APN |
3 |
108,304,826 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02812:Celsr2
|
APN |
3 |
108,321,429 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02894:Celsr2
|
APN |
3 |
108,302,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03281:Celsr2
|
APN |
3 |
108,320,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
barrow
|
UTSW |
3 |
108,302,281 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
goldeneye
|
UTSW |
3 |
108,302,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
1mM(1):Celsr2
|
UTSW |
3 |
108,308,154 (GRCm39) |
missense |
probably benign |
0.01 |
|
ANU74:Celsr2
|
UTSW |
3 |
108,319,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02799:Celsr2
|
UTSW |
3 |
108,321,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0011:Celsr2
|
UTSW |
3 |
108,320,718 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0031:Celsr2
|
UTSW |
3 |
108,320,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0049:Celsr2
|
UTSW |
3 |
108,304,570 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0049:Celsr2
|
UTSW |
3 |
108,304,570 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0090:Celsr2
|
UTSW |
3 |
108,300,643 (GRCm39) |
splice site |
probably benign |
|
|
R0140:Celsr2
|
UTSW |
3 |
108,305,249 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0524:Celsr2
|
UTSW |
3 |
108,308,903 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0607:Celsr2
|
UTSW |
3 |
108,311,211 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0662:Celsr2
|
UTSW |
3 |
108,305,836 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0690:Celsr2
|
UTSW |
3 |
108,322,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0691:Celsr2
|
UTSW |
3 |
108,319,939 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0710:Celsr2
|
UTSW |
3 |
108,320,028 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0730:Celsr2
|
UTSW |
3 |
108,305,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0815:Celsr2
|
UTSW |
3 |
108,308,617 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0848:Celsr2
|
UTSW |
3 |
108,321,654 (GRCm39) |
missense |
probably benign |
|
|
R0989:Celsr2
|
UTSW |
3 |
108,310,588 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1185:Celsr2
|
UTSW |
3 |
108,307,025 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1185:Celsr2
|
UTSW |
3 |
108,307,025 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1185:Celsr2
|
UTSW |
3 |
108,307,025 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1469:Celsr2
|
UTSW |
3 |
108,321,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Celsr2
|
UTSW |
3 |
108,321,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1474:Celsr2
|
UTSW |
3 |
108,301,055 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1608:Celsr2
|
UTSW |
3 |
108,309,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1653:Celsr2
|
UTSW |
3 |
108,320,836 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1659:Celsr2
|
UTSW |
3 |
108,321,411 (GRCm39) |
missense |
probably benign |
|
|
R1689:Celsr2
|
UTSW |
3 |
108,314,620 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1859:Celsr2
|
UTSW |
3 |
108,303,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1918:Celsr2
|
UTSW |
3 |
108,305,966 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1974:Celsr2
|
UTSW |
3 |
108,321,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2042:Celsr2
|
UTSW |
3 |
108,309,811 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2167:Celsr2
|
UTSW |
3 |
108,320,509 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2333:Celsr2
|
UTSW |
3 |
108,305,921 (GRCm39) |
missense |
probably benign |
0.16 |
|
R2434:Celsr2
|
UTSW |
3 |
108,311,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2504:Celsr2
|
UTSW |
3 |
108,320,907 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3420:Celsr2
|
UTSW |
3 |
108,321,732 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3712:Celsr2
|
UTSW |
3 |
108,308,155 (GRCm39) |
missense |
probably benign |
|
|
R3723:Celsr2
|
UTSW |
3 |
108,304,731 (GRCm39) |
splice site |
probably benign |
|
|
R3809:Celsr2
|
UTSW |
3 |
108,310,555 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4018:Celsr2
|
UTSW |
3 |
108,302,281 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4126:Celsr2
|
UTSW |
3 |
108,309,413 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4177:Celsr2
|
UTSW |
3 |
108,321,294 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4232:Celsr2
|
UTSW |
3 |
108,321,088 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4293:Celsr2
|
UTSW |
3 |
108,300,993 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4458:Celsr2
|
UTSW |
3 |
108,302,313 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4621:Celsr2
|
UTSW |
3 |
108,302,532 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4645:Celsr2
|
UTSW |
3 |
108,303,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4700:Celsr2
|
UTSW |
3 |
108,304,547 (GRCm39) |
missense |
probably benign |
0.24 |
|
R4732:Celsr2
|
UTSW |
3 |
108,306,268 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4733:Celsr2
|
UTSW |
3 |
108,306,268 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4901:Celsr2
|
UTSW |
3 |
108,314,303 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4932:Celsr2
|
UTSW |
3 |
108,310,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4989:Celsr2
|
UTSW |
3 |
108,319,945 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5052:Celsr2
|
UTSW |
3 |
108,319,674 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5093:Celsr2
|
UTSW |
3 |
108,320,689 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5114:Celsr2
|
UTSW |
3 |
108,301,312 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5120:Celsr2
|
UTSW |
3 |
108,300,436 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5135:Celsr2
|
UTSW |
3 |
108,305,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5247:Celsr2
|
UTSW |
3 |
108,304,946 (GRCm39) |
missense |
probably benign |
0.34 |
|
R5381:Celsr2
|
UTSW |
3 |
108,310,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5412:Celsr2
|
UTSW |
3 |
108,307,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5445:Celsr2
|
UTSW |
3 |
108,299,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5528:Celsr2
|
UTSW |
3 |
108,320,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5598:Celsr2
|
UTSW |
3 |
108,310,119 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5652:Celsr2
|
UTSW |
3 |
108,304,051 (GRCm39) |
missense |
probably null |
0.49 |
|
R5697:Celsr2
|
UTSW |
3 |
108,311,237 (GRCm39) |
nonsense |
probably null |
|
|
R5718:Celsr2
|
UTSW |
3 |
108,300,674 (GRCm39) |
missense |
probably benign |
|
|
R5869:Celsr2
|
UTSW |
3 |
108,321,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5876:Celsr2
|
UTSW |
3 |
108,321,259 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6021:Celsr2
|
UTSW |
3 |
108,308,561 (GRCm39) |
missense |
probably benign |
|
|
R6054:Celsr2
|
UTSW |
3 |
108,314,279 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6244:Celsr2
|
UTSW |
3 |
108,300,444 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6313:Celsr2
|
UTSW |
3 |
108,308,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6322:Celsr2
|
UTSW |
3 |
108,319,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6555:Celsr2
|
UTSW |
3 |
108,302,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6682:Celsr2
|
UTSW |
3 |
108,307,817 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7062:Celsr2
|
UTSW |
3 |
108,309,826 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7110:Celsr2
|
UTSW |
3 |
108,305,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7139:Celsr2
|
UTSW |
3 |
108,322,675 (GRCm39) |
missense |
unknown |
|
|
R7326:Celsr2
|
UTSW |
3 |
108,302,311 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7425:Celsr2
|
UTSW |
3 |
108,309,773 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7452:Celsr2
|
UTSW |
3 |
108,320,406 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7461:Celsr2
|
UTSW |
3 |
108,302,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7502:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7613:Celsr2
|
UTSW |
3 |
108,302,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7644:Celsr2
|
UTSW |
3 |
108,320,806 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7666:Celsr2
|
UTSW |
3 |
108,305,904 (GRCm39) |
missense |
probably benign |
|
|
R7687:Celsr2
|
UTSW |
3 |
108,305,085 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7695:Celsr2
|
UTSW |
3 |
108,310,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8002:Celsr2
|
UTSW |
3 |
108,311,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8052:Celsr2
|
UTSW |
3 |
108,319,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8283:Celsr2
|
UTSW |
3 |
108,303,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8356:Celsr2
|
UTSW |
3 |
108,320,847 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8381:Celsr2
|
UTSW |
3 |
108,302,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8427:Celsr2
|
UTSW |
3 |
108,299,949 (GRCm39) |
makesense |
probably null |
|
|
R8435:Celsr2
|
UTSW |
3 |
108,321,715 (GRCm39) |
missense |
probably benign |
|
|
R8438:Celsr2
|
UTSW |
3 |
108,301,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8458:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8460:Celsr2
|
UTSW |
3 |
108,304,093 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8462:Celsr2
|
UTSW |
3 |
108,320,167 (GRCm39) |
nonsense |
probably null |
|
|
R8479:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8480:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8512:Celsr2
|
UTSW |
3 |
108,321,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8694:Celsr2
|
UTSW |
3 |
108,314,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8772:Celsr2
|
UTSW |
3 |
108,304,389 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8843:Celsr2
|
UTSW |
3 |
108,303,443 (GRCm39) |
splice site |
probably benign |
|
|
R8888:Celsr2
|
UTSW |
3 |
108,320,880 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8895:Celsr2
|
UTSW |
3 |
108,320,880 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8917:Celsr2
|
UTSW |
3 |
108,303,882 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9119:Celsr2
|
UTSW |
3 |
108,309,288 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9169:Celsr2
|
UTSW |
3 |
108,309,862 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9209:Celsr2
|
UTSW |
3 |
108,321,349 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9342:Celsr2
|
UTSW |
3 |
108,320,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9416:Celsr2
|
UTSW |
3 |
108,322,084 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9493:Celsr2
|
UTSW |
3 |
108,301,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9564:Celsr2
|
UTSW |
3 |
108,321,834 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9598:Celsr2
|
UTSW |
3 |
108,322,578 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9629:Celsr2
|
UTSW |
3 |
108,308,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9691:Celsr2
|
UTSW |
3 |
108,301,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0020:Celsr2
|
UTSW |
3 |
108,303,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0050:Celsr2
|
UTSW |
3 |
108,308,588 (GRCm39) |
missense |
probably benign |
0.09 |
|
Z1088:Celsr2
|
UTSW |
3 |
108,321,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Celsr2
|
UTSW |
3 |
108,319,657 (GRCm39) |
missense |
probably benign |
0.07 |
|
Z1176:Celsr2
|
UTSW |
3 |
108,300,447 (GRCm39) |
missense |
probably benign |
0.10 |
|
Z1177:Celsr2
|
UTSW |
3 |
108,320,887 (GRCm39) |
missense |
probably benign |
0.32 |
|
Z1177:Celsr2
|
UTSW |
3 |
108,319,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1191:Celsr2
|
UTSW |
3 |
108,321,865 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAGAGATGGAGTGTGACCCGTG -3'
(R):5'- TGCACCTGAGCAATATTACAGTC -3'
Sequencing Primer
(F):5'- AGTGTGACCCGTGGCACTG -3'
(R):5'- CAATATTACAGTCGGGGGAGTTCC -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation