Mutagenetix > Incidental Mutation

Incidental Mutation 'R1848:Fat2'

207925

Institutional Source

Beutler Lab

Gene Symbol

Fat2

Ensembl Gene

ENSMUSG00000055333

Gene Name

FAT atypical cadherin 2

Synonyms

mKIAA0811, LOC245827, Fath2, EMI2

MMRRC Submission

039873-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1848 (G1)

Quality Score

202

Status

Validated

Chromosome

Chromosomal Location

55250609-55336564 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 55311558 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 230 (I230T)

Ref Sequence

ENSEMBL: ENSMUSP00000104492 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068853] [ENSMUST00000108864]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000068853
AA Change: I230T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000067556
Gene: ENSMUSG00000055333
AA Change: I230T

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CA	55	146	3.65e-4	SMART
CA	170	254	3.99e-10	SMART
low complexity region	337	348	N/A	INTRINSIC
CA	384	456	5.11e-8	SMART
CA	480	562	2.71e-21	SMART
CA	586	664	1.12e-2	SMART
CA	737	818	1.69e-22	SMART
CA	842	923	9.59e-22	SMART
CA	947	1028	7.39e-14	SMART
CA	1054	1135	3.74e-24	SMART
CA	1159	1240	1.84e-23	SMART
CA	1266	1342	8.9e-8	SMART
CA	1368	1446	7.4e-5	SMART
CA	1470	1553	1.98e-14	SMART
CA	1577	1658	6.84e-18	SMART
CA	1682	1756	2.76e-13	SMART
CA	1787	1870	1.49e-18	SMART
CA	1894	1966	1.11e-1	SMART
CA	1990	2068	2.4e-13	SMART
CA	2092	2171	3.42e-18	SMART
CA	2190	2270	1.9e-16	SMART
CA	2294	2377	1.49e-27	SMART
CA	2401	2479	8.31e-8	SMART
CA	2503	2583	6.48e-19	SMART
CA	2607	2690	1.53e-6	SMART
CA	2714	2797	3e-14	SMART
CA	2821	2906	5.85e-26	SMART
CA	2930	3011	4.58e-19	SMART
CA	3035	3113	2.1e-27	SMART
CA	3137	3218	9.67e-18	SMART
CA	3243	3321	1.92e-12	SMART
CA	3345	3426	4.04e-29	SMART
CA	3450	3531	1.79e-12	SMART
CA	3555	3629	9.3e-2	SMART
LamG	3794	3923	1.77e-28	SMART
EGF	3952	3986	6.5e-5	SMART
EGF	3991	4024	1.6e-4	SMART
transmembrane domain	4051	4073	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000108864
AA Change: I230T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000104492
Gene: ENSMUSG00000055333
AA Change: I230T

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CA	55	146	3.65e-4	SMART
CA	170	254	3.99e-10	SMART
low complexity region	337	348	N/A	INTRINSIC
CA	384	456	5.11e-8	SMART
CA	480	562	2.71e-21	SMART
CA	586	664	1.12e-2	SMART
CA	737	818	1.69e-22	SMART
CA	842	923	9.59e-22	SMART
CA	947	1028	7.39e-14	SMART
CA	1054	1135	3.74e-24	SMART
CA	1159	1240	1.84e-23	SMART
CA	1266	1342	8.9e-8	SMART
CA	1368	1446	7.4e-5	SMART
CA	1470	1553	1.98e-14	SMART
CA	1577	1658	6.84e-18	SMART
CA	1682	1756	2.76e-13	SMART
CA	1787	1870	1.49e-18	SMART
CA	1894	1966	1.11e-1	SMART
CA	1990	2068	2.4e-13	SMART
CA	2092	2171	3.42e-18	SMART
CA	2190	2270	1.9e-16	SMART
CA	2294	2377	1.49e-27	SMART
CA	2401	2479	8.31e-8	SMART
CA	2503	2583	6.48e-19	SMART
CA	2607	2690	1.53e-6	SMART
CA	2714	2797	3e-14	SMART
CA	2821	2906	5.85e-26	SMART
CA	2930	3011	4.58e-19	SMART
CA	3035	3113	2.1e-27	SMART
CA	3137	3218	9.67e-18	SMART
CA	3243	3321	1.92e-12	SMART
CA	3345	3426	4.04e-29	SMART
CA	3450	3531	1.79e-12	SMART
CA	3555	3629	9.3e-2	SMART
LamG	3794	3923	1.77e-28	SMART
EGF	3952	3986	6.5e-5	SMART
EGF	3991	4024	1.6e-4	SMART
transmembrane domain	4051	4073	N/A	INTRINSIC

Meta Mutation Damage Score

0.1365

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 95.2%
20x: 92.2%

Validation Efficiency

98% (120/123)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele are healthy, fertile and overtly normal, with no apparent defects in the development of red blood cells or platelets. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 120 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933402J07Rik	C	A	8: 87,568,493	Y86*	probably null	Het
Aadac	A	G	3: 60,039,697	E272G	probably damaging	Het
Abcc8	A	T	7: 46,166,902	D271E	probably benign	Het
Acan	T	C	7: 79,099,035	F1185L	probably benign	Het
Adam1a	A	T	5: 121,519,620	C537S	probably damaging	Het
Ago2	A	G	15: 73,123,965	V395A	probably benign	Het
Alox15	A	G	11: 70,350,752	V101A	probably damaging	Het
Ankra2	T	C	13: 98,271,124	I194T	probably damaging	Het
Apobec4	C	A	1: 152,756,230	P3H	probably damaging	Het
Arid3b	G	T	9: 57,796,677	Y329*	probably null	Het
Atm	A	T	9: 53,468,012	S1993T	probably benign	Het
Bpgm	T	G	6: 34,487,734	S129A	probably benign	Het
Brat1	A	G	5: 140,718,509	D839G	possibly damaging	Het
Ccdc15	A	T	9: 37,342,570	S128T	probably benign	Het
Cd300lg	A	T	11: 102,046,206		probably benign	Het
Cdc34b	C	A	11: 94,742,477	Q168K	probably damaging	Het
Celsr2	A	T	3: 108,401,310	V1767E	probably benign	Het
Cep350	T	C	1: 155,953,651	D169G	probably benign	Het
Col7a1	A	T	9: 108,969,565	D1762V	possibly damaging	Het
Coro7	A	G	16: 4,630,434	L724P	probably damaging	Het
Crb1	T	A	1: 139,237,012	I1125F	probably damaging	Het
Ctif	T	A	18: 75,519,941	D415V	probably damaging	Het
Dab1	C	T	4: 104,731,751	A524V	probably benign	Het
Dhrs2	A	G	14: 55,240,841	D237G	probably benign	Het
Dhx9	T	C	1: 153,465,753	Q582R	probably damaging	Het
Dnajc1	C	T	2: 18,219,713	R443Q	probably damaging	Het
Dnm2	C	T	9: 21,505,681	R837W	possibly damaging	Het
Dpf2	C	A	19: 5,906,615	Q70H	probably damaging	Het
Dqx1	T	A	6: 83,066,107	D608E	probably damaging	Het
Dync2h1	T	A	9: 7,049,166	T3245S	probably benign	Het
Ect2l	A	G	10: 18,200,033	L35P	probably damaging	Het
Efcab5	A	T	11: 77,103,306	L1285Q	probably damaging	Het
Eif4g1	G	C	16: 20,681,867	R697P	probably damaging	Het
Emsy	T	A	7: 98,600,821	E753V	probably damaging	Het
Entpd3	A	G	9: 120,558,419	I227M	probably damaging	Het
Epn1	T	A	7: 5,089,998	V103E	probably damaging	Het
Esrra	T	C	19: 6,912,010	D337G	probably benign	Het
Fam129c	T	C	8: 71,603,769	M371T	possibly damaging	Het
Fam83e	A	T	7: 45,728,769	K406*	probably null	Het
Fam83e	A	T	7: 45,728,770	K406M	possibly damaging	Het
Fbxl16	A	G	17: 25,816,446	I6V	probably benign	Het
Fgf23	T	C	6: 127,073,193	I55T	probably damaging	Het
Fibcd1	T	A	2: 31,821,549	D288V	probably damaging	Het
Flnb	T	C	14: 7,892,113	I594T	probably damaging	Het
Gabbr2	T	C	4: 46,739,823	E449G	probably benign	Het
Gbf1	T	G	19: 46,272,037	S1130A	possibly damaging	Het
Gipc3	T	C	10: 81,341,265	E157G	probably damaging	Het
Glra3	G	T	8: 55,940,907	A18S	probably benign	Het
Gm6625	A	C	8: 89,146,834		noncoding transcript	Het
Gpx4	A	G	10: 80,056,036		probably benign	Het
Grb10	A	G	11: 11,946,029	F264L	possibly damaging	Het
Grik3	T	C	4: 125,694,138	Y684H	probably damaging	Het
Gstp1	C	T	19: 4,036,795		probably benign	Het
Haus8	G	A	8: 71,256,123		probably benign	Het
Hip1	G	A	5: 135,435,141		probably null	Het
Hist3h2ba	A	T	11: 58,949,102	I55F	possibly damaging	Het
Hspbap1	T	A	16: 35,818,764		probably null	Het
Htr2b	T	A	1: 86,099,429	I452F	possibly damaging	Het
Hydin	T	A	8: 110,569,808	H3656Q	probably benign	Het
Klb	T	A	5: 65,348,837	D142E	probably benign	Het
Lamb3	A	T	1: 193,334,616	T777S	possibly damaging	Het
Lins1	C	A	7: 66,714,322	T650K	probably damaging	Het
Loxhd1	A	G	18: 77,281,971	K5R	possibly damaging	Het
Lpp	G	A	16: 24,761,655	M40I	probably damaging	Het
Mia2	A	T	12: 59,170,251		probably benign	Het
Miip	A	C	4: 147,863,092	F204V	probably damaging	Het
Mmp21	T	C	7: 133,677,153	R323G	probably benign	Het
Mta3	T	A	17: 83,755,551		probably benign	Het
Myh1	A	G	11: 67,213,630	K1004R	probably benign	Het
Myh14	T	A	7: 44,632,429	I810F	probably damaging	Het
Nbas	A	C	12: 13,413,597	D1295A	probably damaging	Het
Npr2	T	G	4: 43,632,384	V67G	probably benign	Het
Oas1f	C	A	5: 120,855,429	Q235K	probably damaging	Het
Olfr109	T	A	17: 37,467,047	S280R	probably damaging	Het
Olfr59	G	T	11: 74,289,213	C189F	probably damaging	Het
Olfr60	T	A	7: 140,345,987	M1L	probably benign	Het
Olfr629	T	C	7: 103,741,174	N22S	probably benign	Het
Olfr857	C	T	9: 19,713,090	H88Y	probably benign	Het
Pafah2	GCCCC	GCCCCC	4: 134,425,541		probably null	Het
Pde1b	A	G	15: 103,525,340		probably null	Het
Pdilt	T	C	7: 119,489,384	T465A	probably benign	Het
Plxnd1	T	C	6: 115,966,546	H1233R	probably damaging	Het
Ppm1b	T	A	17: 84,994,124	M144K	probably benign	Het
Prkdc	T	C	16: 15,808,058	L3316S	probably benign	Het
Prm2	T	A	16: 10,791,591		probably benign	Het
Prmt7	T	C	8: 106,237,008	V240A	probably benign	Het
Prx	C	A	7: 27,518,888	A938E	possibly damaging	Het
Rbm7	A	G	9: 48,490,894	V131A	probably benign	Het
Ric1	T	A	19: 29,600,813		probably null	Het
Rnf150	A	T	8: 82,864,010	M1L	possibly damaging	Het
Rnf20	C	T	4: 49,644,628	R298W	probably damaging	Het
Rp1	T	A	1: 4,347,232	Y1219F	possibly damaging	Het
Scn7a	A	G	2: 66,684,013		probably null	Het
Sdad1	A	G	5: 92,292,651		probably null	Het
Sept9	T	C	11: 117,353,083		probably benign	Het
Serinc3	T	C	2: 163,645,489		probably benign	Het
Shc3	C	T	13: 51,461,388	G178R	probably damaging	Het
Slc4a10	A	T	2: 62,316,606	K1090M	probably damaging	Het
Slco1a1	T	C	6: 141,923,111	I376V	probably benign	Het
Slmap	A	T	14: 26,422,574	F719L	probably benign	Het
Smgc	A	G	15: 91,859,758	N573D	possibly damaging	Het
Spx	G	A	6: 142,414,079		probably null	Het
Srrt	C	G	5: 137,296,945	E308Q	probably damaging	Het
Tas2r130	T	A	6: 131,630,597	R78S	probably benign	Het
Tchhl1	A	G	3: 93,471,101	R371G	probably damaging	Het
Teddm2	C	T	1: 153,850,448	A174T	probably benign	Het
Tktl2	G	A	8: 66,512,347	V186M	probably damaging	Het
Trim33	T	C	3: 103,324,640		probably benign	Het
Tspan31	A	G	10: 127,069,458	V40A	probably damaging	Het
Uevld	A	G	7: 46,945,227		probably benign	Het
Vcl	G	T	14: 21,008,995	A560S	probably benign	Het
Vmn2r24	T	A	6: 123,816,224	C837S	probably damaging	Het
Vmn2r57	C	T	7: 41,428,107	V212M	probably damaging	Het
Vps13c	A	G	9: 67,936,340	T1968A	probably benign	Het
Vtn	A	G	11: 78,500,567	R269G	probably damaging	Het
Wdcp	G	A	12: 4,850,245	V34I	possibly damaging	Het
Zc3h14	A	G	12: 98,752,832	D152G	possibly damaging	Het
Zfp189	C	T	4: 49,529,266	P123L	probably benign	Het
Zfp318	T	C	17: 46,406,055	S1038P	possibly damaging	Het
Zfp873	A	G	10: 82,060,572	D416G	probably benign	Het

Other mutations in Fat2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00720:Fat2	APN	11	55311244	missense	probably benign
IGL00897:Fat2	APN	11	55289252	missense	probably damaging	0.99
IGL01161:Fat2	APN	11	55284191	missense	probably benign
IGL01306:Fat2	APN	11	55310872	missense	probably benign	0.28
IGL01393:Fat2	APN	11	55269309	missense	probably benign	0.00
IGL01529:Fat2	APN	11	55282156	missense	probably damaging	1.00
IGL01530:Fat2	APN	11	55283387	missense	probably benign	0.42
IGL01555:Fat2	APN	11	55278930	missense	probably damaging	0.99
IGL01758:Fat2	APN	11	55296209	missense	probably damaging	1.00
IGL01768:Fat2	APN	11	55262568	missense	probably damaging	1.00
IGL01939:Fat2	APN	11	55283980	missense	probably benign	0.01
IGL01941:Fat2	APN	11	55312005	missense	probably benign	0.01
IGL01967:Fat2	APN	11	55311823	missense	probably damaging	1.00
IGL01978:Fat2	APN	11	55270146	missense	probably benign	0.34
IGL01998:Fat2	APN	11	55296195	missense	probably benign	0.00
IGL02001:Fat2	APN	11	55312245	start codon destroyed	probably null	0.89
IGL02004:Fat2	APN	11	55282840	missense	probably damaging	1.00
IGL02103:Fat2	APN	11	55289296	missense	probably damaging	0.96
IGL02131:Fat2	APN	11	55309042	missense	probably damaging	1.00
IGL02155:Fat2	APN	11	55262419	missense	probably benign	0.00
IGL02223:Fat2	APN	11	55273129	missense	probably benign	0.01
IGL02231:Fat2	APN	11	55281092	missense	probably damaging	0.98
IGL02312:Fat2	APN	11	55270259	missense	probably damaging	1.00
IGL02476:Fat2	APN	11	55311124	missense	probably damaging	1.00
IGL02539:Fat2	APN	11	55281793	missense	probably damaging	1.00
IGL02553:Fat2	APN	11	55311283	missense	probably damaging	1.00
IGL02645:Fat2	APN	11	55282828	missense	probably damaging	1.00
IGL02664:Fat2	APN	11	55311096	missense	probably damaging	1.00
IGL02708:Fat2	APN	11	55282385	missense	probably damaging	0.99
IGL02883:Fat2	APN	11	55256618	missense	probably benign	0.16
IGL02894:Fat2	APN	11	55256653	missense	probably damaging	1.00
IGL02975:Fat2	APN	11	55270194	missense	probably benign	0.00
IGL03085:Fat2	APN	11	55283246	missense	probably benign	0.09
IGL03106:Fat2	APN	11	55311901	missense	probably benign	0.45
IGL03132:Fat2	APN	11	55253920	missense	probably benign	0.25
IGL03133:Fat2	APN	11	55286043	missense	probably benign	0.01
IGL03194:Fat2	APN	11	55310995	missense	probably benign	0.02
IGL03266:Fat2	APN	11	55284029	missense	possibly damaging	0.62
IGL03290:Fat2	APN	11	55256219	missense	probably benign	0.33
IGL03291:Fat2	APN	11	55262595	missense	probably benign
IGL03325:Fat2	APN	11	55282342	missense	probably damaging	1.00
IGL03345:Fat2	APN	11	55282361	missense	probably damaging	1.00
IGL03371:Fat2	APN	11	55311164	missense	probably benign	0.10
ANU23:Fat2	UTSW	11	55310872	missense	probably benign	0.28
BB001:Fat2	UTSW	11	55262787	missense	probably benign	0.03
BB011:Fat2	UTSW	11	55262787	missense	probably benign	0.03
P0040:Fat2	UTSW	11	55282213	missense	possibly damaging	0.89
PIT4504001:Fat2	UTSW	11	55256110	missense	possibly damaging	0.68
R0008:Fat2	UTSW	11	55311249	missense	probably damaging	1.00
R0008:Fat2	UTSW	11	55311249	missense	probably damaging	1.00
R0012:Fat2	UTSW	11	55262871	missense	probably benign	0.16
R0012:Fat2	UTSW	11	55262871	missense	probably benign	0.16
R0048:Fat2	UTSW	11	55310039	missense	probably benign	0.00
R0048:Fat2	UTSW	11	55310039	missense	probably benign	0.00
R0098:Fat2	UTSW	11	55298605	missense	probably damaging	0.98
R0124:Fat2	UTSW	11	55283678	missense	probably damaging	0.98
R0127:Fat2	UTSW	11	55289286	missense	probably benign	0.01
R0130:Fat2	UTSW	11	55252118	missense	probably benign	0.26
R0131:Fat2	UTSW	11	55273211	missense	probably benign
R0158:Fat2	UTSW	11	55296185	missense	probably benign	0.00
R0184:Fat2	UTSW	11	55296288	missense	probably damaging	1.00
R0367:Fat2	UTSW	11	55292093	splice site	probably benign
R0384:Fat2	UTSW	11	55269465	missense	possibly damaging	0.81
R0390:Fat2	UTSW	11	55310777	missense	probably damaging	0.99
R0403:Fat2	UTSW	11	55270349	missense	probably benign	0.42
R0416:Fat2	UTSW	11	55284134	missense	possibly damaging	0.94
R0437:Fat2	UTSW	11	55282799	missense	probably benign	0.02
R0463:Fat2	UTSW	11	55262829	missense	probably damaging	1.00
R0497:Fat2	UTSW	11	55283402	missense	probably benign	0.03
R0617:Fat2	UTSW	11	55311843	missense	possibly damaging	0.60
R0622:Fat2	UTSW	11	55283128	missense	probably damaging	1.00
R0675:Fat2	UTSW	11	55309209	missense	probably damaging	0.97
R0811:Fat2	UTSW	11	55253633	missense	possibly damaging	0.75
R0812:Fat2	UTSW	11	55253633	missense	possibly damaging	0.75
R0869:Fat2	UTSW	11	55311775	missense	probably benign	0.08
R0870:Fat2	UTSW	11	55311775	missense	probably benign	0.08
R0899:Fat2	UTSW	11	55256225	missense	probably damaging	1.00
R1278:Fat2	UTSW	11	55268179	missense	probably damaging	1.00
R1383:Fat2	UTSW	11	55310773	missense	probably benign
R1428:Fat2	UTSW	11	55296087	missense	probably damaging	1.00
R1438:Fat2	UTSW	11	55287811	missense	probably damaging	1.00
R1495:Fat2	UTSW	11	55262673	missense	probably benign
R1506:Fat2	UTSW	11	55284264	missense	probably benign
R1547:Fat2	UTSW	11	55252255	missense	probably benign	0.01
R1554:Fat2	UTSW	11	55253664	missense	probably benign	0.01
R1562:Fat2	UTSW	11	55309974	missense	probably damaging	1.00
R1588:Fat2	UTSW	11	55283404	missense	probably damaging	1.00
R1592:Fat2	UTSW	11	55291870	splice site	probably null
R1601:Fat2	UTSW	11	55282010	missense	probably benign	0.01
R1610:Fat2	UTSW	11	55278924	missense	probably damaging	1.00
R1634:Fat2	UTSW	11	55267684	missense	probably damaging	1.00
R1634:Fat2	UTSW	11	55284719	missense	probably benign
R1644:Fat2	UTSW	11	55287783	missense	possibly damaging	0.91
R1644:Fat2	UTSW	11	55296181	missense	possibly damaging	0.94
R1691:Fat2	UTSW	11	55311852	missense	probably damaging	0.99
R1734:Fat2	UTSW	11	55281371	missense	probably benign	0.00
R1748:Fat2	UTSW	11	55256647	missense	probably damaging	0.97
R1771:Fat2	UTSW	11	55310865	missense	probably benign	0.01
R1800:Fat2	UTSW	11	55283892	missense	probably damaging	1.00
R1807:Fat2	UTSW	11	55289259	missense	probably damaging	1.00
R1823:Fat2	UTSW	11	55256780	missense	probably benign	0.29
R1866:Fat2	UTSW	11	55292014	missense	probably benign	0.00
R1899:Fat2	UTSW	11	55262178	missense	probably benign
R1954:Fat2	UTSW	11	55311084	missense	probably benign	0.06
R2010:Fat2	UTSW	11	55253827	missense	probably damaging	0.99
R2011:Fat2	UTSW	11	55282757	missense	probably damaging	1.00
R2057:Fat2	UTSW	11	55281860	missense	possibly damaging	0.60
R2081:Fat2	UTSW	11	55309677	missense	possibly damaging	0.94
R2106:Fat2	UTSW	11	55256564	missense	probably benign	0.00
R2165:Fat2	UTSW	11	55303716	missense	probably benign	0.00
R2176:Fat2	UTSW	11	55267575	critical splice donor site	probably null
R2284:Fat2	UTSW	11	55282360	missense	probably damaging	1.00
R2338:Fat2	UTSW	11	55311901	missense	possibly damaging	0.93
R2340:Fat2	UTSW	11	55270096	missense	possibly damaging	0.90
R2427:Fat2	UTSW	11	55310812	missense	probably benign	0.15
R2444:Fat2	UTSW	11	55281973	missense	probably damaging	1.00
R2858:Fat2	UTSW	11	55283773	missense	possibly damaging	0.94
R2882:Fat2	UTSW	11	55311305	missense	probably damaging	0.96
R3029:Fat2	UTSW	11	55284709	missense	probably damaging	1.00
R3085:Fat2	UTSW	11	55252171	missense	possibly damaging	0.79
R3121:Fat2	UTSW	11	55311796	missense	probably damaging	1.00
R3418:Fat2	UTSW	11	55278998	missense	probably benign	0.01
R3500:Fat2	UTSW	11	55260516	missense	probably damaging	0.99
R3607:Fat2	UTSW	11	55281685	missense	probably damaging	1.00
R3611:Fat2	UTSW	11	55312069	missense	probably benign
R3620:Fat2	UTSW	11	55256695	missense	probably damaging	0.97
R3688:Fat2	UTSW	11	55281101	missense	probably damaging	0.99
R3704:Fat2	UTSW	11	55309650	missense	probably damaging	1.00
R3784:Fat2	UTSW	11	55256186	missense	probably benign
R3889:Fat2	UTSW	11	55281763	missense	probably damaging	1.00
R3951:Fat2	UTSW	11	55296382	missense	probably benign	0.00
R4211:Fat2	UTSW	11	55283984	missense	probably damaging	1.00
R4249:Fat2	UTSW	11	55284301	missense	probably damaging	0.98
R4406:Fat2	UTSW	11	55262268	missense	probably benign	0.00
R4433:Fat2	UTSW	11	55309640	missense	possibly damaging	0.91
R4436:Fat2	UTSW	11	55296198	missense	probably damaging	1.00
R4498:Fat2	UTSW	11	55270097	missense	possibly damaging	0.90
R4560:Fat2	UTSW	11	55265951	missense	possibly damaging	0.89
R4594:Fat2	UTSW	11	55284752	missense	possibly damaging	0.78
R4663:Fat2	UTSW	11	55296213	nonsense	probably null
R4669:Fat2	UTSW	11	55311615	missense	probably benign	0.01
R4696:Fat2	UTSW	11	55285015	missense	probably benign	0.00
R4734:Fat2	UTSW	11	55311468	missense	probably benign	0.01
R4749:Fat2	UTSW	11	55311468	missense	probably benign	0.01
R4765:Fat2	UTSW	11	55281187	missense	probably damaging	1.00
R4803:Fat2	UTSW	11	55285060	missense	probably benign	0.03
R4805:Fat2	UTSW	11	55283979	missense	probably benign	0.01
R4822:Fat2	UTSW	11	55311318	missense	probably benign	0.02
R4840:Fat2	UTSW	11	55279018	missense	probably benign	0.21
R4849:Fat2	UTSW	11	55310637	missense	probably damaging	1.00
R4943:Fat2	UTSW	11	55279033	missense	probably benign	0.00
R4993:Fat2	UTSW	11	55283092	missense	probably damaging	0.99
R5097:Fat2	UTSW	11	55310704	missense	probably damaging	1.00
R5104:Fat2	UTSW	11	55278988	missense	possibly damaging	0.93
R5115:Fat2	UTSW	11	55296333	missense	probably damaging	1.00
R5213:Fat2	UTSW	11	55253832	missense	probably benign	0.00
R5254:Fat2	UTSW	11	55281175	missense	probably damaging	1.00
R5269:Fat2	UTSW	11	55287878	missense	probably benign	0.00
R5288:Fat2	UTSW	11	55267656	missense	probably benign	0.00
R5355:Fat2	UTSW	11	55282166	missense	probably damaging	1.00
R5375:Fat2	UTSW	11	55262820	missense	probably benign	0.00
R5379:Fat2	UTSW	11	55303941	missense	probably damaging	0.99
R5411:Fat2	UTSW	11	55252226	missense	probably benign	0.23
R5416:Fat2	UTSW	11	55303688	missense	possibly damaging	0.77
R5480:Fat2	UTSW	11	55310086	missense	probably damaging	0.99
R5486:Fat2	UTSW	11	55253681	missense	probably benign	0.00
R5526:Fat2	UTSW	11	55269361	missense	possibly damaging	0.90
R5532:Fat2	UTSW	11	55262337	missense	probably damaging	1.00
R5583:Fat2	UTSW	11	55253889	missense	probably benign	0.00
R5588:Fat2	UTSW	11	55282277	missense	probably damaging	1.00
R5598:Fat2	UTSW	11	55281130	missense	probably damaging	1.00
R5636:Fat2	UTSW	11	55282481	missense	probably damaging	1.00
R5653:Fat2	UTSW	11	55310316	missense	probably damaging	1.00
R5657:Fat2	UTSW	11	55310681	nonsense	probably null
R5660:Fat2	UTSW	11	55284176	missense	probably benign	0.00
R5752:Fat2	UTSW	11	55289237	missense	possibly damaging	0.48
R5757:Fat2	UTSW	11	55252346	missense	probably damaging	1.00
R5792:Fat2	UTSW	11	55262325	missense	possibly damaging	0.77
R5872:Fat2	UTSW	11	55270382	missense	probably damaging	1.00
R5933:Fat2	UTSW	11	55284051	missense	probably damaging	1.00
R6030:Fat2	UTSW	11	55310303	nonsense	probably null
R6030:Fat2	UTSW	11	55310303	nonsense	probably null
R6032:Fat2	UTSW	11	55253934	missense	probably damaging	1.00
R6032:Fat2	UTSW	11	55253934	missense	probably damaging	1.00
R6221:Fat2	UTSW	11	55296072	critical splice donor site	probably null
R6253:Fat2	UTSW	11	55296271	missense	probably damaging	1.00
R6257:Fat2	UTSW	11	55262581	missense	probably benign
R6307:Fat2	UTSW	11	55281280	missense	possibly damaging	0.63
R6450:Fat2	UTSW	11	55289310	missense	probably damaging	0.97
R6453:Fat2	UTSW	11	55282216	missense	probably benign	0.29
R6455:Fat2	UTSW	11	55270457	missense	probably damaging	0.96
R6483:Fat2	UTSW	11	55296345	missense	probably damaging	1.00
R6504:Fat2	UTSW	11	55262397	missense	probably benign	0.00
R6520:Fat2	UTSW	11	55284988	missense	probably damaging	0.99
R6525:Fat2	UTSW	11	55283800	missense	probably damaging	1.00
R6617:Fat2	UTSW	11	55296105	missense	probably benign	0.01
R6652:Fat2	UTSW	11	55252262	missense	probably benign
R6679:Fat2	UTSW	11	55309305	missense	probably damaging	1.00
R6680:Fat2	UTSW	11	55310858	nonsense	probably null
R6762:Fat2	UTSW	11	55253482	splice site	probably null
R6810:Fat2	UTSW	11	55282241	missense	possibly damaging	0.88
R6818:Fat2	UTSW	11	55309341	missense	probably benign	0.31
R6919:Fat2	UTSW	11	55282771	missense	possibly damaging	0.68
R6939:Fat2	UTSW	11	55252474	nonsense	probably null
R6941:Fat2	UTSW	11	55262088	missense	probably benign
R7023:Fat2	UTSW	11	55310502	missense	probably benign	0.00
R7027:Fat2	UTSW	11	55269433	missense	probably benign	0.03
R7027:Fat2	UTSW	11	55281851	nonsense	probably null
R7095:Fat2	UTSW	11	55311331	missense	probably damaging	1.00
R7102:Fat2	UTSW	11	55283434	missense	probably damaging	1.00
R7116:Fat2	UTSW	11	55282336	missense	probably damaging	1.00
R7117:Fat2	UTSW	11	55281262	missense	probably damaging	1.00
R7167:Fat2	UTSW	11	55285001	missense	possibly damaging	0.48
R7213:Fat2	UTSW	11	55281045	nonsense	probably null
R7246:Fat2	UTSW	11	55296382	missense	probably benign	0.00
R7252:Fat2	UTSW	11	55311262	missense	probably damaging	0.98
R7266:Fat2	UTSW	11	55285030	missense	probably damaging	0.99
R7316:Fat2	UTSW	11	55286067	missense	probably damaging	1.00
R7326:Fat2	UTSW	11	55282304	missense	probably damaging	0.99
R7355:Fat2	UTSW	11	55256551	missense	probably benign	0.00
R7431:Fat2	UTSW	11	55309101	missense	probably damaging	1.00
R7459:Fat2	UTSW	11	55303919	missense	probably damaging	1.00
R7460:Fat2	UTSW	11	55278963	missense	probably damaging	1.00
R7466:Fat2	UTSW	11	55310432	missense	probably damaging	1.00
R7475:Fat2	UTSW	11	55303653	missense	probably benign	0.31
R7678:Fat2	UTSW	11	55282330	missense	probably damaging	0.99
R7689:Fat2	UTSW	11	55309840	missense	probably damaging	1.00
R7704:Fat2	UTSW	11	55284347	missense	probably benign	0.03
R7710:Fat2	UTSW	11	55310763	missense	probably benign	0.35
R7724:Fat2	UTSW	11	55284796	missense	probably damaging	1.00
R7731:Fat2	UTSW	11	55310706	missense	probably damaging	1.00
R7739:Fat2	UTSW	11	55281131	nonsense	probably null
R7757:Fat2	UTSW	11	55311421	missense	probably benign	0.00
R7876:Fat2	UTSW	11	55311220	missense	probably benign	0.01
R7883:Fat2	UTSW	11	55253364	splice site	probably null
R7924:Fat2	UTSW	11	55262787	missense	probably benign	0.03
R7936:Fat2	UTSW	11	55310167	missense	probably benign
R7936:Fat2	UTSW	11	55311160	nonsense	probably null
R7938:Fat2	UTSW	11	55273096	missense	probably damaging	1.00
R7947:Fat2	UTSW	11	55287734	missense	probably damaging	1.00
R8049:Fat2	UTSW	11	55312066	missense	probably benign	0.13
R8094:Fat2	UTSW	11	55296139	missense	probably benign	0.06
R8157:Fat2	UTSW	11	55252084	missense	possibly damaging	0.90
R8170:Fat2	UTSW	11	55270455	missense	probably damaging	1.00
R8172:Fat2	UTSW	11	55287812	missense	probably damaging	1.00
R8182:Fat2	UTSW	11	55284397	missense	possibly damaging	0.51
R8188:Fat2	UTSW	11	55273171	missense	probably damaging	0.98
R8204:Fat2	UTSW	11	55284610	missense	probably benign	0.02
R8211:Fat2	UTSW	11	55312209	missense	possibly damaging	0.92
R8255:Fat2	UTSW	11	55270275	missense	probably benign	0.19
R8263:Fat2	UTSW	11	55284136	missense	probably benign
R8269:Fat2	UTSW	11	55282709	missense	possibly damaging	0.48
R8443:Fat2	UTSW	11	55311709	missense	probably damaging	1.00
R8465:Fat2	UTSW	11	55256704	missense	possibly damaging	0.61
R8480:Fat2	UTSW	11	55282968	missense	possibly damaging	0.61
R8511:Fat2	UTSW	11	55309237	missense	probably damaging	0.99
R8680:Fat2	UTSW	11	55253866	missense	probably benign
R8704:Fat2	UTSW	11	55281311	missense	probably damaging	1.00
R8711:Fat2	UTSW	11	55268303	missense	probably benign	0.22
R8724:Fat2	UTSW	11	55282960	missense	probably damaging	1.00
R8788:Fat2	UTSW	11	55281103	missense	possibly damaging	0.90
R8802:Fat2	UTSW	11	55282924	missense	possibly damaging	0.95
R8902:Fat2	UTSW	11	55310070	missense	probably damaging	1.00
R8940:Fat2	UTSW	11	55256810	missense	possibly damaging	0.48
R8956:Fat2	UTSW	11	55282903	missense	probably damaging	1.00
R9035:Fat2	UTSW	11	55303721	missense	probably damaging	0.99
R9100:Fat2	UTSW	11	55262521	missense	probably damaging	1.00
R9132:Fat2	UTSW	11	55298610	missense	possibly damaging	0.88
R9173:Fat2	UTSW	11	55278937	missense	probably damaging	1.00
R9241:Fat2	UTSW	11	55256740	missense	probably benign	0.00
R9253:Fat2	UTSW	11	55310571	missense	probably damaging	1.00
R9280:Fat2	UTSW	11	55310697	missense	probably benign	0.36
R9351:Fat2	UTSW	11	55281301	missense	probably damaging	1.00
R9369:Fat2	UTSW	11	55310688	missense	possibly damaging	0.67
R9404:Fat2	UTSW	11	55253522	critical splice donor site	probably null
R9431:Fat2	UTSW	11	55252012	missense	probably damaging	1.00
R9484:Fat2	UTSW	11	55309926	missense	probably damaging	0.99
R9509:Fat2	UTSW	11	55309887	missense	possibly damaging	0.51
R9514:Fat2	UTSW	11	55284982	missense	probably damaging	0.98
R9606:Fat2	UTSW	11	55289267	missense	probably damaging	1.00
R9630:Fat2	UTSW	11	55256779	missense	probably benign	0.29
R9727:Fat2	UTSW	11	55268311	missense	probably damaging	1.00
R9736:Fat2	UTSW	11	55303925	missense	probably damaging	1.00
X0010:Fat2	UTSW	11	55252260	missense	probably benign	0.00
X0011:Fat2	UTSW	11	55310431	missense	probably damaging	0.98
X0018:Fat2	UTSW	11	55296210	missense	probably damaging	1.00
X0028:Fat2	UTSW	11	55309414	missense	possibly damaging	0.84
X0067:Fat2	UTSW	11	55283234	missense	possibly damaging	0.48
Z1176:Fat2	UTSW	11	55282795	missense	probably damaging	1.00
Z1176:Fat2	UTSW	11	55284991	missense	probably damaging	1.00
Z1176:Fat2	UTSW	11	55303700	missense	probably damaging	1.00
Z1176:Fat2	UTSW	11	55310121	missense	probably damaging	0.96
Z1177:Fat2	UTSW	11	55278966	nonsense	probably null
Z1186:Fat2	UTSW	11	55308970	frame shift	probably null
Z1186:Fat2	UTSW	11	55309799	missense	probably benign
Z1187:Fat2	UTSW	11	55308970	frame shift	probably null
Z1187:Fat2	UTSW	11	55309799	missense	probably benign
Z1188:Fat2	UTSW	11	55308970	frame shift	probably null
Z1188:Fat2	UTSW	11	55309799	missense	probably benign
Z1189:Fat2	UTSW	11	55308970	frame shift	probably null
Z1189:Fat2	UTSW	11	55309799	missense	probably benign
Z1190:Fat2	UTSW	11	55308970	frame shift	probably null
Z1190:Fat2	UTSW	11	55309799	missense	probably benign
Z1191:Fat2	UTSW	11	55308970	frame shift	probably null
Z1191:Fat2	UTSW	11	55309799	missense	probably benign
Z1192:Fat2	UTSW	11	55308970	frame shift	probably null
Z1192:Fat2	UTSW	11	55309799	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- CTTTGAAGTACTTTCCAGGGTCAC -3'
(R):5'- GCAAAGTCACTGCCACAGATG -3'

Sequencing Primer
(F):5'- CTCCAGAGAATCTACTTCAGCTC -3'
(R):5'- CTGCCACAGATGCCGATC -3'

Posted On

2014-06-23