Mutagenetix > Incidental Mutation

Incidental Mutation 'R1848:Prkdc'

207953

Institutional Source

Beutler Lab

Gene Symbol

Prkdc

Ensembl Gene

ENSMUSG00000022672

Gene Name

protein kinase, DNA activated, catalytic polypeptide

Synonyms

slip, DOXNPH, DNA-PKcs, XRCC7, dxnph, DNA-PK, DNAPDcs

MMRRC Submission

039873-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.955) question?

Stock #

R1848 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

15637866-15842235 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 15808058 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Serine at position 3316 (L3316S)

Ref Sequence

ENSEMBL: ENSMUSP00000023352 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023352]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000023352
AA Change: L3316S

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000023352
Gene: ENSMUSG00000022672
AA Change: L3316S

Domain	Start	End	E-Value	Type
low complexity region	125	138	N/A	INTRINSIC
low complexity region	1253	1263	N/A	INTRINSIC
low complexity region	1508	1522	N/A	INTRINSIC
NUC194	1810	2206	2.37e-246	SMART
SCOP:d1gw5a_	2210	2493	5e-3	SMART
low complexity region	2669	2681	N/A	INTRINSIC
low complexity region	2841	2855	N/A	INTRINSIC
Pfam:FAT	3024	3470	8.2e-75	PFAM
PI3Kc	3749	4068	3.67e-86	SMART
FATC	4096	4128	1.57e-9	SMART

Meta Mutation Damage Score

0.4270

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 95.2%
20x: 92.2%

Validation Efficiency

98% (120/123)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
PHENOTYPE: Mutations at this locus effect genome stability, radiation sensitivity and DNA repair. Nonsense (scid) and null homozygotes have severe combined immunodeficiency. A BALB/c variant allele reduces enzyme activity and predisposes to breast cancer. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 120 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933402J07Rik	C	A	8: 87,568,493 (GRCm38)	Y86*	probably null	Het
Aadac	A	G	3: 60,039,697 (GRCm38)	E272G	probably damaging	Het
Abcc8	A	T	7: 46,166,902 (GRCm38)	D271E	probably benign	Het
Acan	T	C	7: 79,099,035 (GRCm38)	F1185L	probably benign	Het
Adam1a	A	T	5: 121,519,620 (GRCm38)	C537S	probably damaging	Het
Ago2	A	G	15: 73,123,965 (GRCm38)	V395A	probably benign	Het
Alox15	A	G	11: 70,350,752 (GRCm38)	V101A	probably damaging	Het
Ankra2	T	C	13: 98,271,124 (GRCm38)	I194T	probably damaging	Het
Apobec4	C	A	1: 152,756,230 (GRCm38)	P3H	probably damaging	Het
Arid3b	G	T	9: 57,796,677 (GRCm38)	Y329*	probably null	Het
Atm	A	T	9: 53,468,012 (GRCm38)	S1993T	probably benign	Het
Bpgm	T	G	6: 34,487,734 (GRCm38)	S129A	probably benign	Het
Brat1	A	G	5: 140,718,509 (GRCm38)	D839G	possibly damaging	Het
Ccdc15	A	T	9: 37,342,570 (GRCm38)	S128T	probably benign	Het
Cd300lg	A	T	11: 102,046,206 (GRCm38)		probably benign	Het
Cdc34b	C	A	11: 94,742,477 (GRCm38)	Q168K	probably damaging	Het
Celsr2	A	T	3: 108,401,310 (GRCm38)	V1767E	probably benign	Het
Cep350	T	C	1: 155,953,651 (GRCm38)	D169G	probably benign	Het
Col7a1	A	T	9: 108,969,565 (GRCm38)	D1762V	possibly damaging	Het
Coro7	A	G	16: 4,630,434 (GRCm38)	L724P	probably damaging	Het
Crb1	T	A	1: 139,237,012 (GRCm38)	I1125F	probably damaging	Het
Ctif	T	A	18: 75,519,941 (GRCm38)	D415V	probably damaging	Het
Dab1	C	T	4: 104,731,751 (GRCm38)	A524V	probably benign	Het
Dhrs2	A	G	14: 55,240,841 (GRCm38)	D237G	probably benign	Het
Dhx9	T	C	1: 153,465,753 (GRCm38)	Q582R	probably damaging	Het
Dnajc1	C	T	2: 18,219,713 (GRCm38)	R443Q	probably damaging	Het
Dnm2	C	T	9: 21,505,681 (GRCm38)	R837W	possibly damaging	Het
Dpf2	C	A	19: 5,906,615 (GRCm38)	Q70H	probably damaging	Het
Dqx1	T	A	6: 83,066,107 (GRCm38)	D608E	probably damaging	Het
Dync2h1	T	A	9: 7,049,166 (GRCm38)	T3245S	probably benign	Het
Ect2l	A	G	10: 18,200,033 (GRCm38)	L35P	probably damaging	Het
Efcab5	A	T	11: 77,103,306 (GRCm38)	L1285Q	probably damaging	Het
Eif4g1	G	C	16: 20,681,867 (GRCm38)	R697P	probably damaging	Het
Emsy	T	A	7: 98,600,821 (GRCm38)	E753V	probably damaging	Het
Entpd3	A	G	9: 120,558,419 (GRCm38)	I227M	probably damaging	Het
Epn1	T	A	7: 5,089,998 (GRCm38)	V103E	probably damaging	Het
Esrra	T	C	19: 6,912,010 (GRCm38)	D337G	probably benign	Het
Fam129c	T	C	8: 71,603,769 (GRCm38)	M371T	possibly damaging	Het
Fam83e	A	T	7: 45,728,770 (GRCm38)	K406M	possibly damaging	Het
Fam83e	A	T	7: 45,728,769 (GRCm38)	K406*	probably null	Het
Fat2	A	G	11: 55,311,558 (GRCm38)	I230T	probably damaging	Het
Fbxl16	A	G	17: 25,816,446 (GRCm38)	I6V	probably benign	Het
Fgf23	T	C	6: 127,073,193 (GRCm38)	I55T	probably damaging	Het
Fibcd1	T	A	2: 31,821,549 (GRCm38)	D288V	probably damaging	Het
Flnb	T	C	14: 7,892,113 (GRCm38)	I594T	probably damaging	Het
Gabbr2	T	C	4: 46,739,823 (GRCm38)	E449G	probably benign	Het
Gbf1	T	G	19: 46,272,037 (GRCm38)	S1130A	possibly damaging	Het
Gipc3	T	C	10: 81,341,265 (GRCm38)	E157G	probably damaging	Het
Glra3	G	T	8: 55,940,907 (GRCm38)	A18S	probably benign	Het
Gm6625	A	C	8: 89,146,834 (GRCm38)		noncoding transcript	Het
Gpx4	A	G	10: 80,056,036 (GRCm38)		probably benign	Het
Grb10	A	G	11: 11,946,029 (GRCm38)	F264L	possibly damaging	Het
Grik3	T	C	4: 125,694,138 (GRCm38)	Y684H	probably damaging	Het
Gstp1	C	T	19: 4,036,795 (GRCm38)		probably benign	Het
Haus8	G	A	8: 71,256,123 (GRCm38)		probably benign	Het
Hip1	G	A	5: 135,435,141 (GRCm38)		probably null	Het
Hist3h2ba	A	T	11: 58,949,102 (GRCm38)	I55F	possibly damaging	Het
Hspbap1	T	A	16: 35,818,764 (GRCm38)		probably null	Het
Htr2b	T	A	1: 86,099,429 (GRCm38)	I452F	possibly damaging	Het
Hydin	T	A	8: 110,569,808 (GRCm38)	H3656Q	probably benign	Het
Klb	T	A	5: 65,348,837 (GRCm38)	D142E	probably benign	Het
Lamb3	A	T	1: 193,334,616 (GRCm38)	T777S	possibly damaging	Het
Lins1	C	A	7: 66,714,322 (GRCm38)	T650K	probably damaging	Het
Loxhd1	A	G	18: 77,281,971 (GRCm38)	K5R	possibly damaging	Het
Lpp	G	A	16: 24,761,655 (GRCm38)	M40I	probably damaging	Het
Mia2	A	T	12: 59,170,251 (GRCm38)		probably benign	Het
Miip	A	C	4: 147,863,092 (GRCm38)	F204V	probably damaging	Het
Mmp21	T	C	7: 133,677,153 (GRCm38)	R323G	probably benign	Het
Mta3	T	A	17: 83,755,551 (GRCm38)		probably benign	Het
Myh1	A	G	11: 67,213,630 (GRCm38)	K1004R	probably benign	Het
Myh14	T	A	7: 44,632,429 (GRCm38)	I810F	probably damaging	Het
Nbas	A	C	12: 13,413,597 (GRCm38)	D1295A	probably damaging	Het
Npr2	T	G	4: 43,632,384 (GRCm38)	V67G	probably benign	Het
Oas1f	C	A	5: 120,855,429 (GRCm38)	Q235K	probably damaging	Het
Olfr109	T	A	17: 37,467,047 (GRCm38)	S280R	probably damaging	Het
Olfr59	G	T	11: 74,289,213 (GRCm38)	C189F	probably damaging	Het
Olfr60	T	A	7: 140,345,987 (GRCm38)	M1L	probably benign	Het
Olfr629	T	C	7: 103,741,174 (GRCm38)	N22S	probably benign	Het
Olfr857	C	T	9: 19,713,090 (GRCm38)	H88Y	probably benign	Het
Pafah2	GCCCC	GCCCCC	4: 134,425,541 (GRCm38)		probably null	Het
Pde1b	A	G	15: 103,525,340 (GRCm38)		probably null	Het
Pdilt	T	C	7: 119,489,384 (GRCm38)	T465A	probably benign	Het
Plxnd1	T	C	6: 115,966,546 (GRCm38)	H1233R	probably damaging	Het
Ppm1b	T	A	17: 84,994,124 (GRCm38)	M144K	probably benign	Het
Prm2	T	A	16: 10,791,591 (GRCm38)		probably benign	Het
Prmt7	T	C	8: 106,237,008 (GRCm38)	V240A	probably benign	Het
Prx	C	A	7: 27,518,888 (GRCm38)	A938E	possibly damaging	Het
Rbm7	A	G	9: 48,490,894 (GRCm38)	V131A	probably benign	Het
Ric1	T	A	19: 29,600,813 (GRCm38)		probably null	Het
Rnf150	A	T	8: 82,864,010 (GRCm38)	M1L	possibly damaging	Het
Rnf20	C	T	4: 49,644,628 (GRCm38)	R298W	probably damaging	Het
Rp1	T	A	1: 4,347,232 (GRCm38)	Y1219F	possibly damaging	Het
Scn7a	A	G	2: 66,684,013 (GRCm38)		probably null	Het
Sdad1	A	G	5: 92,292,651 (GRCm38)		probably null	Het
Sept9	T	C	11: 117,353,083 (GRCm38)		probably benign	Het
Serinc3	T	C	2: 163,645,489 (GRCm38)		probably benign	Het
Shc3	C	T	13: 51,461,388 (GRCm38)	G178R	probably damaging	Het
Slc4a10	A	T	2: 62,316,606 (GRCm38)	K1090M	probably damaging	Het
Slco1a1	T	C	6: 141,923,111 (GRCm38)	I376V	probably benign	Het
Slmap	A	T	14: 26,422,574 (GRCm38)	F719L	probably benign	Het
Smgc	A	G	15: 91,859,758 (GRCm38)	N573D	possibly damaging	Het
Spx	G	A	6: 142,414,079 (GRCm38)		probably null	Het
Srrt	C	G	5: 137,296,945 (GRCm38)	E308Q	probably damaging	Het
Tas2r130	T	A	6: 131,630,597 (GRCm38)	R78S	probably benign	Het
Tchhl1	A	G	3: 93,471,101 (GRCm38)	R371G	probably damaging	Het
Teddm2	C	T	1: 153,850,448 (GRCm38)	A174T	probably benign	Het
Tktl2	G	A	8: 66,512,347 (GRCm38)	V186M	probably damaging	Het
Trim33	T	C	3: 103,324,640 (GRCm38)		probably benign	Het
Tspan31	A	G	10: 127,069,458 (GRCm38)	V40A	probably damaging	Het
Uevld	A	G	7: 46,945,227 (GRCm38)		probably benign	Het
Vcl	G	T	14: 21,008,995 (GRCm38)	A560S	probably benign	Het
Vmn2r24	T	A	6: 123,816,224 (GRCm38)	C837S	probably damaging	Het
Vmn2r57	C	T	7: 41,428,107 (GRCm38)	V212M	probably damaging	Het
Vps13c	A	G	9: 67,936,340 (GRCm38)	T1968A	probably benign	Het
Vtn	A	G	11: 78,500,567 (GRCm38)	R269G	probably damaging	Het
Wdcp	G	A	12: 4,850,245 (GRCm38)	V34I	possibly damaging	Het
Zc3h14	A	G	12: 98,752,832 (GRCm38)	D152G	possibly damaging	Het
Zfp189	C	T	4: 49,529,266 (GRCm38)	P123L	probably benign	Het
Zfp318	T	C	17: 46,406,055 (GRCm38)	S1038P	possibly damaging	Het
Zfp873	A	G	10: 82,060,572 (GRCm38)	D416G	probably benign	Het

Other mutations in Prkdc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Prkdc	APN	16	15,697,226 (GRCm38)	missense	probably damaging	1.00
IGL00225:Prkdc	APN	16	15,809,644 (GRCm38)	missense	possibly damaging	0.64
IGL00481:Prkdc	APN	16	15,790,466 (GRCm38)	missense	probably benign	0.41
IGL00488:Prkdc	APN	16	15,775,847 (GRCm38)	splice site	probably null
IGL00489:Prkdc	APN	16	15,799,926 (GRCm38)	missense	possibly damaging	0.51
IGL00579:Prkdc	APN	16	15,664,239 (GRCm38)	missense	probably damaging	1.00
IGL00587:Prkdc	APN	16	15,652,358 (GRCm38)	splice site	probably benign
IGL00666:Prkdc	APN	16	15,736,835 (GRCm38)	missense	probably damaging	1.00
IGL00675:Prkdc	APN	16	15,787,158 (GRCm38)	missense	probably benign	0.05
IGL00708:Prkdc	APN	16	15,779,426 (GRCm38)	missense	probably damaging	0.97
IGL00725:Prkdc	APN	16	15,816,639 (GRCm38)	missense	probably benign	0.10
IGL00818:Prkdc	APN	16	15,759,754 (GRCm38)	missense	possibly damaging	0.92
IGL00917:Prkdc	APN	16	15,739,564 (GRCm38)	missense	probably damaging	0.98
IGL00990:Prkdc	APN	16	15,702,115 (GRCm38)	missense	probably benign	0.03
IGL01126:Prkdc	APN	16	15,669,321 (GRCm38)	missense	probably benign	0.01
IGL01141:Prkdc	APN	16	15,726,704 (GRCm38)	missense	probably damaging	0.99
IGL01306:Prkdc	APN	16	15,667,731 (GRCm38)	missense	possibly damaging	0.67
IGL01326:Prkdc	APN	16	15,829,692 (GRCm38)	missense	probably benign
IGL01335:Prkdc	APN	16	15,816,896 (GRCm38)	critical splice donor site	probably null
IGL01419:Prkdc	APN	16	15,835,166 (GRCm38)	missense	probably damaging	1.00
IGL01434:Prkdc	APN	16	15,713,587 (GRCm38)	missense	probably benign	0.00
IGL01554:Prkdc	APN	16	15,652,302 (GRCm38)	missense	probably benign	0.05
IGL01671:Prkdc	APN	16	15,667,745 (GRCm38)	missense	possibly damaging	0.90
IGL01871:Prkdc	APN	16	15,783,087 (GRCm38)	missense	probably benign	0.00
IGL01874:Prkdc	APN	16	15,734,994 (GRCm38)	missense	possibly damaging	0.89
IGL01930:Prkdc	APN	16	15,698,887 (GRCm38)	missense	probably damaging	1.00
IGL01984:Prkdc	APN	16	15,708,779 (GRCm38)	missense	probably benign
IGL02121:Prkdc	APN	16	15,717,184 (GRCm38)	missense	probably benign	0.18
IGL02152:Prkdc	APN	16	15,669,285 (GRCm38)	missense	probably benign	0.15
IGL02172:Prkdc	APN	16	15,809,759 (GRCm38)	missense	probably benign	0.10
IGL02336:Prkdc	APN	16	15,785,979 (GRCm38)	missense	probably benign	0.01
IGL02336:Prkdc	APN	16	15,785,978 (GRCm38)	missense	possibly damaging	0.47
IGL02393:Prkdc	APN	16	15,816,758 (GRCm38)	missense	probably benign	0.42
IGL02406:Prkdc	APN	16	15,670,535 (GRCm38)	missense	probably benign	0.00
IGL02500:Prkdc	APN	16	15,714,282 (GRCm38)	critical splice donor site	probably null
IGL02568:Prkdc	APN	16	15,726,542 (GRCm38)	missense	probably damaging	0.98
IGL02579:Prkdc	APN	16	15,670,601 (GRCm38)	missense	possibly damaging	0.83
IGL02652:Prkdc	APN	16	15,783,087 (GRCm38)	missense	probably benign	0.00
IGL02661:Prkdc	APN	16	15,769,825 (GRCm38)	missense	possibly damaging	0.92
IGL02685:Prkdc	APN	16	15,836,043 (GRCm38)	missense	possibly damaging	0.61
IGL02741:Prkdc	APN	16	15,752,726 (GRCm38)	splice site	probably benign
IGL02803:Prkdc	APN	16	15,833,666 (GRCm38)	splice site	probably benign
IGL02866:Prkdc	APN	16	15,831,327 (GRCm38)	missense	probably damaging	1.00
IGL02882:Prkdc	APN	16	15,651,519 (GRCm38)	nonsense	probably null
IGL02989:Prkdc	APN	16	15,800,016 (GRCm38)	missense	possibly damaging	0.67
IGL03053:Prkdc	APN	16	15,834,166 (GRCm38)	missense	probably benign	0.02
IGL03071:Prkdc	APN	16	15,799,984 (GRCm38)	missense	probably benign	0.01
IGL03091:Prkdc	APN	16	15,705,310 (GRCm38)	splice site	probably benign
IGL03100:Prkdc	APN	16	15,713,635 (GRCm38)	missense	probably benign	0.08
IGL03128:Prkdc	APN	16	15,700,744 (GRCm38)	splice site	probably benign
IGL03168:Prkdc	APN	16	15,834,166 (GRCm38)	missense	probably benign	0.02
IGL03204:Prkdc	APN	16	15,769,801 (GRCm38)	missense	probably benign	0.01
IGL03390:Prkdc	APN	16	15,670,626 (GRCm38)	nonsense	probably null
anhimid	UTSW	16	15,725,461 (GRCm38)	critical splice donor site	probably null
anhinga	UTSW	16	15,708,932 (GRCm38)	critical splice donor site	probably null
Bushtit	UTSW	16	15,752,764 (GRCm38)	missense	probably damaging	0.97
clover	UTSW	16	15,702,156 (GRCm38)	splice site	probably benign
crackle	UTSW	16	15,786,050 (GRCm38)	critical splice donor site	probably null
Daffy	UTSW	16	15,829,697 (GRCm38)	missense	possibly damaging	0.86
darter	UTSW	16	15,773,613 (GRCm38)	missense	possibly damaging	0.93
Elmer_fudd	UTSW	16	15,808,058 (GRCm38)	missense	probably benign	0.01
envenomation	UTSW	16	15,835,227 (GRCm38)	nonsense	probably null
hobgoblin	UTSW	16	15,815,986 (GRCm38)	missense	probably damaging	1.00
Incubus	UTSW	16	15,672,327 (GRCm38)	missense	probably damaging	1.00
liming	UTSW	16	15,752,829 (GRCm38)	nonsense	probably null
newt	UTSW	16	15,727,726 (GRCm38)	missense	probably benign	0.04
ornithorhynchus	UTSW	16	15,816,659 (GRCm38)	critical splice donor site	probably null
primitive	UTSW	16	15,835,158 (GRCm38)	frame shift	probably null
roadrunner	UTSW	16	15,833,887 (GRCm38)	missense	probably damaging	1.00
Schreier	UTSW	16	15,670,528 (GRCm38)	missense	probably benign	0.00
screamer	UTSW	16	15,831,282 (GRCm38)	nonsense	probably null
Screamer10	UTSW	16	15,768,025 (GRCm38)	missense	probably damaging	0.98
screamer2	UTSW	16	15,652,552 (GRCm38)	critical splice donor site	probably null
screamer3	UTSW	16	15,740,332 (GRCm38)	critical splice donor site	probably null
screamer4	UTSW	16	15,783,079 (GRCm38)	missense	probably benign	0.00
screamer5	UTSW	16	15,687,404 (GRCm38)	missense	probably benign
screamer6	UTSW	16	15,759,605 (GRCm38)	missense	probably damaging	1.00
screamer7	UTSW	16	15,654,817 (GRCm38)	splice site	probably null
Screamer8	UTSW	16	15,719,433 (GRCm38)	missense	probably benign	0.00
Screamer9	UTSW	16	15,734,922 (GRCm38)	missense	probably benign	0.01
Tweetie	UTSW	16	15,717,801 (GRCm38)	missense	probably damaging	1.00
updock	UTSW	16	15,795,094 (GRCm38)	missense	probably benign
ANU23:Prkdc	UTSW	16	15,667,731 (GRCm38)	missense	possibly damaging	0.67
R0008:Prkdc	UTSW	16	15,708,701 (GRCm38)	splice site	probably benign
R0018:Prkdc	UTSW	16	15,726,542 (GRCm38)	missense	probably benign	0.03
R0018:Prkdc	UTSW	16	15,726,542 (GRCm38)	missense	probably benign	0.03
R0069:Prkdc	UTSW	16	15,726,504 (GRCm38)	missense	probably benign	0.03
R0125:Prkdc	UTSW	16	15,699,007 (GRCm38)	missense	probably damaging	0.98
R0131:Prkdc	UTSW	16	15,713,653 (GRCm38)	missense	probably benign	0.09
R0131:Prkdc	UTSW	16	15,713,653 (GRCm38)	missense	probably benign	0.09
R0132:Prkdc	UTSW	16	15,713,653 (GRCm38)	missense	probably benign	0.09
R0137:Prkdc	UTSW	16	15,740,332 (GRCm38)	critical splice donor site	probably null
R0334:Prkdc	UTSW	16	15,736,799 (GRCm38)	missense	probably benign	0.00
R0373:Prkdc	UTSW	16	15,791,927 (GRCm38)	missense	probably damaging	1.00
R0485:Prkdc	UTSW	16	15,833,740 (GRCm38)	missense	probably damaging	0.97
R0511:Prkdc	UTSW	16	15,831,282 (GRCm38)	nonsense	probably null
R0538:Prkdc	UTSW	16	15,833,788 (GRCm38)	missense	probably damaging	1.00
R0595:Prkdc	UTSW	16	15,808,088 (GRCm38)	missense	probably damaging	1.00
R0607:Prkdc	UTSW	16	15,772,057 (GRCm38)	missense	probably damaging	0.98
R0616:Prkdc	UTSW	16	15,690,407 (GRCm38)	missense	probably damaging	1.00
R0630:Prkdc	UTSW	16	15,810,801 (GRCm38)	missense	probably damaging	1.00
R0694:Prkdc	UTSW	16	15,768,637 (GRCm38)	missense	probably damaging	1.00
R0702:Prkdc	UTSW	16	15,785,971 (GRCm38)	missense	possibly damaging	0.95
R0965:Prkdc	UTSW	16	15,829,716 (GRCm38)	missense	probably benign
R1027:Prkdc	UTSW	16	15,650,712 (GRCm38)	missense	possibly damaging	0.80
R1029:Prkdc	UTSW	16	15,654,749 (GRCm38)	splice site	probably benign
R1033:Prkdc	UTSW	16	15,767,951 (GRCm38)	missense	probably damaging	1.00
R1067:Prkdc	UTSW	16	15,752,782 (GRCm38)	missense	probably damaging	0.99
R1116:Prkdc	UTSW	16	15,783,079 (GRCm38)	missense	probably benign	0.00
R1187:Prkdc	UTSW	16	15,759,746 (GRCm38)	missense	probably damaging	0.98
R1226:Prkdc	UTSW	16	15,673,997 (GRCm38)	missense	possibly damaging	0.80
R1279:Prkdc	UTSW	16	15,690,282 (GRCm38)	missense	probably damaging	1.00
R1304:Prkdc	UTSW	16	15,759,723 (GRCm38)	missense	probably damaging	0.99
R1314:Prkdc	UTSW	16	15,664,227 (GRCm38)	missense	possibly damaging	0.68
R1351:Prkdc	UTSW	16	15,667,700 (GRCm38)	missense	possibly damaging	0.62
R1509:Prkdc	UTSW	16	15,731,566 (GRCm38)	missense	probably damaging	1.00
R1512:Prkdc	UTSW	16	15,687,404 (GRCm38)	missense	probably benign
R1531:Prkdc	UTSW	16	15,772,106 (GRCm38)	missense	probably benign	0.01
R1579:Prkdc	UTSW	16	15,675,328 (GRCm38)	missense	probably benign	0.00
R1669:Prkdc	UTSW	16	15,734,058 (GRCm38)	missense	probably damaging	1.00
R1682:Prkdc	UTSW	16	15,676,989 (GRCm38)	missense	probably benign	0.19
R1713:Prkdc	UTSW	16	15,795,094 (GRCm38)	missense	probably benign
R1762:Prkdc	UTSW	16	15,637,961 (GRCm38)	missense	probably benign
R1789:Prkdc	UTSW	16	15,739,524 (GRCm38)	missense	probably damaging	1.00
R1822:Prkdc	UTSW	16	15,759,605 (GRCm38)	missense	probably damaging	1.00
R1887:Prkdc	UTSW	16	15,829,635 (GRCm38)	missense	probably benign	0.00
R1891:Prkdc	UTSW	16	15,725,436 (GRCm38)	missense	probably benign	0.02
R1921:Prkdc	UTSW	16	15,714,215 (GRCm38)	missense	possibly damaging	0.80
R1922:Prkdc	UTSW	16	15,714,266 (GRCm38)	missense	probably benign	0.00
R1929:Prkdc	UTSW	16	15,654,817 (GRCm38)	splice site	probably null
R1939:Prkdc	UTSW	16	15,835,913 (GRCm38)	missense	possibly damaging	0.95
R2021:Prkdc	UTSW	16	15,677,009 (GRCm38)	missense	probably benign	0.00
R2033:Prkdc	UTSW	16	15,687,352 (GRCm38)	splice site	probably benign
R2056:Prkdc	UTSW	16	15,727,605 (GRCm38)	missense	probably benign	0.03
R2057:Prkdc	UTSW	16	15,727,605 (GRCm38)	missense	probably benign	0.03
R2058:Prkdc	UTSW	16	15,727,605 (GRCm38)	missense	probably benign	0.03
R2082:Prkdc	UTSW	16	15,715,963 (GRCm38)	missense	probably damaging	1.00
R2109:Prkdc	UTSW	16	15,687,390 (GRCm38)	missense	probably benign	0.01
R2124:Prkdc	UTSW	16	15,719,433 (GRCm38)	missense	probably benign	0.00
R2164:Prkdc	UTSW	16	15,705,207 (GRCm38)	missense	probably damaging	1.00
R2174:Prkdc	UTSW	16	15,734,922 (GRCm38)	missense	probably benign	0.01
R2191:Prkdc	UTSW	16	15,698,824 (GRCm38)	missense	probably damaging	1.00
R2270:Prkdc	UTSW	16	15,654,817 (GRCm38)	splice site	probably null
R2271:Prkdc	UTSW	16	15,654,817 (GRCm38)	splice site	probably null
R2272:Prkdc	UTSW	16	15,654,817 (GRCm38)	splice site	probably null
R2356:Prkdc	UTSW	16	15,684,204 (GRCm38)	missense	probably benign
R2852:Prkdc	UTSW	16	15,652,552 (GRCm38)	critical splice donor site	probably null
R3115:Prkdc	UTSW	16	15,664,358 (GRCm38)	missense	probably benign	0.01
R3116:Prkdc	UTSW	16	15,664,358 (GRCm38)	missense	probably benign	0.01
R3499:Prkdc	UTSW	16	15,768,025 (GRCm38)	missense	probably damaging	0.98
R3687:Prkdc	UTSW	16	15,799,967 (GRCm38)	missense	probably benign
R3834:Prkdc	UTSW	16	15,791,946 (GRCm38)	missense	probably damaging	1.00
R3835:Prkdc	UTSW	16	15,791,946 (GRCm38)	missense	probably damaging	1.00
R3961:Prkdc	UTSW	16	15,829,611 (GRCm38)	splice site	probably null
R4151:Prkdc	UTSW	16	15,816,773 (GRCm38)	missense	probably benign
R4233:Prkdc	UTSW	16	15,835,919 (GRCm38)	missense	probably benign	0.11
R4281:Prkdc	UTSW	16	15,806,099 (GRCm38)	splice site	probably null
R4296:Prkdc	UTSW	16	15,737,905 (GRCm38)	missense	probably damaging	0.99
R4344:Prkdc	UTSW	16	15,768,022 (GRCm38)	missense	probably damaging	0.98
R4424:Prkdc	UTSW	16	15,836,082 (GRCm38)	missense	probably damaging	1.00
R4424:Prkdc	UTSW	16	15,773,739 (GRCm38)	missense	probably damaging	0.98
R4497:Prkdc	UTSW	16	15,700,653 (GRCm38)	missense	probably benign	0.43
R4549:Prkdc	UTSW	16	15,736,870 (GRCm38)	missense	possibly damaging	0.89
R4594:Prkdc	UTSW	16	15,767,966 (GRCm38)	missense	possibly damaging	0.64
R4603:Prkdc	UTSW	16	15,810,824 (GRCm38)	missense	probably damaging	0.98
R4615:Prkdc	UTSW	16	15,663,074 (GRCm38)	missense	probably damaging	0.99
R4648:Prkdc	UTSW	16	15,816,774 (GRCm38)	missense	probably benign	0.05
R4662:Prkdc	UTSW	16	15,734,052 (GRCm38)	missense	probably damaging	1.00
R4680:Prkdc	UTSW	16	15,772,030 (GRCm38)	missense	probably benign	0.00
R4700:Prkdc	UTSW	16	15,702,112 (GRCm38)	missense	probably damaging	1.00
R4716:Prkdc	UTSW	16	15,810,837 (GRCm38)	missense	probably benign	0.32
R4720:Prkdc	UTSW	16	15,667,715 (GRCm38)	missense	probably benign
R4785:Prkdc	UTSW	16	15,648,976 (GRCm38)	missense	probably benign	0.21
R4822:Prkdc	UTSW	16	15,650,712 (GRCm38)	missense	possibly damaging	0.80
R4829:Prkdc	UTSW	16	15,702,075 (GRCm38)	missense	possibly damaging	0.80
R4981:Prkdc	UTSW	16	15,678,309 (GRCm38)	missense	probably damaging	1.00
R4989:Prkdc	UTSW	16	15,673,997 (GRCm38)	missense	possibly damaging	0.80
R5059:Prkdc	UTSW	16	15,838,018 (GRCm38)	missense	probably damaging	1.00
R5074:Prkdc	UTSW	16	15,772,048 (GRCm38)	missense	probably damaging	1.00
R5115:Prkdc	UTSW	16	15,790,580 (GRCm38)	missense	probably benign
R5151:Prkdc	UTSW	16	15,716,035 (GRCm38)	missense	probably damaging	1.00
R5165:Prkdc	UTSW	16	15,678,272 (GRCm38)	missense	probably damaging	1.00
R5215:Prkdc	UTSW	16	15,772,121 (GRCm38)	missense	possibly damaging	0.64
R5270:Prkdc	UTSW	16	15,734,955 (GRCm38)	missense	probably damaging	1.00
R5278:Prkdc	UTSW	16	15,714,974 (GRCm38)	missense	probably damaging	1.00
R5351:Prkdc	UTSW	16	15,831,312 (GRCm38)	missense	probably benign	0.03
R5416:Prkdc	UTSW	16	15,805,950 (GRCm38)	missense	probably damaging	1.00
R5418:Prkdc	UTSW	16	15,795,097 (GRCm38)	missense	probably benign	0.20
R5437:Prkdc	UTSW	16	15,769,875 (GRCm38)	missense	possibly damaging	0.46
R5452:Prkdc	UTSW	16	15,768,637 (GRCm38)	missense	possibly damaging	0.96
R5518:Prkdc	UTSW	16	15,678,308 (GRCm38)	missense	probably damaging	1.00
R5538:Prkdc	UTSW	16	15,651,469 (GRCm38)	missense	probably damaging	1.00
R5589:Prkdc	UTSW	16	15,706,791 (GRCm38)	missense	probably benign	0.02
R5618:Prkdc	UTSW	16	15,809,612 (GRCm38)	missense	probably damaging	1.00
R5640:Prkdc	UTSW	16	15,829,769 (GRCm38)	missense	possibly damaging	0.86
R5661:Prkdc	UTSW	16	15,810,770 (GRCm38)	missense	possibly damaging	0.81
R5771:Prkdc	UTSW	16	15,664,233 (GRCm38)	missense	probably damaging	1.00
R5772:Prkdc	UTSW	16	15,779,388 (GRCm38)	missense	possibly damaging	0.49
R5783:Prkdc	UTSW	16	15,717,801 (GRCm38)	missense	probably damaging	1.00
R5792:Prkdc	UTSW	16	15,816,752 (GRCm38)	missense	probably damaging	1.00
R5797:Prkdc	UTSW	16	15,737,834 (GRCm38)	nonsense	probably null
R5826:Prkdc	UTSW	16	15,734,098 (GRCm38)	missense	probably benign
R5883:Prkdc	UTSW	16	15,715,914 (GRCm38)	missense	probably benign
R5895:Prkdc	UTSW	16	15,752,829 (GRCm38)	nonsense	probably null
R5998:Prkdc	UTSW	16	15,783,157 (GRCm38)	missense	probably damaging	1.00
R6000:Prkdc	UTSW	16	15,829,697 (GRCm38)	missense	possibly damaging	0.86
R6120:Prkdc	UTSW	16	15,739,471 (GRCm38)	missense	probably benign	0.00
R6145:Prkdc	UTSW	16	15,772,073 (GRCm38)	missense	probably damaging	1.00
R6209:Prkdc	UTSW	16	15,790,592 (GRCm38)	missense	probably damaging	1.00
R6293:Prkdc	UTSW	16	15,787,155 (GRCm38)	missense	probably benign	0.00
R6321:Prkdc	UTSW	16	15,714,919 (GRCm38)	missense	probably benign
R6376:Prkdc	UTSW	16	15,769,885 (GRCm38)	missense	probably benign	0.06
R6387:Prkdc	UTSW	16	15,698,815 (GRCm38)	missense	probably benign	0.01
R6406:Prkdc	UTSW	16	15,717,801 (GRCm38)	missense	probably damaging	1.00
R6469:Prkdc	UTSW	16	15,795,075 (GRCm38)	missense	probably benign	0.10
R6486:Prkdc	UTSW	16	15,752,764 (GRCm38)	missense	probably damaging	0.97
R6665:Prkdc	UTSW	16	15,786,050 (GRCm38)	critical splice donor site	probably null
R6703:Prkdc	UTSW	16	15,670,528 (GRCm38)	missense	probably benign	0.00
R6774:Prkdc	UTSW	16	15,725,461 (GRCm38)	critical splice donor site	probably null
R6854:Prkdc	UTSW	16	15,651,538 (GRCm38)	missense	probably damaging	1.00
R6878:Prkdc	UTSW	16	15,777,072 (GRCm38)	missense	probably benign	0.31
R6882:Prkdc	UTSW	16	15,808,156 (GRCm38)	missense	probably benign	0.33
R6882:Prkdc	UTSW	16	15,783,263 (GRCm38)	critical splice donor site	probably null
R6949:Prkdc	UTSW	16	15,799,989 (GRCm38)	missense	probably benign
R6950:Prkdc	UTSW	16	15,815,986 (GRCm38)	missense	probably damaging	1.00
R7019:Prkdc	UTSW	16	15,769,966 (GRCm38)	missense	probably benign	0.00
R7064:Prkdc	UTSW	16	15,790,453 (GRCm38)	missense	probably benign	0.00
R7097:Prkdc	UTSW	16	15,689,343 (GRCm38)	missense	probably damaging	1.00
R7201:Prkdc	UTSW	16	15,698,803 (GRCm38)	missense	probably benign	0.12
R7235:Prkdc	UTSW	16	15,714,263 (GRCm38)	missense	probably benign
R7283:Prkdc	UTSW	16	15,717,764 (GRCm38)	missense	probably benign	0.00
R7401:Prkdc	UTSW	16	15,648,738 (GRCm38)	missense	probably damaging	1.00
R7525:Prkdc	UTSW	16	15,672,327 (GRCm38)	missense	probably damaging	1.00
R7647:Prkdc	UTSW	16	15,737,943 (GRCm38)	missense	probably damaging	1.00
R7679:Prkdc	UTSW	16	15,831,319 (GRCm38)	missense	probably damaging	1.00
R7803:Prkdc	UTSW	16	15,806,096 (GRCm38)	missense	probably null	0.05
R7858:Prkdc	UTSW	16	15,689,277 (GRCm38)	missense	probably benign	0.11
R7872:Prkdc	UTSW	16	15,715,006 (GRCm38)	missense	probably benign	0.05
R7896:Prkdc	UTSW	16	15,708,903 (GRCm38)	missense	probably damaging	0.97
R8032:Prkdc	UTSW	16	15,779,451 (GRCm38)	missense	probably benign	0.00
R8055:Prkdc	UTSW	16	15,816,885 (GRCm38)	missense	probably benign	0.09
R8153:Prkdc	UTSW	16	15,664,244 (GRCm38)	missense	probably damaging	1.00
R8281:Prkdc	UTSW	16	15,705,253 (GRCm38)	missense	probably damaging	1.00
R8302:Prkdc	UTSW	16	15,836,082 (GRCm38)	missense	probably damaging	1.00
R8322:Prkdc	UTSW	16	15,714,141 (GRCm38)	splice site	probably benign
R8401:Prkdc	UTSW	16	15,773,613 (GRCm38)	missense	possibly damaging	0.93
R8440:Prkdc	UTSW	16	15,835,158 (GRCm38)	frame shift	probably null
R8458:Prkdc	UTSW	16	15,790,676 (GRCm38)	critical splice donor site	probably null
R8472:Prkdc	UTSW	16	15,651,536 (GRCm38)	missense	probably damaging	1.00
R8478:Prkdc	UTSW	16	15,648,924 (GRCm38)	missense	probably benign	0.00
R8515:Prkdc	UTSW	16	15,664,368 (GRCm38)	missense	probably damaging	1.00
R8546:Prkdc	UTSW	16	15,663,035 (GRCm38)	missense	probably damaging	1.00
R8678:Prkdc	UTSW	16	15,708,932 (GRCm38)	critical splice donor site	probably null
R8739:Prkdc	UTSW	16	15,808,204 (GRCm38)	missense	probably benign	0.01
R8749:Prkdc	UTSW	16	15,783,165 (GRCm38)	missense	possibly damaging	0.85
R8836:Prkdc	UTSW	16	15,727,659 (GRCm38)	missense	probably damaging	1.00
R8904:Prkdc	UTSW	16	15,727,726 (GRCm38)	missense	probably benign	0.04
R8952:Prkdc	UTSW	16	15,673,760 (GRCm38)	intron	probably benign
R8971:Prkdc	UTSW	16	15,675,365 (GRCm38)	missense	probably null	0.99
R8974:Prkdc	UTSW	16	15,799,862 (GRCm38)	splice site	probably null
R9052:Prkdc	UTSW	16	15,690,296 (GRCm38)	missense	probably benign	0.05
R9069:Prkdc	UTSW	16	15,835,227 (GRCm38)	nonsense	probably null
R9200:Prkdc	UTSW	16	15,705,289 (GRCm38)	missense	probably damaging	1.00
R9235:Prkdc	UTSW	16	15,833,887 (GRCm38)	missense	probably damaging	1.00
R9278:Prkdc	UTSW	16	15,816,659 (GRCm38)	critical splice donor site	probably null
R9309:Prkdc	UTSW	16	15,708,928 (GRCm38)	nonsense	probably null
R9386:Prkdc	UTSW	16	15,678,272 (GRCm38)	missense	probably damaging	0.99
R9452:Prkdc	UTSW	16	15,667,601 (GRCm38)	missense	possibly damaging	0.90
R9500:Prkdc	UTSW	16	15,839,215 (GRCm38)	missense	possibly damaging	0.76
R9608:Prkdc	UTSW	16	15,730,471 (GRCm38)	missense	probably damaging	1.00
R9608:Prkdc	UTSW	16	15,730,470 (GRCm38)	missense	possibly damaging	0.96
R9636:Prkdc	UTSW	16	15,730,477 (GRCm38)	missense	probably benign	0.19
R9656:Prkdc	UTSW	16	15,799,954 (GRCm38)	missense	probably benign	0.00
R9674:Prkdc	UTSW	16	15,715,955 (GRCm38)	missense	probably damaging	0.98
R9760:Prkdc	UTSW	16	15,839,180 (GRCm38)	nonsense	probably null
X0023:Prkdc	UTSW	16	15,740,278 (GRCm38)	missense	probably benign
Z1176:Prkdc	UTSW	16	15,687,422 (GRCm38)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- CTATTCATCAGGGAGTATAAGAACATC -3'
(R):5'- CACTTTGTCCTGAGGGCAGC -3'

Sequencing Primer
(F):5'- CTTTCATCAGAAAATGAAGCCAGG -3'
(R):5'- ATACAACAACTTACCGTCTCTGTG -3'

Posted On

2014-06-23