Incidental Mutation 'R1850:Prl2c5'
ID 208020
Institutional Source Beutler Lab
Gene Symbol Prl2c5
Ensembl Gene ENSMUSG00000055360
Gene Name prolactin family 2, subfamily c, member 5
Synonyms MRP-4, Mrpplf4, PLF-4
MMRRC Submission 039874-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R1850 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 13357300-13366508 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 13360377 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 12 (I12V)
Ref Sequence ENSEMBL: ENSMUSP00000021778 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021778] [ENSMUST00000126540] [ENSMUST00000151144]
AlphaFold Q9JLV9
Predicted Effect probably benign
Transcript: ENSMUST00000021778
AA Change: I12V

PolyPhen 2 Score 0.401 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000021778
Gene: ENSMUSG00000055360
AA Change: I12V

DomainStartEndE-ValueType
Pfam:Hormone_1 16 222 2.7e-70 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000126540
AA Change: I15V

PolyPhen 2 Score 0.049 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000115024
Gene: ENSMUSG00000055360
AA Change: I15V

DomainStartEndE-ValueType
Pfam:Hormone_1 19 225 1.5e-73 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143335
Predicted Effect probably benign
Transcript: ENSMUST00000151144
AA Change: I12V

PolyPhen 2 Score 0.162 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000117522
Gene: ENSMUSG00000055360
AA Change: I12V

DomainStartEndE-ValueType
Pfam:Hormone_1 16 172 3.5e-51 PFAM
Meta Mutation Damage Score 0.1961 question?
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 95.1%
  • 20x: 91.8%
Validation Efficiency 99% (67/68)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam28 T A 14: 68,876,644 (GRCm39) Q202L probably benign Het
Adgb C A 10: 10,318,246 (GRCm39) V199F probably damaging Het
Aff1 G T 5: 103,981,773 (GRCm39) R645S probably damaging Het
Aoc1 C T 6: 48,882,202 (GRCm39) S48F probably benign Het
Atf6 A T 1: 170,646,855 (GRCm39) N339K probably damaging Het
Bpifb3 C G 2: 153,771,264 (GRCm39) S392C possibly damaging Het
Camk1d T C 2: 5,366,826 (GRCm39) M130V probably benign Het
Ces1a T A 8: 93,753,954 (GRCm39) N350Y probably damaging Het
Cfap57 G A 4: 118,457,091 (GRCm39) R453C probably damaging Het
Chd4 T A 6: 125,098,619 (GRCm39) N1532K probably damaging Het
Chd5 T C 4: 152,454,990 (GRCm39) L824P probably damaging Het
Ckap5 G A 2: 91,426,058 (GRCm39) R1306H probably damaging Het
Crybg1 A G 10: 43,873,670 (GRCm39) F1146S probably damaging Het
Dusp12 G A 1: 170,708,198 (GRCm39) T173M probably benign Het
Dync2h1 T C 9: 7,001,448 (GRCm39) T3854A probably benign Het
Echdc1 A T 10: 29,220,599 (GRCm39) I252F probably damaging Het
Emc1 A T 4: 139,086,684 (GRCm39) probably benign Het
Fbn2 C A 18: 58,172,377 (GRCm39) probably benign Het
Fsip2 T A 2: 82,814,933 (GRCm39) N3555K possibly damaging Het
Gabra1 T A 11: 42,070,403 (GRCm39) T20S probably benign Het
Igf1 A C 10: 87,697,236 (GRCm39) T2P possibly damaging Het
Insyn1 A T 9: 58,406,392 (GRCm39) M101L probably benign Het
Jcad C A 18: 4,675,730 (GRCm39) T1164N possibly damaging Het
Kalrn A T 16: 33,796,293 (GRCm39) S2830T probably damaging Het
Lepr C A 4: 101,590,620 (GRCm39) A66E possibly damaging Het
Lmntd1 T A 6: 145,359,206 (GRCm39) M315L probably benign Het
Lrch3 A G 16: 32,807,163 (GRCm39) T479A probably benign Het
Macroh2a1 T C 13: 56,244,052 (GRCm39) probably benign Het
Matr3 A G 18: 35,715,110 (GRCm39) N237D probably damaging Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Mtif2 A G 11: 29,490,683 (GRCm39) I462M probably benign Het
Nrip1 T C 16: 76,090,232 (GRCm39) I442V probably damaging Het
Or11g25 G A 14: 50,723,055 (GRCm39) A47T probably benign Het
Or6b2b T A 1: 92,419,124 (GRCm39) M118L possibly damaging Het
Or8k35 A T 2: 86,424,448 (GRCm39) C241* probably null Het
Otogl T A 10: 107,713,925 (GRCm39) Y498F probably damaging Het
Pbx3 A T 2: 34,066,832 (GRCm39) F351I probably benign Het
Pcdh18 T C 3: 49,710,854 (GRCm39) T154A probably benign Het
Pex5l A T 3: 33,005,025 (GRCm39) probably null Het
Plec T C 15: 76,072,432 (GRCm39) I718V probably benign Het
Pparg T A 6: 115,427,941 (GRCm39) Y143N probably damaging Het
Rcor3 T A 1: 191,804,411 (GRCm39) Q246L probably benign Het
Rnf214 A T 9: 45,780,746 (GRCm39) probably benign Het
S1pr5 A T 9: 21,155,425 (GRCm39) S334T probably benign Het
Scg3 C T 9: 75,589,449 (GRCm39) S35N possibly damaging Het
Septin5 A T 16: 18,443,960 (GRCm39) L19Q probably damaging Het
Serpinb7 T C 1: 107,356,025 (GRCm39) F16S probably damaging Het
Sipa1l3 A T 7: 29,038,551 (GRCm39) S365R probably damaging Het
Slc27a1 T C 8: 72,033,347 (GRCm39) probably null Het
Slc2a10 C A 2: 165,357,133 (GRCm39) H264Q probably benign Het
Slc9a3 A G 13: 74,309,889 (GRCm39) I526V probably benign Het
Smchd1 T C 17: 71,696,766 (GRCm39) D1203G probably damaging Het
Spata6l T C 19: 28,916,571 (GRCm39) probably null Het
Sult1b1 A G 5: 87,668,700 (GRCm39) W181R probably damaging Het
Supt6 A G 11: 78,110,703 (GRCm39) probably benign Het
Tcf12 C A 9: 71,775,497 (GRCm39) A418S probably damaging Het
Tesk1 C T 4: 43,443,576 (GRCm39) R48C probably damaging Het
Tiam2 A G 17: 3,487,510 (GRCm39) Q677R probably damaging Het
Tspan8 C T 10: 115,669,130 (GRCm39) A55V probably damaging Het
Txndc11 T C 16: 10,906,268 (GRCm39) N421D probably damaging Het
Vmn1r201 A G 13: 22,658,801 (GRCm39) N5S probably benign Het
Vmn2r120 T A 17: 57,832,826 (GRCm39) I118L probably benign Het
Vps13b A T 15: 35,675,105 (GRCm39) probably benign Het
Wdfy3 A G 5: 102,042,865 (GRCm39) V1962A probably damaging Het
Zswim8 C T 14: 20,760,815 (GRCm39) R107* probably null Het
Other mutations in Prl2c5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00910:Prl2c5 APN 13 13,364,061 (GRCm39) critical splice donor site probably null
IGL01874:Prl2c5 APN 13 13,365,362 (GRCm39) missense probably benign
IGL01878:Prl2c5 APN 13 13,360,402 (GRCm39) missense probably benign 0.00
R0178:Prl2c5 UTSW 13 13,366,390 (GRCm39) missense probably damaging 0.98
R0276:Prl2c5 UTSW 13 13,357,634 (GRCm39) intron probably benign
R0373:Prl2c5 UTSW 13 13,357,609 (GRCm39) intron probably benign
R0539:Prl2c5 UTSW 13 13,363,906 (GRCm39) splice site probably null
R1037:Prl2c5 UTSW 13 13,360,492 (GRCm39) nonsense probably null
R1296:Prl2c5 UTSW 13 13,364,009 (GRCm39) missense probably damaging 1.00
R1458:Prl2c5 UTSW 13 13,365,310 (GRCm39) missense probably benign 0.40
R1557:Prl2c5 UTSW 13 13,365,265 (GRCm39) missense possibly damaging 0.52
R1866:Prl2c5 UTSW 13 13,365,358 (GRCm39) splice site probably null
R1894:Prl2c5 UTSW 13 13,366,263 (GRCm39) missense probably benign 0.04
R2060:Prl2c5 UTSW 13 13,365,238 (GRCm39) missense probably damaging 0.99
R2330:Prl2c5 UTSW 13 13,366,378 (GRCm39) missense possibly damaging 0.67
R4755:Prl2c5 UTSW 13 13,363,970 (GRCm39) missense probably benign
R5229:Prl2c5 UTSW 13 13,360,441 (GRCm39) missense probably damaging 1.00
R5364:Prl2c5 UTSW 13 13,357,627 (GRCm39) missense probably benign 0.01
R6307:Prl2c5 UTSW 13 13,365,175 (GRCm39) missense probably benign 0.01
R6350:Prl2c5 UTSW 13 13,357,631 (GRCm39) critical splice donor site probably null
R6927:Prl2c5 UTSW 13 13,357,503 (GRCm39) splice site probably null
R7397:Prl2c5 UTSW 13 13,366,327 (GRCm39) missense probably benign 0.01
R7965:Prl2c5 UTSW 13 13,360,469 (GRCm39) missense probably benign 0.01
R8084:Prl2c5 UTSW 13 13,360,539 (GRCm39) missense probably benign 0.20
R8959:Prl2c5 UTSW 13 13,365,392 (GRCm39) intron probably benign
R8980:Prl2c5 UTSW 13 13,360,470 (GRCm39) missense probably benign 0.12
R9258:Prl2c5 UTSW 13 13,365,297 (GRCm39) missense probably damaging 0.97
R9465:Prl2c5 UTSW 13 13,360,531 (GRCm39) missense probably benign 0.42
RF020:Prl2c5 UTSW 13 13,360,497 (GRCm39) missense probably benign 0.28
X0025:Prl2c5 UTSW 13 13,366,339 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TAGAATGCAGGGTACTCTTGGG -3'
(R):5'- CTCAGTGAACAGTTCTGAAACTTC -3'

Sequencing Primer
(F):5'- GTAAGTTATCCAGTACTCTCAAAGTG -3'
(R):5'- TGAACAGTTCTGAAACTTCTATACTG -3'
Posted On 2014-06-23