Incidental Mutation 'R1850:Vmn2r120'
ID 208037
Institutional Source Beutler Lab
Gene Symbol Vmn2r120
Ensembl Gene ENSMUSG00000090655
Gene Name vomeronasal 2, receptor 120
Synonyms EG224916
MMRRC Submission 039874-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R1850 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 57815783-57852314 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 57832826 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 118 (I118L)
Ref Sequence ENSEMBL: ENSMUSP00000129296 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165781]
AlphaFold A0A3Q4EG79
Predicted Effect probably benign
Transcript: ENSMUST00000165781
AA Change: I118L

PolyPhen 2 Score 0.187 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000129296
Gene: ENSMUSG00000090655
AA Change: I118L

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 80 474 5.9e-42 PFAM
Pfam:NCD3G 517 570 7.5e-22 PFAM
Pfam:7tm_3 598 836 1.3e-54 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 95.1%
  • 20x: 91.8%
Validation Efficiency 99% (67/68)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam28 T A 14: 68,876,644 (GRCm39) Q202L probably benign Het
Adgb C A 10: 10,318,246 (GRCm39) V199F probably damaging Het
Aff1 G T 5: 103,981,773 (GRCm39) R645S probably damaging Het
Aoc1 C T 6: 48,882,202 (GRCm39) S48F probably benign Het
Atf6 A T 1: 170,646,855 (GRCm39) N339K probably damaging Het
Bpifb3 C G 2: 153,771,264 (GRCm39) S392C possibly damaging Het
Camk1d T C 2: 5,366,826 (GRCm39) M130V probably benign Het
Ces1a T A 8: 93,753,954 (GRCm39) N350Y probably damaging Het
Cfap57 G A 4: 118,457,091 (GRCm39) R453C probably damaging Het
Chd4 T A 6: 125,098,619 (GRCm39) N1532K probably damaging Het
Chd5 T C 4: 152,454,990 (GRCm39) L824P probably damaging Het
Ckap5 G A 2: 91,426,058 (GRCm39) R1306H probably damaging Het
Crybg1 A G 10: 43,873,670 (GRCm39) F1146S probably damaging Het
Dusp12 G A 1: 170,708,198 (GRCm39) T173M probably benign Het
Dync2h1 T C 9: 7,001,448 (GRCm39) T3854A probably benign Het
Echdc1 A T 10: 29,220,599 (GRCm39) I252F probably damaging Het
Emc1 A T 4: 139,086,684 (GRCm39) probably benign Het
Fbn2 C A 18: 58,172,377 (GRCm39) probably benign Het
Fsip2 T A 2: 82,814,933 (GRCm39) N3555K possibly damaging Het
Gabra1 T A 11: 42,070,403 (GRCm39) T20S probably benign Het
Igf1 A C 10: 87,697,236 (GRCm39) T2P possibly damaging Het
Insyn1 A T 9: 58,406,392 (GRCm39) M101L probably benign Het
Jcad C A 18: 4,675,730 (GRCm39) T1164N possibly damaging Het
Kalrn A T 16: 33,796,293 (GRCm39) S2830T probably damaging Het
Lepr C A 4: 101,590,620 (GRCm39) A66E possibly damaging Het
Lmntd1 T A 6: 145,359,206 (GRCm39) M315L probably benign Het
Lrch3 A G 16: 32,807,163 (GRCm39) T479A probably benign Het
Macroh2a1 T C 13: 56,244,052 (GRCm39) probably benign Het
Matr3 A G 18: 35,715,110 (GRCm39) N237D probably damaging Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Mtif2 A G 11: 29,490,683 (GRCm39) I462M probably benign Het
Nrip1 T C 16: 76,090,232 (GRCm39) I442V probably damaging Het
Or11g25 G A 14: 50,723,055 (GRCm39) A47T probably benign Het
Or6b2b T A 1: 92,419,124 (GRCm39) M118L possibly damaging Het
Or8k35 A T 2: 86,424,448 (GRCm39) C241* probably null Het
Otogl T A 10: 107,713,925 (GRCm39) Y498F probably damaging Het
Pbx3 A T 2: 34,066,832 (GRCm39) F351I probably benign Het
Pcdh18 T C 3: 49,710,854 (GRCm39) T154A probably benign Het
Pex5l A T 3: 33,005,025 (GRCm39) probably null Het
Plec T C 15: 76,072,432 (GRCm39) I718V probably benign Het
Pparg T A 6: 115,427,941 (GRCm39) Y143N probably damaging Het
Prl2c5 A G 13: 13,360,377 (GRCm39) I12V probably benign Het
Rcor3 T A 1: 191,804,411 (GRCm39) Q246L probably benign Het
Rnf214 A T 9: 45,780,746 (GRCm39) probably benign Het
S1pr5 A T 9: 21,155,425 (GRCm39) S334T probably benign Het
Scg3 C T 9: 75,589,449 (GRCm39) S35N possibly damaging Het
Septin5 A T 16: 18,443,960 (GRCm39) L19Q probably damaging Het
Serpinb7 T C 1: 107,356,025 (GRCm39) F16S probably damaging Het
Sipa1l3 A T 7: 29,038,551 (GRCm39) S365R probably damaging Het
Slc27a1 T C 8: 72,033,347 (GRCm39) probably null Het
Slc2a10 C A 2: 165,357,133 (GRCm39) H264Q probably benign Het
Slc9a3 A G 13: 74,309,889 (GRCm39) I526V probably benign Het
Smchd1 T C 17: 71,696,766 (GRCm39) D1203G probably damaging Het
Spata6l T C 19: 28,916,571 (GRCm39) probably null Het
Sult1b1 A G 5: 87,668,700 (GRCm39) W181R probably damaging Het
Supt6 A G 11: 78,110,703 (GRCm39) probably benign Het
Tcf12 C A 9: 71,775,497 (GRCm39) A418S probably damaging Het
Tesk1 C T 4: 43,443,576 (GRCm39) R48C probably damaging Het
Tiam2 A G 17: 3,487,510 (GRCm39) Q677R probably damaging Het
Tspan8 C T 10: 115,669,130 (GRCm39) A55V probably damaging Het
Txndc11 T C 16: 10,906,268 (GRCm39) N421D probably damaging Het
Vmn1r201 A G 13: 22,658,801 (GRCm39) N5S probably benign Het
Vps13b A T 15: 35,675,105 (GRCm39) probably benign Het
Wdfy3 A G 5: 102,042,865 (GRCm39) V1962A probably damaging Het
Zswim8 C T 14: 20,760,815 (GRCm39) R107* probably null Het
Other mutations in Vmn2r120
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01335:Vmn2r120 APN 17 57,832,732 (GRCm39) missense possibly damaging 0.86
IGL01346:Vmn2r120 APN 17 57,852,232 (GRCm39) missense probably benign 0.11
IGL01996:Vmn2r120 APN 17 57,832,222 (GRCm39) missense possibly damaging 0.92
IGL02503:Vmn2r120 APN 17 57,816,385 (GRCm39) missense probably benign 0.40
IGL02582:Vmn2r120 APN 17 57,831,724 (GRCm39) missense probably damaging 0.99
IGL02747:Vmn2r120 APN 17 57,831,719 (GRCm39) missense probably benign 0.19
IGL02896:Vmn2r120 APN 17 57,816,008 (GRCm39) missense probably damaging 1.00
IGL03139:Vmn2r120 APN 17 57,831,742 (GRCm39) missense probably benign 0.39
IGL03342:Vmn2r120 APN 17 57,816,372 (GRCm39) missense probably benign 0.03
A4554:Vmn2r120 UTSW 17 57,832,715 (GRCm39) missense probably benign 0.01
R0207:Vmn2r120 UTSW 17 57,832,052 (GRCm39) missense probably benign 0.17
R0472:Vmn2r120 UTSW 17 57,831,518 (GRCm39) missense probably benign 0.03
R0517:Vmn2r120 UTSW 17 57,815,949 (GRCm39) missense probably damaging 1.00
R1109:Vmn2r120 UTSW 17 57,832,829 (GRCm39) missense probably benign 0.09
R1316:Vmn2r120 UTSW 17 57,832,939 (GRCm39) missense probably benign 0.28
R1543:Vmn2r120 UTSW 17 57,829,374 (GRCm39) missense probably benign 0.09
R1795:Vmn2r120 UTSW 17 57,832,038 (GRCm39) missense probably benign 0.35
R1920:Vmn2r120 UTSW 17 57,831,839 (GRCm39) missense probably benign 0.01
R1921:Vmn2r120 UTSW 17 57,831,839 (GRCm39) missense probably benign 0.01
R1922:Vmn2r120 UTSW 17 57,831,839 (GRCm39) missense probably benign 0.01
R2063:Vmn2r120 UTSW 17 57,831,553 (GRCm39) missense possibly damaging 0.88
R2064:Vmn2r120 UTSW 17 57,831,553 (GRCm39) missense possibly damaging 0.88
R2065:Vmn2r120 UTSW 17 57,831,553 (GRCm39) missense possibly damaging 0.88
R2067:Vmn2r120 UTSW 17 57,831,553 (GRCm39) missense possibly damaging 0.88
R2286:Vmn2r120 UTSW 17 57,815,958 (GRCm39) missense probably damaging 1.00
R2291:Vmn2r120 UTSW 17 57,816,479 (GRCm39) missense probably damaging 1.00
R3416:Vmn2r120 UTSW 17 57,816,241 (GRCm39) missense possibly damaging 0.89
R3874:Vmn2r120 UTSW 17 57,831,954 (GRCm39) missense probably benign 0.40
R4023:Vmn2r120 UTSW 17 57,843,718 (GRCm39) missense possibly damaging 0.92
R4024:Vmn2r120 UTSW 17 57,843,718 (GRCm39) missense possibly damaging 0.92
R4348:Vmn2r120 UTSW 17 57,829,466 (GRCm39) missense possibly damaging 0.47
R4409:Vmn2r120 UTSW 17 57,816,477 (GRCm39) missense probably damaging 1.00
R4610:Vmn2r120 UTSW 17 57,816,120 (GRCm39) missense probably damaging 1.00
R4771:Vmn2r120 UTSW 17 57,831,887 (GRCm39) missense probably damaging 1.00
R4786:Vmn2r120 UTSW 17 57,829,048 (GRCm39) missense probably benign 0.14
R4927:Vmn2r120 UTSW 17 57,816,125 (GRCm39) missense probably damaging 1.00
R5285:Vmn2r120 UTSW 17 57,843,703 (GRCm39) missense probably damaging 1.00
R5566:Vmn2r120 UTSW 17 57,852,290 (GRCm39) missense possibly damaging 0.95
R5578:Vmn2r120 UTSW 17 57,829,514 (GRCm39) missense probably benign 0.01
R5643:Vmn2r120 UTSW 17 57,831,977 (GRCm39) missense probably benign 0.01
R5644:Vmn2r120 UTSW 17 57,831,977 (GRCm39) missense probably benign 0.01
R5781:Vmn2r120 UTSW 17 57,831,938 (GRCm39) missense probably benign 0.00
R6084:Vmn2r120 UTSW 17 57,832,721 (GRCm39) missense probably benign 0.15
R6120:Vmn2r120 UTSW 17 57,832,973 (GRCm39) missense probably benign 0.02
R6160:Vmn2r120 UTSW 17 57,816,418 (GRCm39) missense probably benign 0.03
R6248:Vmn2r120 UTSW 17 57,852,287 (GRCm39) missense probably benign 0.03
R6256:Vmn2r120 UTSW 17 57,831,700 (GRCm39) nonsense probably null
R6730:Vmn2r120 UTSW 17 57,832,012 (GRCm39) missense probably benign 0.03
R6821:Vmn2r120 UTSW 17 57,843,659 (GRCm39) missense probably benign 0.00
R6868:Vmn2r120 UTSW 17 57,852,218 (GRCm39) missense probably benign 0.00
R6880:Vmn2r120 UTSW 17 57,816,187 (GRCm39) missense probably damaging 1.00
R6986:Vmn2r120 UTSW 17 57,816,340 (GRCm39) missense probably damaging 1.00
R7276:Vmn2r120 UTSW 17 57,831,881 (GRCm39) missense probably benign 0.11
R7373:Vmn2r120 UTSW 17 57,816,406 (GRCm39) missense probably benign 0.35
R7653:Vmn2r120 UTSW 17 57,816,258 (GRCm39) missense possibly damaging 0.93
R7667:Vmn2r120 UTSW 17 57,843,657 (GRCm39) missense probably benign 0.04
R7775:Vmn2r120 UTSW 17 57,832,942 (GRCm39) missense probably damaging 1.00
R7778:Vmn2r120 UTSW 17 57,832,942 (GRCm39) missense probably damaging 1.00
R7797:Vmn2r120 UTSW 17 57,815,874 (GRCm39) missense probably damaging 1.00
R7824:Vmn2r120 UTSW 17 57,832,942 (GRCm39) missense probably damaging 1.00
R7902:Vmn2r120 UTSW 17 57,816,244 (GRCm39) missense possibly damaging 0.87
R7922:Vmn2r120 UTSW 17 57,831,683 (GRCm39) missense probably damaging 0.99
R8508:Vmn2r120 UTSW 17 57,832,843 (GRCm39) missense probably benign 0.03
R8847:Vmn2r120 UTSW 17 57,816,217 (GRCm39) missense probably benign 0.01
R8882:Vmn2r120 UTSW 17 57,852,229 (GRCm39) missense probably benign 0.01
R9134:Vmn2r120 UTSW 17 57,832,093 (GRCm39) missense probably damaging 1.00
R9161:Vmn2r120 UTSW 17 57,831,864 (GRCm39) missense
R9336:Vmn2r120 UTSW 17 57,832,201 (GRCm39) missense possibly damaging 0.91
RF005:Vmn2r120 UTSW 17 57,828,991 (GRCm39) missense possibly damaging 0.65
Z1177:Vmn2r120 UTSW 17 57,816,245 (GRCm39) missense probably benign 0.00
Z1188:Vmn2r120 UTSW 17 57,829,436 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCCCAAGAGAAAATTGTTGCAC -3'
(R):5'- AAGGTTCATGGGCAGCCTAC -3'

Sequencing Primer
(F):5'- CCCAAGAGAAAATTGTTGCACTCTTC -3'
(R):5'- GGCAGCCTACCTTATTATGGAAG -3'
Posted On 2014-06-23