Incidental Mutation 'R1851:Vmn2r1'
ID 208062
Institutional Source Beutler Lab
Gene Symbol Vmn2r1
Ensembl Gene ENSMUSG00000027824
Gene Name vomeronasal 2, receptor 1
Synonyms V2r83, EG56544
MMRRC Submission 039875-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.133) question?
Stock # R1851 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 63988968-64016905 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 64008926 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 535 (T535I)
Ref Sequence ENSEMBL: ENSMUSP00000029406 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029406]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000029406
AA Change: T535I

PolyPhen 2 Score 0.317 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000029406
Gene: ENSMUSG00000027824
AA Change: T535I

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 86 504 6e-92 PFAM
Pfam:NCD3G 546 599 2.4e-17 PFAM
Pfam:7tm_3 632 866 4.1e-48 PFAM
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 94.9%
  • 20x: 91.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 95 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730507C01Rik A G 12: 18,583,687 (GRCm39) E225G possibly damaging Het
Abcb7 T C X: 103,349,005 (GRCm39) M153V probably benign Het
Abi1 A T 2: 22,840,276 (GRCm39) V329D possibly damaging Het
Ablim3 G A 18: 61,982,466 (GRCm39) H160Y probably benign Het
Acox3 A T 5: 35,766,406 (GRCm39) D624V possibly damaging Het
Adam6b A G 12: 113,455,442 (GRCm39) D753G probably benign Het
Ago1 C A 4: 126,333,788 (GRCm39) R771L probably benign Het
Aktip A G 8: 91,852,505 (GRCm39) V217A possibly damaging Het
Ankk1 A C 9: 49,327,150 (GRCm39) H676Q probably benign Het
Arl1 G C 10: 88,569,408 (GRCm39) probably benign Het
Asxl3 T A 18: 22,650,796 (GRCm39) D928E probably damaging Het
AW209491 T C 13: 14,811,318 (GRCm39) V57A possibly damaging Het
B3galt4 G T 17: 34,169,885 (GRCm39) Q118K probably benign Het
Ccdc187 A T 2: 26,166,080 (GRCm39) M783K probably benign Het
Cdon T G 9: 35,394,454 (GRCm39) M900R probably damaging Het
Ceacam5 G A 7: 17,448,835 (GRCm39) W67* probably null Het
Chd5 A G 4: 152,462,727 (GRCm39) S1356G probably damaging Het
Chil3 C T 3: 106,056,117 (GRCm39) probably null Het
Chmp7 C T 14: 69,956,899 (GRCm39) M336I probably benign Het
Cntn1 C T 15: 92,203,021 (GRCm39) R768C probably damaging Het
Col6a3 T A 1: 90,735,256 (GRCm39) I798F possibly damaging Het
Cpxcr1 T A X: 115,387,758 (GRCm39) L223* probably null Het
Cpz C A 5: 35,659,902 (GRCm39) R581L possibly damaging Het
Cxcr2 A G 1: 74,198,438 (GRCm39) I311V probably benign Het
Cym T A 3: 107,126,030 (GRCm39) I78F probably benign Het
Defb8 A T 8: 19,495,899 (GRCm39) S54T probably benign Het
Dennd4a A G 9: 64,769,312 (GRCm39) T433A probably damaging Het
Dhx29 A G 13: 113,084,815 (GRCm39) T678A probably damaging Het
Dspp T C 5: 104,321,951 (GRCm39) probably null Het
Enkur G T 2: 21,193,988 (GRCm39) A195E probably benign Het
Ero1b T A 13: 12,619,292 (GRCm39) S429T possibly damaging Het
Fh1 A G 1: 175,435,452 (GRCm39) S344P probably damaging Het
Flnc G T 6: 29,443,478 (GRCm39) G553V probably damaging Het
Fmo1 A T 1: 162,657,554 (GRCm39) L529* probably null Het
Frem1 C A 4: 82,868,737 (GRCm39) V1415F probably damaging Het
Gatb T G 3: 85,526,184 (GRCm39) L354R probably damaging Het
Gdpgp1 A T 7: 79,888,349 (GRCm39) N127Y probably damaging Het
Gpat2 A G 2: 127,276,739 (GRCm39) T648A possibly damaging Het
Grk6 C T 13: 55,599,591 (GRCm39) R225* probably null Het
Hells A T 19: 38,948,120 (GRCm39) Q682L probably null Het
Hspa5 T A 2: 34,664,690 (GRCm39) N381K possibly damaging Het
Ighmbp2 T C 19: 3,312,075 (GRCm39) N893S probably benign Het
Ipo11 A T 13: 106,948,765 (GRCm39) V914E possibly damaging Het
Lars1 T C 18: 42,345,673 (GRCm39) N1001S probably benign Het
Lats2 A G 14: 57,934,912 (GRCm39) L606P probably damaging Het
Map4k1 T C 7: 28,699,209 (GRCm39) Y521H probably benign Het
Marchf11 T A 15: 26,387,916 (GRCm39) V257E probably damaging Het
Med23 G A 10: 24,786,768 (GRCm39) probably null Het
Meltf A G 16: 31,715,395 (GRCm39) D696G probably benign Het
Ms4a7 T A 19: 11,301,788 (GRCm39) M212L probably benign Het
Mx1 A T 16: 97,249,403 (GRCm39) L608Q probably damaging Het
Myh1 T C 11: 67,095,224 (GRCm39) Y195H probably damaging Het
Napb G T 2: 148,548,909 (GRCm39) H110Q probably benign Het
Ngly1 C T 14: 16,260,585 (GRCm38) P90S probably damaging Het
Nlrp1b T A 11: 71,073,442 (GRCm39) I134L possibly damaging Het
Nup210 A G 6: 90,993,036 (GRCm39) L1017P probably damaging Het
Nup85 T A 11: 115,472,643 (GRCm39) I233N probably damaging Het
Obsl1 A G 1: 75,469,537 (GRCm39) V965A probably damaging Het
Or4c12 A C 2: 89,774,158 (GRCm39) Y100* probably null Het
Or4f6 T C 2: 111,839,036 (GRCm39) D165G probably benign Het
Or6c5c T C 10: 129,299,370 (GRCm39) L275P probably damaging Het
Pak1ip1 A G 13: 41,164,708 (GRCm39) T264A possibly damaging Het
Pard6g C T 18: 80,160,357 (GRCm39) R157C probably damaging Het
Pcdhb7 A T 18: 37,475,631 (GRCm39) T256S possibly damaging Het
Phrf1 T C 7: 140,820,831 (GRCm39) F153L probably damaging Het
Pigw A T 11: 84,768,874 (GRCm39) F152I probably damaging Het
Pip4k2c A G 10: 127,036,744 (GRCm39) S222P probably damaging Het
Pjvk A G 2: 76,487,775 (GRCm39) probably null Het
Plxnd1 C T 6: 115,940,875 (GRCm39) V1355M probably damaging Het
Pramel26 T C 4: 143,539,396 (GRCm39) I32M probably benign Het
Prss22 G A 17: 24,215,288 (GRCm39) P163S probably damaging Het
Prune2 A G 19: 17,176,503 (GRCm39) I154V probably damaging Het
Rapgef6 T A 11: 54,533,637 (GRCm39) D362E probably benign Het
Retreg2 A G 1: 75,123,319 (GRCm39) K416E probably benign Het
Scn7a T C 2: 66,510,635 (GRCm39) I1256V probably benign Het
Sema4d A G 13: 51,865,258 (GRCm39) V362A possibly damaging Het
Septin4 T A 11: 87,459,741 (GRCm39) D496E probably damaging Het
Slc25a34 G A 4: 141,349,579 (GRCm39) T192I probably benign Het
Tacc3 G T 5: 33,825,544 (GRCm39) V425L probably benign Het
Tfdp2 A T 9: 96,179,762 (GRCm39) K125I probably damaging Het
Tjp2 C T 19: 24,076,899 (GRCm39) R952Q possibly damaging Het
Tk2 G T 8: 104,975,077 (GRCm39) S30* probably null Het
Tmem74 A T 15: 43,730,559 (GRCm39) D161E probably benign Het
Tmprss9 G A 10: 80,728,119 (GRCm39) V570M probably damaging Het
Tnk2 C A 16: 32,498,280 (GRCm39) P26Q probably damaging Het
Tnpo2 T G 8: 85,778,401 (GRCm39) V610G probably damaging Het
Trim37 T C 11: 87,109,132 (GRCm39) F953S probably damaging Het
U2surp T A 9: 95,364,150 (GRCm39) K589* probably null Het
Usp2 G A 9: 43,987,263 (GRCm39) R187H probably benign Het
Wdr20rt T A 12: 65,273,925 (GRCm39) S463T possibly damaging Het
Zbtb25 C A 12: 76,396,488 (GRCm39) G245W probably damaging Het
Zc3h14 T A 12: 98,726,613 (GRCm39) L27* probably null Het
Zfp2 T C 11: 50,791,915 (GRCm39) K43E probably benign Het
Zfp268 T G 4: 145,350,820 (GRCm39) probably benign Het
Zfp654 A G 16: 64,605,491 (GRCm39) Y904H probably benign Het
Other mutations in Vmn2r1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00233:Vmn2r1 APN 3 64,012,389 (GRCm39) nonsense probably null
IGL00335:Vmn2r1 APN 3 64,012,809 (GRCm39) missense probably damaging 0.96
IGL01509:Vmn2r1 APN 3 64,010,466 (GRCm39) missense probably benign 0.03
IGL01641:Vmn2r1 APN 3 64,011,924 (GRCm39) missense probably benign 0.19
IGL01656:Vmn2r1 APN 3 63,989,274 (GRCm39) missense probably damaging 0.96
IGL01927:Vmn2r1 APN 3 63,989,105 (GRCm39) missense probably benign 0.01
IGL02093:Vmn2r1 APN 3 64,012,130 (GRCm39) missense probably benign
IGL02146:Vmn2r1 APN 3 64,012,104 (GRCm39) missense probably benign 0.39
IGL02186:Vmn2r1 APN 3 63,989,138 (GRCm39) missense probably benign 0.01
IGL02320:Vmn2r1 APN 3 63,989,180 (GRCm39) missense possibly damaging 0.61
IGL02423:Vmn2r1 APN 3 63,997,665 (GRCm39) missense probably benign 0.00
IGL02709:Vmn2r1 APN 3 64,012,355 (GRCm39) missense probably benign 0.24
R0034:Vmn2r1 UTSW 3 63,997,435 (GRCm39) missense probably damaging 1.00
R0064:Vmn2r1 UTSW 3 64,012,209 (GRCm39) missense possibly damaging 0.76
R0152:Vmn2r1 UTSW 3 63,989,240 (GRCm39) missense possibly damaging 0.92
R0305:Vmn2r1 UTSW 3 63,997,087 (GRCm39) missense probably damaging 1.00
R0314:Vmn2r1 UTSW 3 63,993,980 (GRCm39) missense probably damaging 1.00
R0317:Vmn2r1 UTSW 3 63,989,240 (GRCm39) missense possibly damaging 0.92
R0465:Vmn2r1 UTSW 3 63,989,180 (GRCm39) missense possibly damaging 0.61
R1144:Vmn2r1 UTSW 3 63,997,541 (GRCm39) missense probably damaging 1.00
R1163:Vmn2r1 UTSW 3 63,994,046 (GRCm39) missense probably benign 0.03
R1448:Vmn2r1 UTSW 3 64,008,734 (GRCm39) missense probably damaging 1.00
R1491:Vmn2r1 UTSW 3 63,997,034 (GRCm39) missense probably damaging 1.00
R1543:Vmn2r1 UTSW 3 63,996,994 (GRCm39) missense probably damaging 1.00
R1611:Vmn2r1 UTSW 3 64,011,958 (GRCm39) nonsense probably null
R1676:Vmn2r1 UTSW 3 63,997,603 (GRCm39) nonsense probably null
R1727:Vmn2r1 UTSW 3 63,989,163 (GRCm39) missense probably benign
R3080:Vmn2r1 UTSW 3 63,997,205 (GRCm39) missense probably damaging 1.00
R3790:Vmn2r1 UTSW 3 63,994,185 (GRCm39) critical splice donor site probably null
R4111:Vmn2r1 UTSW 3 63,997,176 (GRCm39) missense probably benign 0.23
R4689:Vmn2r1 UTSW 3 64,012,074 (GRCm39) missense possibly damaging 0.94
R4747:Vmn2r1 UTSW 3 63,989,267 (GRCm39) missense probably benign 0.00
R4970:Vmn2r1 UTSW 3 63,997,544 (GRCm39) missense possibly damaging 0.81
R5033:Vmn2r1 UTSW 3 64,012,501 (GRCm39) missense probably damaging 1.00
R5086:Vmn2r1 UTSW 3 63,997,418 (GRCm39) missense probably benign 0.00
R5112:Vmn2r1 UTSW 3 63,997,544 (GRCm39) missense possibly damaging 0.81
R5385:Vmn2r1 UTSW 3 64,008,819 (GRCm39) missense possibly damaging 0.89
R5629:Vmn2r1 UTSW 3 64,012,538 (GRCm39) missense possibly damaging 0.87
R5762:Vmn2r1 UTSW 3 63,997,474 (GRCm39) missense probably benign 0.24
R5867:Vmn2r1 UTSW 3 64,011,990 (GRCm39) missense probably benign
R5893:Vmn2r1 UTSW 3 63,993,974 (GRCm39) missense probably damaging 1.00
R6037:Vmn2r1 UTSW 3 63,989,150 (GRCm39) missense probably benign 0.00
R6037:Vmn2r1 UTSW 3 63,989,150 (GRCm39) missense probably benign 0.00
R6290:Vmn2r1 UTSW 3 64,012,873 (GRCm39) missense probably benign 0.02
R6443:Vmn2r1 UTSW 3 64,012,374 (GRCm39) missense possibly damaging 0.78
R6464:Vmn2r1 UTSW 3 64,008,766 (GRCm39) missense probably benign
R6826:Vmn2r1 UTSW 3 64,012,567 (GRCm39) nonsense probably null
R6874:Vmn2r1 UTSW 3 64,012,376 (GRCm39) missense probably damaging 1.00
R6882:Vmn2r1 UTSW 3 63,997,529 (GRCm39) missense possibly damaging 0.64
R6983:Vmn2r1 UTSW 3 63,989,118 (GRCm39) missense probably benign
R7010:Vmn2r1 UTSW 3 64,012,146 (GRCm39) missense probably benign 0.19
R7144:Vmn2r1 UTSW 3 63,997,362 (GRCm39) missense probably damaging 1.00
R7341:Vmn2r1 UTSW 3 64,012,877 (GRCm39) makesense probably null
R7510:Vmn2r1 UTSW 3 63,993,922 (GRCm39) missense probably damaging 1.00
R7557:Vmn2r1 UTSW 3 63,997,475 (GRCm39) missense probably damaging 0.99
R7895:Vmn2r1 UTSW 3 63,997,130 (GRCm39) missense possibly damaging 0.90
R8108:Vmn2r1 UTSW 3 64,010,471 (GRCm39) missense probably damaging 0.98
R8209:Vmn2r1 UTSW 3 63,997,199 (GRCm39) missense possibly damaging 0.64
R8365:Vmn2r1 UTSW 3 63,994,034 (GRCm39) missense possibly damaging 0.80
R8514:Vmn2r1 UTSW 3 63,993,942 (GRCm39) missense probably benign 0.11
R8554:Vmn2r1 UTSW 3 63,997,334 (GRCm39) missense probably damaging 0.98
R8980:Vmn2r1 UTSW 3 64,010,501 (GRCm39) missense
R9140:Vmn2r1 UTSW 3 63,997,465 (GRCm39) missense probably benign 0.05
R9239:Vmn2r1 UTSW 3 64,011,959 (GRCm39) missense probably damaging 0.99
R9441:Vmn2r1 UTSW 3 64,012,674 (GRCm39) missense probably damaging 1.00
R9549:Vmn2r1 UTSW 3 63,997,493 (GRCm39) missense probably benign 0.17
R9771:Vmn2r1 UTSW 3 63,997,559 (GRCm39) missense possibly damaging 0.79
X0065:Vmn2r1 UTSW 3 63,997,678 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ATATTGCCAACCATGCTTGAAG -3'
(R):5'- TGGTCAGAGTACTTGAGAAGGTAAC -3'

Sequencing Primer
(F):5'- CACATGTGGATAGAGATTGTCATAG -3'
(R):5'- AGAGTACTTGAGAAGGTAACATACTG -3'
Posted On 2014-06-23