Mutagenetix > Incidental Mutation

Incidental Mutation 'R1852:Dnah17'

208241

Institutional Source

Beutler Lab

Gene Symbol

Dnah17

Ensembl Gene

ENSMUSG00000033987

Gene Name

dynein, axonemal, heavy chain 17

Synonyms

Dnahcl1, LOC382552, 2810003K23Rik, Dnahc17

MMRRC Submission

039876-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1852 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

117912549-118021460 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 118012742 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 145 (I145F)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084803] [ENSMUST00000106308] [ENSMUST00000132685]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000084803
AA Change: I440F

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000081864
Gene: ENSMUSG00000033987
AA Change: I440F

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	183	766	8.5e-142	PFAM
low complexity region	1015	1028	N/A	INTRINSIC
Pfam:DHC_N2	1260	1673	5.8e-135	PFAM
Pfam:AAA_6	1793	2023	6e-161	PFAM
low complexity region	2092	2104	N/A	INTRINSIC
Pfam:AAA_5	2107	2243	7.8e-13	PFAM
Pfam:AAA_7	2400	2671	1.1e-171	PFAM
Pfam:AAA_8	2748	3015	4.9e-166	PFAM
Pfam:MT	3027	3370	3.4e-214	PFAM
Pfam:AAA_9	3388	3615	2.4e-144	PFAM
Pfam:Dynein_heavy	3742	4452	N/A	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000106308
AA Change: I440F

PolyPhen 2 Score 0.225 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000101915
Gene: ENSMUSG00000033987
AA Change: I440F

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	184	764	1.7e-152	PFAM
low complexity region	1015	1028	N/A	INTRINSIC
Pfam:DHC_N2	1262	1671	4.1e-132	PFAM
Pfam:AAA_6	1793	2023	7e-149	PFAM
low complexity region	2092	2104	N/A	INTRINSIC
Pfam:AAA_5	2107	2243	2.5e-11	PFAM
Pfam:AAA_7	2400	2671	4.4e-169	PFAM
Pfam:AAA_8	2748	3015	7.1e-163	PFAM
Pfam:MT	3027	3370	1.1e-210	PFAM
Pfam:AAA_9	3392	3614	1e-84	PFAM
Pfam:Dynein_heavy	3748	4479	3.5e-230	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000124164
AA Change: I145F

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000115370
Gene: ENSMUSG00000033987
AA Change: I145F

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	1	471	2e-109	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000132685
AA Change: I440F

PolyPhen 2 Score 0.085 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000120542
Gene: ENSMUSG00000033987
AA Change: I440F

Domain	Start	End	E-Value	Type
Pfam:DHC_N2	279	688	3.1e-132	PFAM
Pfam:AAA_6	811	1041	5.3e-149	PFAM
low complexity region	1110	1122	N/A	INTRINSIC
Blast:AAA	1123	1354	1e-104	BLAST
Pfam:AAA_7	1452	1671	8.9e-134	PFAM
Pfam:AAA_8	1763	2030	5.4e-163	PFAM
Pfam:MT	2042	2168	6.8e-52	PFAM
Pfam:MT	2163	2412	8.2e-149	PFAM
Pfam:AAA_9	2434	2656	7.9e-85	PFAM
Pfam:Dynein_heavy	2790	3457	2.6e-209	PFAM
Pfam:Dynein_heavy	3460	3569	4.6e-17	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134069

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 95.0%
20x: 91.6%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. DNAH17 is a heavy chain associated with axonemal dynein (Milisav and Affara, 1998 [PubMed 9545504]).[supplied by OMIM, Mar 2008]

Allele List at MGI

Other mutations in this stock

Total: 106 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2900092C05Rik	A	G	7: 12,246,629 (GRCm39)		probably null	Het
4930433I11Rik	T	A	7: 40,643,037 (GRCm39)	D326E	probably benign	Het
Abca8a	T	C	11: 109,960,212 (GRCm39)	D676G	probably damaging	Het
Abcb7	T	C	X: 103,349,005 (GRCm39)	M153V	probably benign	Het
Ablim3	G	A	18: 61,982,466 (GRCm39)	H160Y	probably benign	Het
Acsl6	T	C	11: 54,251,902 (GRCm39)	I683T	probably damaging	Het
Adgrg5	A	T	8: 95,664,428 (GRCm39)	Y345F	probably damaging	Het
Alg6	T	G	4: 99,634,599 (GRCm39)	F114V	probably benign	Het
Ank2	A	C	3: 126,791,500 (GRCm39)		probably null	Het
Ankrd24	A	T	10: 81,478,775 (GRCm39)		probably benign	Het
Ano8	T	C	8: 71,936,131 (GRCm39)	K222E	probably damaging	Het
Arhgef5	T	C	6: 43,252,119 (GRCm39)	S957P	probably benign	Het
Bltp2	A	G	11: 78,159,299 (GRCm39)	D499G	probably damaging	Het
Bmpr1b	A	T	3: 141,563,163 (GRCm39)		probably null	Het
C3	A	G	17: 57,529,823 (GRCm39)	V2A	probably damaging	Het
Capn1	A	G	19: 6,059,133 (GRCm39)	V276A	possibly damaging	Het
Ccdc57	T	C	11: 120,812,499 (GRCm39)	E85G	probably damaging	Het
Chil3	C	T	3: 106,056,117 (GRCm39)		probably null	Het
Chl1	A	T	6: 103,676,120 (GRCm39)		probably null	Het
Chodl	C	T	16: 78,738,146 (GRCm39)	P38L	probably benign	Het
Clec4a2	G	T	6: 123,116,084 (GRCm39)	E124*	probably null	Het
Cmtr1	T	C	17: 29,921,229 (GRCm39)	V825A	probably benign	Het
Cnksr3	T	C	10: 7,070,539 (GRCm39)	I232V	probably benign	Het
Cntn1	C	T	15: 92,203,021 (GRCm39)	R768C	probably damaging	Het
Col15a1	G	T	4: 47,299,278 (GRCm39)		probably null	Het
Col6a3	T	A	1: 90,735,256 (GRCm39)	I798F	possibly damaging	Het
Cpxcr1	T	A	X: 115,387,758 (GRCm39)	L223*	probably null	Het
Cul1	A	G	6: 47,497,764 (GRCm39)	N615S	probably damaging	Het
Cxcr2	A	G	1: 74,198,438 (GRCm39)	I311V	probably benign	Het
Cyp2c67	C	T	19: 39,605,811 (GRCm39)	G362S	probably benign	Het
D930048N14Rik	T	A	11: 51,544,692 (GRCm39)		probably benign	Het
Ddx49	T	C	8: 70,753,633 (GRCm39)	T79A	probably damaging	Het
Defb46	T	A	8: 19,289,991 (GRCm39)		probably null	Het
Dock8	A	T	19: 25,104,492 (GRCm39)	I725F	probably benign	Het
Dppa4	G	A	16: 48,108,247 (GRCm39)	A11T	probably damaging	Het
Enam	T	A	5: 88,652,324 (GRCm39)	S1278T	possibly damaging	Het
Fndc3a	A	G	14: 72,794,283 (GRCm39)	V829A	probably damaging	Het
Gatb	T	G	3: 85,526,184 (GRCm39)	L354R	probably damaging	Het
Gm10787	A	T	10: 76,857,711 (GRCm39)		noncoding transcript	Het
Gsap	T	A	5: 21,495,543 (GRCm39)		probably null	Het
Gtf2ird1	T	C	5: 134,411,434 (GRCm39)		probably null	Het
Has3	A	T	8: 107,600,711 (GRCm39)	I58F	probably damaging	Het
Haus5	A	T	7: 30,357,926 (GRCm39)		probably null	Het
Hip1r	T	C	5: 124,129,568 (GRCm39)	V169A	probably benign	Het
Hnf1a	T	A	5: 115,108,770 (GRCm39)	D45V	probably damaging	Het
Il20ra	T	A	10: 19,618,767 (GRCm39)	Y72N	probably damaging	Het
Ipo11	A	T	13: 106,948,765 (GRCm39)	V914E	possibly damaging	Het
Itpr1	T	C	6: 108,363,667 (GRCm39)	L763P	probably damaging	Het
Katnal2	C	A	18: 77,103,719 (GRCm39)	R104L	probably benign	Het
Kcng4	G	T	8: 120,352,947 (GRCm39)	P321Q	probably benign	Het
Larp4b	T	C	13: 9,187,339 (GRCm39)		probably null	Het
Lars1	T	C	18: 42,345,673 (GRCm39)	N1001S	probably benign	Het
Lhcgr	T	A	17: 89,072,604 (GRCm39)	I148F	probably damaging	Het
Lsm10	T	A	4: 125,991,756 (GRCm39)	S37R	possibly damaging	Het
Mfsd13a	A	G	19: 46,360,619 (GRCm39)		probably null	Het
Mipep	T	A	14: 61,080,689 (GRCm39)	C560*	probably null	Het
Mme	G	A	3: 63,235,467 (GRCm39)	D172N	probably benign	Het
Mme	A	G	3: 63,235,404 (GRCm39)	S97G	probably benign	Het
Mtrex	A	T	13: 113,009,461 (GRCm39)	H979Q	probably benign	Het
Mx1	A	T	16: 97,249,403 (GRCm39)	L608Q	probably damaging	Het
Myt1l	T	C	12: 29,901,660 (GRCm39)	M208T	probably benign	Het
Neb	T	C	2: 52,118,554 (GRCm39)	I3987V	probably damaging	Het
Nelfcd	A	G	2: 174,265,771 (GRCm39)		probably null	Het
Neto1	T	C	18: 86,414,009 (GRCm39)	M1T	probably null	Het
Nom1	T	C	5: 29,651,876 (GRCm39)	F738S	possibly damaging	Het
Or10v1	C	A	19: 11,874,249 (GRCm39)	P288H	probably damaging	Het
Or4f61	C	A	2: 111,922,192 (GRCm39)	V285L	probably benign	Het
Or51h5	C	T	7: 102,577,648 (GRCm39)	S271L	probably damaging	Het
Or5b123	C	T	19: 13,596,967 (GRCm39)	S147F	probably damaging	Het
Or5w14	T	C	2: 87,541,317 (GRCm39)		probably null	Het
Or6c203	T	C	10: 129,010,197 (GRCm39)	K231R	probably benign	Het
Or6f2	T	A	7: 139,756,474 (GRCm39)	L147*	probably null	Het
Or9m1b	T	G	2: 87,836,865 (GRCm39)	I86L	probably damaging	Het
Pak1ip1	A	G	13: 41,164,708 (GRCm39)	T264A	possibly damaging	Het
Palb2	G	T	7: 121,713,537 (GRCm39)	D915E	possibly damaging	Het
Pank4	T	C	4: 155,060,816 (GRCm39)	L491P	probably damaging	Het
Paqr7	T	C	4: 134,234,980 (GRCm39)	V279A	probably benign	Het
Pcif1	G	A	2: 164,730,386 (GRCm39)	R373Q	probably damaging	Het
Pdgfa	T	A	5: 138,964,927 (GRCm39)	N185I	probably benign	Het
Plcd4	T	C	1: 74,588,520 (GRCm39)	V123A	possibly damaging	Het
Pramel26	T	C	4: 143,539,396 (GRCm39)	I32M	probably benign	Het
Prune2	A	G	19: 17,176,503 (GRCm39)	I154V	probably damaging	Het
Rac3	T	G	11: 120,614,320 (GRCm39)	L148R	possibly damaging	Het
Rapgef6	T	A	11: 54,533,637 (GRCm39)	D362E	probably benign	Het
Rbl1	A	G	2: 157,016,823 (GRCm39)	I592T	probably benign	Het
Rbl2	A	C	8: 91,822,191 (GRCm39)	D408A	possibly damaging	Het
Retreg2	A	G	1: 75,123,319 (GRCm39)	K416E	probably benign	Het
Rorb	A	T	19: 18,939,447 (GRCm39)	L234H	probably damaging	Het
Rpp40	T	G	13: 36,080,897 (GRCm39)	D279A	probably benign	Het
Siglec1	C	A	2: 130,923,420 (GRCm39)	V442L	probably damaging	Het
Sik3	C	G	9: 46,132,387 (GRCm39)	H1276Q	probably benign	Het
Slc25a34	G	A	4: 141,349,579 (GRCm39)	T192I	probably benign	Het
Sp140l1	G	A	1: 85,062,852 (GRCm39)		probably benign	Het
Sptbn5	T	C	2: 119,902,125 (GRCm39)	I126M	possibly damaging	Het
Strada	A	G	11: 106,062,047 (GRCm39)	V94A	possibly damaging	Het
Stxbp5	C	A	10: 9,688,042 (GRCm39)	V420F	possibly damaging	Het
Tgm1	T	C	14: 55,942,398 (GRCm39)	Y651C	probably damaging	Het
Tmem200c	T	A	17: 69,147,612 (GRCm39)	V65E	probably damaging	Het
Tmem74	A	T	15: 43,730,559 (GRCm39)	D161E	probably benign	Het
Trgc3	A	T	13: 19,445,261 (GRCm39)	M70L	probably damaging	Het
Vcan	T	G	13: 89,853,511 (GRCm39)	E483A	probably damaging	Het
Vmn2r124	A	G	17: 18,283,436 (GRCm39)	T377A	probably benign	Het
Vmn2r3	A	C	3: 64,166,815 (GRCm39)	I772S	probably damaging	Het
Wdfy3	A	G	5: 102,063,242 (GRCm39)	V1342A	probably benign	Het
Zfp507	T	C	7: 35,487,176 (GRCm39)	H764R	probably damaging	Het
Znrf3	A	G	11: 5,237,455 (GRCm39)	I218T	possibly damaging	Het

Other mutations in Dnah17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00231:Dnah17	APN	11	117,979,040 (GRCm39)	missense	possibly damaging	0.81
IGL00531:Dnah17	APN	11	117,933,999 (GRCm39)	missense	probably damaging	0.97
IGL00764:Dnah17	APN	11	117,987,311 (GRCm39)	missense	probably damaging	0.99
IGL00795:Dnah17	APN	11	117,984,460 (GRCm39)	missense	probably benign	0.35
IGL00823:Dnah17	APN	11	117,937,987 (GRCm39)	missense	probably benign	0.22
IGL01145:Dnah17	APN	11	117,937,999 (GRCm39)	missense	possibly damaging	0.63
IGL01433:Dnah17	APN	11	117,940,760 (GRCm39)	missense	probably damaging	1.00
IGL01454:Dnah17	APN	11	117,949,223 (GRCm39)	missense	probably damaging	1.00
IGL01545:Dnah17	APN	11	118,010,394 (GRCm39)	missense	probably damaging	1.00
IGL01548:Dnah17	APN	11	117,989,438 (GRCm39)	missense	probably benign	0.21
IGL01557:Dnah17	APN	11	117,964,512 (GRCm39)	missense	probably damaging	0.98
IGL01632:Dnah17	APN	11	117,924,707 (GRCm39)	missense	probably damaging	1.00
IGL01636:Dnah17	APN	11	117,931,882 (GRCm39)	missense	probably benign	0.03
IGL01672:Dnah17	APN	11	117,932,986 (GRCm39)	missense	probably damaging	0.97
IGL01822:Dnah17	APN	11	117,972,819 (GRCm39)	missense	probably damaging	1.00
IGL01869:Dnah17	APN	11	117,943,502 (GRCm39)	missense	probably benign	0.09
IGL01916:Dnah17	APN	11	118,016,114 (GRCm39)	missense	probably benign	0.00
IGL02131:Dnah17	APN	11	117,963,734 (GRCm39)	missense	probably damaging	1.00
IGL02154:Dnah17	APN	11	118,015,087 (GRCm39)	missense	probably benign	0.01
IGL02220:Dnah17	APN	11	117,963,793 (GRCm39)	nonsense	probably null
IGL02454:Dnah17	APN	11	117,971,593 (GRCm39)	missense	probably damaging	0.98
IGL02458:Dnah17	APN	11	117,927,176 (GRCm39)	missense	probably damaging	1.00
IGL02588:Dnah17	APN	11	117,916,479 (GRCm39)	missense	possibly damaging	0.95
IGL02865:Dnah17	APN	11	117,964,374 (GRCm39)	missense	probably damaging	1.00
IGL02881:Dnah17	APN	11	117,932,944 (GRCm39)	missense	probably damaging	1.00
IGL02952:Dnah17	APN	11	117,979,094 (GRCm39)	missense	probably benign	0.03
IGL03382:Dnah17	APN	11	117,972,769 (GRCm39)	missense	probably damaging	1.00
IGL03389:Dnah17	APN	11	117,985,805 (GRCm39)	missense	probably damaging	1.00
ergos	UTSW	11	117,931,984 (GRCm39)	splice site	probably benign
watt	UTSW	11	117,971,592 (GRCm39)	missense	probably damaging	0.96
PIT4280001:Dnah17	UTSW	11	117,989,408 (GRCm39)	missense	possibly damaging	0.85
R0004:Dnah17	UTSW	11	117,950,918 (GRCm39)	missense	possibly damaging	0.90
R0112:Dnah17	UTSW	11	117,965,260 (GRCm39)	missense	possibly damaging	0.82
R0116:Dnah17	UTSW	11	117,949,132 (GRCm39)	missense	probably benign	0.01
R0157:Dnah17	UTSW	11	118,017,997 (GRCm39)	missense	probably benign
R0320:Dnah17	UTSW	11	117,943,500 (GRCm39)	missense	possibly damaging	0.56
R0362:Dnah17	UTSW	11	117,989,365 (GRCm39)	missense	probably benign	0.10
R0382:Dnah17	UTSW	11	118,019,822 (GRCm39)	missense	probably damaging	1.00
R0383:Dnah17	UTSW	11	117,958,373 (GRCm39)	missense	probably benign
R0400:Dnah17	UTSW	11	117,972,904 (GRCm39)	missense	probably damaging	1.00
R0420:Dnah17	UTSW	11	117,930,765 (GRCm39)	missense	probably damaging	1.00
R0483:Dnah17	UTSW	11	117,937,950 (GRCm39)	missense	probably benign
R0533:Dnah17	UTSW	11	118,001,363 (GRCm39)	missense	possibly damaging	0.50
R0562:Dnah17	UTSW	11	117,963,726 (GRCm39)	missense	probably damaging	1.00
R0564:Dnah17	UTSW	11	117,973,807 (GRCm39)	missense	probably damaging	1.00
R0604:Dnah17	UTSW	11	118,012,297 (GRCm39)	missense	probably benign	0.00
R0608:Dnah17	UTSW	11	117,981,575 (GRCm39)	nonsense	probably null
R0614:Dnah17	UTSW	11	117,961,394 (GRCm39)	splice site	probably benign
R0632:Dnah17	UTSW	11	117,958,508 (GRCm39)	splice site	probably benign
R0831:Dnah17	UTSW	11	117,951,097 (GRCm39)	missense	probably damaging	0.99
R0838:Dnah17	UTSW	11	117,950,930 (GRCm39)	missense	probably damaging	1.00
R0879:Dnah17	UTSW	11	117,947,661 (GRCm39)	splice site	probably benign
R1061:Dnah17	UTSW	11	117,943,514 (GRCm39)	missense	possibly damaging	0.51
R1190:Dnah17	UTSW	11	117,933,001 (GRCm39)	missense	probably damaging	1.00
R1293:Dnah17	UTSW	11	118,017,963 (GRCm39)	critical splice donor site	probably null
R1297:Dnah17	UTSW	11	118,012,192 (GRCm39)	splice site	probably benign
R1332:Dnah17	UTSW	11	117,934,041 (GRCm39)	missense	possibly damaging	0.70
R1336:Dnah17	UTSW	11	117,934,041 (GRCm39)	missense	possibly damaging	0.70
R1364:Dnah17	UTSW	11	118,016,432 (GRCm39)	splice site	probably benign
R1418:Dnah17	UTSW	11	117,964,849 (GRCm39)	missense	probably damaging	0.98
R1432:Dnah17	UTSW	11	117,914,153 (GRCm39)	missense	probably damaging	1.00
R1497:Dnah17	UTSW	11	118,005,059 (GRCm39)	missense	probably damaging	1.00
R1500:Dnah17	UTSW	11	117,991,879 (GRCm39)	missense	probably benign
R1506:Dnah17	UTSW	11	118,016,213 (GRCm39)	missense	possibly damaging	0.53
R1512:Dnah17	UTSW	11	117,985,841 (GRCm39)	missense	probably benign
R1567:Dnah17	UTSW	11	118,016,811 (GRCm39)	missense	probably damaging	1.00
R1597:Dnah17	UTSW	11	117,994,324 (GRCm39)	splice site	probably benign
R1665:Dnah17	UTSW	11	118,012,321 (GRCm39)	splice site	probably benign
R1703:Dnah17	UTSW	11	117,917,575 (GRCm39)	missense	probably damaging	1.00
R1716:Dnah17	UTSW	11	117,923,424 (GRCm39)	missense	probably benign	0.00
R1727:Dnah17	UTSW	11	117,987,362 (GRCm39)	nonsense	probably null
R1727:Dnah17	UTSW	11	117,961,315 (GRCm39)	missense	probably damaging	0.98
R1728:Dnah17	UTSW	11	117,960,345 (GRCm39)	missense	possibly damaging	0.76
R1784:Dnah17	UTSW	11	117,960,345 (GRCm39)	missense	possibly damaging	0.76
R1869:Dnah17	UTSW	11	117,938,015 (GRCm39)	nonsense	probably null
R1886:Dnah17	UTSW	11	117,998,987 (GRCm39)	missense	possibly damaging	0.62
R1893:Dnah17	UTSW	11	117,957,794 (GRCm39)	missense	probably benign	0.00
R1954:Dnah17	UTSW	11	117,915,557 (GRCm39)	missense	probably damaging	1.00
R1969:Dnah17	UTSW	11	117,995,361 (GRCm39)	missense	probably benign	0.00
R1971:Dnah17	UTSW	11	117,995,361 (GRCm39)	missense	probably benign	0.00
R1975:Dnah17	UTSW	11	117,987,362 (GRCm39)	nonsense	probably null
R1977:Dnah17	UTSW	11	118,003,417 (GRCm39)	missense	possibly damaging	0.52
R2055:Dnah17	UTSW	11	117,958,357 (GRCm39)	missense	probably benign	0.00
R2115:Dnah17	UTSW	11	118,010,628 (GRCm39)	missense	probably benign	0.00
R2132:Dnah17	UTSW	11	117,924,573 (GRCm39)	missense	probably damaging	0.98
R2200:Dnah17	UTSW	11	117,993,235 (GRCm39)	splice site	probably benign
R2277:Dnah17	UTSW	11	117,987,387 (GRCm39)	missense	possibly damaging	0.81
R2279:Dnah17	UTSW	11	117,987,387 (GRCm39)	missense	possibly damaging	0.81
R2400:Dnah17	UTSW	11	118,017,210 (GRCm39)	critical splice acceptor site	probably null
R2402:Dnah17	UTSW	11	118,016,800 (GRCm39)	missense	probably benign	0.10
R2497:Dnah17	UTSW	11	117,977,850 (GRCm39)	splice site	probably null
R2923:Dnah17	UTSW	11	117,984,373 (GRCm39)	missense	probably damaging	1.00
R3121:Dnah17	UTSW	11	117,931,912 (GRCm39)	missense	probably damaging	1.00
R3236:Dnah17	UTSW	11	117,985,680 (GRCm39)	missense	probably benign	0.08
R3237:Dnah17	UTSW	11	117,985,680 (GRCm39)	missense	probably benign	0.08
R3498:Dnah17	UTSW	11	117,971,675 (GRCm39)	splice site	probably benign
R3499:Dnah17	UTSW	11	117,971,675 (GRCm39)	splice site	probably benign
R3746:Dnah17	UTSW	11	117,973,742 (GRCm39)	missense	probably benign	0.00
R3749:Dnah17	UTSW	11	117,973,742 (GRCm39)	missense	probably benign	0.00
R3762:Dnah17	UTSW	11	117,995,352 (GRCm39)	missense	probably benign	0.00
R3826:Dnah17	UTSW	11	117,931,984 (GRCm39)	splice site	probably benign
R3828:Dnah17	UTSW	11	117,931,984 (GRCm39)	splice site	probably benign
R3829:Dnah17	UTSW	11	117,931,984 (GRCm39)	splice site	probably benign
R3877:Dnah17	UTSW	11	117,915,533 (GRCm39)	missense	probably damaging	1.00
R3899:Dnah17	UTSW	11	117,985,634 (GRCm39)	missense	possibly damaging	0.78
R3900:Dnah17	UTSW	11	117,985,634 (GRCm39)	missense	possibly damaging	0.78
R3911:Dnah17	UTSW	11	117,971,675 (GRCm39)	splice site	probably benign
R3913:Dnah17	UTSW	11	117,971,675 (GRCm39)	splice site	probably benign
R3930:Dnah17	UTSW	11	117,971,675 (GRCm39)	splice site	probably benign
R3931:Dnah17	UTSW	11	117,971,675 (GRCm39)	splice site	probably benign
R3969:Dnah17	UTSW	11	117,931,984 (GRCm39)	splice site	probably benign
R3970:Dnah17	UTSW	11	117,931,984 (GRCm39)	splice site	probably benign
R4056:Dnah17	UTSW	11	117,961,364 (GRCm39)	missense	probably benign	0.05
R4113:Dnah17	UTSW	11	118,003,420 (GRCm39)	missense	possibly damaging	0.50
R4295:Dnah17	UTSW	11	118,009,598 (GRCm39)	missense	probably damaging	1.00
R4324:Dnah17	UTSW	11	117,985,039 (GRCm39)	missense	probably benign	0.01
R4412:Dnah17	UTSW	11	117,964,509 (GRCm39)	missense	probably damaging	1.00
R4413:Dnah17	UTSW	11	117,915,994 (GRCm39)	missense	probably benign	0.00
R4422:Dnah17	UTSW	11	117,972,799 (GRCm39)	missense	possibly damaging	0.91
R4552:Dnah17	UTSW	11	117,943,769 (GRCm39)	missense	possibly damaging	0.79
R4669:Dnah17	UTSW	11	117,965,119 (GRCm39)	missense	probably benign	0.02
R4677:Dnah17	UTSW	11	118,010,640 (GRCm39)	missense	probably damaging	1.00
R4716:Dnah17	UTSW	11	117,964,474 (GRCm39)	missense	probably benign	0.02
R4832:Dnah17	UTSW	11	117,917,606 (GRCm39)	missense	probably damaging	1.00
R4868:Dnah17	UTSW	11	117,999,038 (GRCm39)	missense	probably benign	0.03
R4897:Dnah17	UTSW	11	117,969,419 (GRCm39)	missense	probably damaging	1.00
R4928:Dnah17	UTSW	11	117,918,259 (GRCm39)	missense	probably damaging	1.00
R4937:Dnah17	UTSW	11	117,932,980 (GRCm39)	missense	probably damaging	1.00
R4957:Dnah17	UTSW	11	117,965,124 (GRCm39)	missense	probably benign	0.44
R5008:Dnah17	UTSW	11	118,001,403 (GRCm39)	missense	probably benign	0.01
R5016:Dnah17	UTSW	11	117,971,592 (GRCm39)	missense	probably damaging	0.96
R5027:Dnah17	UTSW	11	117,993,365 (GRCm39)	missense	probably benign	0.01
R5133:Dnah17	UTSW	11	118,007,939 (GRCm39)	missense	probably benign	0.00
R5140:Dnah17	UTSW	11	117,977,771 (GRCm39)	missense	probably damaging	1.00
R5146:Dnah17	UTSW	11	118,005,005 (GRCm39)	missense	probably damaging	0.99
R5151:Dnah17	UTSW	11	117,918,293 (GRCm39)	missense	probably damaging	1.00
R5153:Dnah17	UTSW	11	117,973,800 (GRCm39)	nonsense	probably null
R5192:Dnah17	UTSW	11	117,925,185 (GRCm39)	missense	possibly damaging	0.96
R5315:Dnah17	UTSW	11	118,018,109 (GRCm39)	missense	possibly damaging	0.79
R5317:Dnah17	UTSW	11	118,018,109 (GRCm39)	missense	possibly damaging	0.79
R5335:Dnah17	UTSW	11	118,003,340 (GRCm39)	missense	probably damaging	1.00
R5379:Dnah17	UTSW	11	118,008,029 (GRCm39)	intron	probably benign
R5396:Dnah17	UTSW	11	118,018,108 (GRCm39)	missense	probably benign
R5418:Dnah17	UTSW	11	117,985,810 (GRCm39)	missense	probably benign	0.04
R5534:Dnah17	UTSW	11	117,943,596 (GRCm39)	missense	possibly damaging	0.83
R5539:Dnah17	UTSW	11	117,964,486 (GRCm39)	missense	probably benign	0.03
R5594:Dnah17	UTSW	11	117,934,055 (GRCm39)	splice site	probably null
R5634:Dnah17	UTSW	11	117,943,752 (GRCm39)	splice site	probably null
R5696:Dnah17	UTSW	11	117,991,882 (GRCm39)	missense	probably benign	0.44
R5802:Dnah17	UTSW	11	117,927,272 (GRCm39)	missense	possibly damaging	0.79
R5826:Dnah17	UTSW	11	117,925,193 (GRCm39)	missense	probably damaging	1.00
R5873:Dnah17	UTSW	11	117,947,723 (GRCm39)	missense	probably benign	0.01
R5898:Dnah17	UTSW	11	118,005,039 (GRCm39)	missense	probably benign	0.00
R5934:Dnah17	UTSW	11	117,931,928 (GRCm39)	missense	probably benign
R6030:Dnah17	UTSW	11	117,916,375 (GRCm39)	missense	probably benign	0.32
R6030:Dnah17	UTSW	11	117,916,375 (GRCm39)	missense	probably benign	0.32
R6038:Dnah17	UTSW	11	117,946,715 (GRCm39)	missense	probably benign	0.00
R6038:Dnah17	UTSW	11	117,946,715 (GRCm39)	missense	probably benign	0.00
R6113:Dnah17	UTSW	11	118,017,101 (GRCm39)	missense	probably damaging	1.00
R6117:Dnah17	UTSW	11	118,010,397 (GRCm39)	missense	probably benign	0.00
R6137:Dnah17	UTSW	11	117,916,480 (GRCm39)	missense	probably damaging	1.00
R6173:Dnah17	UTSW	11	117,930,772 (GRCm39)	missense	probably damaging	1.00
R6258:Dnah17	UTSW	11	118,017,149 (GRCm39)	nonsense	probably null
R6258:Dnah17	UTSW	11	118,017,148 (GRCm39)	missense	probably damaging	1.00
R6258:Dnah17	UTSW	11	118,017,150 (GRCm39)	missense	probably damaging	1.00
R6260:Dnah17	UTSW	11	118,017,150 (GRCm39)	missense	probably damaging	1.00
R6260:Dnah17	UTSW	11	118,017,148 (GRCm39)	missense	probably damaging	1.00
R6260:Dnah17	UTSW	11	118,017,149 (GRCm39)	nonsense	probably null
R6278:Dnah17	UTSW	11	118,017,116 (GRCm39)	missense	probably damaging	0.99
R6298:Dnah17	UTSW	11	117,998,987 (GRCm39)	missense	probably benign	0.00
R6300:Dnah17	UTSW	11	117,925,136 (GRCm39)	missense	probably damaging	1.00
R6302:Dnah17	UTSW	11	118,019,981 (GRCm39)	missense	probably benign	0.09
R6363:Dnah17	UTSW	11	118,001,331 (GRCm39)	missense	probably benign
R6381:Dnah17	UTSW	11	118,020,011 (GRCm39)	missense	probably benign	0.08
R6418:Dnah17	UTSW	11	118,020,023 (GRCm39)	missense	probably damaging	0.99
R6660:Dnah17	UTSW	11	117,991,014 (GRCm39)	missense	probably benign
R6803:Dnah17	UTSW	11	118,016,198 (GRCm39)	missense	probably benign	0.00
R6820:Dnah17	UTSW	11	117,959,826 (GRCm39)	missense	probably damaging	0.99
R6885:Dnah17	UTSW	11	117,981,598 (GRCm39)	missense	possibly damaging	0.47
R6921:Dnah17	UTSW	11	117,932,310 (GRCm39)	missense	probably damaging	0.98
R6932:Dnah17	UTSW	11	117,950,905 (GRCm39)	missense	possibly damaging	0.95
R6954:Dnah17	UTSW	11	117,957,258 (GRCm39)	missense	probably damaging	1.00
R7000:Dnah17	UTSW	11	117,916,528 (GRCm39)	critical splice acceptor site	probably null
R7007:Dnah17	UTSW	11	118,009,697 (GRCm39)	missense	possibly damaging	0.92
R7048:Dnah17	UTSW	11	117,936,944 (GRCm39)	missense	possibly damaging	0.80
R7056:Dnah17	UTSW	11	118,016,212 (GRCm39)	missense	probably benign
R7131:Dnah17	UTSW	11	117,970,484 (GRCm39)	missense	probably benign	0.14
R7143:Dnah17	UTSW	11	117,976,956 (GRCm39)	missense	probably damaging	1.00
R7146:Dnah17	UTSW	11	117,972,936 (GRCm39)	missense	probably damaging	0.98
R7147:Dnah17	UTSW	11	117,985,755 (GRCm39)	missense	probably benign	0.31
R7172:Dnah17	UTSW	11	117,931,957 (GRCm39)	nonsense	probably null
R7183:Dnah17	UTSW	11	118,020,014 (GRCm39)	missense	probably benign
R7297:Dnah17	UTSW	11	117,994,182 (GRCm39)	missense	probably damaging	0.98
R7297:Dnah17	UTSW	11	117,946,556 (GRCm39)	critical splice donor site	probably null
R7367:Dnah17	UTSW	11	118,006,022 (GRCm39)	missense	probably benign
R7398:Dnah17	UTSW	11	117,971,550 (GRCm39)	missense	probably damaging	0.96
R7426:Dnah17	UTSW	11	117,981,543 (GRCm39)	missense	probably null	0.79
R7524:Dnah17	UTSW	11	118,012,307 (GRCm39)	missense	probably benign	0.03
R7529:Dnah17	UTSW	11	117,940,692 (GRCm39)	critical splice donor site	probably null
R7615:Dnah17	UTSW	11	118,001,373 (GRCm39)	nonsense	probably null
R7681:Dnah17	UTSW	11	117,916,012 (GRCm39)	missense	probably damaging	1.00
R7702:Dnah17	UTSW	11	118,012,304 (GRCm39)	missense	possibly damaging	0.64
R7702:Dnah17	UTSW	11	117,916,466 (GRCm39)	missense	probably benign	0.00
R7713:Dnah17	UTSW	11	117,915,997 (GRCm39)	missense	probably benign	0.02
R7809:Dnah17	UTSW	11	117,995,462 (GRCm39)	missense	probably benign	0.09
R7842:Dnah17	UTSW	11	117,970,508 (GRCm39)	critical splice acceptor site	probably null
R7935:Dnah17	UTSW	11	118,018,048 (GRCm39)	missense	probably benign	0.20
R7951:Dnah17	UTSW	11	118,009,592 (GRCm39)	missense	possibly damaging	0.64
R8070:Dnah17	UTSW	11	117,915,497 (GRCm39)	missense	probably damaging	0.97
R8098:Dnah17	UTSW	11	117,941,193 (GRCm39)	missense	probably damaging	1.00
R8101:Dnah17	UTSW	11	118,016,744 (GRCm39)	missense	probably benign
R8177:Dnah17	UTSW	11	118,019,753 (GRCm39)	missense	possibly damaging	0.60
R8343:Dnah17	UTSW	11	118,005,021 (GRCm39)	missense	probably benign
R8350:Dnah17	UTSW	11	117,977,873 (GRCm39)	missense	probably damaging	0.98
R8393:Dnah17	UTSW	11	117,947,855 (GRCm39)	missense	probably damaging	1.00
R8401:Dnah17	UTSW	11	117,915,485 (GRCm39)	missense	probably damaging	0.96
R8418:Dnah17	UTSW	11	117,994,284 (GRCm39)	missense	probably benign	0.01
R8450:Dnah17	UTSW	11	117,977,873 (GRCm39)	missense	probably damaging	0.98
R8546:Dnah17	UTSW	11	118,015,101 (GRCm39)	missense	probably benign	0.00
R8697:Dnah17	UTSW	11	117,976,985 (GRCm39)	missense	possibly damaging	0.96
R8710:Dnah17	UTSW	11	117,932,973 (GRCm39)	missense	probably damaging	1.00
R8713:Dnah17	UTSW	11	117,979,028 (GRCm39)	missense	probably damaging	1.00
R8722:Dnah17	UTSW	11	117,961,283 (GRCm39)	nonsense	probably null
R8797:Dnah17	UTSW	11	117,992,201 (GRCm39)	missense	probably benign	0.00
R8953:Dnah17	UTSW	11	118,016,238 (GRCm39)	splice site	probably benign
R8965:Dnah17	UTSW	11	117,915,492 (GRCm39)	missense	probably damaging	1.00
R8976:Dnah17	UTSW	11	117,917,666 (GRCm39)	missense	probably damaging	1.00
R9090:Dnah17	UTSW	11	117,931,870 (GRCm39)	missense	probably damaging	1.00
R9128:Dnah17	UTSW	11	117,937,004 (GRCm39)	missense	possibly damaging	0.76
R9134:Dnah17	UTSW	11	117,978,972 (GRCm39)	missense	probably damaging	1.00
R9245:Dnah17	UTSW	11	118,016,503 (GRCm39)	missense	probably benign	0.02
R9251:Dnah17	UTSW	11	118,012,618 (GRCm39)	missense	probably benign	0.03
R9271:Dnah17	UTSW	11	117,931,870 (GRCm39)	missense	probably damaging	1.00
R9367:Dnah17	UTSW	11	118,012,212 (GRCm39)	missense	possibly damaging	0.93
R9367:Dnah17	UTSW	11	117,987,464 (GRCm39)	missense	possibly damaging	0.95
R9381:Dnah17	UTSW	11	117,914,219 (GRCm39)	missense	probably benign
R9405:Dnah17	UTSW	11	118,009,737 (GRCm39)	missense	probably benign
R9449:Dnah17	UTSW	11	117,987,452 (GRCm39)	missense	probably benign	0.07
R9517:Dnah17	UTSW	11	117,915,440 (GRCm39)	missense	possibly damaging	0.76
R9588:Dnah17	UTSW	11	118,012,783 (GRCm39)	missense	probably benign	0.00
R9629:Dnah17	UTSW	11	117,979,804 (GRCm39)	missense	probably damaging	1.00
R9654:Dnah17	UTSW	11	117,927,156 (GRCm39)	critical splice donor site	probably null
R9655:Dnah17	UTSW	11	117,971,649 (GRCm39)	missense	possibly damaging	0.94
R9662:Dnah17	UTSW	11	117,925,166 (GRCm39)	missense	probably damaging	0.97
R9686:Dnah17	UTSW	11	117,979,048 (GRCm39)	missense	possibly damaging	0.46
R9689:Dnah17	UTSW	11	117,963,731 (GRCm39)	missense	probably damaging	1.00
R9706:Dnah17	UTSW	11	118,017,026 (GRCm39)	missense	probably damaging	1.00
X0058:Dnah17	UTSW	11	117,973,751 (GRCm39)	missense	probably damaging	1.00
Z1176:Dnah17	UTSW	11	118,017,992 (GRCm39)	missense	probably benign	0.01
Z1177:Dnah17	UTSW	11	117,977,786 (GRCm39)	missense	probably damaging	1.00
Z1177:Dnah17	UTSW	11	117,969,389 (GRCm39)	missense	possibly damaging	0.91
Z1177:Dnah17	UTSW	11	118,017,968 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- AAAGTTCTTAGCTCCCCGGG -3'
(R):5'- AACTGCTGTGAAGGGTACGG -3'

Sequencing Primer
(F):5'- CGGGACTACCTGTCACTCAC -3'
(R):5'- CTGTGAAGGGTACGGGCACTG -3'

Posted On

2014-06-23