Mutagenetix > Incidental Mutations

Incidental Mutation 'R0117:Olfr1098'

20859

Institutional Source

Beutler Lab

Gene Symbol

Olfr1098

Ensembl Gene

ENSMUSG00000075169

Gene Name

olfactory receptor 1098

Synonyms

MOR206-1, GA_x6K02T2Q125-48410458-48409511

MMRRC Submission

038403-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

R0117 (G1)

Quality Score

225

Status

Validated (trace)

Chromosome

Chromosomal Location

86920949-86924545 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 86922870 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 221 (I221F)

Ref Sequence

ENSEMBL: ENSMUSP00000107200 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099872] [ENSMUST00000111574]

Predicted Effect

probably damaging
Transcript: ENSMUST00000099872
AA Change: I221F

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000097457
Gene: ENSMUSG00000075169
AA Change: I221F

Domain	Start	End	E-Value	Type
Pfam:7tm_1	41	290	7e-29	PFAM
Pfam:7tm_4	140	283	3.3e-41	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000111574
AA Change: I221F

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000107200
Gene: ENSMUSG00000075169
AA Change: I221F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	1.8e-52	PFAM
Pfam:7tm_1	41	309	8.1e-20	PFAM

Meta Mutation Damage Score

0.4446

Coding Region Coverage

1x: 99.0%
3x: 98.0%
10x: 95.2%
20x: 88.1%

Validation Efficiency

95% (59/62)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Angptl4	A	T	17: 33,780,802	I141K	probably damaging	Het
Bbs10	T	A	10: 111,299,333	D102E	possibly damaging	Het
Btaf1	A	G	19: 36,969,968	T486A	probably benign	Het
Casp8ap2	A	G	4: 32,640,817	T624A	probably benign	Het
Cep192	T	C	18: 67,850,737		probably null	Het
Cep76	T	C	18: 67,626,674	Y323C	possibly damaging	Het
CK137956	T	A	4: 127,946,792	T374S	possibly damaging	Het
Cyp2b23	A	T	7: 26,673,114	F359I	probably benign	Het
Cyp4f13	G	T	17: 32,930,606	H194Q	probably damaging	Het
Dach1	C	T	14: 98,168,748	G188R	probably damaging	Het
Def8	G	A	8: 123,456,495	A278T	probably damaging	Het
Dscam	T	C	16: 96,673,678	H1228R	probably benign	Het
Eps15	T	A	4: 109,382,819	D667E	probably damaging	Het
Fig4	G	A	10: 41,230,041	R716*	probably null	Het
Fmnl3	G	C	15: 99,322,738		probably benign	Het
Gm10639	C	T	9: 78,304,418	T154I	probably damaging	Het
Gmpr	T	A	13: 45,517,084		probably null	Het
Helz2	C	A	2: 181,232,759	G1981C	probably damaging	Het
Herc2	C	A	7: 56,213,611		probably benign	Het
Htr2a	G	A	14: 74,645,093	R173H	probably damaging	Het
Impg2	A	G	16: 56,261,642	N979S	probably damaging	Het
Kcna2	A	G	3: 107,105,354	Y417C	probably damaging	Het
Lmf1	G	T	17: 25,655,991		probably benign	Het
Lmntd2	G	A	7: 141,210,123	R659C	possibly damaging	Het
Mcm9	A	G	10: 53,537,736	V416A	possibly damaging	Het
Mgarp	G	T	3: 51,396,712		probably benign	Het
Mpp3	G	A	11: 102,000,573	P580S	probably damaging	Het
Nfat5	C	T	8: 107,339,075	R156W	probably damaging	Het
Ninl	G	A	2: 150,937,673	R269W	probably damaging	Het
Olfr27	T	A	9: 39,144,850	I250N	probably damaging	Het
Olfr862	T	C	9: 19,884,299	E2G	probably damaging	Het
Pcnt	A	T	10: 76,408,727	L1173*	probably null	Het
Pde6c	A	G	19: 38,151,531	E314G	probably damaging	Het
Phldb1	T	C	9: 44,711,706	M1V	probably null	Het
Pkdrej	T	A	15: 85,816,099		probably null	Het
Plch2	T	A	4: 154,985,358		probably benign	Het
Pld2	G	A	11: 70,557,388	R887Q	probably benign	Het
Plxnb1	A	G	9: 109,105,218	D838G	possibly damaging	Het
Postn	C	T	3: 54,383,481		probably benign	Het
Prl8a8	T	A	13: 27,508,490	I172F	probably damaging	Het
Psmc4	A	T	7: 28,042,740		probably benign	Het
Rabgap1	T	A	2: 37,561,885		probably null	Het
Rapgef2	A	G	3: 79,079,177	S1017P	probably benign	Het
Rbak	G	T	5: 143,173,632	Y555*	probably null	Het
Serpina1c	T	G	12: 103,895,012	*414C	probably null	Het
Sntb1	A	G	15: 55,906,353	V80A	probably benign	Het
Sorl1	A	G	9: 42,033,577	V884A	probably benign	Het
Stmnd1	C	A	13: 46,285,486	Q65K	possibly damaging	Het
Tgm5	C	T	2: 121,075,102		probably null	Het
Tmem189	A	G	2: 167,644,758		probably benign	Het
Tubb1	T	C	2: 174,457,784	S420P	probably benign	Het
Tvp23b	T	C	11: 62,879,604		probably benign	Het
Xirp2	C	T	2: 67,517,120	A3235V	possibly damaging	Het
Zc3h15	T	C	2: 83,658,083	S122P	possibly damaging	Het

Other mutations in Olfr1098

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01318:Olfr1098	APN	2	86922949	missense	probably benign
IGL02547:Olfr1098	APN	2	86923028	missense	probably damaging	1.00
IGL02881:Olfr1098	APN	2	86922713	missense	possibly damaging	0.94
IGL03073:Olfr1098	APN	2	86923353	missense	probably damaging	1.00
R0808:Olfr1098	UTSW	2	86923451	missense	probably damaging	1.00
R1061:Olfr1098	UTSW	2	86922782	missense	possibly damaging	0.93
R1471:Olfr1098	UTSW	2	86922578	splice site	probably null
R1571:Olfr1098	UTSW	2	86923445	missense	probably benign	0.01
R1680:Olfr1098	UTSW	2	86923161	missense	probably benign	0.10
R2341:Olfr1098	UTSW	2	86922638	missense	possibly damaging	0.63
R2368:Olfr1098	UTSW	2	86923107	missense	probably benign
R3158:Olfr1098	UTSW	2	86922606	missense	probably benign
R3425:Olfr1098	UTSW	2	86922606	missense	probably benign
R3499:Olfr1098	UTSW	2	86923029	missense	possibly damaging	0.94
R4156:Olfr1098	UTSW	2	86922878	missense	probably damaging	1.00
R4526:Olfr1098	UTSW	2	86922995	missense	possibly damaging	0.90
R5743:Olfr1098	UTSW	2	86923205	missense	probably benign	0.01
R5942:Olfr1098	UTSW	2	86923406	missense	probably damaging	1.00
R6372:Olfr1098	UTSW	2	86923155	missense	probably damaging	1.00
R6409:Olfr1098	UTSW	2	86923171	nonsense	probably null
R6517:Olfr1098	UTSW	2	86923097	missense	probably benign	0.05
R6661:Olfr1098	UTSW	2	86923148	missense	probably benign	0.02
R7075:Olfr1098	UTSW	2	86922646	missense	possibly damaging	0.88
R7166:Olfr1098	UTSW	2	86922748	missense	probably damaging	0.97
R8058:Olfr1098	UTSW	2	86922807	missense	probably benign	0.32
R8234:Olfr1098	UTSW	2	86922969	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TTTTGTGCCAAGAGCAAAGCTGAAG -3'
(R):5'- GCACACTGGATTTCTGCAACTCCAC -3'

Sequencing Primer
(F):5'- TGGGTTCAGCATGGGAATCAC -3'
(R):5'- TGCAACTCCACGGTAATTCATC -3'

Posted On

2013-04-11