Incidental Mutation 'R1865:Arap2'
| ID |
208600 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arap2
|
| Ensembl Gene |
ENSMUSG00000037999 |
| Gene Name |
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
| Synonyms |
Centd1 |
| MMRRC Submission |
039888-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1865 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
62759788-62923502 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 62855606 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 610
(V610A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000075924
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000076623]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000076623
AA Change: V610A
PolyPhen 2
Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000075924
Gene: ENSMUSG00000037999
AA Change: V610A
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
3 |
70 |
3.69e-7 |
SMART |
|
low complexity region
|
222 |
233 |
N/A |
INTRINSIC |
|
PH
|
481 |
574 |
6.45e-17 |
SMART |
|
PH
|
586 |
679 |
9.05e-12 |
SMART |
|
ArfGap
|
684 |
805 |
9.2e-33 |
SMART |
|
PH
|
891 |
1003 |
1.51e-8 |
SMART |
|
PH
|
1013 |
1112 |
9.21e-4 |
SMART |
|
RhoGAP
|
1124 |
1300 |
1.36e-50 |
SMART |
|
Pfam:RA
|
1325 |
1416 |
2.1e-7 |
PFAM |
|
PH
|
1429 |
1533 |
2.68e-14 |
SMART |
|
coiled coil region
|
1561 |
1590 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.3514 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.2%
- 20x: 92.3%
|
| Validation Efficiency |
98% (99/101) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1600012P17Rik |
A |
G |
1: 158,797,094 (GRCm39) |
|
noncoding transcript |
Het |
| Aatk |
G |
A |
11: 119,901,048 (GRCm39) |
T1059M |
probably benign |
Het |
| Adgrg2 |
G |
A |
X: 159,265,347 (GRCm39) |
M532I |
probably benign |
Het |
| Agrn |
GCTCT |
GCTCTCT |
4: 156,250,976 (GRCm39) |
|
probably null |
Het |
| Ahcyl2 |
G |
A |
6: 29,908,354 (GRCm39) |
V575M |
probably damaging |
Het |
| Apobr |
A |
G |
7: 126,185,140 (GRCm39) |
D217G |
probably benign |
Het |
| Aqp9 |
A |
C |
9: 71,019,658 (GRCm39) |
N267K |
probably benign |
Het |
| Arhgap21 |
T |
C |
2: 20,866,015 (GRCm39) |
E893G |
probably damaging |
Het |
| Atn1 |
T |
C |
6: 124,722,259 (GRCm39) |
|
probably benign |
Het |
| Bcl7a |
A |
T |
5: 123,494,032 (GRCm39) |
D68V |
probably damaging |
Het |
| Cbl |
A |
C |
9: 44,075,462 (GRCm39) |
C394W |
probably damaging |
Het |
| Ccdc18 |
T |
A |
5: 108,341,668 (GRCm39) |
D854E |
probably benign |
Het |
| Ccdc93 |
A |
T |
1: 121,426,956 (GRCm39) |
E580V |
probably damaging |
Het |
| Cd180 |
T |
A |
13: 102,842,517 (GRCm39) |
M521K |
probably benign |
Het |
| Cd300ld2 |
T |
G |
11: 114,903,444 (GRCm39) |
|
probably benign |
Het |
| Cdh10 |
T |
C |
15: 18,899,690 (GRCm39) |
F6L |
probably benign |
Het |
| Cep78 |
A |
G |
19: 15,933,368 (GRCm39) |
S737P |
probably damaging |
Het |
| Ces1f |
G |
T |
8: 94,000,893 (GRCm39) |
|
probably benign |
Het |
| Clcn1 |
T |
A |
6: 42,282,475 (GRCm39) |
D442E |
probably damaging |
Het |
| Col20a1 |
T |
C |
2: 180,657,606 (GRCm39) |
L1250P |
possibly damaging |
Het |
| Crispld2 |
G |
A |
8: 120,737,306 (GRCm39) |
G19E |
probably benign |
Het |
| Ctbp2 |
C |
T |
7: 132,592,283 (GRCm39) |
A849T |
probably benign |
Het |
| Cts6 |
A |
G |
13: 61,349,393 (GRCm39) |
I105T |
probably benign |
Het |
| Cul4a |
A |
G |
8: 13,192,589 (GRCm39) |
T617A |
possibly damaging |
Het |
| Cyp2c68 |
G |
T |
19: 39,722,733 (GRCm39) |
R272S |
probably benign |
Het |
| Cystm1 |
A |
G |
18: 36,499,729 (GRCm39) |
Y48C |
unknown |
Het |
| Dach1 |
T |
A |
14: 98,077,645 (GRCm39) |
R579S |
possibly damaging |
Het |
| Ddrgk1 |
A |
T |
2: 130,496,215 (GRCm39) |
I270N |
probably damaging |
Het |
| Dhx32 |
A |
T |
7: 133,339,025 (GRCm39) |
C197S |
probably benign |
Het |
| Dnah10 |
A |
C |
5: 124,909,590 (GRCm39) |
|
probably null |
Het |
| Ecm2 |
T |
C |
13: 49,683,621 (GRCm39) |
V533A |
probably benign |
Het |
| Eif4g1 |
A |
G |
16: 20,497,398 (GRCm39) |
T202A |
probably damaging |
Het |
| Ephb4 |
A |
T |
5: 137,361,572 (GRCm39) |
Q525L |
possibly damaging |
Het |
| F2 |
T |
C |
2: 91,465,539 (GRCm39) |
D82G |
probably benign |
Het |
| Fam184b |
G |
T |
5: 45,689,231 (GRCm39) |
N868K |
possibly damaging |
Het |
| Fbxo25 |
A |
G |
8: 13,985,248 (GRCm39) |
T314A |
probably damaging |
Het |
| Folh1 |
A |
G |
7: 86,375,114 (GRCm39) |
M624T |
possibly damaging |
Het |
| Gabra5 |
G |
A |
7: 57,138,940 (GRCm39) |
R71* |
probably null |
Het |
| Gmpr |
G |
T |
13: 45,696,101 (GRCm39) |
V278F |
probably damaging |
Het |
| Hmcn1 |
A |
T |
1: 150,479,563 (GRCm39) |
C4634S |
probably damaging |
Het |
| Hspa5 |
T |
C |
2: 34,664,553 (GRCm39) |
F336L |
probably damaging |
Het |
| Igfbp4 |
G |
A |
11: 98,932,512 (GRCm39) |
G64R |
probably damaging |
Het |
| Itch |
G |
A |
2: 155,010,666 (GRCm39) |
V45I |
probably damaging |
Het |
| Itgb1 |
T |
A |
8: 129,446,938 (GRCm39) |
F484L |
probably benign |
Het |
| Itpr3 |
A |
G |
17: 27,338,997 (GRCm39) |
I2593V |
probably benign |
Het |
| Kcnj8 |
T |
A |
6: 142,515,966 (GRCm39) |
H47L |
probably damaging |
Het |
| Lcn2 |
T |
C |
2: 32,275,434 (GRCm39) |
T194A |
possibly damaging |
Het |
| Mast4 |
A |
T |
13: 102,930,625 (GRCm39) |
V209D |
probably damaging |
Het |
| Matn3 |
T |
A |
12: 9,002,041 (GRCm39) |
D84E |
probably damaging |
Het |
| Mcm7 |
T |
A |
5: 138,168,637 (GRCm39) |
Q18L |
possibly damaging |
Het |
| Mctp1 |
G |
A |
13: 76,533,267 (GRCm39) |
C205Y |
possibly damaging |
Het |
| Megf11 |
A |
G |
9: 64,587,581 (GRCm39) |
T460A |
probably benign |
Het |
| Mlh1 |
A |
T |
9: 111,086,092 (GRCm39) |
|
probably benign |
Het |
| Mylk |
T |
A |
16: 34,732,600 (GRCm39) |
S627T |
probably benign |
Het |
| Nat2 |
A |
G |
8: 67,954,204 (GRCm39) |
M105V |
possibly damaging |
Het |
| Nav2 |
A |
G |
7: 49,197,943 (GRCm39) |
T2A |
possibly damaging |
Het |
| Ndst3 |
A |
T |
3: 123,465,120 (GRCm39) |
I284N |
probably damaging |
Het |
| Nfix |
A |
G |
8: 85,498,904 (GRCm39) |
V23A |
possibly damaging |
Het |
| Nr2f1 |
T |
C |
13: 78,338,045 (GRCm39) |
Y200C |
probably damaging |
Het |
| Or14a258 |
T |
C |
7: 86,035,769 (GRCm39) |
Y33C |
probably damaging |
Het |
| Or2g25 |
T |
C |
17: 37,970,754 (GRCm39) |
I157V |
possibly damaging |
Het |
| Or6b13 |
G |
A |
7: 139,782,285 (GRCm39) |
R133C |
probably damaging |
Het |
| Or8d1b |
T |
C |
9: 38,887,200 (GRCm39) |
V76A |
probably benign |
Het |
| Or8u8 |
T |
G |
2: 86,011,882 (GRCm39) |
D191A |
probably damaging |
Het |
| Pcdhb21 |
T |
C |
18: 37,647,648 (GRCm39) |
V259A |
possibly damaging |
Het |
| Phip |
A |
T |
9: 82,827,845 (GRCm39) |
V127E |
probably damaging |
Het |
| Pik3r5 |
A |
G |
11: 68,383,318 (GRCm39) |
D379G |
probably damaging |
Het |
| Pkdrej |
A |
T |
15: 85,704,525 (GRCm39) |
C470* |
probably null |
Het |
| Plxnd1 |
A |
T |
6: 115,946,402 (GRCm39) |
|
probably null |
Het |
| Polr1a |
G |
A |
6: 71,943,508 (GRCm39) |
V1248I |
probably damaging |
Het |
| Pou3f2 |
A |
T |
4: 22,486,917 (GRCm39) |
C405* |
probably null |
Het |
| Ppp1r3a |
A |
T |
6: 14,718,404 (GRCm39) |
S837T |
probably damaging |
Het |
| Rest |
T |
A |
5: 77,428,745 (GRCm39) |
V388E |
probably damaging |
Het |
| Rnft2 |
A |
T |
5: 118,370,540 (GRCm39) |
W220R |
probably damaging |
Het |
| Rnpc3 |
A |
T |
3: 113,415,559 (GRCm39) |
Y107* |
probably null |
Het |
| Senp8 |
G |
A |
9: 59,644,835 (GRCm39) |
S94F |
probably damaging |
Het |
| Ski |
A |
G |
4: 155,306,698 (GRCm39) |
S94P |
possibly damaging |
Het |
| Skint8 |
A |
G |
4: 111,794,192 (GRCm39) |
D194G |
probably damaging |
Het |
| Slc35c2 |
C |
A |
2: 165,120,303 (GRCm39) |
R232L |
probably benign |
Het |
| Slc43a3 |
T |
A |
2: 84,777,245 (GRCm39) |
V198D |
possibly damaging |
Het |
| Slc8b1 |
A |
T |
5: 120,667,717 (GRCm39) |
N467I |
probably damaging |
Het |
| Srbd1 |
A |
G |
17: 86,422,732 (GRCm39) |
|
probably benign |
Het |
| Sstr3 |
T |
C |
15: 78,424,168 (GRCm39) |
H193R |
probably damaging |
Het |
| Sv2c |
A |
C |
13: 96,113,283 (GRCm39) |
S555R |
probably benign |
Het |
| Tagln3 |
A |
G |
16: 45,532,013 (GRCm39) |
V173A |
possibly damaging |
Het |
| Tctn2 |
C |
A |
5: 124,757,143 (GRCm39) |
|
noncoding transcript |
Het |
| Tfap2a |
G |
T |
13: 40,881,884 (GRCm39) |
H167Q |
probably damaging |
Het |
| Tmem213 |
A |
G |
6: 38,086,487 (GRCm39) |
T48A |
possibly damaging |
Het |
| Tmem30c |
A |
G |
16: 57,090,352 (GRCm39) |
|
probably benign |
Het |
| Tmem37 |
A |
G |
1: 119,995,952 (GRCm39) |
S42P |
probably damaging |
Het |
| Tnxb |
C |
T |
17: 34,922,431 (GRCm39) |
Q2415* |
probably null |
Het |
| Ttyh1 |
T |
C |
7: 4,122,730 (GRCm39) |
L26P |
probably damaging |
Het |
| Ubn2 |
T |
A |
6: 38,417,425 (GRCm39) |
D154E |
possibly damaging |
Het |
| Vdac3 |
A |
T |
8: 23,070,553 (GRCm39) |
Y119* |
probably null |
Het |
| Vmn2r58 |
T |
C |
7: 41,486,682 (GRCm39) |
I738V |
possibly damaging |
Het |
| Zfp704 |
A |
G |
3: 9,539,551 (GRCm39) |
|
probably benign |
Het |
| Znfx1 |
G |
A |
2: 166,880,729 (GRCm39) |
R352W |
probably damaging |
Het |
|
| Other mutations in Arap2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00481:Arap2
|
APN |
5 |
62,793,305 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00642:Arap2
|
APN |
5 |
62,890,401 (GRCm39) |
nonsense |
probably null |
|
|
IGL00705:Arap2
|
APN |
5 |
62,835,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00942:Arap2
|
APN |
5 |
62,855,732 (GRCm39) |
nonsense |
probably null |
|
|
IGL01069:Arap2
|
APN |
5 |
62,807,199 (GRCm39) |
missense |
probably benign |
|
|
IGL01601:Arap2
|
APN |
5 |
62,798,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01986:Arap2
|
APN |
5 |
62,779,265 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02032:Arap2
|
APN |
5 |
62,828,340 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02262:Arap2
|
APN |
5 |
62,800,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02331:Arap2
|
APN |
5 |
62,807,025 (GRCm39) |
splice site |
probably benign |
|
|
IGL02527:Arap2
|
APN |
5 |
62,906,650 (GRCm39) |
missense |
probably benign |
|
|
IGL02803:Arap2
|
APN |
5 |
62,906,452 (GRCm39) |
missense |
probably benign |
|
|
IGL02864:Arap2
|
APN |
5 |
62,835,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03078:Arap2
|
APN |
5 |
62,890,408 (GRCm39) |
splice site |
probably benign |
|
|
IGL03154:Arap2
|
APN |
5 |
62,800,268 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03213:Arap2
|
APN |
5 |
62,906,438 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03279:Arap2
|
APN |
5 |
62,779,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03288:Arap2
|
APN |
5 |
62,761,959 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4354001:Arap2
|
UTSW |
5 |
62,811,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0012:Arap2
|
UTSW |
5 |
62,840,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0013:Arap2
|
UTSW |
5 |
62,840,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0013:Arap2
|
UTSW |
5 |
62,840,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0166:Arap2
|
UTSW |
5 |
62,833,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0472:Arap2
|
UTSW |
5 |
62,864,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0506:Arap2
|
UTSW |
5 |
62,763,474 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0551:Arap2
|
UTSW |
5 |
62,798,666 (GRCm39) |
splice site |
probably null |
|
|
R0607:Arap2
|
UTSW |
5 |
62,763,474 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0617:Arap2
|
UTSW |
5 |
62,807,250 (GRCm39) |
splice site |
probably benign |
|
|
R0975:Arap2
|
UTSW |
5 |
62,888,229 (GRCm39) |
splice site |
probably benign |
|
|
R0976:Arap2
|
UTSW |
5 |
62,807,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1164:Arap2
|
UTSW |
5 |
62,840,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1268:Arap2
|
UTSW |
5 |
62,887,964 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1480:Arap2
|
UTSW |
5 |
62,826,472 (GRCm39) |
nonsense |
probably null |
|
|
R1502:Arap2
|
UTSW |
5 |
62,761,747 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1543:Arap2
|
UTSW |
5 |
62,763,498 (GRCm39) |
nonsense |
probably null |
|
|
R1962:Arap2
|
UTSW |
5 |
62,834,007 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R2040:Arap2
|
UTSW |
5 |
62,906,259 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2118:Arap2
|
UTSW |
5 |
62,864,028 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Arap2
|
UTSW |
5 |
62,835,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2201:Arap2
|
UTSW |
5 |
62,864,028 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2215:Arap2
|
UTSW |
5 |
62,834,519 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3027:Arap2
|
UTSW |
5 |
62,827,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3053:Arap2
|
UTSW |
5 |
62,906,200 (GRCm39) |
missense |
probably benign |
0.35 |
|
R3975:Arap2
|
UTSW |
5 |
62,906,237 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4272:Arap2
|
UTSW |
5 |
62,828,322 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R4273:Arap2
|
UTSW |
5 |
62,828,322 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R4326:Arap2
|
UTSW |
5 |
62,779,206 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4327:Arap2
|
UTSW |
5 |
62,779,206 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4328:Arap2
|
UTSW |
5 |
62,779,206 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4451:Arap2
|
UTSW |
5 |
62,906,513 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4659:Arap2
|
UTSW |
5 |
62,811,469 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4665:Arap2
|
UTSW |
5 |
62,827,312 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4715:Arap2
|
UTSW |
5 |
62,906,437 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4808:Arap2
|
UTSW |
5 |
62,887,984 (GRCm39) |
missense |
probably benign |
0.23 |
|
R4941:Arap2
|
UTSW |
5 |
62,906,821 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4983:Arap2
|
UTSW |
5 |
62,833,868 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5095:Arap2
|
UTSW |
5 |
62,811,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5156:Arap2
|
UTSW |
5 |
62,826,524 (GRCm39) |
nonsense |
probably null |
|
|
R5201:Arap2
|
UTSW |
5 |
62,840,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5346:Arap2
|
UTSW |
5 |
62,872,089 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5359:Arap2
|
UTSW |
5 |
62,840,762 (GRCm39) |
nonsense |
probably null |
|
|
R5426:Arap2
|
UTSW |
5 |
62,800,159 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5503:Arap2
|
UTSW |
5 |
62,787,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5605:Arap2
|
UTSW |
5 |
62,772,410 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5764:Arap2
|
UTSW |
5 |
62,800,197 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5813:Arap2
|
UTSW |
5 |
62,834,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5846:Arap2
|
UTSW |
5 |
62,807,116 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6084:Arap2
|
UTSW |
5 |
62,828,297 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6173:Arap2
|
UTSW |
5 |
62,906,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6175:Arap2
|
UTSW |
5 |
62,872,074 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6249:Arap2
|
UTSW |
5 |
62,803,536 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6386:Arap2
|
UTSW |
5 |
62,761,865 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6424:Arap2
|
UTSW |
5 |
62,840,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6744:Arap2
|
UTSW |
5 |
62,906,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6766:Arap2
|
UTSW |
5 |
62,834,443 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6990:Arap2
|
UTSW |
5 |
62,833,860 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7067:Arap2
|
UTSW |
5 |
62,811,387 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7098:Arap2
|
UTSW |
5 |
62,833,293 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7107:Arap2
|
UTSW |
5 |
62,763,551 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7156:Arap2
|
UTSW |
5 |
62,761,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7174:Arap2
|
UTSW |
5 |
62,761,621 (GRCm39) |
missense |
probably benign |
|
|
R7187:Arap2
|
UTSW |
5 |
62,826,396 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7197:Arap2
|
UTSW |
5 |
62,798,729 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7214:Arap2
|
UTSW |
5 |
62,906,681 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7317:Arap2
|
UTSW |
5 |
62,807,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7392:Arap2
|
UTSW |
5 |
62,855,728 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7438:Arap2
|
UTSW |
5 |
62,906,818 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7452:Arap2
|
UTSW |
5 |
62,833,892 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7495:Arap2
|
UTSW |
5 |
62,833,893 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7796:Arap2
|
UTSW |
5 |
62,888,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7936:Arap2
|
UTSW |
5 |
62,888,048 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8116:Arap2
|
UTSW |
5 |
62,887,954 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8172:Arap2
|
UTSW |
5 |
62,779,324 (GRCm39) |
splice site |
probably null |
|
|
R8277:Arap2
|
UTSW |
5 |
62,771,335 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8369:Arap2
|
UTSW |
5 |
62,761,669 (GRCm39) |
nonsense |
probably null |
|
|
R8398:Arap2
|
UTSW |
5 |
62,906,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8893:Arap2
|
UTSW |
5 |
62,888,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8973:Arap2
|
UTSW |
5 |
62,855,668 (GRCm39) |
nonsense |
probably null |
|
|
R9102:Arap2
|
UTSW |
5 |
62,906,341 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9121:Arap2
|
UTSW |
5 |
62,906,326 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9174:Arap2
|
UTSW |
5 |
62,855,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9222:Arap2
|
UTSW |
5 |
62,828,421 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R9281:Arap2
|
UTSW |
5 |
62,906,848 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9399:Arap2
|
UTSW |
5 |
62,763,455 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R9450:Arap2
|
UTSW |
5 |
62,855,762 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9467:Arap2
|
UTSW |
5 |
62,887,900 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9567:Arap2
|
UTSW |
5 |
62,761,841 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9577:Arap2
|
UTSW |
5 |
62,769,060 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9626:Arap2
|
UTSW |
5 |
62,906,878 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9688:Arap2
|
UTSW |
5 |
62,872,109 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACAGCAGTCAACCAGATTTTC -3'
(R):5'- GCATCTGTACATTGGCTTCAGAG -3'
Sequencing Primer
(F):5'- GCTAAGCACAGTCGCTAT -3'
(R):5'- TCAGAGCAAGATCTTAGGTTGATAC -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation