Incidental Mutation 'R1866:Trip12'
| ID |
208684 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip12
|
| Ensembl Gene |
ENSMUSG00000026219 |
| Gene Name |
thyroid hormone receptor interactor 12 |
| Synonyms |
Gtl6, 1110036I07Rik, 6720416K24Rik |
| MMRRC Submission |
039889-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1866 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
84698910-84818237 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 84722781 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 128
(D128G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140789
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027421]
[ENSMUST00000185909]
[ENSMUST00000186465]
[ENSMUST00000186648]
[ENSMUST00000189670]
[ENSMUST00000189841]
|
| AlphaFold |
G5E870 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000027421
AA Change: D1323G
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000027421
Gene: ENSMUSG00000026219
AA Change: D1323G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
765 |
831 |
7.6e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000185909
|
| SMART Domains |
Protein: ENSMUSP00000139986
Gene: ENSMUSG00000026219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
195 |
214 |
N/A |
INTRINSIC |
|
low complexity region
|
219 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
257 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
289 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186465
AA Change: D1323G
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000140224
Gene: ENSMUSG00000026219
AA Change: D1323G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
761 |
831 |
2.2e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186648
AA Change: D1290G
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000139563
Gene: ENSMUSG00000026219
AA Change: D1290G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
386 |
400 |
N/A |
INTRINSIC |
|
low complexity region
|
410 |
421 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
440 |
654 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
441 |
635 |
1e-5 |
PDB |
|
low complexity region
|
950 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1029 |
1040 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1311 |
N/A |
INTRINSIC |
|
low complexity region
|
1312 |
1329 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1330 |
1384 |
7e-8 |
BLAST |
|
Blast:HECTc
|
1540 |
1596 |
2e-24 |
BLAST |
|
HECTc
|
1603 |
1992 |
6.2e-180 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000189670
AA Change: D128G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000140789
Gene: ENSMUSG00000026219
AA Change: D128G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
138 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
150 |
167 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
168 |
222 |
5e-8 |
BLAST |
|
Blast:HECTc
|
378 |
434 |
1e-24 |
BLAST |
|
HECTc
|
441 |
830 |
6.2e-180 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189841
|
| SMART Domains |
Protein: ENSMUSP00000140879
Gene: ENSMUSG00000026219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
1 |
24 |
N/A |
INTRINSIC |
|
low complexity region
|
51 |
63 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000190125
|
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.3%
- 20x: 92.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a targeted allele exhibit complete embryonic lethality during organogenesis associated with embryonic growth retardation and abnormal placenta development. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Apba1 |
A |
T |
19: 23,870,195 (GRCm39) |
E9V |
probably benign |
Het |
| Armc8 |
T |
A |
9: 99,418,333 (GRCm39) |
T32S |
probably benign |
Het |
| Atr |
T |
A |
9: 95,752,658 (GRCm39) |
|
probably null |
Het |
| Blm |
A |
G |
7: 80,143,862 (GRCm39) |
L859P |
probably benign |
Het |
| Cacna2d3 |
A |
T |
14: 28,691,171 (GRCm39) |
F51L |
probably damaging |
Het |
| Cdcp2 |
A |
G |
4: 106,964,197 (GRCm39) |
N349S |
probably damaging |
Het |
| Cfap57 |
G |
A |
4: 118,457,124 (GRCm39) |
H442Y |
possibly damaging |
Het |
| Chrm3 |
A |
G |
13: 9,928,517 (GRCm39) |
L173P |
probably damaging |
Het |
| Cpb1 |
C |
G |
3: 20,317,920 (GRCm39) |
M201I |
probably benign |
Het |
| Dgcr8 |
A |
T |
16: 18,076,178 (GRCm39) |
N2K |
probably damaging |
Het |
| Dnah3 |
A |
T |
7: 119,528,079 (GRCm39) |
|
probably null |
Het |
| Dnah6 |
T |
A |
6: 73,077,071 (GRCm39) |
Q2398L |
probably benign |
Het |
| Dpep2 |
A |
T |
8: 106,716,080 (GRCm39) |
|
probably null |
Het |
| Eif2ak4 |
C |
A |
2: 118,303,142 (GRCm39) |
T1504K |
probably damaging |
Het |
| Exoc6b |
A |
G |
6: 84,828,896 (GRCm39) |
V496A |
probably damaging |
Het |
| Fam174a |
A |
C |
1: 95,241,620 (GRCm39) |
S27R |
probably benign |
Het |
| Fat2 |
T |
A |
11: 55,182,840 (GRCm39) |
Q1339L |
probably benign |
Het |
| Fkbpl |
T |
A |
17: 34,864,797 (GRCm39) |
D188E |
possibly damaging |
Het |
| Focad |
A |
G |
4: 88,325,402 (GRCm39) |
D89G |
possibly damaging |
Het |
| Fstl4 |
C |
A |
11: 53,077,225 (GRCm39) |
Q661K |
probably benign |
Het |
| Gck |
T |
C |
11: 5,853,253 (GRCm39) |
Y289C |
probably benign |
Het |
| Gm16181 |
T |
A |
17: 35,442,913 (GRCm39) |
|
probably benign |
Het |
| Herc1 |
G |
A |
9: 66,358,073 (GRCm39) |
G2385S |
probably damaging |
Het |
| Igfn1 |
T |
C |
1: 135,902,606 (GRCm39) |
|
probably null |
Het |
| Il12b |
T |
C |
11: 44,299,353 (GRCm39) |
W141R |
probably damaging |
Het |
| Itga6 |
T |
A |
2: 71,664,414 (GRCm39) |
S517T |
probably benign |
Het |
| Kank1 |
A |
G |
19: 25,388,813 (GRCm39) |
S801G |
probably benign |
Het |
| Klrh1 |
A |
G |
6: 129,752,343 (GRCm39) |
|
probably null |
Het |
| Lctl |
A |
G |
9: 64,039,003 (GRCm39) |
D205G |
probably damaging |
Het |
| Lhx3 |
A |
C |
2: 26,093,986 (GRCm39) |
V79G |
probably damaging |
Het |
| Lrrc9 |
T |
C |
12: 72,543,912 (GRCm39) |
I1127T |
probably damaging |
Het |
| Ltbp3 |
A |
T |
19: 5,797,877 (GRCm39) |
E505D |
probably benign |
Het |
| Man1c1 |
G |
C |
4: 134,430,749 (GRCm39) |
P11R |
probably damaging |
Het |
| Map6 |
A |
G |
7: 98,965,083 (GRCm39) |
S291G |
probably damaging |
Het |
| Mapk7 |
A |
G |
11: 61,380,239 (GRCm39) |
F671L |
probably benign |
Het |
| Mau2 |
A |
G |
8: 70,484,142 (GRCm39) |
W149R |
probably damaging |
Het |
| Mb21d2 |
C |
T |
16: 28,647,267 (GRCm39) |
V236I |
possibly damaging |
Het |
| Mc5r |
C |
G |
18: 68,471,741 (GRCm39) |
|
probably null |
Het |
| Mical1 |
C |
A |
10: 41,361,466 (GRCm39) |
P797Q |
probably benign |
Het |
| Mnx1 |
G |
A |
5: 29,679,043 (GRCm39) |
R347C |
unknown |
Het |
| Mslnl |
G |
A |
17: 25,961,908 (GRCm39) |
V128M |
probably damaging |
Het |
| Nlrp2 |
G |
T |
7: 5,330,715 (GRCm39) |
C560* |
probably null |
Het |
| Npat |
T |
A |
9: 53,474,416 (GRCm39) |
L736H |
probably damaging |
Het |
| Nup155 |
T |
A |
15: 8,145,010 (GRCm39) |
V147E |
probably damaging |
Het |
| Nxpe2 |
A |
G |
9: 48,238,121 (GRCm39) |
F45L |
probably benign |
Het |
| Obscn |
T |
C |
11: 58,951,741 (GRCm39) |
D4370G |
probably benign |
Het |
| Or2d3b |
A |
G |
7: 106,514,273 (GRCm39) |
I289M |
probably damaging |
Het |
| Or4a79 |
T |
C |
2: 89,551,550 (GRCm39) |
K302E |
probably benign |
Het |
| Or4c35 |
T |
C |
2: 89,808,671 (GRCm39) |
L183S |
probably damaging |
Het |
| Or4d10 |
A |
G |
19: 12,051,183 (GRCm39) |
V271A |
probably benign |
Het |
| Or52n4 |
A |
G |
7: 104,294,004 (GRCm39) |
S190P |
probably benign |
Het |
| Or5g23 |
T |
A |
2: 85,439,188 (GRCm39) |
H22L |
probably benign |
Het |
| Or8k3 |
A |
C |
2: 86,059,072 (GRCm39) |
M81R |
probably damaging |
Het |
| Pcx |
T |
C |
19: 4,671,249 (GRCm39) |
I1157T |
possibly damaging |
Het |
| Pias2 |
T |
A |
18: 77,240,412 (GRCm39) |
S589R |
probably benign |
Het |
| Plcb1 |
T |
C |
2: 135,186,093 (GRCm39) |
F687L |
probably benign |
Het |
| Plk5 |
G |
T |
10: 80,196,403 (GRCm39) |
|
probably null |
Het |
| Pnpla2 |
T |
A |
7: 141,035,329 (GRCm39) |
Y44N |
probably damaging |
Het |
| Ppp1r12a |
T |
A |
10: 108,098,292 (GRCm39) |
D337E |
possibly damaging |
Het |
| Prl2c5 |
G |
T |
13: 13,365,358 (GRCm39) |
|
probably null |
Het |
| Prom2 |
T |
C |
2: 127,378,514 (GRCm39) |
D460G |
probably damaging |
Het |
| Pros1 |
A |
G |
16: 62,748,498 (GRCm39) |
H657R |
possibly damaging |
Het |
| Prune2 |
A |
G |
19: 17,100,856 (GRCm39) |
E2120G |
probably damaging |
Het |
| Rap2a |
T |
A |
14: 120,716,347 (GRCm39) |
L70Q |
probably damaging |
Het |
| Rbl2 |
A |
T |
8: 91,839,157 (GRCm39) |
E858D |
probably benign |
Het |
| Rbm48 |
T |
C |
5: 3,645,997 (GRCm39) |
Y69C |
probably damaging |
Het |
| Rgs12 |
T |
A |
5: 35,123,018 (GRCm39) |
I267N |
probably damaging |
Het |
| Rpusd2 |
G |
T |
2: 118,865,728 (GRCm39) |
A142S |
probably benign |
Het |
| Rspo2 |
A |
T |
15: 42,939,332 (GRCm39) |
W153R |
probably damaging |
Het |
| Sdk2 |
C |
T |
11: 113,729,472 (GRCm39) |
|
silent |
Het |
| Serinc5 |
T |
A |
13: 92,842,771 (GRCm39) |
M407K |
probably damaging |
Het |
| Slain2 |
T |
C |
5: 73,114,665 (GRCm39) |
S299P |
probably damaging |
Het |
| Slc17a4 |
A |
G |
13: 24,084,528 (GRCm39) |
Y419H |
possibly damaging |
Het |
| Slc1a6 |
T |
A |
10: 78,627,183 (GRCm39) |
D173E |
probably damaging |
Het |
| Slc22a19 |
A |
T |
19: 7,688,506 (GRCm39) |
I18N |
probably damaging |
Het |
| Slc37a3 |
A |
T |
6: 39,336,902 (GRCm39) |
F91L |
probably damaging |
Het |
| Spag5 |
C |
A |
11: 78,195,281 (GRCm39) |
T196K |
possibly damaging |
Het |
| Susd2 |
G |
T |
10: 75,475,566 (GRCm39) |
A326D |
probably damaging |
Het |
| Syna |
G |
T |
5: 134,588,769 (GRCm39) |
A60D |
probably damaging |
Het |
| Tchh |
A |
T |
3: 93,355,067 (GRCm39) |
E1502D |
unknown |
Het |
| Tecta |
T |
C |
9: 42,303,320 (GRCm39) |
H104R |
probably damaging |
Het |
| Tmed1 |
T |
C |
9: 21,420,387 (GRCm39) |
D102G |
probably damaging |
Het |
| Uroc1 |
A |
G |
6: 90,338,506 (GRCm39) |
M656V |
probably benign |
Het |
| Usp47 |
T |
A |
7: 111,701,077 (GRCm39) |
V1096D |
possibly damaging |
Het |
| Utp20 |
T |
A |
10: 88,598,632 (GRCm39) |
K115* |
probably null |
Het |
| Vmn2r19 |
G |
T |
6: 123,308,597 (GRCm39) |
|
probably null |
Het |
| Vmn2r86 |
A |
T |
10: 130,282,255 (GRCm39) |
V787D |
probably damaging |
Het |
| Vmn2r87 |
A |
T |
10: 130,308,441 (GRCm39) |
I599N |
possibly damaging |
Het |
| Vwf |
A |
G |
6: 125,644,492 (GRCm39) |
D2449G |
possibly damaging |
Het |
| Zbtb7c |
T |
A |
18: 76,269,977 (GRCm39) |
C22S |
probably benign |
Het |
| Zc3h7a |
A |
G |
16: 10,965,168 (GRCm39) |
I655T |
possibly damaging |
Het |
| Zfp764l1 |
A |
G |
7: 126,992,503 (GRCm39) |
W36R |
probably damaging |
Het |
|
| Other mutations in Trip12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00331:Trip12
|
APN |
1 |
84,708,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00430:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00465:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00819:Trip12
|
APN |
1 |
84,731,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00900:Trip12
|
APN |
1 |
84,702,485 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL00990:Trip12
|
APN |
1 |
84,729,605 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01087:Trip12
|
APN |
1 |
84,735,580 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01400:Trip12
|
APN |
1 |
84,729,699 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01521:Trip12
|
APN |
1 |
84,743,919 (GRCm39) |
splice site |
probably benign |
|
|
IGL01619:Trip12
|
APN |
1 |
84,792,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01796:Trip12
|
APN |
1 |
84,705,999 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01975:Trip12
|
APN |
1 |
84,792,534 (GRCm39) |
splice site |
probably benign |
|
|
IGL02190:Trip12
|
APN |
1 |
84,743,791 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02474:Trip12
|
APN |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
IGL02517:Trip12
|
APN |
1 |
84,721,535 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02631:Trip12
|
APN |
1 |
84,743,729 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02991:Trip12
|
APN |
1 |
84,716,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03161:Trip12
|
APN |
1 |
84,738,853 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03388:Trip12
|
APN |
1 |
84,720,907 (GRCm39) |
missense |
probably damaging |
0.99 |
|
cardamom
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
pungent
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
spices
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
sulfuric
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
Turmeric
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
LCD18:Trip12
|
UTSW |
1 |
84,754,482 (GRCm38) |
unclassified |
probably benign |
|
|
R0090:Trip12
|
UTSW |
1 |
84,709,857 (GRCm39) |
splice site |
probably benign |
|
|
R0111:Trip12
|
UTSW |
1 |
84,736,854 (GRCm39) |
unclassified |
probably benign |
|
|
R0471:Trip12
|
UTSW |
1 |
84,703,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0486:Trip12
|
UTSW |
1 |
84,738,805 (GRCm39) |
nonsense |
probably null |
|
|
R0557:Trip12
|
UTSW |
1 |
84,702,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0570:Trip12
|
UTSW |
1 |
84,729,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Trip12
|
UTSW |
1 |
84,735,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0627:Trip12
|
UTSW |
1 |
84,746,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Trip12
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0657:Trip12
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0741:Trip12
|
UTSW |
1 |
84,722,902 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0862:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0864:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1124:Trip12
|
UTSW |
1 |
84,714,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1252:Trip12
|
UTSW |
1 |
84,754,071 (GRCm39) |
nonsense |
probably null |
|
|
R1455:Trip12
|
UTSW |
1 |
84,736,821 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1487:Trip12
|
UTSW |
1 |
84,746,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1702:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1781:Trip12
|
UTSW |
1 |
84,708,342 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1847:Trip12
|
UTSW |
1 |
84,726,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1854:Trip12
|
UTSW |
1 |
84,705,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1926:Trip12
|
UTSW |
1 |
84,727,012 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1935:Trip12
|
UTSW |
1 |
84,771,822 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1950:Trip12
|
UTSW |
1 |
84,738,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1994:Trip12
|
UTSW |
1 |
84,726,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2014:Trip12
|
UTSW |
1 |
84,738,587 (GRCm39) |
nonsense |
probably null |
|
|
R2391:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2423:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2433:Trip12
|
UTSW |
1 |
84,721,544 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R2905:Trip12
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3040:Trip12
|
UTSW |
1 |
84,719,966 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3735:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R3907:Trip12
|
UTSW |
1 |
84,709,827 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4394:Trip12
|
UTSW |
1 |
84,703,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4540:Trip12
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4859:Trip12
|
UTSW |
1 |
84,771,531 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5240:Trip12
|
UTSW |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
R5278:Trip12
|
UTSW |
1 |
84,739,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5377:Trip12
|
UTSW |
1 |
84,735,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Trip12
|
UTSW |
1 |
84,746,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5542:Trip12
|
UTSW |
1 |
84,727,065 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5550:Trip12
|
UTSW |
1 |
84,738,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5886:Trip12
|
UTSW |
1 |
84,708,179 (GRCm39) |
intron |
probably benign |
|
|
R5893:Trip12
|
UTSW |
1 |
84,736,884 (GRCm39) |
unclassified |
probably benign |
|
|
R5914:Trip12
|
UTSW |
1 |
84,741,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5925:Trip12
|
UTSW |
1 |
84,726,974 (GRCm39) |
nonsense |
probably null |
|
|
R5985:Trip12
|
UTSW |
1 |
84,703,492 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6135:Trip12
|
UTSW |
1 |
84,738,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6158:Trip12
|
UTSW |
1 |
84,738,733 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6419:Trip12
|
UTSW |
1 |
84,771,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7144:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7194:Trip12
|
UTSW |
1 |
84,771,943 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7355:Trip12
|
UTSW |
1 |
84,792,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Trip12
|
UTSW |
1 |
84,728,163 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7588:Trip12
|
UTSW |
1 |
84,738,604 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7705:Trip12
|
UTSW |
1 |
84,755,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7818:Trip12
|
UTSW |
1 |
84,738,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7918:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8127:Trip12
|
UTSW |
1 |
84,716,463 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8221:Trip12
|
UTSW |
1 |
84,743,771 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8336:Trip12
|
UTSW |
1 |
84,743,762 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8373:Trip12
|
UTSW |
1 |
84,773,488 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8719:Trip12
|
UTSW |
1 |
84,722,790 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8771:Trip12
|
UTSW |
1 |
84,721,018 (GRCm39) |
unclassified |
probably benign |
|
|
R8997:Trip12
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9146:Trip12
|
UTSW |
1 |
84,771,881 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9236:Trip12
|
UTSW |
1 |
84,703,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9338:Trip12
|
UTSW |
1 |
84,727,019 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9391:Trip12
|
UTSW |
1 |
84,773,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9516:Trip12
|
UTSW |
1 |
84,735,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0023:Trip12
|
UTSW |
1 |
84,738,508 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0065:Trip12
|
UTSW |
1 |
84,726,884 (GRCm39) |
missense |
probably benign |
0.21 |
|
Z1088:Trip12
|
UTSW |
1 |
84,743,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCTATTAAGCAAGTTCAACATATGCC -3'
(R):5'- AGTGGCTAGAGATCATGTTCATTTC -3'
Sequencing Primer
(F):5'- CTATTTCTAATAGGACCAGAGGTTCC -3'
(R):5'- GCTTTTCATATGCAGAAAAACCGAC -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation