Incidental Mutation 'R0118:Or1n1b'
ID 20904
Institutional Source Beutler Lab
Gene Symbol Or1n1b
Ensembl Gene ENSMUSG00000075382
Gene Name olfactory receptor family 1 subfamily N member 1B
Synonyms GA_x6K02T2NLDC-33585366-33584431, Olfr353, MOR127-3
MMRRC Submission 038404-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.211) question?
Stock # R0118 (G1)
Quality Score 180
Status Validated (trace)
Chromosome 2
Chromosomal Location 36779923-36780858 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 36780035 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 275 (M275T)
Ref Sequence ENSEMBL: ENSMUSP00000149378 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100149] [ENSMUST00000215925] [ENSMUST00000217215]
AlphaFold Q8VGK0
Predicted Effect probably benign
Transcript: ENSMUST00000100149
AA Change: M275T

PolyPhen 2 Score 0.070 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000097726
Gene: ENSMUSG00000075382
AA Change: M275T

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 2.3e-56 PFAM
Pfam:7tm_1 39 288 3e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215925
AA Change: M275T

PolyPhen 2 Score 0.070 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000217215
AA Change: M275T

PolyPhen 2 Score 0.070 (Sensitivity: 0.94; Specificity: 0.84)
Meta Mutation Damage Score 0.3334 question?
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.2%
  • 10x: 89.3%
  • 20x: 67.4%
Validation Efficiency 98% (50/51)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts15 T C 9: 30,823,040 (GRCm39) R343G probably damaging Het
Asxl2 T G 12: 3,546,923 (GRCm39) V569G probably damaging Het
Azin2 A C 4: 128,843,430 (GRCm39) H85Q probably damaging Het
Cacna1a C T 8: 85,262,712 (GRCm39) R324C probably damaging Het
Ccr3 C A 9: 123,829,647 (GRCm39) Y327* probably null Het
Cers2 T C 3: 95,227,537 (GRCm39) F55S probably benign Het
Cic C T 7: 24,985,459 (GRCm39) S301L probably damaging Het
Cntnap2 T C 6: 45,037,326 (GRCm39) probably null Het
Cpn2 T C 16: 30,079,186 (GRCm39) R172G probably benign Het
Ctdnep1 T C 11: 69,879,557 (GRCm39) probably null Het
Dennd3 T A 15: 73,436,925 (GRCm39) Y1051N probably damaging Het
Dmap1 T G 4: 117,533,680 (GRCm39) Y196S probably damaging Het
Entpd7 G A 19: 43,692,751 (GRCm39) W102* probably null Het
Frem2 A T 3: 53,442,664 (GRCm39) C2624* probably null Het
Gdpd3 A G 7: 126,370,165 (GRCm39) Y238C probably damaging Het
Gjb3 A G 4: 127,220,451 (GRCm39) V27A probably damaging Het
Kat6b T C 14: 21,720,042 (GRCm39) F1465L probably damaging Het
Klra17 A T 6: 129,808,552 (GRCm39) M227K probably benign Het
Map6 A G 7: 98,966,824 (GRCm39) D348G possibly damaging Het
Mapkbp1 T C 2: 119,855,696 (GRCm39) S1472P probably benign Het
Megf6 C A 4: 154,339,098 (GRCm39) P545Q probably damaging Het
Mertk C T 2: 128,601,086 (GRCm39) R357W probably damaging Het
Mesd T A 7: 83,544,835 (GRCm39) I104N probably damaging Het
Mrm3 T A 11: 76,140,781 (GRCm39) V263E possibly damaging Het
Ndst4 T A 3: 125,405,210 (GRCm39) Y488* probably null Het
Nfat5 C T 8: 108,065,707 (GRCm39) R156W probably damaging Het
Nfs1 T C 2: 155,976,444 (GRCm39) H150R probably damaging Het
Odad3 A T 9: 21,906,353 (GRCm39) N224K probably benign Het
Or8b56 T C 9: 38,739,154 (GRCm39) S50P possibly damaging Het
Or8g19 T A 9: 39,055,399 (GRCm39) M1K probably null Het
Or9q1 A G 19: 13,804,929 (GRCm39) F277S possibly damaging Het
Pcdh8 T C 14: 80,004,848 (GRCm39) Y1059C probably damaging Het
Pik3r5 T A 11: 68,381,306 (GRCm39) L164Q probably damaging Het
Polr3g T C 13: 81,824,240 (GRCm39) probably benign Het
Ppm1e T A 11: 87,122,564 (GRCm39) K464N probably benign Het
Rims1 T C 1: 22,416,631 (GRCm39) T1037A probably damaging Het
Rpgrip1l A T 8: 91,996,750 (GRCm39) I108N probably damaging Het
Sfi1 CCTCTC CCTCTCTC 11: 3,127,419 (GRCm39) probably benign Het
Spem1 T C 11: 69,712,371 (GRCm39) K98E possibly damaging Het
St7l T C 3: 104,796,619 (GRCm39) V237A probably damaging Het
Tbc1d16 T C 11: 119,048,642 (GRCm39) H337R probably damaging Het
Tbc1d32 T A 10: 55,893,701 (GRCm39) I1291F probably benign Het
Tnfaip6 G T 2: 51,933,827 (GRCm39) E61* probably null Het
Trib2 A T 12: 15,843,929 (GRCm39) W102R probably damaging Het
Uimc1 G T 13: 55,233,457 (GRCm39) N66K probably damaging Het
Vmn1r63 T A 7: 5,805,838 (GRCm39) T265S probably benign Het
Vps35 G A 8: 86,021,582 (GRCm39) T3I probably benign Het
Yeats2 T A 16: 19,975,692 (GRCm39) L63* probably null Het
Zfp282 A G 6: 47,869,866 (GRCm39) R304G probably benign Het
Other mutations in Or1n1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02706:Or1n1b APN 2 36,780,731 (GRCm39) missense probably damaging 1.00
IGL02944:Or1n1b APN 2 36,780,800 (GRCm39) missense possibly damaging 0.83
R0101:Or1n1b UTSW 2 36,780,138 (GRCm39) missense probably damaging 1.00
R0276:Or1n1b UTSW 2 36,780,035 (GRCm39) missense probably benign 0.26
R0944:Or1n1b UTSW 2 36,780,698 (GRCm39) missense probably damaging 1.00
R0975:Or1n1b UTSW 2 36,780,562 (GRCm39) missense possibly damaging 0.52
R1895:Or1n1b UTSW 2 36,780,458 (GRCm39) missense possibly damaging 0.92
R1946:Or1n1b UTSW 2 36,780,458 (GRCm39) missense possibly damaging 0.92
R2847:Or1n1b UTSW 2 36,780,536 (GRCm39) missense probably damaging 1.00
R4573:Or1n1b UTSW 2 36,780,202 (GRCm39) missense probably damaging 1.00
R4631:Or1n1b UTSW 2 36,780,630 (GRCm39) missense probably benign 0.01
R4647:Or1n1b UTSW 2 36,780,663 (GRCm39) missense probably benign 0.00
R4918:Or1n1b UTSW 2 36,780,344 (GRCm39) missense probably damaging 0.98
R4967:Or1n1b UTSW 2 36,780,719 (GRCm39) missense probably damaging 1.00
R5102:Or1n1b UTSW 2 36,780,056 (GRCm39) missense possibly damaging 0.87
R5188:Or1n1b UTSW 2 36,780,405 (GRCm39) missense probably benign
R5392:Or1n1b UTSW 2 36,780,686 (GRCm39) missense probably benign 0.34
R5608:Or1n1b UTSW 2 36,780,527 (GRCm39) missense probably damaging 1.00
R6527:Or1n1b UTSW 2 36,780,594 (GRCm39) missense probably benign 0.02
R8508:Or1n1b UTSW 2 36,780,366 (GRCm39) missense probably damaging 1.00
R8820:Or1n1b UTSW 2 36,780,622 (GRCm39) missense probably benign 0.01
R9052:Or1n1b UTSW 2 36,780,105 (GRCm39) missense probably damaging 1.00
X0017:Or1n1b UTSW 2 36,779,999 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCAGAGCTTAGCTCCAGGCACATAG -3'
(R):5'- TTAGGGTCCAGACTTCTGGCGG -3'

Sequencing Primer
(F):5'- GGACAATAATCTCTTGGTTAGCAAGC -3'
(R):5'- CTTCTGGCGGGAGTTCAAAG -3'
Posted On 2013-04-11