Incidental Mutation 'R1881:Zfp345'
ID 209093
Institutional Source Beutler Lab
Gene Symbol Zfp345
Ensembl Gene ENSMUSG00000074731
Gene Name zinc finger protein 345
Synonyms OTTMUSG00000015743
MMRRC Submission 039902-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.172) question?
Stock # R1881 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 150312911-150326983 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 150314275 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 421 (Y421H)
Ref Sequence ENSEMBL: ENSMUSP00000105540 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109914]
AlphaFold A2AQA1
Predicted Effect probably damaging
Transcript: ENSMUST00000109914
AA Change: Y421H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000105540
Gene: ENSMUSG00000074731
AA Change: Y421H

DomainStartEndE-ValueType
KRAB 4 66 9.5e-20 SMART
ZnF_C2H2 103 125 2e-2 SMART
ZnF_C2H2 131 153 2.9e-6 SMART
ZnF_C2H2 159 181 4.1e-3 SMART
ZnF_C2H2 215 237 2.6e-7 SMART
ZnF_C2H2 243 265 1.6e-5 SMART
ZnF_C2H2 271 293 4e-7 SMART
ZnF_C2H2 299 321 1.1e-5 SMART
ZnF_C2H2 327 349 5.9e-7 SMART
ZnF_C2H2 365 387 4.4e-7 SMART
ZnF_C2H2 393 415 7.3e-6 SMART
ZnF_C2H2 421 443 2.7e-5 SMART
ZnF_C2H2 449 471 1.5e-4 SMART
ZnF_C2H2 477 499 1.3e-5 SMART
ZnF_C2H2 505 527 5.1e-6 SMART
ZnF_C2H2 533 555 9.2e-7 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000117906
Meta Mutation Damage Score 0.3967 question?
Coding Region Coverage
  • 1x: 97.3%
  • 3x: 96.7%
  • 10x: 95.1%
  • 20x: 92.3%
Validation Efficiency 96% (71/74)
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca C A 11: 84,161,213 (GRCm39) Y1026* probably null Het
Acaca T G 11: 84,191,297 (GRCm39) probably benign Het
Adcy8 C T 15: 64,678,503 (GRCm39) M483I probably damaging Het
Adgrb2 G A 4: 129,904,078 (GRCm39) G735S probably damaging Het
Akap9 A G 5: 4,100,173 (GRCm39) T2612A probably benign Het
Armc1 A T 3: 19,189,060 (GRCm39) S202T possibly damaging Het
Arsj T C 3: 126,232,486 (GRCm39) S411P probably damaging Het
Ash1l T C 3: 88,888,862 (GRCm39) V247A probably benign Het
Camta2 T C 11: 70,562,842 (GRCm39) D935G probably benign Het
Cc2d2a G T 5: 43,898,170 (GRCm39) V1626F probably damaging Het
Cpne3 T A 4: 19,535,266 (GRCm39) R255S probably benign Het
Cramp1 A G 17: 25,196,656 (GRCm39) probably benign Het
Csf2rb2 C T 15: 78,176,735 (GRCm39) probably null Het
Cstf3 A T 2: 104,484,563 (GRCm39) M396L probably benign Het
Ctnnd2 A G 15: 31,005,227 (GRCm39) probably benign Het
Cul7 A T 17: 46,962,888 (GRCm39) Y173F probably damaging Het
Dach1 A T 14: 98,138,832 (GRCm39) M537K probably benign Het
Ddhd2 T C 8: 26,217,727 (GRCm39) I717V probably damaging Het
Dnm1 C T 2: 32,213,742 (GRCm39) V475I probably damaging Het
Dnm3 C T 1: 162,305,517 (GRCm39) probably benign Het
Dsg1c T A 18: 20,405,597 (GRCm39) probably benign Het
Eaf2 A T 16: 36,620,941 (GRCm39) probably benign Het
En1 T A 1: 120,530,904 (GRCm39) V48E unknown Het
Eral1 T A 11: 77,966,875 (GRCm39) H180L possibly damaging Het
Fry T A 5: 150,401,511 (GRCm39) C2760S probably damaging Het
Gtf2h3 C T 5: 124,722,336 (GRCm39) A113V probably benign Het
Hmcn1 C T 1: 150,514,651 (GRCm39) V3574M probably benign Het
Ifnl2 T A 7: 28,209,112 (GRCm39) R68W probably damaging Het
Il6st A G 13: 112,640,947 (GRCm39) T908A probably damaging Het
Krtap4-1 C T 11: 99,518,990 (GRCm39) G7S probably null Het
Ly75 T C 2: 60,180,284 (GRCm39) E631G probably benign Het
Mup5 C A 4: 61,752,868 (GRCm39) E52* probably null Het
Myh15 A G 16: 48,891,446 (GRCm39) I189V probably damaging Het
Nav3 T A 10: 109,688,420 (GRCm39) Q619L probably damaging Het
Or14a257 T C 7: 86,138,646 (GRCm39) M38V probably benign Het
Or1p1 A T 11: 74,179,492 (GRCm39) T7S probably benign Het
Or4n4b A G 14: 50,536,472 (GRCm39) I98T probably damaging Het
Or5e1 T C 7: 108,354,335 (GRCm39) S91P probably damaging Het
Pam T C 1: 97,850,876 (GRCm39) T161A probably benign Het
Phf8-ps T A 17: 33,284,258 (GRCm39) D848V probably damaging Het
Pigs T C 11: 78,232,582 (GRCm39) V472A probably benign Het
Plek A T 11: 16,940,111 (GRCm39) N176K probably benign Het
Poc5 A G 13: 96,535,239 (GRCm39) N168S probably benign Het
Pomt2 G T 12: 87,182,370 (GRCm39) A219D probably damaging Het
Rttn T A 18: 89,033,336 (GRCm39) S716T probably damaging Het
Sema4b A T 7: 79,866,540 (GRCm39) S207C probably damaging Het
Slc25a20 G A 9: 108,557,408 (GRCm39) probably null Het
Slc5a6 A T 5: 31,194,155 (GRCm39) L634Q probably damaging Het
Slfn3 A G 11: 83,104,202 (GRCm39) I235V possibly damaging Het
Smarcc1 T A 9: 110,004,167 (GRCm39) L407Q probably damaging Het
Spata32 T C 11: 103,101,561 (GRCm39) probably benign Het
Tdrd3 A G 14: 87,723,783 (GRCm39) probably null Het
Thada A G 17: 84,744,130 (GRCm39) V726A probably benign Het
Tmed7 A T 18: 46,721,622 (GRCm39) probably null Het
Tmem161a G A 8: 70,633,435 (GRCm39) G94S probably null Het
Tmem81 T A 1: 132,435,948 (GRCm39) probably benign Het
Trim63 C A 4: 134,043,702 (GRCm39) A55E probably damaging Het
Trmt1 A C 8: 85,415,896 (GRCm39) probably benign Het
Trpv4 C T 5: 114,761,687 (GRCm39) V814M probably benign Het
Tshz3 T C 7: 36,471,079 (GRCm39) S1023P possibly damaging Het
Upk3bl G A 5: 136,086,157 (GRCm39) R31Q probably benign Het
Usp40 T C 1: 87,921,993 (GRCm39) D290G probably benign Het
Vmn1r192 G T 13: 22,371,764 (GRCm39) A152E probably benign Het
Vmn1r26 T A 6: 57,985,650 (GRCm39) T180S probably benign Het
Wdr48 G T 9: 119,738,606 (GRCm39) V89L probably benign Het
Wdr6 G T 9: 108,450,378 (GRCm39) probably null Het
Other mutations in Zfp345
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00833:Zfp345 APN 2 150,314,649 (GRCm39) missense probably damaging 1.00
IGL00846:Zfp345 APN 2 150,314,538 (GRCm39) missense possibly damaging 0.76
IGL01020:Zfp345 APN 2 150,314,967 (GRCm39) missense possibly damaging 0.68
IGL01931:Zfp345 APN 2 150,315,270 (GRCm39) missense probably benign 0.38
IGL02237:Zfp345 APN 2 150,316,805 (GRCm39) splice site probably benign
IGL02335:Zfp345 APN 2 150,316,463 (GRCm39) missense possibly damaging 0.92
IGL02592:Zfp345 APN 2 150,315,229 (GRCm39) missense probably benign 0.36
IGL02736:Zfp345 APN 2 150,316,474 (GRCm39) missense probably damaging 0.99
R0095:Zfp345 UTSW 2 150,314,220 (GRCm39) missense probably damaging 1.00
R0096:Zfp345 UTSW 2 150,314,220 (GRCm39) missense probably damaging 1.00
R0143:Zfp345 UTSW 2 150,314,475 (GRCm39) missense probably benign
R0371:Zfp345 UTSW 2 150,313,983 (GRCm39) missense possibly damaging 0.81
R0412:Zfp345 UTSW 2 150,315,323 (GRCm39) missense probably benign 0.00
R0415:Zfp345 UTSW 2 150,316,479 (GRCm39) splice site probably benign
R0420:Zfp345 UTSW 2 150,315,163 (GRCm39) missense possibly damaging 0.74
R0697:Zfp345 UTSW 2 150,314,829 (GRCm39) missense probably benign 0.13
R0799:Zfp345 UTSW 2 150,314,271 (GRCm39) missense probably benign 0.27
R1954:Zfp345 UTSW 2 150,316,741 (GRCm39) missense probably damaging 1.00
R2004:Zfp345 UTSW 2 150,314,038 (GRCm39) missense possibly damaging 0.90
R2152:Zfp345 UTSW 2 150,314,578 (GRCm39) missense probably benign 0.00
R2153:Zfp345 UTSW 2 150,314,578 (GRCm39) missense probably benign 0.00
R3051:Zfp345 UTSW 2 150,316,772 (GRCm39) missense probably benign 0.07
R3880:Zfp345 UTSW 2 150,314,075 (GRCm39) missense possibly damaging 0.91
R3939:Zfp345 UTSW 2 150,314,473 (GRCm39) missense probably damaging 1.00
R4801:Zfp345 UTSW 2 150,315,228 (GRCm39) missense possibly damaging 0.91
R4802:Zfp345 UTSW 2 150,315,228 (GRCm39) missense possibly damaging 0.91
R4897:Zfp345 UTSW 2 150,314,608 (GRCm39) missense probably benign 0.05
R5606:Zfp345 UTSW 2 150,316,788 (GRCm39) nonsense probably null
R6009:Zfp345 UTSW 2 150,314,437 (GRCm39) missense probably damaging 1.00
R6191:Zfp345 UTSW 2 150,315,010 (GRCm39) missense probably benign 0.11
R6194:Zfp345 UTSW 2 150,314,551 (GRCm39) missense probably damaging 1.00
R6782:Zfp345 UTSW 2 150,315,274 (GRCm39) missense probably damaging 0.97
R6932:Zfp345 UTSW 2 150,315,331 (GRCm39) missense probably damaging 0.99
R7356:Zfp345 UTSW 2 150,314,209 (GRCm39) missense probably damaging 1.00
R7980:Zfp345 UTSW 2 150,314,723 (GRCm39) nonsense probably null
R8387:Zfp345 UTSW 2 150,314,740 (GRCm39) missense probably damaging 0.96
R8515:Zfp345 UTSW 2 150,314,348 (GRCm39) missense probably benign 0.01
R8940:Zfp345 UTSW 2 150,314,277 (GRCm39) missense probably benign 0.40
R9038:Zfp345 UTSW 2 150,313,864 (GRCm39) missense probably benign 0.02
R9383:Zfp345 UTSW 2 150,314,503 (GRCm39) missense possibly damaging 0.89
R9480:Zfp345 UTSW 2 150,315,212 (GRCm39) nonsense probably null
R9723:Zfp345 UTSW 2 150,314,189 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TCCAGTATGTGTTCTTTTATGCATTC -3'
(R):5'- ATACAGTGTGGTAAAGCCTTTGC -3'

Sequencing Primer
(F):5'- GAAGGATTTACCACATTCGTTGC -3'
(R):5'- GCACGTTTAAGTATTCTCCGAAGAC -3'
Posted On 2014-06-30