Mutagenetix > Incidental Mutation

Incidental Mutation 'R1886:Dmxl1'

209599

Institutional Source

Beutler Lab

Gene Symbol

Dmxl1

Ensembl Gene

ENSMUSG00000037416

Gene Name

Dmx-like 1

Synonyms

C630007L23Rik

MMRRC Submission

039907-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.956) question?

Stock #

R1886 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

49965737-50098540 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 49992202 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Histidine at position 316 (R316H)

Ref Sequence

ENSEMBL: ENSMUSP00000137871 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041772] [ENSMUST00000180611]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000041772
AA Change: R316H

PolyPhen 2 Score 0.042 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000045559
Gene: ENSMUSG00000037416
AA Change: R316H

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
Pfam:Rav1p_C	1102	1877	4.3e-84	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2371	2385	N/A	INTRINSIC
low complexity region	2397	2410	N/A	INTRINSIC
low complexity region	2449	2466	N/A	INTRINSIC
WD40	2735	2770	1.07e1	SMART
WD40	2773	2813	3.7e0	SMART
WD40	2825	2867	1.07e0	SMART
WD40	2873	2912	1.05e-2	SMART
WD40	2915	2954	4.51e-7	SMART
Blast:WD40	2957	3005	9e-26	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000180611
AA Change: R316H

PolyPhen 2 Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000137871
Gene: ENSMUSG00000037416
AA Change: R316H

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
low complexity region	1195	1206	N/A	INTRINSIC
low complexity region	1258	1271	N/A	INTRINSIC
Pfam:Rav1p_C	1287	1876	9.4e-72	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2385	2398	N/A	INTRINSIC
low complexity region	2437	2454	N/A	INTRINSIC
WD40	2723	2758	1.07e1	SMART
WD40	2761	2801	3.7e0	SMART
WD40	2813	2855	1.07e0	SMART
WD40	2861	2900	1.05e-2	SMART
WD40	2903	2942	4.51e-7	SMART
Blast:WD40	2945	2993	9e-26	BLAST

Coding Region Coverage

1x: 97.2%
3x: 96.2%
10x: 93.1%
20x: 85.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the WD repeat superfamily of proteins, which have regulatory functions. This gene is expressed in many tissue types including several types of eye tissue, and it has been associated with ocular phenotypes. In addition, it is upregulated in cultured cells that overexpress growth factor independence 1B, a transcription factor that is essential for hematopoietic cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Allele List at MGI

Other mutations in this stock

Total: 87 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700102P08Rik	T	A	9: 108,270,809 (GRCm39)	D124E	possibly damaging	Het
Aarsd1	T	C	11: 101,302,227 (GRCm39)	T278A	probably benign	Het
Acacb	T	A	5: 114,357,020 (GRCm39)	L1317Q	probably damaging	Het
Acsf3	T	C	8: 123,510,741 (GRCm39)	V293A	probably damaging	Het
Adora3	A	C	3: 105,812,152 (GRCm39)	N13H	possibly damaging	Het
Aen	A	T	7: 78,557,073 (GRCm39)	D307V	probably damaging	Het
Ahnak	G	A	19: 8,993,343 (GRCm39)	D4876N	probably damaging	Het
Ap2b1	T	A	11: 83,281,561 (GRCm39)	N822K	probably damaging	Het
Arhgdia	T	C	11: 120,470,244 (GRCm39)	D143G	probably benign	Het
Bcl9	G	T	3: 97,122,713 (GRCm39)	R29S	probably benign	Het
Bhmt2	T	A	13: 93,798,998 (GRCm39)	K274N	probably benign	Het
Brip1	C	A	11: 86,029,641 (GRCm39)	G631V	probably damaging	Het
Cacna1i	A	G	15: 80,243,145 (GRCm39)	E434G	probably damaging	Het
Ccdc81	T	C	7: 89,515,819 (GRCm39)	E620G	possibly damaging	Het
Cdhr18	A	C	14: 13,828,607 (GRCm38)	Y718D	probably damaging	Het
Cfap299	A	G	5: 98,949,690 (GRCm39)	N208S	probably benign	Het
Cit	A	G	5: 116,071,545 (GRCm39)	Y584C	probably damaging	Het
Crebl2	T	C	6: 134,828,059 (GRCm39)	M77T	probably benign	Het
Dach2	G	A	X: 112,208,305 (GRCm39)	G61D	probably benign	Het
Ddx4	A	T	13: 112,759,199 (GRCm39)	D237E	probably damaging	Het
Dgcr8	A	G	16: 18,096,218 (GRCm39)	I490T	possibly damaging	Het
Dnah17	T	A	11: 117,998,987 (GRCm39)	I929F	possibly damaging	Het
Eif3f	A	G	7: 108,539,958 (GRCm39)	T289A	probably benign	Het
Ercc5	A	T	1: 44,215,136 (GRCm39)	K890*	probably null	Het
Esrp2	A	T	8: 106,860,489 (GRCm39)	V247E	probably damaging	Het
Evpl	C	T	11: 116,118,402 (GRCm39)	G735E	probably damaging	Het
Ezhip	GTCATCATCATCATC	GTCATCATCATCATCATC	X: 5,994,645 (GRCm39)		probably benign	Het
Fbxl21	A	G	13: 56,674,906 (GRCm39)	I60V	probably benign	Het
Frem3	A	G	8: 81,340,514 (GRCm39)	I936V	probably benign	Het
Fsd1l	T	C	4: 53,696,984 (GRCm39)		probably null	Het
Gad1-ps	T	C	10: 99,281,444 (GRCm39)		noncoding transcript	Het
Gbp2b	A	G	3: 142,314,063 (GRCm39)	T448A	probably benign	Het
Gfus	G	T	15: 75,798,838 (GRCm39)	T123N	possibly damaging	Het
Gmppa	T	C	1: 75,419,152 (GRCm39)	V353A	probably damaging	Het
Hmcn1	T	C	1: 150,453,046 (GRCm39)	E5423G	probably benign	Het
Hmgxb3	A	G	18: 61,270,473 (GRCm39)		probably null	Het
Krt12	T	C	11: 99,309,402 (GRCm39)	D286G	probably damaging	Het
Krt75	A	T	15: 101,479,532 (GRCm39)	M266K	probably damaging	Het
Ksr1	C	A	11: 78,911,204 (GRCm39)	V11F	probably null	Het
Lag3	T	C	6: 124,886,402 (GRCm39)	N184D	probably damaging	Het
Lsm10	C	G	4: 125,991,741 (GRCm39)	D32E	probably benign	Het
Mettl5	A	G	2: 69,711,149 (GRCm39)	V123A	probably damaging	Het
Mfrp	A	G	9: 44,014,785 (GRCm39)	D274G	possibly damaging	Het
Mgat3	A	G	15: 80,095,820 (GRCm39)	I216V	probably benign	Het
Mkrn3	G	A	7: 62,068,486 (GRCm39)	A435V	probably benign	Het
Mob3a	G	A	10: 80,527,068 (GRCm39)	Q86*	probably null	Het
Mplkipl1	A	G	19: 61,164,136 (GRCm39)	F100L	probably damaging	Het
Mttp	A	T	3: 137,798,376 (GRCm39)	V840D	probably damaging	Het
Nadk2	A	C	15: 9,103,446 (GRCm39)	N308H	possibly damaging	Het
Ncoa7	T	C	10: 30,524,448 (GRCm39)	N823S	possibly damaging	Het
Nlk	T	A	11: 78,477,754 (GRCm39)	I330F	probably damaging	Het
Ofcc1	T	C	13: 40,360,100 (GRCm39)	S310G	possibly damaging	Het
Or5p57	T	C	7: 107,665,985 (GRCm39)	N7D	probably benign	Het
Or5p73	A	T	7: 108,064,947 (GRCm39)	M139L	probably benign	Het
Orc2	T	C	1: 58,510,247 (GRCm39)		probably null	Het
Orc3	A	G	4: 34,584,829 (GRCm39)	Y459H	probably damaging	Het
Pah	T	A	10: 87,364,190 (GRCm39)	N30K	possibly damaging	Het
Pcsk4	T	C	10: 80,164,794 (GRCm39)	K74E	probably benign	Het
Pdlim7	C	T	13: 55,653,981 (GRCm39)	G212D	probably benign	Het
Pfkm	A	G	15: 98,025,627 (GRCm39)	N547S	probably damaging	Het
Por	A	G	5: 135,763,128 (GRCm39)	E546G	probably damaging	Het
Ppp1r13l	T	C	7: 19,111,496 (GRCm39)	S774P	probably damaging	Het
Prdm1	T	A	10: 44,315,754 (GRCm39)	D794V	probably damaging	Het
Prdx5	A	G	19: 6,885,558 (GRCm39)	I32T	probably benign	Het
Prlhr	G	T	19: 60,455,932 (GRCm39)	C211*	probably null	Het
Ripk3	C	T	14: 56,025,694 (GRCm39)		probably null	Het
Rmnd5b	G	A	11: 51,518,465 (GRCm39)	A137V	probably damaging	Het
Rwdd2b	A	T	16: 87,234,013 (GRCm39)	F72I	probably benign	Het
Scml4	A	G	10: 42,788,223 (GRCm39)	Y51C	probably damaging	Het
Septin1	A	G	7: 126,813,937 (GRCm39)		probably benign	Het
Serpinb9h	C	T	13: 33,588,203 (GRCm39)	R263C	possibly damaging	Het
Slc30a10	T	A	1: 185,195,061 (GRCm39)	I291N	probably damaging	Het
Slc7a9	T	G	7: 35,152,827 (GRCm39)	C20W	possibly damaging	Het
Slc7a9	G	C	7: 35,152,828 (GRCm39)	A21P	probably damaging	Het
Slco1b2	A	T	6: 141,628,951 (GRCm39)	Y551F	probably damaging	Het
Sra1	T	C	18: 36,801,830 (GRCm39)	M87V	probably benign	Het
Syvn1	T	C	19: 6,099,257 (GRCm39)	S169P	possibly damaging	Het
Tmc7	A	T	7: 118,160,310 (GRCm39)	F176I	possibly damaging	Het
Tmem62	A	T	2: 120,817,151 (GRCm39)	I236F	probably damaging	Het
Trip4	T	A	9: 65,782,163 (GRCm39)	I190F	probably null	Het
Trpa1	T	C	1: 14,959,649 (GRCm39)	D679G	probably benign	Het
Ttc22	T	A	4: 106,494,063 (GRCm39)		probably null	Het
Ttn	A	T	2: 76,641,587 (GRCm39)	L5176Q	possibly damaging	Het
Tyrp1	T	A	4: 80,759,043 (GRCm39)		probably null	Het
Ubap2	C	T	4: 41,199,872 (GRCm39)	A752T	probably benign	Het
Usp36	A	T	11: 118,163,784 (GRCm39)	Y255N	probably damaging	Het
Zfp944	A	T	17: 22,558,960 (GRCm39)	Y96N	probably benign	Het

Other mutations in Dmxl1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Dmxl1	APN	18	49,984,534 (GRCm39)	missense	probably damaging	1.00
IGL00668:Dmxl1	APN	18	50,072,620 (GRCm39)	missense	possibly damaging	0.64
IGL00740:Dmxl1	APN	18	50,050,735 (GRCm39)	missense	probably benign	0.00
IGL00969:Dmxl1	APN	18	50,045,792 (GRCm39)	missense	probably benign	0.02
IGL01113:Dmxl1	APN	18	50,045,818 (GRCm39)	missense	probably benign	0.01
IGL01384:Dmxl1	APN	18	49,990,401 (GRCm39)	missense	probably benign
IGL01475:Dmxl1	APN	18	50,004,781 (GRCm39)	missense	probably damaging	1.00
IGL01559:Dmxl1	APN	18	50,054,005 (GRCm39)	missense	probably damaging	0.99
IGL01578:Dmxl1	APN	18	50,095,272 (GRCm39)	missense	probably damaging	1.00
IGL01632:Dmxl1	APN	18	49,996,092 (GRCm39)	missense	probably damaging	0.99
IGL01814:Dmxl1	APN	18	49,997,935 (GRCm39)	missense	probably damaging	1.00
IGL01843:Dmxl1	APN	18	50,011,449 (GRCm39)	nonsense	probably null
IGL01933:Dmxl1	APN	18	50,010,852 (GRCm39)	missense	probably benign	0.17
IGL01952:Dmxl1	APN	18	50,023,721 (GRCm39)	missense	probably benign	0.11
IGL02120:Dmxl1	APN	18	50,027,245 (GRCm39)	missense	possibly damaging	0.83
IGL02162:Dmxl1	APN	18	50,094,230 (GRCm39)	missense	probably benign	0.00
IGL02213:Dmxl1	APN	18	50,010,741 (GRCm39)	splice site	probably benign
IGL02261:Dmxl1	APN	18	49,973,566 (GRCm39)	missense	possibly damaging	0.85
IGL02689:Dmxl1	APN	18	49,997,962 (GRCm39)	missense	probably damaging	1.00
IGL02892:Dmxl1	APN	18	49,992,187 (GRCm39)	missense	probably damaging	0.96
IGL03232:Dmxl1	APN	18	50,011,247 (GRCm39)	missense	probably benign	0.01
IGL03258:Dmxl1	APN	18	50,053,960 (GRCm39)	missense	probably damaging	1.00
IGL03298:Dmxl1	APN	18	49,997,885 (GRCm39)	missense	probably benign
capture	UTSW	18	50,095,328 (GRCm39)	missense	probably damaging	1.00
carnivora	UTSW	18	49,997,450 (GRCm39)	missense	probably damaging	0.99
digestion	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
drowning	UTSW	18	50,011,292 (GRCm39)	missense	possibly damaging	0.55
hibiscus	UTSW	18	50,022,534 (GRCm39)	missense	probably damaging	1.00
impound	UTSW	18	50,026,316 (GRCm39)	missense	probably benign
pitcher	UTSW	18	49,997,215 (GRCm39)	missense	probably damaging	1.00
PIT4810001:Dmxl1	UTSW	18	50,065,030 (GRCm39)	missense	probably damaging	1.00
R0001:Dmxl1	UTSW	18	50,021,964 (GRCm39)	splice site	probably benign
R0027:Dmxl1	UTSW	18	50,090,362 (GRCm39)	splice site	probably benign
R0042:Dmxl1	UTSW	18	49,997,102 (GRCm39)	missense	probably benign	0.03
R0042:Dmxl1	UTSW	18	49,997,102 (GRCm39)	missense	probably benign	0.03
R0046:Dmxl1	UTSW	18	50,011,149 (GRCm39)	missense	probably benign	0.22
R0046:Dmxl1	UTSW	18	50,011,149 (GRCm39)	missense	probably benign	0.22
R0257:Dmxl1	UTSW	18	50,088,870 (GRCm39)	splice site	probably benign
R0349:Dmxl1	UTSW	18	50,012,349 (GRCm39)	missense	probably damaging	0.99
R0390:Dmxl1	UTSW	18	50,012,429 (GRCm39)	missense	probably benign	0.14
R0511:Dmxl1	UTSW	18	50,024,534 (GRCm39)	nonsense	probably null
R0539:Dmxl1	UTSW	18	49,990,497 (GRCm39)	splice site	probably benign
R0542:Dmxl1	UTSW	18	50,026,761 (GRCm39)	missense	probably benign	0.05
R0587:Dmxl1	UTSW	18	50,068,374 (GRCm39)	missense	probably benign	0.39
R0635:Dmxl1	UTSW	18	49,984,490 (GRCm39)	splice site	probably benign
R0744:Dmxl1	UTSW	18	49,966,215 (GRCm39)	missense	probably damaging	1.00
R0836:Dmxl1	UTSW	18	49,966,215 (GRCm39)	missense	probably damaging	1.00
R0845:Dmxl1	UTSW	18	50,026,469 (GRCm39)	missense	probably damaging	1.00
R1218:Dmxl1	UTSW	18	50,026,678 (GRCm39)	missense	probably damaging	1.00
R1278:Dmxl1	UTSW	18	50,026,292 (GRCm39)	missense	probably benign
R1313:Dmxl1	UTSW	18	50,011,550 (GRCm39)	missense	probably damaging	1.00
R1313:Dmxl1	UTSW	18	50,011,550 (GRCm39)	missense	probably damaging	1.00
R1349:Dmxl1	UTSW	18	50,021,920 (GRCm39)	missense	probably damaging	1.00
R1453:Dmxl1	UTSW	18	49,990,316 (GRCm39)	missense	probably benign	0.05
R1522:Dmxl1	UTSW	18	49,985,434 (GRCm39)	missense	probably benign	0.05
R1629:Dmxl1	UTSW	18	49,992,353 (GRCm39)	critical splice donor site	probably null
R1638:Dmxl1	UTSW	18	50,023,834 (GRCm39)	nonsense	probably null
R1646:Dmxl1	UTSW	18	50,095,328 (GRCm39)	missense	probably damaging	1.00
R1719:Dmxl1	UTSW	18	50,067,704 (GRCm39)	missense	probably damaging	1.00
R1732:Dmxl1	UTSW	18	50,036,055 (GRCm39)	missense	probably benign
R1732:Dmxl1	UTSW	18	50,026,511 (GRCm39)	nonsense	probably null
R1887:Dmxl1	UTSW	18	49,992,202 (GRCm39)	missense	probably benign	0.09
R1895:Dmxl1	UTSW	18	50,088,981 (GRCm39)	splice site	probably null
R1911:Dmxl1	UTSW	18	50,011,230 (GRCm39)	missense	probably benign	0.00
R2020:Dmxl1	UTSW	18	50,022,625 (GRCm39)	nonsense	probably null
R2116:Dmxl1	UTSW	18	50,011,884 (GRCm39)	missense	probably damaging	1.00
R2196:Dmxl1	UTSW	18	50,050,698 (GRCm39)	missense	probably benign	0.00
R2206:Dmxl1	UTSW	18	50,027,161 (GRCm39)	missense	probably benign	0.12
R2216:Dmxl1	UTSW	18	50,026,990 (GRCm39)	missense	probably benign	0.00
R2255:Dmxl1	UTSW	18	49,979,706 (GRCm39)	missense	probably benign	0.34
R2333:Dmxl1	UTSW	18	50,053,043 (GRCm39)	splice site	probably null
R2343:Dmxl1	UTSW	18	50,023,745 (GRCm39)	missense	probably damaging	1.00
R2496:Dmxl1	UTSW	18	50,013,858 (GRCm39)	missense	possibly damaging	0.51
R3757:Dmxl1	UTSW	18	50,068,384 (GRCm39)	missense	probably damaging	0.98
R3758:Dmxl1	UTSW	18	50,068,384 (GRCm39)	missense	probably damaging	0.98
R3783:Dmxl1	UTSW	18	49,998,189 (GRCm39)	missense	probably damaging	1.00
R3786:Dmxl1	UTSW	18	49,998,189 (GRCm39)	missense	probably damaging	1.00
R3787:Dmxl1	UTSW	18	49,998,189 (GRCm39)	missense	probably damaging	1.00
R3885:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3886:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3887:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3888:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3889:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R4014:Dmxl1	UTSW	18	49,997,029 (GRCm39)	missense	probably benign
R4033:Dmxl1	UTSW	18	49,984,498 (GRCm39)	missense	possibly damaging	0.95
R4096:Dmxl1	UTSW	18	50,094,264 (GRCm39)	missense	probably damaging	1.00
R4366:Dmxl1	UTSW	18	50,011,084 (GRCm39)	nonsense	probably null
R4406:Dmxl1	UTSW	18	50,022,620 (GRCm39)	missense	probably damaging	1.00
R4412:Dmxl1	UTSW	18	49,981,828 (GRCm39)	missense	probably benign
R4454:Dmxl1	UTSW	18	50,026,399 (GRCm39)	missense	probably benign	0.01
R4459:Dmxl1	UTSW	18	50,094,283 (GRCm39)	missense	possibly damaging	0.80
R4569:Dmxl1	UTSW	18	49,985,427 (GRCm39)	missense	probably damaging	1.00
R4570:Dmxl1	UTSW	18	49,985,427 (GRCm39)	missense	probably damaging	1.00
R4606:Dmxl1	UTSW	18	50,095,248 (GRCm39)	missense	probably damaging	0.98
R4649:Dmxl1	UTSW	18	50,011,698 (GRCm39)	missense	probably damaging	0.99
R4683:Dmxl1	UTSW	18	50,011,088 (GRCm39)	missense	probably damaging	1.00
R4782:Dmxl1	UTSW	18	49,996,059 (GRCm39)	missense	probably damaging	1.00
R4878:Dmxl1	UTSW	18	49,984,543 (GRCm39)	missense	probably damaging	1.00
R4879:Dmxl1	UTSW	18	50,022,534 (GRCm39)	missense	probably damaging	1.00
R4881:Dmxl1	UTSW	18	50,090,348 (GRCm39)	intron	probably benign
R4885:Dmxl1	UTSW	18	50,011,862 (GRCm39)	missense	probably damaging	0.99
R4916:Dmxl1	UTSW	18	50,010,764 (GRCm39)	missense	probably damaging	1.00
R5022:Dmxl1	UTSW	18	50,028,194 (GRCm39)	missense	probably damaging	0.99
R5056:Dmxl1	UTSW	18	50,003,990 (GRCm39)	missense	probably benign	0.00
R5177:Dmxl1	UTSW	18	50,026,651 (GRCm39)	missense	probably damaging	0.99
R5342:Dmxl1	UTSW	18	50,084,302 (GRCm39)	missense	probably damaging	0.96
R5421:Dmxl1	UTSW	18	49,996,186 (GRCm39)	critical splice donor site	probably null
R5433:Dmxl1	UTSW	18	50,000,966 (GRCm39)	splice site	probably null
R5484:Dmxl1	UTSW	18	50,022,531 (GRCm39)	missense	probably damaging	1.00
R5598:Dmxl1	UTSW	18	49,997,545 (GRCm39)	missense	probably benign	0.04
R5633:Dmxl1	UTSW	18	50,010,764 (GRCm39)	missense	probably damaging	1.00
R5638:Dmxl1	UTSW	18	50,024,693 (GRCm39)	missense	possibly damaging	0.95
R5694:Dmxl1	UTSW	18	50,027,324 (GRCm39)	missense	probably damaging	1.00
R5696:Dmxl1	UTSW	18	50,065,008 (GRCm39)	nonsense	probably null
R5706:Dmxl1	UTSW	18	50,090,462 (GRCm39)	critical splice donor site	probably null
R5745:Dmxl1	UTSW	18	49,979,653 (GRCm39)	missense	probably benign
R5876:Dmxl1	UTSW	18	50,004,051 (GRCm39)	missense	possibly damaging	0.70
R6054:Dmxl1	UTSW	18	49,990,453 (GRCm39)	missense	probably benign	0.00
R6145:Dmxl1	UTSW	18	50,045,833 (GRCm39)	missense	possibly damaging	0.90
R6189:Dmxl1	UTSW	18	50,026,402 (GRCm39)	missense	probably benign	0.33
R6213:Dmxl1	UTSW	18	49,996,082 (GRCm39)	missense	possibly damaging	0.93
R6219:Dmxl1	UTSW	18	50,035,434 (GRCm39)	missense	probably damaging	0.99
R6221:Dmxl1	UTSW	18	50,004,799 (GRCm39)	missense	probably damaging	0.96
R6276:Dmxl1	UTSW	18	49,979,653 (GRCm39)	missense	probably benign
R6319:Dmxl1	UTSW	18	49,985,367 (GRCm39)	missense	probably benign	0.00
R6426:Dmxl1	UTSW	18	49,997,645 (GRCm39)	missense	probably damaging	0.99
R6567:Dmxl1	UTSW	18	49,992,246 (GRCm39)	missense	probably damaging	0.99
R6739:Dmxl1	UTSW	18	50,011,313 (GRCm39)	missense	probably benign	0.03
R6743:Dmxl1	UTSW	18	50,013,847 (GRCm39)	missense	possibly damaging	0.95
R6776:Dmxl1	UTSW	18	50,027,041 (GRCm39)	missense	probably damaging	1.00
R6827:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6828:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6829:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6830:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6833:Dmxl1	UTSW	18	50,088,890 (GRCm39)	missense	probably damaging	0.99
R6834:Dmxl1	UTSW	18	50,088,890 (GRCm39)	missense	probably damaging	0.99
R6856:Dmxl1	UTSW	18	49,985,355 (GRCm39)	nonsense	probably null
R6857:Dmxl1	UTSW	18	49,997,902 (GRCm39)	missense	probably damaging	0.99
R6881:Dmxl1	UTSW	18	50,068,372 (GRCm39)	missense	probably benign	0.00
R6882:Dmxl1	UTSW	18	49,976,851 (GRCm39)	critical splice acceptor site	probably null
R6892:Dmxl1	UTSW	18	50,053,969 (GRCm39)	missense	probably damaging	0.98
R6897:Dmxl1	UTSW	18	49,996,124 (GRCm39)	missense	possibly damaging	0.51
R6897:Dmxl1	UTSW	18	49,984,562 (GRCm39)	missense	probably null	0.99
R6917:Dmxl1	UTSW	18	49,997,215 (GRCm39)	missense	probably damaging	1.00
R7192:Dmxl1	UTSW	18	50,088,920 (GRCm39)	missense	probably damaging	0.99
R7447:Dmxl1	UTSW	18	49,997,681 (GRCm39)	missense	probably damaging	0.99
R7460:Dmxl1	UTSW	18	50,011,679 (GRCm39)	missense	probably benign	0.00
R7570:Dmxl1	UTSW	18	50,027,024 (GRCm39)	missense	possibly damaging	0.82
R7626:Dmxl1	UTSW	18	50,035,861 (GRCm39)	missense	probably benign
R7629:Dmxl1	UTSW	18	49,992,337 (GRCm39)	missense	probably damaging	1.00
R7644:Dmxl1	UTSW	18	50,026,619 (GRCm39)	missense	probably benign
R7688:Dmxl1	UTSW	18	50,088,938 (GRCm39)	missense	probably benign	0.03
R7689:Dmxl1	UTSW	18	49,979,685 (GRCm39)	missense	probably benign	0.00
R7712:Dmxl1	UTSW	18	50,026,528 (GRCm39)	missense	probably damaging	0.99
R7808:Dmxl1	UTSW	18	50,011,382 (GRCm39)	missense	probably benign	0.00
R7834:Dmxl1	UTSW	18	50,054,044 (GRCm39)	missense	probably damaging	1.00
R7848:Dmxl1	UTSW	18	49,973,557 (GRCm39)	missense	possibly damaging	0.88
R7849:Dmxl1	UTSW	18	50,094,214 (GRCm39)	missense	probably benign	0.00
R7881:Dmxl1	UTSW	18	49,997,450 (GRCm39)	missense	probably damaging	0.99
R7884:Dmxl1	UTSW	18	50,026,474 (GRCm39)	missense	possibly damaging	0.65
R8073:Dmxl1	UTSW	18	50,011,500 (GRCm39)	missense	probably damaging	1.00
R8089:Dmxl1	UTSW	18	50,021,897 (GRCm39)	missense	probably damaging	0.99
R8266:Dmxl1	UTSW	18	49,976,878 (GRCm39)	missense	probably benign	0.17
R8371:Dmxl1	UTSW	18	50,031,781 (GRCm39)	missense	probably benign	0.08
R8402:Dmxl1	UTSW	18	50,011,409 (GRCm39)	missense	probably benign
R8402:Dmxl1	UTSW	18	50,011,393 (GRCm39)	nonsense	probably null
R8402:Dmxl1	UTSW	18	50,011,394 (GRCm39)	missense	probably benign	0.09
R8423:Dmxl1	UTSW	18	49,998,183 (GRCm39)	missense	probably damaging	1.00
R8678:Dmxl1	UTSW	18	50,004,759 (GRCm39)	nonsense	probably null
R8702:Dmxl1	UTSW	18	49,992,202 (GRCm39)	missense	probably benign	0.09
R8749:Dmxl1	UTSW	18	50,088,937 (GRCm39)	missense	probably damaging	1.00
R8813:Dmxl1	UTSW	18	50,090,406 (GRCm39)	missense	probably damaging	0.99
R8877:Dmxl1	UTSW	18	50,011,292 (GRCm39)	missense	possibly damaging	0.55
R8945:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	50,026,741 (GRCm39)	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	49,997,575 (GRCm39)	missense	possibly damaging	0.96
R8978:Dmxl1	UTSW	18	50,055,679 (GRCm39)	missense	probably benign	0.37
R8987:Dmxl1	UTSW	18	50,026,919 (GRCm39)	missense
R9011:Dmxl1	UTSW	18	49,997,240 (GRCm39)	missense	probably damaging	1.00
R9124:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9131:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9132:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9156:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9165:Dmxl1	UTSW	18	50,011,992 (GRCm39)	missense	probably damaging	1.00
R9244:Dmxl1	UTSW	18	50,026,316 (GRCm39)	missense	probably benign
R9254:Dmxl1	UTSW	18	50,024,567 (GRCm39)	missense	possibly damaging	0.67
R9262:Dmxl1	UTSW	18	49,976,919 (GRCm39)	missense	probably benign	0.03
R9335:Dmxl1	UTSW	18	49,992,187 (GRCm39)	missense	probably damaging	0.96
R9375:Dmxl1	UTSW	18	50,091,477 (GRCm39)	missense	probably damaging	1.00
R9379:Dmxl1	UTSW	18	50,024,567 (GRCm39)	missense	possibly damaging	0.67
R9434:Dmxl1	UTSW	18	50,010,788 (GRCm39)	missense	probably damaging	0.98
R9470:Dmxl1	UTSW	18	50,026,777 (GRCm39)	missense	possibly damaging	0.69
R9500:Dmxl1	UTSW	18	50,011,271 (GRCm39)	missense	probably damaging	1.00
R9507:Dmxl1	UTSW	18	50,024,567 (GRCm39)	missense	possibly damaging	0.94
R9617:Dmxl1	UTSW	18	49,998,228 (GRCm39)	missense	probably damaging	1.00
R9642:Dmxl1	UTSW	18	50,013,825 (GRCm39)	missense	probably damaging	1.00
RF009:Dmxl1	UTSW	18	50,026,461 (GRCm39)	missense	probably damaging	0.96
X0025:Dmxl1	UTSW	18	49,997,435 (GRCm39)	missense	probably damaging	0.98
X0066:Dmxl1	UTSW	18	50,052,966 (GRCm39)	missense	probably damaging	1.00
Z1088:Dmxl1	UTSW	18	50,054,032 (GRCm39)	missense	probably benign
Z1188:Dmxl1	UTSW	18	50,001,070 (GRCm39)	missense	probably damaging	0.96
Z1189:Dmxl1	UTSW	18	50,001,070 (GRCm39)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- GTAGGCCGGGTACTTATTCTTC -3'
(R):5'- AATGCATCATCTGTGACCCCTG -3'

Sequencing Primer
(F):5'- GGCCGGGTACTTATTCTTCAAGATTC -3'
(R):5'- GTTCACAGGTACCTATCCAGATGG -3'

Posted On

2014-06-30