Incidental Mutation 'R1909:Ttc28'
| ID |
210135 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ttc28
|
| Ensembl Gene |
ENSMUSG00000033209 |
| Gene Name |
tetratricopeptide repeat domain 28 |
| Synonyms |
TPRBK, 2310015L07Rik |
| MMRRC Submission |
039928-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1909 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
111027669-111437646 bp(+) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
T to C
at 111431920 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000137609
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040111]
[ENSMUST00000156290]
|
| AlphaFold |
Q80XJ3 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000040111
|
| SMART Domains |
Protein: ENSMUSP00000136116
Gene: ENSMUSG00000033209
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
28 |
N/A |
INTRINSIC |
|
TPR
|
52 |
85 |
2.84e1 |
SMART |
|
TPR
|
86 |
119 |
5.03e-1 |
SMART |
|
TPR
|
120 |
153 |
2.11e-3 |
SMART |
|
TPR
|
268 |
301 |
8.51e0 |
SMART |
|
TPR
|
339 |
372 |
1.78e-1 |
SMART |
|
TPR
|
379 |
412 |
2.82e-4 |
SMART |
|
TPR
|
419 |
452 |
9.98e-5 |
SMART |
|
TPR
|
459 |
492 |
1.88e0 |
SMART |
|
TPR
|
499 |
532 |
1.11e1 |
SMART |
|
TPR
|
539 |
572 |
2.93e-2 |
SMART |
|
TPR
|
579 |
612 |
1.21e-3 |
SMART |
|
TPR
|
619 |
652 |
4.91e-4 |
SMART |
|
TPR
|
659 |
692 |
7.56e-5 |
SMART |
|
TPR
|
699 |
732 |
8.29e0 |
SMART |
|
TPR
|
739 |
772 |
1.63e0 |
SMART |
|
TPR
|
779 |
812 |
1.24e0 |
SMART |
|
TPR
|
819 |
852 |
7.98e-4 |
SMART |
|
TPR
|
859 |
892 |
8.74e0 |
SMART |
|
TPR
|
902 |
935 |
5.43e-6 |
SMART |
|
TPR
|
942 |
975 |
4.09e-1 |
SMART |
|
TPR
|
982 |
1015 |
9.98e-5 |
SMART |
|
TPR
|
1022 |
1055 |
7.12e-1 |
SMART |
|
TPR
|
1062 |
1095 |
5.69e0 |
SMART |
|
TPR
|
1102 |
1135 |
3.14e-2 |
SMART |
|
TPR
|
1142 |
1175 |
2.84e1 |
SMART |
|
low complexity region
|
1259 |
1277 |
N/A |
INTRINSIC |
|
Pfam:CHAT
|
1415 |
1738 |
7.3e-77 |
PFAM |
|
low complexity region
|
1972 |
1990 |
N/A |
INTRINSIC |
|
low complexity region
|
2014 |
2031 |
N/A |
INTRINSIC |
|
low complexity region
|
2033 |
2045 |
N/A |
INTRINSIC |
|
low complexity region
|
2155 |
2171 |
N/A |
INTRINSIC |
|
low complexity region
|
2283 |
2293 |
N/A |
INTRINSIC |
|
low complexity region
|
2327 |
2352 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000156290
|
| SMART Domains |
Protein: ENSMUSP00000137609
Gene: ENSMUSG00000033209
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
28 |
N/A |
INTRINSIC |
|
TPR
|
52 |
85 |
2.84e1 |
SMART |
|
TPR
|
86 |
119 |
5.03e-1 |
SMART |
|
TPR
|
120 |
153 |
2.11e-3 |
SMART |
|
TPR
|
268 |
301 |
8.51e0 |
SMART |
|
TPR
|
308 |
341 |
1.78e-1 |
SMART |
|
TPR
|
348 |
381 |
2.82e-4 |
SMART |
|
TPR
|
388 |
421 |
9.98e-5 |
SMART |
|
TPR
|
428 |
461 |
1.88e0 |
SMART |
|
TPR
|
468 |
501 |
1.11e1 |
SMART |
|
TPR
|
508 |
541 |
2.93e-2 |
SMART |
|
TPR
|
548 |
581 |
1.21e-3 |
SMART |
|
TPR
|
588 |
621 |
4.91e-4 |
SMART |
|
TPR
|
628 |
661 |
7.56e-5 |
SMART |
|
TPR
|
668 |
701 |
8.29e0 |
SMART |
|
TPR
|
708 |
741 |
1.63e0 |
SMART |
|
TPR
|
748 |
781 |
1.24e0 |
SMART |
|
TPR
|
788 |
821 |
7.98e-4 |
SMART |
|
TPR
|
828 |
861 |
8.74e0 |
SMART |
|
TPR
|
871 |
904 |
5.43e-6 |
SMART |
|
TPR
|
911 |
944 |
4.09e-1 |
SMART |
|
TPR
|
951 |
984 |
9.98e-5 |
SMART |
|
TPR
|
991 |
1024 |
7.12e-1 |
SMART |
|
TPR
|
1031 |
1064 |
5.69e0 |
SMART |
|
TPR
|
1071 |
1104 |
3.14e-2 |
SMART |
|
TPR
|
1111 |
1144 |
2.84e1 |
SMART |
|
low complexity region
|
1228 |
1246 |
N/A |
INTRINSIC |
|
Pfam:CHAT
|
1384 |
1707 |
1.1e-76 |
PFAM |
|
low complexity region
|
1941 |
1959 |
N/A |
INTRINSIC |
|
low complexity region
|
1983 |
2000 |
N/A |
INTRINSIC |
|
low complexity region
|
2002 |
2014 |
N/A |
INTRINSIC |
|
low complexity region
|
2124 |
2140 |
N/A |
INTRINSIC |
|
low complexity region
|
2252 |
2262 |
N/A |
INTRINSIC |
|
low complexity region
|
2296 |
2321 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.4%
- 20x: 93.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 112 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aarsd1 |
A |
C |
11: 101,301,057 (GRCm39) |
|
probably null |
Het |
| Abcc5 |
A |
G |
16: 20,195,259 (GRCm39) |
|
probably null |
Het |
| Abcc6 |
T |
C |
7: 45,669,558 (GRCm39) |
|
probably null |
Het |
| Adam15 |
C |
A |
3: 89,252,637 (GRCm39) |
M317I |
probably benign |
Het |
| Ago3 |
T |
C |
4: 126,240,530 (GRCm39) |
T111A |
probably damaging |
Het |
| Amz1 |
G |
T |
5: 140,738,216 (GRCm39) |
S492I |
probably benign |
Het |
| Arid1a |
T |
C |
4: 133,421,072 (GRCm39) |
N911S |
unknown |
Het |
| Ascl2 |
C |
A |
7: 142,521,900 (GRCm39) |
A115S |
probably damaging |
Het |
| Ash1l |
T |
C |
3: 88,891,835 (GRCm39) |
V1238A |
probably benign |
Het |
| Asxl2 |
G |
T |
12: 3,524,577 (GRCm39) |
V202F |
probably damaging |
Het |
| Atp10a |
A |
T |
7: 58,478,460 (GRCm39) |
Q1501L |
probably benign |
Het |
| Avpr1a |
A |
T |
10: 122,288,113 (GRCm39) |
I374L |
probably benign |
Het |
| Bmal2 |
A |
T |
6: 146,712,308 (GRCm39) |
E111V |
probably benign |
Het |
| Bmx |
T |
C |
X: 163,022,411 (GRCm39) |
H157R |
probably benign |
Het |
| Camk4 |
T |
A |
18: 33,291,869 (GRCm39) |
|
probably null |
Het |
| Ccdc103 |
G |
A |
11: 102,773,392 (GRCm39) |
D5N |
probably benign |
Het |
| Ccdc186 |
A |
T |
19: 56,781,793 (GRCm39) |
N70K |
probably damaging |
Het |
| Cebpz |
A |
T |
17: 79,242,336 (GRCm39) |
Y439* |
probably null |
Het |
| Cfap206 |
A |
C |
4: 34,722,714 (GRCm39) |
S122R |
probably benign |
Het |
| Cnst |
T |
C |
1: 179,450,356 (GRCm39) |
S607P |
probably damaging |
Het |
| Col8a2 |
C |
A |
4: 126,205,926 (GRCm39) |
D645E |
possibly damaging |
Het |
| Cpsf4l |
A |
T |
11: 113,594,204 (GRCm39) |
|
probably null |
Het |
| Crim1 |
C |
T |
17: 78,620,556 (GRCm39) |
T332I |
probably benign |
Het |
| Csmd1 |
A |
T |
8: 15,956,116 (GRCm39) |
Y3364N |
probably damaging |
Het |
| D5Ertd579e |
A |
T |
5: 36,771,402 (GRCm39) |
S998T |
probably benign |
Het |
| Dab2ip |
C |
G |
2: 35,608,827 (GRCm39) |
A587G |
probably damaging |
Het |
| Dach1 |
C |
T |
14: 98,138,829 (GRCm39) |
G486D |
probably damaging |
Het |
| Ddx24 |
T |
C |
12: 103,376,241 (GRCm39) |
I752V |
probably damaging |
Het |
| Dennd2b |
G |
A |
7: 109,124,533 (GRCm39) |
Q686* |
probably null |
Het |
| Dhx33 |
A |
G |
11: 70,879,933 (GRCm39) |
V359A |
probably benign |
Het |
| Dip2c |
A |
T |
13: 9,583,386 (GRCm39) |
T123S |
probably benign |
Het |
| Dync1h1 |
G |
A |
12: 110,629,063 (GRCm39) |
E4207K |
probably damaging |
Het |
| Eef1b2 |
G |
T |
1: 63,216,431 (GRCm39) |
D21Y |
probably damaging |
Het |
| Eif3b |
T |
C |
5: 140,418,692 (GRCm39) |
S462P |
probably damaging |
Het |
| Elmod2 |
G |
C |
8: 84,042,998 (GRCm39) |
R277G |
probably benign |
Het |
| Epg5 |
T |
A |
18: 78,002,247 (GRCm39) |
D555E |
probably benign |
Het |
| Ercc8 |
A |
T |
13: 108,312,100 (GRCm39) |
K172* |
probably null |
Het |
| Fat3 |
T |
C |
9: 15,909,411 (GRCm39) |
N2197S |
probably benign |
Het |
| Fbf1 |
A |
G |
11: 116,036,818 (GRCm39) |
V972A |
possibly damaging |
Het |
| Fcgbpl1 |
T |
C |
7: 27,843,773 (GRCm39) |
V887A |
possibly damaging |
Het |
| Fes |
T |
C |
7: 80,036,609 (GRCm39) |
R113G |
probably damaging |
Het |
| Fzd1 |
G |
T |
5: 4,807,481 (GRCm39) |
H34N |
probably benign |
Het |
| Galnt17 |
T |
A |
5: 131,140,676 (GRCm39) |
Y147F |
probably benign |
Het |
| Garre1 |
T |
A |
7: 33,957,461 (GRCm39) |
I59L |
probably benign |
Het |
| Gdf6 |
T |
C |
4: 9,859,971 (GRCm39) |
L351P |
probably damaging |
Het |
| Gm10277 |
TC |
T |
11: 77,676,828 (GRCm39) |
|
probably null |
Het |
| Gm2381 |
A |
T |
7: 42,469,352 (GRCm39) |
H257Q |
probably damaging |
Het |
| Hivep1 |
A |
T |
13: 42,309,122 (GRCm39) |
K454M |
probably benign |
Het |
| Hmmr |
T |
A |
11: 40,598,925 (GRCm39) |
E566D |
probably damaging |
Het |
| Hydin |
T |
G |
8: 111,314,404 (GRCm39) |
V4296G |
probably damaging |
Het |
| Il18r1 |
T |
A |
1: 40,514,074 (GRCm39) |
D93E |
probably damaging |
Het |
| Iqgap1 |
T |
C |
7: 80,393,576 (GRCm39) |
D667G |
probably benign |
Het |
| Lama3 |
T |
C |
18: 12,714,855 (GRCm39) |
I3278T |
probably benign |
Het |
| Lrp4 |
T |
A |
2: 91,328,753 (GRCm39) |
V1551D |
possibly damaging |
Het |
| Mdn1 |
CGGAGGAGGAGGAGGAG |
CGGAGGAGGAGGAG |
4: 32,760,839 (GRCm39) |
|
probably benign |
Het |
| Mga |
T |
A |
2: 119,757,075 (GRCm39) |
H1018Q |
possibly damaging |
Het |
| Ncoa7 |
A |
T |
10: 30,565,796 (GRCm39) |
M666K |
probably damaging |
Het |
| Ndnf |
T |
G |
6: 65,680,297 (GRCm39) |
V192G |
possibly damaging |
Het |
| Nr4a1 |
T |
A |
15: 101,172,108 (GRCm39) |
I594N |
probably damaging |
Het |
| Or13a27 |
T |
C |
7: 139,925,378 (GRCm39) |
I175V |
probably benign |
Het |
| Or2ag16 |
T |
C |
7: 106,352,202 (GRCm39) |
N131S |
probably benign |
Het |
| Or4k44 |
T |
A |
2: 111,368,359 (GRCm39) |
I92F |
probably damaging |
Het |
| Or51q1 |
G |
A |
7: 103,628,997 (GRCm39) |
W199* |
probably null |
Het |
| Or52z13 |
A |
G |
7: 103,246,550 (GRCm39) |
N9S |
probably benign |
Het |
| Paxbp1 |
T |
C |
16: 90,841,193 (GRCm39) |
|
probably benign |
Het |
| Pcdhb8 |
A |
G |
18: 37,489,015 (GRCm39) |
E231G |
possibly damaging |
Het |
| Pcsk5 |
A |
T |
19: 17,410,825 (GRCm39) |
Y1856N |
probably benign |
Het |
| Pde3a |
T |
C |
6: 141,195,965 (GRCm39) |
V217A |
probably benign |
Het |
| Phf11 |
A |
T |
14: 59,496,062 (GRCm39) |
S17R |
probably benign |
Het |
| Pira13 |
A |
T |
7: 3,825,918 (GRCm39) |
I317N |
probably benign |
Het |
| Pirb |
A |
T |
7: 3,717,587 (GRCm39) |
D674E |
probably benign |
Het |
| Pnisr |
T |
A |
4: 21,869,517 (GRCm39) |
M335K |
possibly damaging |
Het |
| Pnpla7 |
T |
A |
2: 24,887,300 (GRCm39) |
M48K |
possibly damaging |
Het |
| Pomgnt2 |
A |
T |
9: 121,811,257 (GRCm39) |
I508N |
possibly damaging |
Het |
| Ppp2r5e |
C |
G |
12: 75,516,341 (GRCm39) |
A239P |
probably damaging |
Het |
| Prkca |
A |
T |
11: 107,830,438 (GRCm39) |
D217E |
possibly damaging |
Het |
| Rac3 |
A |
C |
11: 120,614,163 (GRCm39) |
I142L |
probably benign |
Het |
| Ralgapb |
G |
T |
2: 158,286,595 (GRCm39) |
A347S |
probably damaging |
Het |
| Rbm43 |
G |
C |
2: 51,815,446 (GRCm39) |
S258R |
possibly damaging |
Het |
| Rnf182 |
T |
A |
13: 43,821,899 (GRCm39) |
V150E |
probably benign |
Het |
| Rsph10b |
T |
C |
5: 143,922,309 (GRCm39) |
F409L |
probably benign |
Het |
| Ryr2 |
A |
T |
13: 11,715,235 (GRCm39) |
L2778M |
probably damaging |
Het |
| Scn1a |
T |
C |
2: 66,161,696 (GRCm39) |
N284S |
possibly damaging |
Het |
| Scyl2 |
A |
T |
10: 89,476,767 (GRCm39) |
M786K |
probably benign |
Het |
| Sema4g |
C |
A |
19: 44,986,061 (GRCm39) |
R301S |
probably damaging |
Het |
| Senp6 |
A |
T |
9: 80,021,056 (GRCm39) |
E245D |
possibly damaging |
Het |
| Setx |
T |
C |
2: 29,053,021 (GRCm39) |
V2095A |
possibly damaging |
Het |
| Slc13a2 |
A |
T |
11: 78,290,968 (GRCm39) |
M412K |
possibly damaging |
Het |
| Slc25a4 |
T |
C |
8: 46,662,437 (GRCm39) |
N74D |
probably damaging |
Het |
| Slc28a1 |
T |
A |
7: 80,791,783 (GRCm39) |
F316L |
probably damaging |
Het |
| Slfn8 |
G |
A |
11: 82,894,447 (GRCm39) |
Q731* |
probably null |
Het |
| Slitrk4 |
A |
G |
X: 63,316,229 (GRCm39) |
I146T |
probably damaging |
Het |
| Smg1 |
A |
G |
7: 117,753,422 (GRCm39) |
|
probably benign |
Het |
| Smg8 |
G |
T |
11: 86,971,439 (GRCm39) |
Y777* |
probably null |
Het |
| Smyd1 |
T |
A |
6: 71,216,563 (GRCm39) |
K61N |
probably benign |
Het |
| Sod2 |
T |
C |
17: 13,234,056 (GRCm39) |
*223R |
probably null |
Het |
| Sp6 |
G |
T |
11: 96,912,334 (GRCm39) |
A16S |
probably benign |
Het |
| Spata31d1a |
A |
C |
13: 59,850,509 (GRCm39) |
Y540D |
probably damaging |
Het |
| Spatc1l |
A |
G |
10: 76,399,751 (GRCm39) |
D91G |
probably damaging |
Het |
| Spg7 |
A |
G |
8: 123,807,480 (GRCm39) |
T419A |
probably benign |
Het |
| St8sia4 |
A |
G |
1: 95,555,298 (GRCm39) |
I244T |
probably damaging |
Het |
| Tbl2 |
C |
T |
5: 135,181,845 (GRCm39) |
R27W |
probably damaging |
Het |
| Tmed4 |
G |
A |
11: 6,224,694 (GRCm39) |
P47L |
probably damaging |
Het |
| Tmsb10b |
T |
C |
7: 24,561,731 (GRCm39) |
I10T |
possibly damaging |
Het |
| Tmtc1 |
T |
C |
6: 148,345,546 (GRCm39) |
D51G |
possibly damaging |
Het |
| Unc13d |
A |
G |
11: 115,961,121 (GRCm39) |
F412S |
probably damaging |
Het |
| Unc45b |
A |
C |
11: 82,816,913 (GRCm39) |
K451T |
probably damaging |
Het |
| Vmn2r16 |
A |
G |
5: 109,511,853 (GRCm39) |
M687V |
probably benign |
Het |
| Vmn2r68 |
T |
A |
7: 84,883,260 (GRCm39) |
H164L |
probably benign |
Het |
| Vps51 |
A |
G |
19: 6,119,499 (GRCm39) |
V625A |
probably benign |
Het |
| Wapl |
T |
A |
14: 34,413,869 (GRCm39) |
W244R |
probably damaging |
Het |
| Wdr75 |
C |
T |
1: 45,862,563 (GRCm39) |
T794I |
probably benign |
Het |
|
| Other mutations in Ttc28 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Ttc28
|
APN |
5 |
111,373,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00963:Ttc28
|
APN |
5 |
111,434,255 (GRCm39) |
nonsense |
probably null |
|
|
IGL00969:Ttc28
|
APN |
5 |
111,373,606 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01366:Ttc28
|
APN |
5 |
111,233,037 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01528:Ttc28
|
APN |
5 |
111,249,826 (GRCm39) |
splice site |
probably benign |
|
|
IGL01558:Ttc28
|
APN |
5 |
111,431,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01973:Ttc28
|
APN |
5 |
111,372,101 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02040:Ttc28
|
APN |
5 |
111,040,802 (GRCm39) |
nonsense |
probably null |
|
|
IGL02432:Ttc28
|
APN |
5 |
111,371,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02531:Ttc28
|
APN |
5 |
111,373,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02819:Ttc28
|
APN |
5 |
111,414,449 (GRCm39) |
missense |
probably benign |
|
|
IGL02830:Ttc28
|
APN |
5 |
111,434,105 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02893:Ttc28
|
APN |
5 |
111,433,251 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03387:Ttc28
|
APN |
5 |
111,381,208 (GRCm39) |
missense |
probably benign |
0.07 |
|
PIT4131001:Ttc28
|
UTSW |
5 |
111,040,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0142:Ttc28
|
UTSW |
5 |
111,425,323 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0166:Ttc28
|
UTSW |
5 |
111,373,500 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0328:Ttc28
|
UTSW |
5 |
111,431,933 (GRCm39) |
splice site |
probably benign |
|
|
R0582:Ttc28
|
UTSW |
5 |
111,331,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0744:Ttc28
|
UTSW |
5 |
111,378,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0811:Ttc28
|
UTSW |
5 |
111,383,366 (GRCm39) |
missense |
probably benign |
0.24 |
|
R0812:Ttc28
|
UTSW |
5 |
111,383,366 (GRCm39) |
missense |
probably benign |
0.24 |
|
R0828:Ttc28
|
UTSW |
5 |
111,371,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0833:Ttc28
|
UTSW |
5 |
111,378,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1013:Ttc28
|
UTSW |
5 |
111,424,831 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1168:Ttc28
|
UTSW |
5 |
111,378,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1194:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1196:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1205:Ttc28
|
UTSW |
5 |
111,433,635 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1386:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Ttc28
|
UTSW |
5 |
111,433,254 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1467:Ttc28
|
UTSW |
5 |
111,433,254 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1537:Ttc28
|
UTSW |
5 |
111,433,184 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1539:Ttc28
|
UTSW |
5 |
111,248,677 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1558:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1560:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1561:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1566:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1768:Ttc28
|
UTSW |
5 |
111,425,034 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1775:Ttc28
|
UTSW |
5 |
111,424,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1911:Ttc28
|
UTSW |
5 |
111,428,616 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1970:Ttc28
|
UTSW |
5 |
111,383,501 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1990:Ttc28
|
UTSW |
5 |
111,424,188 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1992:Ttc28
|
UTSW |
5 |
111,424,188 (GRCm39) |
missense |
probably benign |
0.37 |
|
R2066:Ttc28
|
UTSW |
5 |
111,373,799 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2112:Ttc28
|
UTSW |
5 |
111,424,139 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2158:Ttc28
|
UTSW |
5 |
111,325,483 (GRCm39) |
intron |
probably benign |
|
|
R2192:Ttc28
|
UTSW |
5 |
111,371,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2267:Ttc28
|
UTSW |
5 |
111,373,869 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R2384:Ttc28
|
UTSW |
5 |
111,424,074 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2989:Ttc28
|
UTSW |
5 |
111,371,881 (GRCm39) |
missense |
probably benign |
0.29 |
|
R3881:Ttc28
|
UTSW |
5 |
111,331,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3919:Ttc28
|
UTSW |
5 |
111,433,245 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4455:Ttc28
|
UTSW |
5 |
111,371,924 (GRCm39) |
frame shift |
probably null |
|
|
R4456:Ttc28
|
UTSW |
5 |
111,371,924 (GRCm39) |
frame shift |
probably null |
|
|
R4522:Ttc28
|
UTSW |
5 |
111,428,038 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4548:Ttc28
|
UTSW |
5 |
111,419,090 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4591:Ttc28
|
UTSW |
5 |
111,371,147 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4633:Ttc28
|
UTSW |
5 |
111,371,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4700:Ttc28
|
UTSW |
5 |
111,424,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4714:Ttc28
|
UTSW |
5 |
111,433,095 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4790:Ttc28
|
UTSW |
5 |
111,372,083 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4803:Ttc28
|
UTSW |
5 |
111,425,329 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4840:Ttc28
|
UTSW |
5 |
111,433,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4969:Ttc28
|
UTSW |
5 |
111,424,121 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5019:Ttc28
|
UTSW |
5 |
111,249,930 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5130:Ttc28
|
UTSW |
5 |
111,040,722 (GRCm39) |
missense |
probably benign |
|
|
R5150:Ttc28
|
UTSW |
5 |
111,373,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5214:Ttc28
|
UTSW |
5 |
111,325,489 (GRCm39) |
intron |
probably benign |
|
|
R5254:Ttc28
|
UTSW |
5 |
111,419,104 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5518:Ttc28
|
UTSW |
5 |
111,373,794 (GRCm39) |
missense |
probably benign |
0.17 |
|
R5851:Ttc28
|
UTSW |
5 |
111,383,335 (GRCm39) |
splice site |
probably benign |
|
|
R5931:Ttc28
|
UTSW |
5 |
111,232,975 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6011:Ttc28
|
UTSW |
5 |
111,434,309 (GRCm39) |
missense |
probably benign |
|
|
R6176:Ttc28
|
UTSW |
5 |
111,371,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6221:Ttc28
|
UTSW |
5 |
111,419,114 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6398:Ttc28
|
UTSW |
5 |
111,424,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6717:Ttc28
|
UTSW |
5 |
111,433,302 (GRCm39) |
missense |
probably benign |
|
|
R6770:Ttc28
|
UTSW |
5 |
111,434,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6901:Ttc28
|
UTSW |
5 |
111,424,891 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7038:Ttc28
|
UTSW |
5 |
111,414,445 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7073:Ttc28
|
UTSW |
5 |
111,371,282 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R7101:Ttc28
|
UTSW |
5 |
111,232,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7135:Ttc28
|
UTSW |
5 |
111,427,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7350:Ttc28
|
UTSW |
5 |
111,373,903 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7454:Ttc28
|
UTSW |
5 |
111,433,350 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7461:Ttc28
|
UTSW |
5 |
111,371,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7596:Ttc28
|
UTSW |
5 |
111,427,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7613:Ttc28
|
UTSW |
5 |
111,371,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7625:Ttc28
|
UTSW |
5 |
111,433,085 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7648:Ttc28
|
UTSW |
5 |
111,331,258 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7735:Ttc28
|
UTSW |
5 |
111,414,544 (GRCm39) |
splice site |
probably null |
|
|
R8030:Ttc28
|
UTSW |
5 |
111,433,922 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8205:Ttc28
|
UTSW |
5 |
111,373,596 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8246:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8247:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8269:Ttc28
|
UTSW |
5 |
111,425,325 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8292:Ttc28
|
UTSW |
5 |
111,371,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8346:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8356:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8423:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8424:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8426:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8441:Ttc28
|
UTSW |
5 |
111,325,507 (GRCm39) |
nonsense |
probably null |
|
|
R8494:Ttc28
|
UTSW |
5 |
111,383,506 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8508:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8510:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8729:Ttc28
|
UTSW |
5 |
111,383,509 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8845:Ttc28
|
UTSW |
5 |
111,372,041 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9003:Ttc28
|
UTSW |
5 |
111,424,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9185:Ttc28
|
UTSW |
5 |
111,371,342 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9187:Ttc28
|
UTSW |
5 |
111,249,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9245:Ttc28
|
UTSW |
5 |
111,325,525 (GRCm39) |
missense |
unknown |
|
|
R9251:Ttc28
|
UTSW |
5 |
111,040,698 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R9372:Ttc28
|
UTSW |
5 |
111,331,073 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9466:Ttc28
|
UTSW |
5 |
111,330,895 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9563:Ttc28
|
UTSW |
5 |
111,371,092 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9606:Ttc28
|
UTSW |
5 |
111,433,140 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9691:Ttc28
|
UTSW |
5 |
111,431,879 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9709:Ttc28
|
UTSW |
5 |
111,433,637 (GRCm39) |
missense |
probably damaging |
0.97 |
|
V8831:Ttc28
|
UTSW |
5 |
111,248,578 (GRCm39) |
missense |
probably benign |
0.11 |
|
Z1088:Ttc28
|
UTSW |
5 |
111,434,181 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Ttc28
|
UTSW |
5 |
111,414,432 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
Z1177:Ttc28
|
UTSW |
5 |
111,433,605 (GRCm39) |
missense |
probably benign |
0.10 |
|
Z1177:Ttc28
|
UTSW |
5 |
111,426,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGAGAAAGGCAGCCTGATC -3'
(R):5'- TGCTGTTCCTGAGGCCTTAG -3'
Sequencing Primer
(F):5'- AAAGGCAGCCTGATCTCCTGATG -3'
(R):5'- CCTTAGTTCCTTATGCTGGAGTAAGC -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation