Incidental Mutation 'R1909:Olfr618'
ID 210160
Institutional Source Beutler Lab
Gene Symbol Olfr618
Ensembl Gene ENSMUSG00000073945
Gene Name olfactory receptor 618
Synonyms MOR31-9, GA_x6K02T2PBJ9-6320148-6321104
MMRRC Submission 039928-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R1909 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 103590103-103600448 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 103597343 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 9 (N9S)
Ref Sequence ENSEMBL: ENSMUSP00000151147 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098197] [ENSMUST00000214883] [ENSMUST00000215732]
AlphaFold K7N6B3
Predicted Effect probably benign
Transcript: ENSMUST00000098197
AA Change: N9S

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000095799
Gene: ENSMUSG00000073945
AA Change: N9S

Pfam:7tm_4 34 314 3.1e-109 PFAM
Pfam:7TM_GPCR_Srsx 38 311 6.3e-12 PFAM
Pfam:7tm_1 44 296 8.2e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214883
AA Change: N9S

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
Predicted Effect probably benign
Transcript: ENSMUST00000215732
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 95.4%
  • 20x: 93.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 112 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931406P16Rik T A 7: 34,258,036 (GRCm38) I59L probably benign Het
9530053A07Rik T C 7: 28,144,348 (GRCm38) V887A possibly damaging Het
Aarsd1 A C 11: 101,410,231 (GRCm38) probably null Het
Abcc5 A G 16: 20,376,509 (GRCm38) probably null Het
Abcc6 T C 7: 46,020,134 (GRCm38) probably null Het
Adam15 C A 3: 89,345,330 (GRCm38) M317I probably benign Het
Ago3 T C 4: 126,346,737 (GRCm38) T111A probably damaging Het
Amz1 G T 5: 140,752,461 (GRCm38) S492I probably benign Het
Arid1a T C 4: 133,693,761 (GRCm38) N911S unknown Het
Arntl2 A T 6: 146,810,810 (GRCm38) E111V probably benign Het
Ascl2 C A 7: 142,968,163 (GRCm38) A115S probably damaging Het
Ash1l T C 3: 88,984,528 (GRCm38) V1238A probably benign Het
Asxl2 G T 12: 3,474,577 (GRCm38) V202F probably damaging Het
Atp10a A T 7: 58,828,712 (GRCm38) Q1501L probably benign Het
Avpr1a A T 10: 122,452,208 (GRCm38) I374L probably benign Het
Bmx T C X: 164,239,415 (GRCm38) H157R probably benign Het
Camk4 T A 18: 33,158,816 (GRCm38) probably null Het
Ccdc103 G A 11: 102,882,566 (GRCm38) D5N probably benign Het
Ccdc186 A T 19: 56,793,361 (GRCm38) N70K probably damaging Het
Cebpz A T 17: 78,934,907 (GRCm38) Y439* probably null Het
Cfap206 A C 4: 34,722,714 (GRCm38) S122R probably benign Het
Cnst T C 1: 179,622,791 (GRCm38) S607P probably damaging Het
Col8a2 C A 4: 126,312,133 (GRCm38) D645E possibly damaging Het
Cpsf4l A T 11: 113,703,378 (GRCm38) probably null Het
Crim1 C T 17: 78,313,127 (GRCm38) T332I probably benign Het
Csmd1 A T 8: 15,906,116 (GRCm38) Y3364N probably damaging Het
D5Ertd579e A T 5: 36,614,058 (GRCm38) S998T probably benign Het
Dab2ip C G 2: 35,718,815 (GRCm38) A587G probably damaging Het
Dach1 C T 14: 97,901,393 (GRCm38) G486D probably damaging Het
Ddx24 T C 12: 103,409,982 (GRCm38) I752V probably damaging Het
Dhx33 A G 11: 70,989,107 (GRCm38) V359A probably benign Het
Dip2c A T 13: 9,533,350 (GRCm38) T123S probably benign Het
Dync1h1 G A 12: 110,662,629 (GRCm38) E4207K probably damaging Het
Eef1b2 G T 1: 63,177,272 (GRCm38) D21Y probably damaging Het
Eif3b T C 5: 140,432,937 (GRCm38) S462P probably damaging Het
Elmod2 G C 8: 83,316,369 (GRCm38) R277G probably benign Het
Epg5 T A 18: 77,959,032 (GRCm38) D555E probably benign Het
Ercc8 A T 13: 108,175,566 (GRCm38) K172* probably null Het
Fat3 T C 9: 15,998,115 (GRCm38) N2197S probably benign Het
Fbf1 A G 11: 116,145,992 (GRCm38) V972A possibly damaging Het
Fes T C 7: 80,386,861 (GRCm38) R113G probably damaging Het
Fzd1 G T 5: 4,757,481 (GRCm38) H34N probably benign Het
Galnt17 T A 5: 131,111,838 (GRCm38) Y147F probably benign Het
Gdf6 T C 4: 9,859,971 (GRCm38) L351P probably damaging Het
Gm10277 TC T 11: 77,786,002 (GRCm38) probably null Het
Gm15448 A T 7: 3,822,919 (GRCm38) I317N probably benign Het
Gm2381 A T 7: 42,819,928 (GRCm38) H257Q probably damaging Het
Gm6904 A T 14: 59,258,613 (GRCm38) S17R probably benign Het
Gm9844 T C 7: 24,862,306 (GRCm38) I10T possibly damaging Het
Hivep1 A T 13: 42,155,646 (GRCm38) K454M probably benign Het
Hmmr T A 11: 40,708,098 (GRCm38) E566D probably damaging Het
Hydin T G 8: 110,587,772 (GRCm38) V4296G probably damaging Het
Il18r1 T A 1: 40,474,914 (GRCm38) D93E probably damaging Het
Iqgap1 T C 7: 80,743,828 (GRCm38) D667G probably benign Het
Lama3 T C 18: 12,581,798 (GRCm38) I3278T probably benign Het
Lrp4 T A 2: 91,498,408 (GRCm38) V1551D possibly damaging Het
Mdn1 CGGAGGAGGAGGAGGAG CGGAGGAGGAGGAG 4: 32,760,839 (GRCm38) probably benign Het
Mga T A 2: 119,926,594 (GRCm38) H1018Q possibly damaging Het
Ncoa7 A T 10: 30,689,800 (GRCm38) M666K probably damaging Het
Ndnf T G 6: 65,703,313 (GRCm38) V192G possibly damaging Het
Nr4a1 T A 15: 101,274,227 (GRCm38) I594N probably damaging Het
Olfr1294 T A 2: 111,538,014 (GRCm38) I92F probably damaging Het
Olfr60 T C 7: 140,345,465 (GRCm38) I175V probably benign Het
Olfr635 G A 7: 103,979,790 (GRCm38) W199* probably null Het
Olfr698 T C 7: 106,752,995 (GRCm38) N131S probably benign Het
Paxbp1 T C 16: 91,044,305 (GRCm38) probably benign Het
Pcdhb8 A G 18: 37,355,962 (GRCm38) E231G possibly damaging Het
Pcsk5 A T 19: 17,433,461 (GRCm38) Y1856N probably benign Het
Pde3a T C 6: 141,250,239 (GRCm38) V217A probably benign Het
Pirb A T 7: 3,714,588 (GRCm38) D674E probably benign Het
Pnisr T A 4: 21,869,517 (GRCm38) M335K possibly damaging Het
Pnpla7 T A 2: 24,997,288 (GRCm38) M48K possibly damaging Het
Pomgnt2 A T 9: 121,982,191 (GRCm38) I508N possibly damaging Het
Ppp2r5e C G 12: 75,469,567 (GRCm38) A239P probably damaging Het
Prkca A T 11: 107,939,612 (GRCm38) D217E possibly damaging Het
Rac3 A C 11: 120,723,337 (GRCm38) I142L probably benign Het
Ralgapb G T 2: 158,444,675 (GRCm38) A347S probably damaging Het
Rbm43 G C 2: 51,925,434 (GRCm38) S258R possibly damaging Het
Rnf182 T A 13: 43,668,423 (GRCm38) V150E probably benign Het
Rsph10b T C 5: 143,985,491 (GRCm38) F409L probably benign Het
Ryr2 A T 13: 11,700,349 (GRCm38) L2778M probably damaging Het
Scn1a T C 2: 66,331,352 (GRCm38) N284S possibly damaging Het
Scyl2 A T 10: 89,640,905 (GRCm38) M786K probably benign Het
Sema4g C A 19: 44,997,622 (GRCm38) R301S probably damaging Het
Senp6 A T 9: 80,113,774 (GRCm38) E245D possibly damaging Het
Setx T C 2: 29,163,009 (GRCm38) V2095A possibly damaging Het
Slc13a2 A T 11: 78,400,142 (GRCm38) M412K possibly damaging Het
Slc25a4 T C 8: 46,209,400 (GRCm38) N74D probably damaging Het
Slc28a1 T A 7: 81,142,035 (GRCm38) F316L probably damaging Het
Slfn8 G A 11: 83,003,621 (GRCm38) Q731* probably null Het
Slitrk4 A G X: 64,272,623 (GRCm38) I146T probably damaging Het
Smg1 A G 7: 118,154,199 (GRCm38) probably benign Het
Smg8 G T 11: 87,080,613 (GRCm38) Y777* probably null Het
Smyd1 T A 6: 71,239,579 (GRCm38) K61N probably benign Het
Sod2 T C 17: 13,015,169 (GRCm38) *223R probably null Het
Sp6 G T 11: 97,021,508 (GRCm38) A16S probably benign Het
Spata31d1a A C 13: 59,702,695 (GRCm38) Y540D probably damaging Het
Spatc1l A G 10: 76,563,917 (GRCm38) D91G probably damaging Het
Spg7 A G 8: 123,080,741 (GRCm38) T419A probably benign Het
St5 G A 7: 109,525,326 (GRCm38) Q686* probably null Het
St8sia4 A G 1: 95,627,573 (GRCm38) I244T probably damaging Het
Tbl2 C T 5: 135,152,991 (GRCm38) R27W probably damaging Het
Tmed4 G A 11: 6,274,694 (GRCm38) P47L probably damaging Het
Tmtc1 T C 6: 148,444,048 (GRCm38) D51G possibly damaging Het
Ttc28 T C 5: 111,284,054 (GRCm38) probably null Het
Unc13d A G 11: 116,070,295 (GRCm38) F412S probably damaging Het
Unc45b A C 11: 82,926,087 (GRCm38) K451T probably damaging Het
Vmn2r16 A G 5: 109,363,987 (GRCm38) M687V probably benign Het
Vmn2r68 T A 7: 85,234,052 (GRCm38) H164L probably benign Het
Vps51 A G 19: 6,069,469 (GRCm38) V625A probably benign Het
Wapl T A 14: 34,691,912 (GRCm38) W244R probably damaging Het
Wdr75 C T 1: 45,823,403 (GRCm38) T794I probably benign Het
Other mutations in Olfr618
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00926:Olfr618 APN 7 103,598,162 (GRCm38) missense possibly damaging 0.65
IGL00963:Olfr618 APN 7 103,597,637 (GRCm38) splice site probably null
IGL01772:Olfr618 APN 7 103,597,913 (GRCm38) missense probably benign 0.12
IGL02014:Olfr618 APN 7 103,597,730 (GRCm38) missense probably damaging 1.00
IGL03409:Olfr618 APN 7 103,597,367 (GRCm38) missense possibly damaging 0.51
R0087:Olfr618 UTSW 7 103,597,721 (GRCm38) missense probably benign 0.44
R0831:Olfr618 UTSW 7 103,598,131 (GRCm38) missense probably benign 0.02
R1779:Olfr618 UTSW 7 103,597,900 (GRCm38) missense probably damaging 1.00
R5903:Olfr618 UTSW 7 103,597,921 (GRCm38) nonsense probably null
R5952:Olfr618 UTSW 7 103,597,967 (GRCm38) missense probably damaging 1.00
R6328:Olfr618 UTSW 7 103,597,866 (GRCm38) missense probably damaging 1.00
R7264:Olfr618 UTSW 7 103,597,748 (GRCm38) missense probably damaging 0.97
R7573:Olfr618 UTSW 7 103,597,528 (GRCm38) missense probably benign 0.08
R7870:Olfr618 UTSW 7 103,598,266 (GRCm38) missense probably damaging 1.00
R8394:Olfr618 UTSW 7 103,598,197 (GRCm38) missense probably damaging 1.00
R8833:Olfr618 UTSW 7 103,598,237 (GRCm38) missense possibly damaging 0.75
R9563:Olfr618 UTSW 7 103,598,018 (GRCm38) missense probably benign
R9601:Olfr618 UTSW 7 103,597,391 (GRCm38) missense probably benign 0.20
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2014-06-30