Mutagenetix > Incidental Mutation

Incidental Mutation 'R1909:Smg1'

210164

Institutional Source

Beutler Lab

Gene Symbol

Smg1

Ensembl Gene

ENSMUSG00000030655

Gene Name

SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)

Synonyms

2610207I05Rik, 5430435M13Rik, C130002K18Rik

MMRRC Submission

039928-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1909 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

118131308-118243670 bp(-) (GRCm38)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

A to G at 118154199 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032891]

AlphaFold

no structure available at present

Predicted Effect

unknown
Transcript: ENSMUST00000032891
AA Change: V2675A

SMART Domains

Protein: ENSMUSP00000032891
Gene: ENSMUSG00000030655
AA Change: V2675A

Domain	Start	End	E-Value	Type
low complexity region	42	55	N/A	INTRINSIC
SCOP:d1gw5a_	147	621	7e-7	SMART
Pfam:SMG1	629	1240	9.8e-249	PFAM
low complexity region	1540	1551	N/A	INTRINSIC
SCOP:d1gw5a_	1680	1942	8e-3	SMART
low complexity region	2125	2141	N/A	INTRINSIC
PI3Kc	2149	2493	7.93e-50	SMART
low complexity region	2759	2770	N/A	INTRINSIC
low complexity region	3425	3442	N/A	INTRINSIC
FATC	3626	3658	8.66e-12	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000083940

Predicted Effect

probably benign
Transcript: ENSMUST00000179331

SMART Domains

Protein: ENSMUSP00000137592
Gene: ENSMUSG00000030655

Domain	Start	End	E-Value	Type
low complexity region	18	31	N/A	INTRINSIC
SCOP:d1gw5a_	71	545	1e-6	SMART
low complexity region	602	612	N/A	INTRINSIC
low complexity region	631	646	N/A	INTRINSIC
low complexity region	698	718	N/A	INTRINSIC
low complexity region	898	915	N/A	INTRINSIC
low complexity region	1135	1147	N/A	INTRINSIC
low complexity region	1464	1475	N/A	INTRINSIC
low complexity region	2049	2065	N/A	INTRINSIC
PI3Kc	2073	2417	7.93e-50	SMART
low complexity region	2683	2694	N/A	INTRINSIC
low complexity region	3349	3366	N/A	INTRINSIC
FATC	3550	3582	8.66e-12	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208025

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 95.4%
20x: 93.1%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit early embryonic lethality. Mice heteroygous for a gene trap allele exhibit abnormal tooth development, chronic inflammation, increased body weight, increased incidence of tumor formation and premature death. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 112 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931406P16Rik	T	A	7: 34,258,036 (GRCm38)	I59L	probably benign	Het
9530053A07Rik	T	C	7: 28,144,348 (GRCm38)	V887A	possibly damaging	Het
Aarsd1	A	C	11: 101,410,231 (GRCm38)		probably null	Het
Abcc5	A	G	16: 20,376,509 (GRCm38)		probably null	Het
Abcc6	T	C	7: 46,020,134 (GRCm38)		probably null	Het
Adam15	C	A	3: 89,345,330 (GRCm38)	M317I	probably benign	Het
Ago3	T	C	4: 126,346,737 (GRCm38)	T111A	probably damaging	Het
Amz1	G	T	5: 140,752,461 (GRCm38)	S492I	probably benign	Het
Arid1a	T	C	4: 133,693,761 (GRCm38)	N911S	unknown	Het
Arntl2	A	T	6: 146,810,810 (GRCm38)	E111V	probably benign	Het
Ascl2	C	A	7: 142,968,163 (GRCm38)	A115S	probably damaging	Het
Ash1l	T	C	3: 88,984,528 (GRCm38)	V1238A	probably benign	Het
Asxl2	G	T	12: 3,474,577 (GRCm38)	V202F	probably damaging	Het
Atp10a	A	T	7: 58,828,712 (GRCm38)	Q1501L	probably benign	Het
Avpr1a	A	T	10: 122,452,208 (GRCm38)	I374L	probably benign	Het
Bmx	T	C	X: 164,239,415 (GRCm38)	H157R	probably benign	Het
Camk4	T	A	18: 33,158,816 (GRCm38)		probably null	Het
Ccdc103	G	A	11: 102,882,566 (GRCm38)	D5N	probably benign	Het
Ccdc186	A	T	19: 56,793,361 (GRCm38)	N70K	probably damaging	Het
Cebpz	A	T	17: 78,934,907 (GRCm38)	Y439*	probably null	Het
Cfap206	A	C	4: 34,722,714 (GRCm38)	S122R	probably benign	Het
Cnst	T	C	1: 179,622,791 (GRCm38)	S607P	probably damaging	Het
Col8a2	C	A	4: 126,312,133 (GRCm38)	D645E	possibly damaging	Het
Cpsf4l	A	T	11: 113,703,378 (GRCm38)		probably null	Het
Crim1	C	T	17: 78,313,127 (GRCm38)	T332I	probably benign	Het
Csmd1	A	T	8: 15,906,116 (GRCm38)	Y3364N	probably damaging	Het
D5Ertd579e	A	T	5: 36,614,058 (GRCm38)	S998T	probably benign	Het
Dab2ip	C	G	2: 35,718,815 (GRCm38)	A587G	probably damaging	Het
Dach1	C	T	14: 97,901,393 (GRCm38)	G486D	probably damaging	Het
Ddx24	T	C	12: 103,409,982 (GRCm38)	I752V	probably damaging	Het
Dhx33	A	G	11: 70,989,107 (GRCm38)	V359A	probably benign	Het
Dip2c	A	T	13: 9,533,350 (GRCm38)	T123S	probably benign	Het
Dync1h1	G	A	12: 110,662,629 (GRCm38)	E4207K	probably damaging	Het
Eef1b2	G	T	1: 63,177,272 (GRCm38)	D21Y	probably damaging	Het
Eif3b	T	C	5: 140,432,937 (GRCm38)	S462P	probably damaging	Het
Elmod2	G	C	8: 83,316,369 (GRCm38)	R277G	probably benign	Het
Epg5	T	A	18: 77,959,032 (GRCm38)	D555E	probably benign	Het
Ercc8	A	T	13: 108,175,566 (GRCm38)	K172*	probably null	Het
Fat3	T	C	9: 15,998,115 (GRCm38)	N2197S	probably benign	Het
Fbf1	A	G	11: 116,145,992 (GRCm38)	V972A	possibly damaging	Het
Fes	T	C	7: 80,386,861 (GRCm38)	R113G	probably damaging	Het
Fzd1	G	T	5: 4,757,481 (GRCm38)	H34N	probably benign	Het
Galnt17	T	A	5: 131,111,838 (GRCm38)	Y147F	probably benign	Het
Gdf6	T	C	4: 9,859,971 (GRCm38)	L351P	probably damaging	Het
Gm10277	TC	T	11: 77,786,002 (GRCm38)		probably null	Het
Gm15448	A	T	7: 3,822,919 (GRCm38)	I317N	probably benign	Het
Gm2381	A	T	7: 42,819,928 (GRCm38)	H257Q	probably damaging	Het
Gm6904	A	T	14: 59,258,613 (GRCm38)	S17R	probably benign	Het
Gm9844	T	C	7: 24,862,306 (GRCm38)	I10T	possibly damaging	Het
Hivep1	A	T	13: 42,155,646 (GRCm38)	K454M	probably benign	Het
Hmmr	T	A	11: 40,708,098 (GRCm38)	E566D	probably damaging	Het
Hydin	T	G	8: 110,587,772 (GRCm38)	V4296G	probably damaging	Het
Il18r1	T	A	1: 40,474,914 (GRCm38)	D93E	probably damaging	Het
Iqgap1	T	C	7: 80,743,828 (GRCm38)	D667G	probably benign	Het
Lama3	T	C	18: 12,581,798 (GRCm38)	I3278T	probably benign	Het
Lrp4	T	A	2: 91,498,408 (GRCm38)	V1551D	possibly damaging	Het
Mdn1	CGGAGGAGGAGGAGGAG	CGGAGGAGGAGGAG	4: 32,760,839 (GRCm38)		probably benign	Het
Mga	T	A	2: 119,926,594 (GRCm38)	H1018Q	possibly damaging	Het
Ncoa7	A	T	10: 30,689,800 (GRCm38)	M666K	probably damaging	Het
Ndnf	T	G	6: 65,703,313 (GRCm38)	V192G	possibly damaging	Het
Nr4a1	T	A	15: 101,274,227 (GRCm38)	I594N	probably damaging	Het
Olfr1294	T	A	2: 111,538,014 (GRCm38)	I92F	probably damaging	Het
Olfr60	T	C	7: 140,345,465 (GRCm38)	I175V	probably benign	Het
Olfr618	A	G	7: 103,597,343 (GRCm38)	N9S	probably benign	Het
Olfr635	G	A	7: 103,979,790 (GRCm38)	W199*	probably null	Het
Olfr698	T	C	7: 106,752,995 (GRCm38)	N131S	probably benign	Het
Paxbp1	T	C	16: 91,044,305 (GRCm38)		probably benign	Het
Pcdhb8	A	G	18: 37,355,962 (GRCm38)	E231G	possibly damaging	Het
Pcsk5	A	T	19: 17,433,461 (GRCm38)	Y1856N	probably benign	Het
Pde3a	T	C	6: 141,250,239 (GRCm38)	V217A	probably benign	Het
Pirb	A	T	7: 3,714,588 (GRCm38)	D674E	probably benign	Het
Pnisr	T	A	4: 21,869,517 (GRCm38)	M335K	possibly damaging	Het
Pnpla7	T	A	2: 24,997,288 (GRCm38)	M48K	possibly damaging	Het
Pomgnt2	A	T	9: 121,982,191 (GRCm38)	I508N	possibly damaging	Het
Ppp2r5e	C	G	12: 75,469,567 (GRCm38)	A239P	probably damaging	Het
Prkca	A	T	11: 107,939,612 (GRCm38)	D217E	possibly damaging	Het
Rac3	A	C	11: 120,723,337 (GRCm38)	I142L	probably benign	Het
Ralgapb	G	T	2: 158,444,675 (GRCm38)	A347S	probably damaging	Het
Rbm43	G	C	2: 51,925,434 (GRCm38)	S258R	possibly damaging	Het
Rnf182	T	A	13: 43,668,423 (GRCm38)	V150E	probably benign	Het
Rsph10b	T	C	5: 143,985,491 (GRCm38)	F409L	probably benign	Het
Ryr2	A	T	13: 11,700,349 (GRCm38)	L2778M	probably damaging	Het
Scn1a	T	C	2: 66,331,352 (GRCm38)	N284S	possibly damaging	Het
Scyl2	A	T	10: 89,640,905 (GRCm38)	M786K	probably benign	Het
Sema4g	C	A	19: 44,997,622 (GRCm38)	R301S	probably damaging	Het
Senp6	A	T	9: 80,113,774 (GRCm38)	E245D	possibly damaging	Het
Setx	T	C	2: 29,163,009 (GRCm38)	V2095A	possibly damaging	Het
Slc13a2	A	T	11: 78,400,142 (GRCm38)	M412K	possibly damaging	Het
Slc25a4	T	C	8: 46,209,400 (GRCm38)	N74D	probably damaging	Het
Slc28a1	T	A	7: 81,142,035 (GRCm38)	F316L	probably damaging	Het
Slfn8	G	A	11: 83,003,621 (GRCm38)	Q731*	probably null	Het
Slitrk4	A	G	X: 64,272,623 (GRCm38)	I146T	probably damaging	Het
Smg8	G	T	11: 87,080,613 (GRCm38)	Y777*	probably null	Het
Smyd1	T	A	6: 71,239,579 (GRCm38)	K61N	probably benign	Het
Sod2	T	C	17: 13,015,169 (GRCm38)	*223R	probably null	Het
Sp6	G	T	11: 97,021,508 (GRCm38)	A16S	probably benign	Het
Spata31d1a	A	C	13: 59,702,695 (GRCm38)	Y540D	probably damaging	Het
Spatc1l	A	G	10: 76,563,917 (GRCm38)	D91G	probably damaging	Het
Spg7	A	G	8: 123,080,741 (GRCm38)	T419A	probably benign	Het
St5	G	A	7: 109,525,326 (GRCm38)	Q686*	probably null	Het
St8sia4	A	G	1: 95,627,573 (GRCm38)	I244T	probably damaging	Het
Tbl2	C	T	5: 135,152,991 (GRCm38)	R27W	probably damaging	Het
Tmed4	G	A	11: 6,274,694 (GRCm38)	P47L	probably damaging	Het
Tmtc1	T	C	6: 148,444,048 (GRCm38)	D51G	possibly damaging	Het
Ttc28	T	C	5: 111,284,054 (GRCm38)		probably null	Het
Unc13d	A	G	11: 116,070,295 (GRCm38)	F412S	probably damaging	Het
Unc45b	A	C	11: 82,926,087 (GRCm38)	K451T	probably damaging	Het
Vmn2r16	A	G	5: 109,363,987 (GRCm38)	M687V	probably benign	Het
Vmn2r68	T	A	7: 85,234,052 (GRCm38)	H164L	probably benign	Het
Vps51	A	G	19: 6,069,469 (GRCm38)	V625A	probably benign	Het
Wapl	T	A	14: 34,691,912 (GRCm38)	W244R	probably damaging	Het
Wdr75	C	T	1: 45,823,403 (GRCm38)	T794I	probably benign	Het

Other mutations in Smg1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00272:Smg1	APN	7	118,198,271 (GRCm38)	utr 3 prime	probably benign
IGL00481:Smg1	APN	7	118,210,794 (GRCm38)	missense	possibly damaging	0.67
IGL00503:Smg1	APN	7	118,185,483 (GRCm38)	utr 3 prime	probably benign
IGL00927:Smg1	APN	7	118,140,632 (GRCm38)	missense	probably damaging	1.00
IGL01333:Smg1	APN	7	118,163,378 (GRCm38)	splice site	probably benign
IGL01344:Smg1	APN	7	118,190,836 (GRCm38)	utr 3 prime	probably benign
IGL01397:Smg1	APN	7	118,163,221 (GRCm38)	utr 3 prime	probably benign
IGL01403:Smg1	APN	7	118,158,132 (GRCm38)	utr 3 prime	probably benign
IGL01573:Smg1	APN	7	118,167,962 (GRCm38)	utr 3 prime	probably benign
IGL01872:Smg1	APN	7	118,148,944 (GRCm38)	utr 3 prime	probably benign
IGL02010:Smg1	APN	7	118,186,146 (GRCm38)	utr 3 prime	probably benign
IGL02158:Smg1	APN	7	118,212,946 (GRCm38)	missense	possibly damaging	0.77
IGL02268:Smg1	APN	7	118,182,541 (GRCm38)	missense	probably benign	0.19
IGL02314:Smg1	APN	7	118,154,709 (GRCm38)	utr 3 prime	probably benign
IGL02552:Smg1	APN	7	118,195,894 (GRCm38)	utr 3 prime	probably benign
IGL02577:Smg1	APN	7	118,203,122 (GRCm38)	missense	probably damaging	0.99
IGL02859:Smg1	APN	7	118,148,933 (GRCm38)	utr 3 prime	probably benign
IGL02890:Smg1	APN	7	118,185,501 (GRCm38)	utr 3 prime	probably benign
IGL02892:Smg1	APN	7	118,167,955 (GRCm38)	utr 3 prime	probably benign
IGL03119:Smg1	APN	7	118,195,113 (GRCm38)	utr 3 prime	probably benign
IGL03123:Smg1	APN	7	118,157,181 (GRCm38)	utr 3 prime	probably benign
IGL03128:Smg1	APN	7	118,203,059 (GRCm38)	missense	probably benign	0.03
IGL03184:Smg1	APN	7	118,180,380 (GRCm38)	missense	possibly damaging	0.86
PIT4508001:Smg1	UTSW	7	118,185,541 (GRCm38)	missense	unknown
R0010:Smg1	UTSW	7	118,171,859 (GRCm38)	utr 3 prime	probably benign
R0010:Smg1	UTSW	7	118,171,859 (GRCm38)	utr 3 prime	probably benign
R0025:Smg1	UTSW	7	118,212,443 (GRCm38)	missense	possibly damaging	0.92
R0025:Smg1	UTSW	7	118,212,443 (GRCm38)	missense	possibly damaging	0.92
R0098:Smg1	UTSW	7	118,145,467 (GRCm38)	missense	probably benign	0.02
R0139:Smg1	UTSW	7	118,152,675 (GRCm38)	critical splice donor site	probably null
R0371:Smg1	UTSW	7	118,168,300 (GRCm38)	utr 3 prime	probably benign
R0415:Smg1	UTSW	7	118,182,468 (GRCm38)	missense	probably benign	0.34
R0416:Smg1	UTSW	7	118,184,461 (GRCm38)	splice site	probably benign
R0423:Smg1	UTSW	7	118,176,880 (GRCm38)	missense	possibly damaging	0.53
R0600:Smg1	UTSW	7	118,160,383 (GRCm38)	utr 3 prime	probably benign
R0626:Smg1	UTSW	7	118,182,383 (GRCm38)	missense	possibly damaging	0.82
R0627:Smg1	UTSW	7	118,167,861 (GRCm38)	utr 3 prime	probably benign
R0727:Smg1	UTSW	7	118,166,422 (GRCm38)	utr 3 prime	probably benign
R0729:Smg1	UTSW	7	118,146,289 (GRCm38)	utr 3 prime	probably benign
R0841:Smg1	UTSW	7	118,143,301 (GRCm38)	missense	possibly damaging	0.96
R1114:Smg1	UTSW	7	118,159,790 (GRCm38)	utr 3 prime	probably benign
R1256:Smg1	UTSW	7	118,203,087 (GRCm38)	missense	probably damaging	1.00
R1298:Smg1	UTSW	7	118,168,211 (GRCm38)	utr 3 prime	probably benign
R1370:Smg1	UTSW	7	118,159,752 (GRCm38)	utr 3 prime	probably benign
R1591:Smg1	UTSW	7	118,156,919 (GRCm38)	utr 3 prime	probably benign
R1736:Smg1	UTSW	7	118,165,967 (GRCm38)	splice site	probably null
R1755:Smg1	UTSW	7	118,203,064 (GRCm38)	nonsense	probably null
R1765:Smg1	UTSW	7	118,139,715 (GRCm38)	missense	probably benign	0.03
R1789:Smg1	UTSW	7	118,145,798 (GRCm38)	missense	possibly damaging	0.73
R1845:Smg1	UTSW	7	118,154,622 (GRCm38)	utr 3 prime	probably benign
R1908:Smg1	UTSW	7	118,154,199 (GRCm38)	utr 3 prime	probably benign
R1942:Smg1	UTSW	7	118,158,103 (GRCm38)	utr 3 prime	probably benign
R2064:Smg1	UTSW	7	118,156,867 (GRCm38)	utr 3 prime	probably benign
R2072:Smg1	UTSW	7	118,163,166 (GRCm38)	utr 3 prime	probably benign
R2154:Smg1	UTSW	7	118,158,076 (GRCm38)	utr 3 prime	probably benign
R2895:Smg1	UTSW	7	118,189,143 (GRCm38)	utr 3 prime	probably benign
R2915:Smg1	UTSW	7	118,210,879 (GRCm38)	splice site	probably benign
R3416:Smg1	UTSW	7	118,148,853 (GRCm38)	utr 3 prime	probably benign
R3417:Smg1	UTSW	7	118,148,853 (GRCm38)	utr 3 prime	probably benign
R3873:Smg1	UTSW	7	118,154,662 (GRCm38)	utr 3 prime	probably benign
R4082:Smg1	UTSW	7	118,160,246 (GRCm38)	utr 3 prime	probably benign
R4230:Smg1	UTSW	7	118,148,733 (GRCm38)	critical splice donor site	probably null
R4304:Smg1	UTSW	7	118,139,518 (GRCm38)	missense	probably benign	0.03
R4549:Smg1	UTSW	7	118,159,683 (GRCm38)	utr 3 prime	probably benign
R4571:Smg1	UTSW	7	118,139,465 (GRCm38)	missense	possibly damaging	0.72
R4638:Smg1	UTSW	7	118,195,926 (GRCm38)	utr 3 prime	probably benign
R4642:Smg1	UTSW	7	118,154,264 (GRCm38)	utr 3 prime	probably benign
R4656:Smg1	UTSW	7	118,212,951 (GRCm38)	missense	probably benign	0.00
R4754:Smg1	UTSW	7	118,156,731 (GRCm38)	utr 3 prime	probably benign
R4798:Smg1	UTSW	7	118,180,474 (GRCm38)	missense	probably benign	0.32
R4906:Smg1	UTSW	7	118,152,408 (GRCm38)	utr 3 prime	probably benign
R4978:Smg1	UTSW	7	118,154,247 (GRCm38)	utr 3 prime	probably benign
R4989:Smg1	UTSW	7	118,208,051 (GRCm38)	missense	probably benign
R4989:Smg1	UTSW	7	118,158,100 (GRCm38)	utr 3 prime	probably benign
R5026:Smg1	UTSW	7	118,193,545 (GRCm38)	utr 3 prime	probably benign
R5124:Smg1	UTSW	7	118,213,012 (GRCm38)	missense	probably benign	0.00
R5318:Smg1	UTSW	7	118,160,204 (GRCm38)	utr 3 prime	probably benign
R5356:Smg1	UTSW	7	118,195,133 (GRCm38)	utr 3 prime	probably benign
R5404:Smg1	UTSW	7	118,206,908 (GRCm38)	missense	probably damaging	1.00
R5423:Smg1	UTSW	7	118,146,071 (GRCm38)	missense	possibly damaging	0.70
R5441:Smg1	UTSW	7	118,195,081 (GRCm38)	utr 3 prime	probably benign
R5490:Smg1	UTSW	7	118,139,436 (GRCm38)	missense	possibly damaging	0.86
R5541:Smg1	UTSW	7	118,157,163 (GRCm38)	utr 3 prime	probably benign
R5564:Smg1	UTSW	7	118,189,819 (GRCm38)	utr 3 prime	probably benign
R5580:Smg1	UTSW	7	118,148,902 (GRCm38)	utr 3 prime	probably benign
R5600:Smg1	UTSW	7	118,167,884 (GRCm38)	utr 3 prime	probably benign
R5628:Smg1	UTSW	7	118,154,701 (GRCm38)	utr 3 prime	probably benign
R5646:Smg1	UTSW	7	118,212,559 (GRCm38)	missense	probably benign	0.42
R5656:Smg1	UTSW	7	118,154,664 (GRCm38)	utr 3 prime	probably benign
R5660:Smg1	UTSW	7	118,143,347 (GRCm38)	missense	probably benign	0.33
R5706:Smg1	UTSW	7	118,145,590 (GRCm38)	missense	possibly damaging	0.86
R5786:Smg1	UTSW	7	118,212,897 (GRCm38)	missense	probably benign	0.12
R5890:Smg1	UTSW	7	118,190,586 (GRCm38)	utr 3 prime	probably benign
R5912:Smg1	UTSW	7	118,154,586 (GRCm38)	utr 3 prime	probably benign
R5977:Smg1	UTSW	7	118,141,357 (GRCm38)	utr 3 prime	probably benign
R5993:Smg1	UTSW	7	118,140,509 (GRCm38)	missense	probably benign	0.33
R6161:Smg1	UTSW	7	118,163,330 (GRCm38)	utr 3 prime	probably benign
R6187:Smg1	UTSW	7	118,189,163 (GRCm38)	utr 3 prime	probably benign
R6264:Smg1	UTSW	7	118,166,087 (GRCm38)	utr 3 prime	probably benign
R6331:Smg1	UTSW	7	118,154,277 (GRCm38)	utr 3 prime	probably benign
R6561:Smg1	UTSW	7	118,166,077 (GRCm38)	utr 3 prime	probably benign
R6571:Smg1	UTSW	7	118,184,514 (GRCm38)	utr 3 prime	probably benign
R6736:Smg1	UTSW	7	118,157,166 (GRCm38)	utr 3 prime	probably benign
R6752:Smg1	UTSW	7	118,163,316 (GRCm38)	utr 3 prime	probably benign
R6777:Smg1	UTSW	7	118,189,117 (GRCm38)	utr 3 prime	probably benign
R6788:Smg1	UTSW	7	118,184,571 (GRCm38)	utr 3 prime	probably benign
R6883:Smg1	UTSW	7	118,168,180 (GRCm38)	utr 3 prime	probably benign
R6991:Smg1	UTSW	7	118,167,868 (GRCm38)	utr 3 prime	probably benign
R7056:Smg1	UTSW	7	118,146,400 (GRCm38)	splice site	probably benign
R7058:Smg1	UTSW	7	118,198,279 (GRCm38)	utr 3 prime	probably benign
R7100:Smg1	UTSW	7	118,184,520 (GRCm38)	missense	unknown
R7133:Smg1	UTSW	7	118,152,908 (GRCm38)	missense	unknown
R7221:Smg1	UTSW	7	118,182,797 (GRCm38)	missense	possibly damaging	0.86
R7229:Smg1	UTSW	7	118,176,955 (GRCm38)	missense	probably benign	0.03
R7293:Smg1	UTSW	7	118,166,099 (GRCm38)	missense	unknown
R7361:Smg1	UTSW	7	118,184,977 (GRCm38)	missense	unknown
R7438:Smg1	UTSW	7	118,195,893 (GRCm38)	missense	unknown
R7686:Smg1	UTSW	7	118,167,858 (GRCm38)	missense	unknown
R7798:Smg1	UTSW	7	118,171,939 (GRCm38)	missense	possibly damaging	0.73
R7908:Smg1	UTSW	7	118,186,134 (GRCm38)	missense	unknown
R7923:Smg1	UTSW	7	118,143,322 (GRCm38)	missense	possibly damaging	0.96
R7978:Smg1	UTSW	7	118,193,655 (GRCm38)	missense	unknown
R7997:Smg1	UTSW	7	118,173,142 (GRCm38)	missense	unknown
R7997:Smg1	UTSW	7	118,173,141 (GRCm38)	missense	unknown
R8025:Smg1	UTSW	7	118,206,989 (GRCm38)	nonsense	probably null
R8056:Smg1	UTSW	7	118,160,366 (GRCm38)	missense	unknown
R8061:Smg1	UTSW	7	118,152,387 (GRCm38)	missense	unknown
R8095:Smg1	UTSW	7	118,173,062 (GRCm38)	missense	unknown
R8198:Smg1	UTSW	7	118,145,606 (GRCm38)	missense	probably benign	0.03
R8399:Smg1	UTSW	7	118,190,571 (GRCm38)	missense	unknown
R8445:Smg1	UTSW	7	118,136,977 (GRCm38)	missense	possibly damaging	0.72
R8519:Smg1	UTSW	7	118,171,759 (GRCm38)	utr 3 prime	probably benign
R8817:Smg1	UTSW	7	118,159,664 (GRCm38)	missense	unknown
R8832:Smg1	UTSW	7	118,139,783 (GRCm38)	missense	probably benign	0.33
R8855:Smg1	UTSW	7	118,206,899 (GRCm38)	missense	unknown
R8866:Smg1	UTSW	7	118,206,899 (GRCm38)	missense	unknown
R8946:Smg1	UTSW	7	118,152,677 (GRCm38)	missense	probably null
R8954:Smg1	UTSW	7	118,206,992 (GRCm38)	missense	probably damaging	1.00
R8967:Smg1	UTSW	7	118,166,516 (GRCm38)	missense	unknown
R9072:Smg1	UTSW	7	118,183,809 (GRCm38)	missense	unknown
R9090:Smg1	UTSW	7	118,212,563 (GRCm38)	missense	unknown
R9156:Smg1	UTSW	7	118,154,661 (GRCm38)	missense	unknown
R9198:Smg1	UTSW	7	118,195,956 (GRCm38)	missense	unknown
R9240:Smg1	UTSW	7	118,139,808 (GRCm38)	missense	probably benign	0.18
R9271:Smg1	UTSW	7	118,212,563 (GRCm38)	missense	unknown
R9289:Smg1	UTSW	7	118,145,416 (GRCm38)	missense	possibly damaging	0.53
R9378:Smg1	UTSW	7	118,178,775 (GRCm38)	nonsense	probably null
R9396:Smg1	UTSW	7	118,208,080 (GRCm38)	missense	unknown
R9469:Smg1	UTSW	7	118,140,551 (GRCm38)	missense	possibly damaging	0.72
R9539:Smg1	UTSW	7	118,145,753 (GRCm38)	missense	probably benign	0.03
R9549:Smg1	UTSW	7	118,196,031 (GRCm38)	missense	unknown
R9563:Smg1	UTSW	7	118,212,985 (GRCm38)	missense	unknown
R9564:Smg1	UTSW	7	118,212,985 (GRCm38)	missense	unknown
R9597:Smg1	UTSW	7	118,213,047 (GRCm38)	missense	unknown
R9643:Smg1	UTSW	7	118,156,710 (GRCm38)	missense	unknown
R9703:Smg1	UTSW	7	118,140,521 (GRCm38)	missense	possibly damaging	0.73
R9730:Smg1	UTSW	7	118,183,781 (GRCm38)	missense	unknown
Z1088:Smg1	UTSW	7	118,178,399 (GRCm38)	missense	possibly damaging	0.96
Z1088:Smg1	UTSW	7	118,168,661 (GRCm38)	nonsense	probably null
Z1088:Smg1	UTSW	7	118,154,635 (GRCm38)	utr 3 prime	probably benign
Z1176:Smg1	UTSW	7	118,206,907 (GRCm38)	missense	unknown
Z1176:Smg1	UTSW	7	118,206,887 (GRCm38)	missense	unknown
Z1177:Smg1	UTSW	7	118,213,033 (GRCm38)	missense	unknown
Z1177:Smg1	UTSW	7	118,168,608 (GRCm38)	missense	probably null

Predicted Primers

PCR Primer
(F):5'- AGGTACTTCACTGAAATTTCATCTG -3'
(R):5'- CCAGTGTGAGCAGCTAGAG -3'

Sequencing Primer
(F):5'- CCAGATTGCCTGCCTGTAAAGATG -3'
(R):5'- AGGGGGAAGTTGGCGCTC -3'

Posted On

2014-06-30