|Institutional Source||Beutler Lab|
|Gene Name||adhesion G protein-coupled receptor A3|
|Synonyms||Gpr125, Tem5-like, 3830613O22Rik|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R0121 (G1)|
|Chromosomal Location||49959956-50059006 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to C at 50025786 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000030971 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000030971]|
|Predicted Effect||probably benign
|Coding Region Coverage||
|Validation Efficiency||100% (63/63)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]
PHENOTYPE: Homozygous mutant mice are fertile and grossly normal. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Adgra3||
(F):5'- GGCTCATTACTGCCGGAATCACTTG -3'
(R):5'- TCCGTGGTGACCAGCTTTACCTTG -3'
(F):5'- TTGATCACTTCACGGCAGAG -3'
(R):5'- GTGACCAGCTTTACCTTGTATTGAAC -3'