|Institutional Source||Beutler Lab|
|Gene Name||protein tyrosine phosphatase, receptor type, O|
|Synonyms||Ptpn15, PTP-oc, GLEPP1, PTP-U2, PTP-BK, PTP-phi, D28, PTPROt|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R1911 (G1)|
|Chromosomal Location||137252319-137463233 bp(+) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to C at 137400619 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000127112 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000077115] [ENSMUST00000167679]|
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||99% (99/100)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]
PHENOTYPE: Mice homozygous for one allele display impaired glomerular filtration due to podocyte structural anomalies and a predisposition for hypertension. Mice homozygous for a second allele exhibit susceptibility to pharmacologically induced seizures. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ptpro||
(F):5'- GAGCTTACATTCAAACAATCCAGTC -3'
(R):5'- AGGGATGCAAACGCTCCTTC -3'
(F):5'- TCCAGTCCAGCAATAACATAATAGTC -3'
(R):5'- GCATCTTCAGCAAACACTCCTTC -3'