Incidental Mutation 'R1912:Mgam'
| ID |
210380 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mgam
|
| Ensembl Gene |
ENSMUSG00000068587 |
| Gene Name |
maltase-glucoamylase |
| Synonyms |
6030407P20Rik |
| MMRRC Submission |
039930-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.231)
|
| Stock # |
R1912 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
40628831-40769123 bp(+) (GRCm38) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to T
at 40764185 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 959
(Q959*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000144680
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071535]
[ENSMUST00000201148]
[ENSMUST00000202779]
[ENSMUST00000202966]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000071535
AA Change: Q1705*
|
| SMART Domains |
Protein: ENSMUSP00000071466
Gene: ENSMUSG00000068587
AA Change: Q1705*
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
12 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
47 |
59 |
N/A |
INTRINSIC |
|
PD
|
63 |
111 |
1.81e-8 |
SMART |
|
Pfam:NtCtMGAM_N
|
124 |
233 |
6.2e-36 |
PFAM |
|
Pfam:Glyco_hydro_31
|
323 |
795 |
3.4e-145 |
PFAM |
|
PD
|
924 |
977 |
4.52e-9 |
SMART |
|
Pfam:NtCtMGAM_N
|
988 |
1101 |
1.5e-30 |
PFAM |
|
Blast:ANK
|
1141 |
1171 |
1e-7 |
BLAST |
|
Pfam:Glyco_hydro_31
|
1189 |
1691 |
2e-139 |
PFAM |
|
low complexity region
|
1776 |
1791 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000201148
AA Change: Q1705*
|
| SMART Domains |
Protein: ENSMUSP00000143946
Gene: ENSMUSG00000068587
AA Change: Q1705*
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
12 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
47 |
59 |
N/A |
INTRINSIC |
|
PD
|
63 |
111 |
1.81e-8 |
SMART |
|
Pfam:NtCtMGAM_N
|
124 |
233 |
6.2e-36 |
PFAM |
|
Pfam:Glyco_hydro_31
|
323 |
795 |
3.4e-145 |
PFAM |
|
PD
|
924 |
977 |
4.52e-9 |
SMART |
|
Pfam:NtCtMGAM_N
|
988 |
1101 |
1.5e-30 |
PFAM |
|
Blast:ANK
|
1141 |
1171 |
1e-7 |
BLAST |
|
Pfam:Glyco_hydro_31
|
1189 |
1691 |
2e-139 |
PFAM |
|
low complexity region
|
1776 |
1791 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000202775
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000202779
AA Change: Q1078*
|
| SMART Domains |
Protein: ENSMUSP00000144627
Gene: ENSMUSG00000068587
AA Change: Q1078*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Glyco_hydro_31
|
2 |
170 |
1.4e-53 |
PFAM |
|
PD
|
297 |
350 |
1.4e-14 |
SMART |
|
Pfam:NtCtMGAM_N
|
361 |
474 |
1.5e-26 |
PFAM |
|
Blast:ANK
|
514 |
544 |
7e-8 |
BLAST |
|
Pfam:Glyco_hydro_31
|
562 |
1064 |
2.2e-137 |
PFAM |
|
low complexity region
|
1149 |
1164 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000202966
AA Change: Q959*
|
| SMART Domains |
Protein: ENSMUSP00000144680
Gene: ENSMUSG00000068587
AA Change: Q959*
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
2 |
88 |
2.6e-19 |
PROSPERO |
|
PD
|
178 |
231 |
1.4e-14 |
SMART |
|
Pfam:NtCtMGAM_N
|
242 |
355 |
1.1e-26 |
PFAM |
|
Blast:ANK
|
395 |
425 |
6e-8 |
BLAST |
|
Pfam:Glyco_hydro_31
|
443 |
945 |
1.3e-137 |
PFAM |
|
| Coding Region Coverage |
- 1x: 97.3%
- 3x: 96.8%
- 10x: 95.3%
- 20x: 92.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele display abnormalities in starch digestion and prandial glucose homeostasis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 122 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2900092C05Rik |
A |
G |
7: 12,554,655 (GRCm38) |
M132V |
probably benign |
Het |
| 4921524L21Rik |
T |
A |
18: 6,620,205 (GRCm38) |
I45N |
possibly damaging |
Het |
| Abcb6 |
A |
G |
1: 75,179,955 (GRCm38) |
V55A |
probably benign |
Het |
| Adam28 |
A |
T |
14: 68,644,331 (GRCm38) |
D105E |
probably benign |
Het |
| Ahnak |
T |
C |
19: 9,017,881 (GRCm38) |
S5510P |
probably damaging |
Het |
| Aldh3b1 |
T |
G |
19: 3,921,187 (GRCm38) |
D159A |
probably damaging |
Het |
| Alx1 |
A |
G |
10: 103,025,361 (GRCm38) |
L102P |
probably damaging |
Het |
| Ankrd50 |
C |
T |
3: 38,456,776 (GRCm38) |
V481I |
probably benign |
Het |
| Aox4 |
G |
T |
1: 58,264,402 (GRCm38) |
G1200W |
probably damaging |
Het |
| Arhgap45 |
A |
C |
10: 80,020,690 (GRCm38) |
D24A |
probably benign |
Het |
| Arhgef16 |
A |
T |
4: 154,280,323 (GRCm38) |
|
probably null |
Het |
| Asic4 |
A |
T |
1: 75,469,232 (GRCm38) |
Y235F |
possibly damaging |
Het |
| Asph |
T |
C |
4: 9,453,335 (GRCm38) |
E646G |
probably damaging |
Het |
| Atg4d |
A |
G |
9: 21,272,639 (GRCm38) |
D350G |
probably damaging |
Het |
| Auts2 |
T |
C |
5: 131,443,574 (GRCm38) |
T347A |
probably damaging |
Het |
| Bsnd |
A |
T |
4: 106,488,030 (GRCm38) |
L73* |
probably null |
Het |
| Cachd1 |
A |
T |
4: 100,953,169 (GRCm38) |
S323C |
probably damaging |
Het |
| Cacna1e |
A |
G |
1: 154,436,449 (GRCm38) |
I1290T |
probably damaging |
Het |
| Cdh8 |
T |
A |
8: 99,098,870 (GRCm38) |
N498Y |
probably damaging |
Het |
| Cdkn3 |
A |
G |
14: 46,769,834 (GRCm38) |
|
probably null |
Het |
| Celf2 |
A |
T |
2: 6,615,753 (GRCm38) |
M40K |
probably damaging |
Het |
| Cfap57 |
A |
C |
4: 118,615,010 (GRCm38) |
S57R |
probably damaging |
Het |
| Cfh |
A |
G |
1: 140,136,141 (GRCm38) |
|
probably null |
Het |
| Chdh |
A |
G |
14: 30,032,788 (GRCm38) |
S252G |
probably benign |
Het |
| Col8a1 |
T |
A |
16: 57,627,924 (GRCm38) |
I408F |
unknown |
Het |
| Corin |
C |
T |
5: 72,358,403 (GRCm38) |
C303Y |
probably damaging |
Het |
| Crlf2 |
C |
T |
5: 109,557,141 (GRCm38) |
C66Y |
possibly damaging |
Het |
| Csmd1 |
C |
T |
8: 16,233,998 (GRCm38) |
|
probably null |
Het |
| Cyp4f16 |
T |
C |
17: 32,545,044 (GRCm38) |
V270A |
probably damaging |
Het |
| Defa29 |
T |
A |
8: 21,326,012 (GRCm38) |
H113L |
possibly damaging |
Het |
| Dhx35 |
A |
T |
2: 158,842,307 (GRCm38) |
N501Y |
probably damaging |
Het |
| Dipk1b |
A |
G |
2: 26,632,704 (GRCm38) |
E55G |
probably damaging |
Het |
| Dst |
A |
G |
1: 34,291,850 (GRCm38) |
R4690G |
probably damaging |
Het |
| Elac2 |
T |
A |
11: 64,994,263 (GRCm38) |
D439E |
probably benign |
Het |
| Ercc6 |
A |
G |
14: 32,576,803 (GRCm38) |
R1383G |
probably damaging |
Het |
| Fat3 |
T |
A |
9: 15,969,988 (GRCm38) |
Y3196F |
probably damaging |
Het |
| Fbxw13 |
A |
T |
9: 109,181,543 (GRCm38) |
D342E |
probably benign |
Het |
| Fmod |
A |
G |
1: 134,040,720 (GRCm38) |
N166S |
possibly damaging |
Het |
| Folh1 |
A |
G |
7: 86,762,967 (GRCm38) |
S199P |
possibly damaging |
Het |
| Fv1 |
A |
G |
4: 147,869,778 (GRCm38) |
N267S |
possibly damaging |
Het |
| Fyn |
T |
C |
10: 39,526,832 (GRCm38) |
V200A |
possibly damaging |
Het |
| Gfus |
A |
T |
15: 75,925,649 (GRCm38) |
D278E |
possibly damaging |
Het |
| Ggnbp2 |
T |
C |
11: 84,862,296 (GRCm38) |
N39S |
probably benign |
Het |
| Gm10509 |
A |
T |
17: 21,690,924 (GRCm38) |
I53F |
possibly damaging |
Het |
| Gpr139 |
A |
T |
7: 119,144,879 (GRCm38) |
I161N |
possibly damaging |
Het |
| Grhl2 |
C |
T |
15: 37,358,407 (GRCm38) |
T148I |
probably damaging |
Het |
| Hmcn1 |
C |
A |
1: 150,604,882 (GRCm38) |
M4514I |
probably benign |
Het |
| Igsf10 |
T |
G |
3: 59,329,572 (GRCm38) |
T1063P |
probably benign |
Het |
| Itgav |
A |
G |
2: 83,795,486 (GRCm38) |
Y792C |
possibly damaging |
Het |
| Itgb2l |
T |
C |
16: 96,426,935 (GRCm38) |
Q456R |
probably benign |
Het |
| Jph4 |
G |
A |
14: 55,108,361 (GRCm38) |
A613V |
probably benign |
Het |
| Kcna2 |
A |
G |
3: 107,105,401 (GRCm38) |
T433A |
probably benign |
Het |
| Kmt2e |
A |
G |
5: 23,492,395 (GRCm38) |
K97R |
probably benign |
Het |
| Krba1 |
C |
A |
6: 48,415,765 (GRCm38) |
A871E |
probably benign |
Het |
| Loxhd1 |
T |
C |
18: 77,340,137 (GRCm38) |
F468L |
probably benign |
Het |
| Lpin1 |
A |
G |
12: 16,546,727 (GRCm38) |
V713A |
probably damaging |
Het |
| Ltbp2 |
T |
A |
12: 84,785,863 (GRCm38) |
I67F |
probably damaging |
Het |
| Mdc1 |
A |
G |
17: 35,850,811 (GRCm38) |
D872G |
probably benign |
Het |
| Mdc1 |
G |
A |
17: 35,844,538 (GRCm38) |
R35H |
probably benign |
Het |
| Mttp |
T |
A |
3: 138,116,027 (GRCm38) |
T260S |
probably benign |
Het |
| Naalad2 |
A |
T |
9: 18,376,535 (GRCm38) |
D266E |
probably benign |
Het |
| Nans |
T |
A |
4: 46,500,162 (GRCm38) |
L182H |
probably damaging |
Het |
| Nbas |
T |
A |
12: 13,566,144 (GRCm38) |
C2228S |
probably benign |
Het |
| Nfix |
A |
T |
8: 84,721,677 (GRCm38) |
V407E |
probably damaging |
Het |
| Nktr |
T |
A |
9: 121,750,240 (GRCm38) |
|
probably benign |
Het |
| Nlrp10 |
G |
A |
7: 108,925,395 (GRCm38) |
R293* |
probably null |
Het |
| Nrxn3 |
T |
C |
12: 88,795,342 (GRCm38) |
F53S |
probably damaging |
Het |
| Or11h4 |
G |
A |
14: 50,736,778 (GRCm38) |
P128L |
probably damaging |
Het |
| Or12e7 |
T |
C |
2: 87,457,383 (GRCm38) |
S73P |
probably damaging |
Het |
| Or1e21 |
A |
T |
11: 73,453,994 (GRCm38) |
F73I |
probably damaging |
Het |
| Or2f2 |
T |
C |
6: 42,790,477 (GRCm38) |
I146T |
probably benign |
Het |
| Or3a1c |
T |
C |
11: 74,155,885 (GRCm38) |
C244R |
probably damaging |
Het |
| Or5ak24 |
T |
A |
2: 85,430,260 (GRCm38) |
N190Y |
probably damaging |
Het |
| Or5p68 |
A |
G |
7: 108,346,807 (GRCm38) |
L58P |
probably damaging |
Het |
| Or6d12 |
A |
G |
6: 116,515,989 (GRCm38) |
T71A |
probably benign |
Het |
| Oxld1 |
A |
G |
11: 120,456,906 (GRCm38) |
V155A |
probably damaging |
Het |
| Pamr1 |
T |
A |
2: 102,642,300 (GRCm38) |
F648Y |
probably damaging |
Het |
| Parg |
T |
C |
14: 32,210,540 (GRCm38) |
W446R |
probably damaging |
Het |
| Pate13 |
A |
T |
9: 35,908,619 (GRCm38) |
T23S |
probably benign |
Het |
| Phf3 |
A |
T |
1: 30,804,345 (GRCm38) |
H1844Q |
probably damaging |
Het |
| Phf7 |
T |
C |
14: 31,240,324 (GRCm38) |
I175V |
possibly damaging |
Het |
| Pibf1 |
G |
A |
14: 99,187,809 (GRCm38) |
|
probably null |
Het |
| Plcxd1 |
A |
G |
5: 110,103,442 (GRCm38) |
I295V |
probably benign |
Het |
| Pole2 |
A |
C |
12: 69,209,990 (GRCm38) |
Y254D |
probably damaging |
Het |
| Ppm1e |
T |
A |
11: 87,244,370 (GRCm38) |
I225F |
probably benign |
Het |
| Pttg1ip2 |
C |
A |
5: 5,452,019 (GRCm38) |
W144C |
probably benign |
Het |
| Rem1 |
G |
A |
2: 152,634,535 (GRCm38) |
V238M |
probably damaging |
Het |
| Resf1 |
T |
A |
6: 149,328,844 (GRCm38) |
D1129E |
possibly damaging |
Het |
| Rnase2b |
T |
G |
14: 51,162,900 (GRCm38) |
V146G |
probably damaging |
Het |
| Rnf169 |
G |
A |
7: 99,926,254 (GRCm38) |
T378I |
probably damaging |
Het |
| Rpf2 |
A |
G |
10: 40,236,201 (GRCm38) |
F80L |
probably benign |
Het |
| Sec11c |
T |
A |
18: 65,814,874 (GRCm38) |
D128E |
probably damaging |
Het |
| Septin12 |
A |
G |
16: 4,988,553 (GRCm38) |
V248A |
probably damaging |
Het |
| Serinc1 |
T |
C |
10: 57,525,451 (GRCm38) |
N82S |
probably benign |
Het |
| Serpina9 |
A |
C |
12: 104,001,249 (GRCm38) |
W296G |
probably damaging |
Het |
| Sgo2b |
A |
C |
8: 63,931,469 (GRCm38) |
D164E |
probably damaging |
Het |
| Slc15a3 |
A |
G |
19: 10,848,613 (GRCm38) |
N223D |
probably damaging |
Het |
| Slc44a3 |
A |
G |
3: 121,532,166 (GRCm38) |
Y12H |
probably benign |
Het |
| Slco3a1 |
A |
G |
7: 74,504,611 (GRCm38) |
F42S |
probably damaging |
Het |
| Snrnp40 |
C |
G |
4: 130,378,043 (GRCm38) |
|
probably null |
Het |
| Snx7 |
A |
T |
3: 117,829,668 (GRCm38) |
|
probably null |
Het |
| Sorl1 |
A |
T |
9: 42,081,950 (GRCm38) |
D259E |
probably damaging |
Het |
| Stpg2 |
G |
A |
3: 139,522,981 (GRCm38) |
|
probably null |
Het |
| Strn |
T |
A |
17: 78,684,395 (GRCm38) |
Y165F |
probably damaging |
Het |
| Sval2 |
T |
A |
6: 41,864,320 (GRCm38) |
*106R |
probably null |
Het |
| Tcaf3 |
A |
G |
6: 42,596,688 (GRCm38) |
S197P |
possibly damaging |
Het |
| Tespa1 |
C |
A |
10: 130,354,723 (GRCm38) |
T73N |
probably benign |
Het |
| Tex10 |
C |
T |
4: 48,456,800 (GRCm38) |
R637Q |
probably benign |
Het |
| Thoc5 |
C |
A |
11: 4,915,561 (GRCm38) |
T380K |
probably benign |
Het |
| Tmprss7 |
T |
A |
16: 45,656,548 (GRCm38) |
R784* |
probably null |
Het |
| Trank1 |
A |
T |
9: 111,390,709 (GRCm38) |
L2171F |
probably benign |
Het |
| Trpm2 |
T |
G |
10: 77,945,876 (GRCm38) |
K303T |
probably benign |
Het |
| Unc80 |
G |
A |
1: 66,510,625 (GRCm38) |
V681M |
probably damaging |
Het |
| Usp40 |
A |
G |
1: 87,946,646 (GRCm38) |
F1131L |
probably benign |
Het |
| Vmn1r215 |
A |
T |
13: 23,076,503 (GRCm38) |
I238F |
possibly damaging |
Het |
| Vwa3a |
A |
T |
7: 120,795,627 (GRCm38) |
Y890F |
probably damaging |
Het |
| Zdhhc18 |
A |
G |
4: 133,613,860 (GRCm38) |
L234P |
probably damaging |
Het |
| Zfp109 |
A |
G |
7: 24,228,251 (GRCm38) |
S578P |
probably damaging |
Het |
| Zfp704 |
T |
C |
3: 9,609,358 (GRCm38) |
D121G |
unknown |
Het |
| Zgrf1 |
G |
T |
3: 127,563,137 (GRCm38) |
V671L |
probably benign |
Het |
| Zkscan8 |
A |
T |
13: 21,520,757 (GRCm38) |
C265* |
probably null |
Het |
| Zscan26 |
T |
C |
13: 21,445,140 (GRCm38) |
I398V |
possibly damaging |
Het |
|
| Other mutations in Mgam |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01024:Mgam
|
APN |
6 |
40,643,010 (GRCm38) |
missense |
probably benign |
|
|
IGL01065:Mgam
|
APN |
6 |
40,662,710 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL01402:Mgam
|
APN |
6 |
40,644,945 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01404:Mgam
|
APN |
6 |
40,644,945 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01413:Mgam
|
APN |
6 |
40,661,277 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01546:Mgam
|
APN |
6 |
40,654,693 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01596:Mgam
|
APN |
6 |
40,658,270 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02133:Mgam
|
APN |
6 |
40,643,076 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL02734:Mgam
|
APN |
6 |
40,662,694 (GRCm38) |
missense |
probably damaging |
1.00 |
|
BB002:Mgam
|
UTSW |
6 |
40,759,051 (GRCm38) |
missense |
probably damaging |
0.99 |
|
BB012:Mgam
|
UTSW |
6 |
40,759,051 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0012:Mgam
|
UTSW |
6 |
40,765,256 (GRCm38) |
splice site |
probably null |
|
|
R0116:Mgam
|
UTSW |
6 |
40,658,987 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0310:Mgam
|
UTSW |
6 |
40,761,035 (GRCm38) |
splice site |
probably benign |
|
|
R0452:Mgam
|
UTSW |
6 |
40,759,090 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0497:Mgam
|
UTSW |
6 |
40,664,892 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0699:Mgam
|
UTSW |
6 |
40,643,019 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R0738:Mgam
|
UTSW |
6 |
40,754,935 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1033:Mgam
|
UTSW |
6 |
40,680,624 (GRCm38) |
missense |
probably benign |
0.07 |
|
R1403:Mgam
|
UTSW |
6 |
40,666,881 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R1403:Mgam
|
UTSW |
6 |
40,666,881 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R1430:Mgam
|
UTSW |
6 |
40,756,371 (GRCm38) |
missense |
probably benign |
0.08 |
|
R1432:Mgam
|
UTSW |
6 |
40,756,367 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1443:Mgam
|
UTSW |
6 |
40,759,780 (GRCm38) |
nonsense |
probably null |
|
|
R1470:Mgam
|
UTSW |
6 |
40,759,128 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1470:Mgam
|
UTSW |
6 |
40,759,128 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1519:Mgam
|
UTSW |
6 |
40,661,683 (GRCm38) |
missense |
probably benign |
0.45 |
|
R1654:Mgam
|
UTSW |
6 |
40,757,487 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1667:Mgam
|
UTSW |
6 |
40,677,044 (GRCm38) |
missense |
possibly damaging |
0.62 |
|
R1730:Mgam
|
UTSW |
6 |
40,664,860 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R1781:Mgam
|
UTSW |
6 |
40,669,863 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1783:Mgam
|
UTSW |
6 |
40,664,860 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R1829:Mgam
|
UTSW |
6 |
40,666,892 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1833:Mgam
|
UTSW |
6 |
40,654,718 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1872:Mgam
|
UTSW |
6 |
40,661,300 (GRCm38) |
nonsense |
probably null |
|
|
R1977:Mgam
|
UTSW |
6 |
40,664,880 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2048:Mgam
|
UTSW |
6 |
40,656,429 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R2086:Mgam
|
UTSW |
6 |
40,761,028 (GRCm38) |
splice site |
probably null |
|
|
R2138:Mgam
|
UTSW |
6 |
40,756,450 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2224:Mgam
|
UTSW |
6 |
40,764,274 (GRCm38) |
splice site |
probably null |
|
|
R2408:Mgam
|
UTSW |
6 |
40,686,522 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2508:Mgam
|
UTSW |
6 |
40,759,783 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2842:Mgam
|
UTSW |
6 |
40,661,345 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2847:Mgam
|
UTSW |
6 |
40,652,715 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R2848:Mgam
|
UTSW |
6 |
40,652,715 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R2965:Mgam
|
UTSW |
6 |
40,768,220 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R2966:Mgam
|
UTSW |
6 |
40,768,220 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R3035:Mgam
|
UTSW |
6 |
40,663,530 (GRCm38) |
missense |
probably benign |
|
|
R3895:Mgam
|
UTSW |
6 |
40,759,120 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4027:Mgam
|
UTSW |
6 |
40,754,902 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4030:Mgam
|
UTSW |
6 |
40,754,902 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4302:Mgam
|
UTSW |
6 |
40,763,085 (GRCm38) |
missense |
probably benign |
0.02 |
|
R4707:Mgam
|
UTSW |
6 |
40,714,632 (GRCm38) |
splice site |
probably null |
|
|
R4826:Mgam
|
UTSW |
6 |
40,680,648 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R4898:Mgam
|
UTSW |
6 |
40,643,054 (GRCm38) |
missense |
probably benign |
|
|
R5438:Mgam
|
UTSW |
6 |
40,684,521 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5492:Mgam
|
UTSW |
6 |
40,756,363 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5770:Mgam
|
UTSW |
6 |
40,669,804 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5839:Mgam
|
UTSW |
6 |
40,740,064 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R5845:Mgam
|
UTSW |
6 |
40,675,323 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R5847:Mgam
|
UTSW |
6 |
40,684,055 (GRCm38) |
missense |
probably benign |
0.42 |
|
R5891:Mgam
|
UTSW |
6 |
40,744,348 (GRCm38) |
missense |
probably benign |
|
|
R6158:Mgam
|
UTSW |
6 |
40,757,714 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6193:Mgam
|
UTSW |
6 |
40,747,920 (GRCm38) |
nonsense |
probably null |
|
|
R6423:Mgam
|
UTSW |
6 |
40,677,045 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R6706:Mgam
|
UTSW |
6 |
40,744,786 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6813:Mgam
|
UTSW |
6 |
40,750,165 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6863:Mgam
|
UTSW |
6 |
40,729,009 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6906:Mgam
|
UTSW |
6 |
40,747,919 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7091:Mgam
|
UTSW |
6 |
40,768,276 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R7099:Mgam
|
UTSW |
6 |
40,661,716 (GRCm38) |
missense |
probably benign |
0.09 |
|
R7282:Mgam
|
UTSW |
6 |
40,763,111 (GRCm38) |
missense |
probably benign |
|
|
R7282:Mgam
|
UTSW |
6 |
40,656,512 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R7354:Mgam
|
UTSW |
6 |
40,744,798 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7374:Mgam
|
UTSW |
6 |
40,757,439 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R7399:Mgam
|
UTSW |
6 |
40,666,854 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7406:Mgam
|
UTSW |
6 |
40,663,525 (GRCm38) |
missense |
probably benign |
0.13 |
|
R7446:Mgam
|
UTSW |
6 |
40,746,332 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7466:Mgam
|
UTSW |
6 |
40,744,789 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7525:Mgam
|
UTSW |
6 |
40,766,020 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7530:Mgam
|
UTSW |
6 |
40,709,218 (GRCm38) |
splice site |
probably null |
|
|
R7570:Mgam
|
UTSW |
6 |
40,746,433 (GRCm38) |
missense |
probably benign |
0.16 |
|
R7669:Mgam
|
UTSW |
6 |
40,659,010 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7679:Mgam
|
UTSW |
6 |
40,643,046 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7746:Mgam
|
UTSW |
6 |
40,668,193 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7859:Mgam
|
UTSW |
6 |
40,740,179 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R7925:Mgam
|
UTSW |
6 |
40,759,051 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8206:Mgam
|
UTSW |
6 |
40,680,235 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8244:Mgam
|
UTSW |
6 |
40,750,586 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8309:Mgam
|
UTSW |
6 |
40,745,177 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R8472:Mgam
|
UTSW |
6 |
40,694,526 (GRCm38) |
splice site |
probably null |
|
|
R8758:Mgam
|
UTSW |
6 |
40,729,043 (GRCm38) |
missense |
probably benign |
0.41 |
|
R8777:Mgam
|
UTSW |
6 |
40,655,251 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8777-TAIL:Mgam
|
UTSW |
6 |
40,655,251 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8783:Mgam
|
UTSW |
6 |
40,656,489 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8939:Mgam
|
UTSW |
6 |
40,763,203 (GRCm38) |
critical splice donor site |
probably null |
|
|
R8968:Mgam
|
UTSW |
6 |
40,757,811 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R8987:Mgam
|
UTSW |
6 |
40,729,636 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9055:Mgam
|
UTSW |
6 |
40,714,729 (GRCm38) |
intron |
probably benign |
|
|
R9171:Mgam
|
UTSW |
6 |
40,768,212 (GRCm38) |
missense |
possibly damaging |
0.76 |
|
R9252:Mgam
|
UTSW |
6 |
40,729,643 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9258:Mgam
|
UTSW |
6 |
40,680,187 (GRCm38) |
missense |
probably benign |
|
|
R9262:Mgam
|
UTSW |
6 |
40,746,488 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9287:Mgam
|
UTSW |
6 |
40,728,971 (GRCm38) |
intron |
probably benign |
|
|
R9521:Mgam
|
UTSW |
6 |
40,745,184 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9589:Mgam
|
UTSW |
6 |
40,750,585 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9658:Mgam
|
UTSW |
6 |
40,744,377 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R9784:Mgam
|
UTSW |
6 |
40,759,090 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF011:Mgam
|
UTSW |
6 |
40,757,436 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF020:Mgam
|
UTSW |
6 |
40,685,309 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF023:Mgam
|
UTSW |
6 |
40,680,708 (GRCm38) |
missense |
probably benign |
|
|
X0021:Mgam
|
UTSW |
6 |
40,659,047 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1088:Mgam
|
UTSW |
6 |
40,643,060 (GRCm38) |
missense |
probably benign |
0.01 |
|
Z1176:Mgam
|
UTSW |
6 |
40,729,066 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Mgam
|
UTSW |
6 |
40,677,644 (GRCm38) |
critical splice donor site |
probably null |
|
|
Z1177:Mgam
|
UTSW |
6 |
40,740,071 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAGTGGTCCAGTAATTTCTGC -3'
(R):5'- CTGGGGAACTGGTCATGTAG -3'
Sequencing Primer
(F):5'- CTGCATGGATGTAGAACTGCTGTAC -3'
(R):5'- AACTGGTCATGTAGTTGGAGAATG -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation