Incidental Mutation 'R1869:Ranbp2'
| ID |
210563 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ranbp2
|
| Ensembl Gene |
ENSMUSG00000003226 |
| Gene Name |
RAN binding protein 2 |
| Synonyms |
A430087B05Rik |
| MMRRC Submission |
039891-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1869 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
58282674-58329977 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 58328383 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 2800
(I2800V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000003310
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000003310]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000003310
AA Change: I2800V
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000003310
Gene: ENSMUSG00000003226
AA Change: I2800V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TPR_1
|
60 |
93 |
1.8e-7 |
PFAM |
|
Pfam:TPR_8
|
60 |
93 |
8.9e-6 |
PFAM |
|
low complexity region
|
235 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
778 |
801 |
N/A |
INTRINSIC |
|
coiled coil region
|
808 |
832 |
N/A |
INTRINSIC |
|
RanBD
|
1166 |
1295 |
6.47e-64 |
SMART |
|
ZnF_RBZ
|
1348 |
1372 |
5.49e-2 |
SMART |
|
ZnF_RBZ
|
1412 |
1436 |
3.06e-6 |
SMART |
|
ZnF_RBZ
|
1471 |
1495 |
4.16e-8 |
SMART |
|
ZnF_RBZ
|
1500 |
1524 |
4.57e-5 |
SMART |
|
ZnF_RBZ
|
1560 |
1584 |
3.52e-6 |
SMART |
|
ZnF_RBZ
|
1619 |
1643 |
1.35e-7 |
SMART |
|
RanBD
|
1850 |
1979 |
2.84e-60 |
SMART |
|
low complexity region
|
2034 |
2048 |
N/A |
INTRINSIC |
|
low complexity region
|
2069 |
2090 |
N/A |
INTRINSIC |
|
low complexity region
|
2106 |
2121 |
N/A |
INTRINSIC |
|
RanBD
|
2147 |
2276 |
4.96e-83 |
SMART |
|
low complexity region
|
2310 |
2317 |
N/A |
INTRINSIC |
|
low complexity region
|
2328 |
2342 |
N/A |
INTRINSIC |
|
Pfam:IR1-M
|
2468 |
2530 |
2.5e-27 |
PFAM |
|
Pfam:IR1-M
|
2544 |
2604 |
7e-30 |
PFAM |
|
low complexity region
|
2673 |
2684 |
N/A |
INTRINSIC |
|
low complexity region
|
2722 |
2732 |
N/A |
INTRINSIC |
|
RanBD
|
2741 |
2869 |
5e-79 |
SMART |
|
Pfam:Pro_isomerase
|
2896 |
3052 |
4.5e-45 |
PFAM |
|
| Meta Mutation Damage Score |
0.1700 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.4%
- 20x: 92.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a gene trap allele display embryonic lethality. Heterozygous mice on some backgrounds display reduced ATP levels in the CNS, decreased glucose clearance, decreased weight gain on a high fat diet, and reduced scotopic responses. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 127 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921536K21Rik |
A |
G |
11: 3,840,067 (GRCm39) |
L110P |
probably damaging |
Het |
| 6030458C11Rik |
T |
C |
15: 12,817,993 (GRCm39) |
D168G |
probably damaging |
Het |
| Abca13 |
A |
T |
11: 9,242,134 (GRCm39) |
E1332D |
probably benign |
Het |
| Abhd11 |
A |
G |
5: 135,040,471 (GRCm39) |
Y168C |
probably damaging |
Het |
| Actr5 |
A |
C |
2: 158,480,643 (GRCm39) |
T554P |
probably damaging |
Het |
| Adam34l |
A |
T |
8: 44,078,132 (GRCm39) |
Y697* |
probably null |
Het |
| Adamts16 |
A |
G |
13: 70,883,866 (GRCm39) |
L1103P |
probably damaging |
Het |
| Adgrb3 |
A |
T |
1: 25,865,519 (GRCm39) |
I108K |
possibly damaging |
Het |
| Agbl4 |
T |
A |
4: 111,423,826 (GRCm39) |
M284K |
possibly damaging |
Het |
| Aoc3 |
T |
A |
11: 101,222,293 (GRCm39) |
Y176* |
probably null |
Het |
| Aox1 |
A |
G |
1: 58,115,262 (GRCm39) |
E749G |
probably damaging |
Het |
| Ap4b1 |
T |
A |
3: 103,728,184 (GRCm39) |
Y399* |
probably null |
Het |
| Arhgef5 |
A |
T |
6: 43,265,616 (GRCm39) |
I1553F |
probably damaging |
Het |
| Bag6 |
T |
C |
17: 35,361,802 (GRCm39) |
V541A |
probably benign |
Het |
| Bdp1 |
A |
C |
13: 100,178,709 (GRCm39) |
V1879G |
probably damaging |
Het |
| Bod1l |
G |
A |
5: 41,991,018 (GRCm39) |
S179F |
possibly damaging |
Het |
| Bsnd |
C |
T |
4: 106,343,833 (GRCm39) |
V158I |
probably benign |
Het |
| Cachd1 |
C |
A |
4: 100,840,587 (GRCm39) |
H880N |
probably damaging |
Het |
| Ccdc27 |
T |
C |
4: 154,111,220 (GRCm39) |
|
probably null |
Het |
| Cd74 |
C |
T |
18: 60,943,484 (GRCm39) |
P190S |
probably benign |
Het |
| Cep68 |
A |
T |
11: 20,190,217 (GRCm39) |
L265Q |
probably damaging |
Het |
| Cfap70 |
G |
A |
14: 20,458,678 (GRCm39) |
Q772* |
probably null |
Het |
| CK137956 |
T |
A |
4: 127,864,327 (GRCm39) |
S101C |
possibly damaging |
Het |
| Clca3a2 |
G |
A |
3: 144,512,164 (GRCm39) |
T524M |
probably benign |
Het |
| Cxcr6 |
T |
C |
9: 123,639,022 (GRCm39) |
S15P |
probably benign |
Het |
| Cyfip2 |
T |
A |
11: 46,114,995 (GRCm39) |
Y904F |
probably benign |
Het |
| D130040H23Rik |
T |
A |
8: 69,755,354 (GRCm39) |
I253N |
probably benign |
Het |
| Ddx56 |
C |
T |
11: 6,213,993 (GRCm39) |
V389M |
possibly damaging |
Het |
| Dmp1 |
A |
T |
5: 104,359,942 (GRCm39) |
D206V |
probably damaging |
Het |
| Dnah17 |
A |
T |
11: 117,938,015 (GRCm39) |
C3350* |
probably null |
Het |
| Dst |
A |
T |
1: 34,291,913 (GRCm39) |
S877C |
probably damaging |
Het |
| Ermp1 |
A |
G |
19: 29,623,415 (GRCm39) |
S192P |
possibly damaging |
Het |
| F13b |
G |
A |
1: 139,438,672 (GRCm39) |
D359N |
probably benign |
Het |
| Fam171a1 |
A |
T |
2: 3,227,189 (GRCm39) |
Q769L |
possibly damaging |
Het |
| Fap |
T |
C |
2: 62,359,071 (GRCm39) |
R411G |
probably damaging |
Het |
| Fbn1 |
A |
G |
2: 125,193,947 (GRCm39) |
V1340A |
probably benign |
Het |
| Fbxw19 |
T |
C |
9: 109,311,100 (GRCm39) |
I370V |
probably benign |
Het |
| Foxi1 |
A |
T |
11: 34,157,937 (GRCm39) |
N29K |
possibly damaging |
Het |
| Frem2 |
T |
G |
3: 53,442,617 (GRCm39) |
D2640A |
probably benign |
Het |
| Fzd4 |
T |
C |
7: 89,056,454 (GRCm39) |
V167A |
probably benign |
Het |
| Galnt3 |
T |
C |
2: 65,928,123 (GRCm39) |
I258V |
possibly damaging |
Het |
| Galr2 |
T |
C |
11: 116,174,069 (GRCm39) |
V233A |
possibly damaging |
Het |
| Gldc |
G |
T |
19: 30,116,732 (GRCm39) |
Q407K |
probably benign |
Het |
| Gmcl1 |
T |
C |
6: 86,674,498 (GRCm39) |
D460G |
probably benign |
Het |
| Gpr89 |
A |
G |
3: 96,782,975 (GRCm39) |
I325T |
probably benign |
Het |
| Grap |
T |
A |
11: 61,555,015 (GRCm39) |
Y61N |
possibly damaging |
Het |
| Hbs1l |
G |
T |
10: 21,234,305 (GRCm39) |
|
probably null |
Het |
| Hexb |
T |
A |
13: 97,327,767 (GRCm39) |
E134D |
probably benign |
Het |
| Hydin |
T |
A |
8: 111,227,337 (GRCm39) |
V1507D |
possibly damaging |
Het |
| Igkv8-16 |
C |
A |
6: 70,363,971 (GRCm39) |
G17V |
probably benign |
Het |
| Kdm4a |
T |
A |
4: 117,996,068 (GRCm39) |
Q987L |
probably null |
Het |
| Krt76 |
A |
G |
15: 101,797,922 (GRCm39) |
|
probably null |
Het |
| Lap3 |
T |
C |
5: 45,660,729 (GRCm39) |
S238P |
probably benign |
Het |
| Letm2 |
T |
C |
8: 26,071,729 (GRCm39) |
D391G |
probably damaging |
Het |
| Lipn |
A |
G |
19: 34,058,139 (GRCm39) |
T287A |
possibly damaging |
Het |
| Macf1 |
T |
C |
4: 123,244,921 (GRCm39) |
S466G |
probably damaging |
Het |
| Map3k5 |
C |
A |
10: 20,007,855 (GRCm39) |
S1220* |
probably null |
Het |
| Map4 |
T |
A |
9: 109,897,996 (GRCm39) |
S754R |
possibly damaging |
Het |
| Map4 |
T |
C |
9: 109,864,032 (GRCm39) |
V419A |
probably benign |
Het |
| Mroh9 |
A |
G |
1: 162,854,082 (GRCm39) |
S773P |
probably damaging |
Het |
| Mtus1 |
A |
C |
8: 41,529,267 (GRCm39) |
|
probably null |
Het |
| Muc1 |
C |
T |
3: 89,139,117 (GRCm39) |
P533S |
probably damaging |
Het |
| Muc13 |
A |
T |
16: 33,624,970 (GRCm39) |
I282F |
probably damaging |
Het |
| Mucl3 |
A |
G |
17: 35,949,305 (GRCm39) |
L98P |
possibly damaging |
Het |
| Myh14 |
T |
A |
7: 44,261,067 (GRCm39) |
Q1816L |
possibly damaging |
Het |
| Nalcn |
A |
C |
14: 123,831,965 (GRCm39) |
V103G |
possibly damaging |
Het |
| Nlrp9c |
G |
A |
7: 26,084,245 (GRCm39) |
Q445* |
probably null |
Het |
| Olfml2b |
A |
G |
1: 170,496,812 (GRCm39) |
D481G |
probably damaging |
Het |
| Or13g1 |
T |
A |
7: 85,955,875 (GRCm39) |
I149F |
possibly damaging |
Het |
| Or2ag19 |
T |
G |
7: 106,444,301 (GRCm39) |
I161S |
probably benign |
Het |
| Or5g23 |
A |
G |
2: 85,438,844 (GRCm39) |
S137P |
probably benign |
Het |
| Or8b37 |
T |
A |
9: 37,959,498 (GRCm39) |
|
probably null |
Het |
| Or8k3b |
T |
A |
2: 86,520,735 (GRCm39) |
I195F |
probably damaging |
Het |
| Pcdhb2 |
A |
T |
18: 37,430,408 (GRCm39) |
|
probably null |
Het |
| Pcdhb22 |
A |
C |
18: 37,652,200 (GRCm39) |
T223P |
probably damaging |
Het |
| Pcdhga1 |
T |
A |
18: 37,973,143 (GRCm39) |
N907K |
probably damaging |
Het |
| Pcnt |
T |
C |
10: 76,215,740 (GRCm39) |
E2347G |
probably null |
Het |
| Phax |
T |
A |
18: 56,706,176 (GRCm39) |
V22D |
probably benign |
Het |
| Pik3ca |
T |
C |
3: 32,504,499 (GRCm39) |
F667S |
probably damaging |
Het |
| Pkd1 |
T |
C |
17: 24,813,905 (GRCm39) |
F4123S |
probably damaging |
Het |
| Pkhd1 |
A |
G |
1: 20,685,491 (GRCm39) |
|
probably null |
Het |
| Plcb1 |
G |
A |
2: 135,152,934 (GRCm39) |
R368K |
probably benign |
Het |
| Prrc2a |
G |
T |
17: 35,372,284 (GRCm39) |
R1739S |
possibly damaging |
Het |
| Psg23 |
A |
T |
7: 18,348,543 (GRCm39) |
M88K |
probably benign |
Het |
| Pstk |
T |
A |
7: 130,989,526 (GRCm39) |
Y354N |
probably damaging |
Het |
| Rab39 |
A |
G |
9: 53,617,231 (GRCm39) |
I62T |
possibly damaging |
Het |
| Rasgrp1 |
T |
C |
2: 117,120,828 (GRCm39) |
Y431C |
probably damaging |
Het |
| Rest |
T |
A |
5: 77,416,209 (GRCm39) |
V141E |
possibly damaging |
Het |
| Rnf167 |
T |
A |
11: 70,540,965 (GRCm39) |
I197N |
possibly damaging |
Het |
| Rtn1 |
A |
G |
12: 72,354,942 (GRCm39) |
S335P |
probably damaging |
Het |
| Ryr2 |
G |
T |
13: 11,676,961 (GRCm39) |
R3297S |
probably damaging |
Het |
| S1pr3 |
A |
C |
13: 51,573,952 (GRCm39) |
K378Q |
probably benign |
Het |
| Scgb1b24 |
T |
C |
7: 33,443,469 (GRCm39) |
Y43H |
probably damaging |
Het |
| Sh3rf3 |
T |
A |
10: 58,919,335 (GRCm39) |
M484K |
probably damaging |
Het |
| Shank1 |
A |
T |
7: 43,991,539 (GRCm39) |
R69* |
probably null |
Het |
| Siglecf |
A |
G |
7: 43,004,967 (GRCm39) |
N399S |
probably benign |
Het |
| Slc1a7 |
A |
G |
4: 107,865,561 (GRCm39) |
T350A |
probably damaging |
Het |
| Slc25a54 |
T |
A |
3: 108,987,932 (GRCm39) |
Y24* |
probably null |
Het |
| Slk |
T |
C |
19: 47,613,891 (GRCm39) |
F916L |
probably damaging |
Het |
| Snap91 |
T |
A |
9: 86,672,194 (GRCm39) |
|
probably null |
Het |
| Snrpb2 |
A |
T |
2: 142,907,106 (GRCm39) |
R25S |
possibly damaging |
Het |
| Specc1l |
T |
C |
10: 75,097,659 (GRCm39) |
Y811H |
probably damaging |
Het |
| Sprr2h |
A |
G |
3: 92,293,925 (GRCm39) |
|
probably benign |
Het |
| Sult2a5 |
A |
T |
7: 13,358,045 (GRCm39) |
I26F |
probably benign |
Het |
| Syt13 |
C |
T |
2: 92,776,448 (GRCm39) |
T245I |
possibly damaging |
Het |
| Tecrl |
T |
A |
5: 83,502,706 (GRCm39) |
T33S |
probably benign |
Het |
| Telo2 |
T |
A |
17: 25,333,968 (GRCm39) |
D93V |
probably benign |
Het |
| Tet2 |
A |
T |
3: 133,187,202 (GRCm39) |
|
probably null |
Het |
| Tgm7 |
A |
T |
2: 120,931,570 (GRCm39) |
C198S |
probably damaging |
Het |
| Ticrr |
T |
C |
7: 79,328,883 (GRCm39) |
F674S |
probably damaging |
Het |
| Tmem129 |
C |
A |
5: 33,811,843 (GRCm39) |
C31F |
probably damaging |
Het |
| Tmem132a |
T |
A |
19: 10,836,052 (GRCm39) |
D826V |
possibly damaging |
Het |
| Tpd52 |
T |
C |
3: 9,018,862 (GRCm39) |
|
probably null |
Het |
| Trub2 |
A |
G |
2: 29,667,678 (GRCm39) |
S321P |
probably benign |
Het |
| Ttc29 |
A |
G |
8: 79,009,014 (GRCm39) |
T295A |
probably benign |
Het |
| Tubb1 |
G |
A |
2: 174,298,482 (GRCm39) |
S89N |
probably benign |
Het |
| Tut4 |
T |
A |
4: 108,386,497 (GRCm39) |
F1122L |
probably damaging |
Het |
| Ubap2 |
C |
A |
4: 41,233,617 (GRCm39) |
G91V |
probably damaging |
Het |
| Ugt2b35 |
A |
G |
5: 87,149,147 (GRCm39) |
N133D |
probably damaging |
Het |
| Usp34 |
A |
G |
11: 23,314,479 (GRCm39) |
H807R |
probably benign |
Het |
| Vmn1r220 |
A |
C |
13: 23,368,457 (GRCm39) |
C80G |
probably damaging |
Het |
| Vmn1r79 |
A |
G |
7: 11,910,574 (GRCm39) |
E152G |
probably benign |
Het |
| Vmn2r28 |
T |
C |
7: 5,489,345 (GRCm39) |
Y498C |
probably benign |
Het |
| Wif1 |
A |
G |
10: 120,920,824 (GRCm39) |
I215M |
probably benign |
Het |
| Wnk1 |
T |
C |
6: 119,928,050 (GRCm39) |
T1134A |
probably damaging |
Het |
| Zfp90 |
A |
G |
8: 107,145,755 (GRCm39) |
H29R |
probably benign |
Het |
| Zfp972 |
A |
G |
2: 177,563,480 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Ranbp2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00229:Ranbp2
|
APN |
10 |
58,313,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00336:Ranbp2
|
APN |
10 |
58,287,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00486:Ranbp2
|
APN |
10 |
58,313,434 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL00800:Ranbp2
|
APN |
10 |
58,326,526 (GRCm39) |
missense |
probably benign |
|
|
IGL00834:Ranbp2
|
APN |
10 |
58,289,145 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL00852:Ranbp2
|
APN |
10 |
58,313,723 (GRCm39) |
missense |
probably benign |
|
|
IGL00984:Ranbp2
|
APN |
10 |
58,297,786 (GRCm39) |
nonsense |
probably null |
|
|
IGL01299:Ranbp2
|
APN |
10 |
58,328,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01325:Ranbp2
|
APN |
10 |
58,312,120 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01444:Ranbp2
|
APN |
10 |
58,311,122 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL01545:Ranbp2
|
APN |
10 |
58,314,703 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL01619:Ranbp2
|
APN |
10 |
58,299,900 (GRCm39) |
splice site |
probably null |
|
|
IGL01782:Ranbp2
|
APN |
10 |
58,314,131 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02020:Ranbp2
|
APN |
10 |
58,315,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02096:Ranbp2
|
APN |
10 |
58,297,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02182:Ranbp2
|
APN |
10 |
58,321,582 (GRCm39) |
nonsense |
probably null |
|
|
IGL02211:Ranbp2
|
APN |
10 |
58,314,064 (GRCm39) |
missense |
probably benign |
|
|
IGL02249:Ranbp2
|
APN |
10 |
58,315,900 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02268:Ranbp2
|
APN |
10 |
58,329,475 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02421:Ranbp2
|
APN |
10 |
58,316,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03080:Ranbp2
|
APN |
10 |
58,312,613 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03119:Ranbp2
|
APN |
10 |
58,287,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03206:Ranbp2
|
APN |
10 |
58,301,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03237:Ranbp2
|
APN |
10 |
58,328,783 (GRCm39) |
missense |
probably damaging |
0.98 |
|
En_passant
|
UTSW |
10 |
58,287,839 (GRCm39) |
missense |
probably damaging |
1.00 |
|
red_river
|
UTSW |
10 |
58,301,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02799:Ranbp2
|
UTSW |
10 |
58,316,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0058:Ranbp2
|
UTSW |
10 |
58,316,353 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0058:Ranbp2
|
UTSW |
10 |
58,316,353 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0145:Ranbp2
|
UTSW |
10 |
58,315,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0309:Ranbp2
|
UTSW |
10 |
58,315,690 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0375:Ranbp2
|
UTSW |
10 |
58,313,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0441:Ranbp2
|
UTSW |
10 |
58,321,590 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0494:Ranbp2
|
UTSW |
10 |
58,303,254 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0542:Ranbp2
|
UTSW |
10 |
58,314,236 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0565:Ranbp2
|
UTSW |
10 |
58,312,158 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0608:Ranbp2
|
UTSW |
10 |
58,329,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0661:Ranbp2
|
UTSW |
10 |
58,314,555 (GRCm39) |
missense |
probably benign |
|
|
R0670:Ranbp2
|
UTSW |
10 |
58,316,520 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0760:Ranbp2
|
UTSW |
10 |
58,312,613 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0811:Ranbp2
|
UTSW |
10 |
58,301,351 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0812:Ranbp2
|
UTSW |
10 |
58,301,351 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1180:Ranbp2
|
UTSW |
10 |
58,301,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1196:Ranbp2
|
UTSW |
10 |
58,312,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1216:Ranbp2
|
UTSW |
10 |
58,319,034 (GRCm39) |
splice site |
probably benign |
|
|
R1374:Ranbp2
|
UTSW |
10 |
58,321,715 (GRCm39) |
splice site |
probably benign |
|
|
R1541:Ranbp2
|
UTSW |
10 |
58,318,916 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1589:Ranbp2
|
UTSW |
10 |
58,299,808 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1711:Ranbp2
|
UTSW |
10 |
58,296,341 (GRCm39) |
missense |
probably benign |
0.11 |
|
R1761:Ranbp2
|
UTSW |
10 |
58,321,563 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1831:Ranbp2
|
UTSW |
10 |
58,315,044 (GRCm39) |
nonsense |
probably null |
|
|
R1840:Ranbp2
|
UTSW |
10 |
58,314,588 (GRCm39) |
missense |
probably benign |
0.41 |
|
R1871:Ranbp2
|
UTSW |
10 |
58,328,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1892:Ranbp2
|
UTSW |
10 |
58,299,921 (GRCm39) |
missense |
probably benign |
0.36 |
|
R2270:Ranbp2
|
UTSW |
10 |
58,291,749 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2363:Ranbp2
|
UTSW |
10 |
58,314,758 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R3844:Ranbp2
|
UTSW |
10 |
58,313,717 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3937:Ranbp2
|
UTSW |
10 |
58,312,294 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3938:Ranbp2
|
UTSW |
10 |
58,312,294 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4025:Ranbp2
|
UTSW |
10 |
58,316,378 (GRCm39) |
missense |
probably benign |
0.23 |
|
R4183:Ranbp2
|
UTSW |
10 |
58,301,488 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4247:Ranbp2
|
UTSW |
10 |
58,314,686 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4334:Ranbp2
|
UTSW |
10 |
58,299,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4656:Ranbp2
|
UTSW |
10 |
58,289,244 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4746:Ranbp2
|
UTSW |
10 |
58,328,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4852:Ranbp2
|
UTSW |
10 |
58,312,878 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4863:Ranbp2
|
UTSW |
10 |
58,328,243 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5011:Ranbp2
|
UTSW |
10 |
58,297,717 (GRCm39) |
missense |
probably benign |
0.36 |
|
R5014:Ranbp2
|
UTSW |
10 |
58,299,942 (GRCm39) |
missense |
probably benign |
0.40 |
|
R5145:Ranbp2
|
UTSW |
10 |
58,315,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5178:Ranbp2
|
UTSW |
10 |
58,312,607 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5199:Ranbp2
|
UTSW |
10 |
58,300,265 (GRCm39) |
missense |
probably benign |
|
|
R5294:Ranbp2
|
UTSW |
10 |
58,314,490 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5508:Ranbp2
|
UTSW |
10 |
58,315,827 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5511:Ranbp2
|
UTSW |
10 |
58,329,561 (GRCm39) |
missense |
probably benign |
0.29 |
|
R5575:Ranbp2
|
UTSW |
10 |
58,328,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5617:Ranbp2
|
UTSW |
10 |
58,301,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5630:Ranbp2
|
UTSW |
10 |
58,314,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5733:Ranbp2
|
UTSW |
10 |
58,321,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5751:Ranbp2
|
UTSW |
10 |
58,300,086 (GRCm39) |
splice site |
probably null |
|
|
R5767:Ranbp2
|
UTSW |
10 |
58,312,647 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6122:Ranbp2
|
UTSW |
10 |
58,301,351 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6147:Ranbp2
|
UTSW |
10 |
58,315,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6286:Ranbp2
|
UTSW |
10 |
58,315,394 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6344:Ranbp2
|
UTSW |
10 |
58,319,708 (GRCm39) |
splice site |
probably null |
|
|
R6452:Ranbp2
|
UTSW |
10 |
58,313,979 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6487:Ranbp2
|
UTSW |
10 |
58,321,563 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6620:Ranbp2
|
UTSW |
10 |
58,291,629 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6759:Ranbp2
|
UTSW |
10 |
58,293,559 (GRCm39) |
nonsense |
probably null |
|
|
R7010:Ranbp2
|
UTSW |
10 |
58,290,393 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7071:Ranbp2
|
UTSW |
10 |
58,328,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7083:Ranbp2
|
UTSW |
10 |
58,315,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7088:Ranbp2
|
UTSW |
10 |
58,299,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7102:Ranbp2
|
UTSW |
10 |
58,299,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7194:Ranbp2
|
UTSW |
10 |
58,312,591 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7217:Ranbp2
|
UTSW |
10 |
58,287,839 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7318:Ranbp2
|
UTSW |
10 |
58,318,909 (GRCm39) |
nonsense |
probably null |
|
|
R7341:Ranbp2
|
UTSW |
10 |
58,321,619 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7398:Ranbp2
|
UTSW |
10 |
58,303,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7424:Ranbp2
|
UTSW |
10 |
58,315,016 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7727:Ranbp2
|
UTSW |
10 |
58,291,260 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7795:Ranbp2
|
UTSW |
10 |
58,319,729 (GRCm39) |
nonsense |
probably null |
|
|
R7812:Ranbp2
|
UTSW |
10 |
58,303,224 (GRCm39) |
missense |
probably benign |
|
|
R7845:Ranbp2
|
UTSW |
10 |
58,282,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7875:Ranbp2
|
UTSW |
10 |
58,314,277 (GRCm39) |
nonsense |
probably null |
|
|
R7934:Ranbp2
|
UTSW |
10 |
58,312,297 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8022:Ranbp2
|
UTSW |
10 |
58,321,683 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8050:Ranbp2
|
UTSW |
10 |
58,315,441 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8100:Ranbp2
|
UTSW |
10 |
58,326,470 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8194:Ranbp2
|
UTSW |
10 |
58,291,747 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8258:Ranbp2
|
UTSW |
10 |
58,291,755 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8259:Ranbp2
|
UTSW |
10 |
58,291,755 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8461:Ranbp2
|
UTSW |
10 |
58,312,216 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8722:Ranbp2
|
UTSW |
10 |
58,312,049 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8755:Ranbp2
|
UTSW |
10 |
58,300,969 (GRCm39) |
nonsense |
probably null |
|
|
R8794:Ranbp2
|
UTSW |
10 |
58,328,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8879:Ranbp2
|
UTSW |
10 |
58,313,711 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8994:Ranbp2
|
UTSW |
10 |
58,315,891 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9023:Ranbp2
|
UTSW |
10 |
58,315,343 (GRCm39) |
nonsense |
probably null |
|
|
R9124:Ranbp2
|
UTSW |
10 |
58,328,719 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9133:Ranbp2
|
UTSW |
10 |
58,313,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9145:Ranbp2
|
UTSW |
10 |
58,291,736 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9190:Ranbp2
|
UTSW |
10 |
58,313,117 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9369:Ranbp2
|
UTSW |
10 |
58,316,486 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9394:Ranbp2
|
UTSW |
10 |
58,291,698 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9642:Ranbp2
|
UTSW |
10 |
58,318,907 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9673:Ranbp2
|
UTSW |
10 |
58,300,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0018:Ranbp2
|
UTSW |
10 |
58,314,406 (GRCm39) |
missense |
probably benign |
0.13 |
|
X0022:Ranbp2
|
UTSW |
10 |
58,300,977 (GRCm39) |
missense |
probably benign |
0.33 |
|
Z1088:Ranbp2
|
UTSW |
10 |
58,328,715 (GRCm39) |
missense |
probably benign |
0.35 |
|
Z1088:Ranbp2
|
UTSW |
10 |
58,313,805 (GRCm39) |
frame shift |
probably null |
|
|
Z1088:Ranbp2
|
UTSW |
10 |
58,313,794 (GRCm39) |
frame shift |
probably null |
|
|
Z1176:Ranbp2
|
UTSW |
10 |
58,297,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Ranbp2
|
UTSW |
10 |
58,329,713 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GTAAAACCTGTTGGCACTGG -3'
(R):5'- CCATCTGTTATAAGGAGTGGAGG -3'
Sequencing Primer
(F):5'- CACTGGTTAATGGATTTGTCATGAC -3'
(R):5'- AAACTTACATTCAAAGCATGTGTATG -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation