Incidental Mutation 'R0121:Zfp944'
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ID21058
Institutional Source Beutler Lab
Gene Symbol Zfp944
Ensembl Gene ENSMUSG00000033972
Gene Namezinc finger protein 944
Synonyms6330416L07Rik
MMRRC Submission 038406-MU
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.516) question?
Stock #R0121 (G1)
Quality Score209
Status Validated (trace)
Chromosome17
Chromosomal Location22337989-22361400 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 22339268 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Serine at position 333 (T333S)
Ref Sequence ENSEMBL: ENSMUSP00000111197 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115535]
Predicted Effect possibly damaging
Transcript: ENSMUST00000115535
AA Change: T333S

PolyPhen 2 Score 0.692 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000111197
Gene: ENSMUSG00000033972
AA Change: T333S

DomainStartEndE-ValueType
KRAB 13 76 2.08e-21 SMART
ZnF_C2H2 183 205 1.01e-1 SMART
ZnF_C2H2 211 233 1.07e0 SMART
ZnF_C2H2 239 261 1.95e-3 SMART
ZnF_C2H2 267 289 1.22e-4 SMART
ZnF_C2H2 295 317 2.24e-3 SMART
ZnF_C2H2 323 345 1.82e-3 SMART
ZnF_C2H2 351 373 5.99e-4 SMART
ZnF_C2H2 379 401 4.79e-3 SMART
ZnF_C2H2 407 429 2.99e-4 SMART
ZnF_C2H2 435 457 4.17e-3 SMART
ZnF_C2H2 463 485 1.36e-2 SMART
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.5%
  • 20x: 89.8%
Validation Efficiency 100% (63/63)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,259,786 probably null Het
Adgra3 T C 5: 50,025,786 probably benign Het
Anxa7 A T 14: 20,460,159 L386M probably damaging Het
Ap2b1 A G 11: 83,321,967 M58V possibly damaging Het
Arfip2 A G 7: 105,636,371 L224P probably damaging Het
Arhgap20 A G 9: 51,838,951 N373S possibly damaging Het
Asph T C 4: 9,635,918 D73G probably damaging Het
Atp1a2 T A 1: 172,289,342 E236V probably damaging Het
Atp2a1 A G 7: 126,457,944 S170P probably damaging Het
Atp4a C G 7: 30,720,101 R659G probably benign Het
B4galnt3 C T 6: 120,215,038 R578H probably benign Het
Ccdc178 C A 18: 21,845,024 probably null Het
Ccnh T A 13: 85,206,193 M252K probably damaging Het
Clec4b2 A G 6: 123,204,172 D172G probably benign Het
Col1a1 A G 11: 94,938,069 E79G unknown Het
Csf3r A G 4: 126,029,849 N51D probably benign Het
Cul7 C T 17: 46,663,373 L1489F probably damaging Het
Cyp2b13 G A 7: 26,086,585 C309Y probably benign Het
Dync2h1 A T 9: 7,001,327 probably benign Het
Edn1 A G 13: 42,305,265 T135A probably benign Het
Ephb2 A G 4: 136,771,057 I237T probably damaging Het
Fam111a T A 19: 12,584,080 F12L probably benign Het
Foxi2 C A 7: 135,411,911 A290E probably benign Het
Gabra6 A G 11: 42,314,971 S353P probably benign Het
Gm4847 T C 1: 166,642,288 D72G probably damaging Het
Grhl3 A G 4: 135,552,549 I398T probably damaging Het
Gtdc1 T C 2: 44,565,538 probably benign Het
Kel A C 6: 41,702,064 probably benign Het
L3mbtl3 C T 10: 26,313,870 D499N unknown Het
Lama1 T A 17: 67,798,513 probably benign Het
Mamdc2 T A 19: 23,310,859 E605V probably benign Het
Nolc1 G A 19: 46,081,378 probably benign Het
Nudt12 A T 17: 59,007,639 S317T possibly damaging Het
Olfr1085 A G 2: 86,657,819 V213A probably benign Het
Olfr1153 A G 2: 87,897,090 K297R possibly damaging Het
Olfr1277 A T 2: 111,270,314 C18S probably benign Het
Olfr937 T A 9: 39,059,760 K302M probably damaging Het
Optn C T 2: 5,024,115 G526R probably damaging Het
Pbld1 C T 10: 63,071,503 probably benign Het
Prl8a9 T G 13: 27,560,606 N84T probably benign Het
Psph T A 5: 129,791,570 probably benign Het
Sbf2 A G 7: 110,489,219 probably null Het
Senp6 A G 9: 80,116,670 D405G probably benign Het
Serpinb1a T A 13: 32,848,771 probably benign Het
Slc2a9 T C 5: 38,398,743 I287V probably benign Het
Sptbn2 T C 19: 4,745,293 F1593S probably damaging Het
Tcf21 T C 10: 22,819,807 T33A probably benign Het
Tdrd3 A T 14: 87,539,479 Q727L probably damaging Het
Tecpr1 C T 5: 144,210,199 E450K probably benign Het
Tenm3 G A 8: 48,342,659 T532I probably damaging Het
Tg A T 15: 66,740,781 Q396L probably benign Het
Tmtc3 A G 10: 100,458,908 probably benign Het
Twnk T C 19: 45,009,265 probably benign Het
Ubac1 A G 2: 26,008,859 probably null Het
Ubn2 T C 6: 38,452,858 probably benign Het
Other mutations in Zfp944
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00595:Zfp944 APN 17 22339205 missense probably benign 0.10
IGL00917:Zfp944 APN 17 22339784 missense probably benign 0.00
IGL01093:Zfp944 APN 17 22343634 splice site probably benign
IGL02113:Zfp944 APN 17 22339066 missense possibly damaging 0.88
IGL02694:Zfp944 APN 17 22339918 missense probably benign 0.05
IGL03135:Zfp944 APN 17 22339756 missense probably benign 0.00
IGL03172:Zfp944 APN 17 22340037 missense probably damaging 0.98
R0336:Zfp944 UTSW 17 22339028 missense probably damaging 1.00
R0755:Zfp944 UTSW 17 22339908 missense possibly damaging 0.63
R1536:Zfp944 UTSW 17 22339716 nonsense probably null
R1708:Zfp944 UTSW 17 22339045 missense probably damaging 0.98
R1886:Zfp944 UTSW 17 22339979 missense probably benign 0.04
R1928:Zfp944 UTSW 17 22341084 missense probably damaging 0.96
R1950:Zfp944 UTSW 17 22339700 missense probably benign 0.16
R2075:Zfp944 UTSW 17 22339197 nonsense probably null
R2101:Zfp944 UTSW 17 22339828 missense probably benign 0.41
R2433:Zfp944 UTSW 17 22339212 nonsense probably null
R4698:Zfp944 UTSW 17 22339199 missense probably damaging 1.00
R4986:Zfp944 UTSW 17 22339230 missense probably damaging 1.00
R6451:Zfp944 UTSW 17 22338865 missense probably benign 0.40
R6566:Zfp944 UTSW 17 22339745 missense possibly damaging 0.96
R6752:Zfp944 UTSW 17 22339519 missense probably benign 0.01
R7064:Zfp944 UTSW 17 22339579 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACATGCCACATGTTTTCCAGCAGa -3'
(R):5'- AATACTCGGGCTGAAACAAACCAATAGT -3'

Sequencing Primer
(F):5'- gggtttgtgtcatttgtttcatttg -3'
(R):5'- caatgtgacaaatgcttttccc -3'
Posted On2013-04-11