Mutagenetix > Incidental Mutation

Incidental Mutation 'R1872:Nbea'

210813

Institutional Source

Beutler Lab

Gene Symbol

Nbea

Ensembl Gene

ENSMUSG00000027799

Gene Name

neurobeachin

Synonyms

MMRRC Submission

039894-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1872 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

55625195-56183701 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 55642889 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 2706 (V2706A)

Ref Sequence

ENSEMBL: ENSMUSP00000029374 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000029374]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000029374
AA Change: V2706A

PolyPhen 2 Score 0.120 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000029374
Gene: ENSMUSG00000027799
AA Change: V2706A

Domain	Start	End	E-Value	Type
low complexity region	19	40	N/A	INTRINSIC
Pfam:Laminin_G_3	228	393	2.8e-13	PFAM
Pfam:DUF4704	462	733	4e-113	PFAM
low complexity region	792	802	N/A	INTRINSIC
low complexity region	964	969	N/A	INTRINSIC
low complexity region	1781	1790	N/A	INTRINSIC
low complexity region	1791	1807	N/A	INTRINSIC
low complexity region	1835	1845	N/A	INTRINSIC
Pfam:DUF1088	1956	2122	3.5e-91	PFAM
Pfam:PH_BEACH	2148	2245	2.6e-32	PFAM
Beach	2276	2553	1.3e-205	SMART
WD40	2659	2696	2.12e2	SMART
WD40	2699	2742	2.22e0	SMART
WD40	2759	2798	9.21e0	SMART
WD40	2842	2880	2.88e-1	SMART
WD40	2883	2922	8.91e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000199535

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000199803

Meta Mutation Damage Score

0.3772

Coding Region Coverage

1x: 97.3%
3x: 96.8%
10x: 95.4%
20x: 93.0%

Validation Efficiency

97% (113/117)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined.[provided by RefSeq, Feb 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele or transgene insertion die shortly after birth, are cyanotic, and exhibit no response to tactile stimuli, no spontaneous movement, and impaired CNS synaptic transmission. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Gene trapped(3) Transgenic(1)

Other mutations in this stock

Total: 108 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700003H04Rik	C	T	3: 124,556,844 (GRCm38)	C133Y	unknown	Het
8430408G22Rik	G	A	6: 116,651,722 (GRCm38)	V9M	possibly damaging	Het
Abce1	A	G	8: 79,690,251 (GRCm38)	M377T	possibly damaging	Het
Adam25	A	T	8: 40,755,226 (GRCm38)	R510*	probably null	Het
Adamts12	G	T	15: 11,217,880 (GRCm38)	E308*	probably null	Het
Adgrg3	C	A	8: 95,033,442 (GRCm38)	N96K	possibly damaging	Het
Afdn	T	C	17: 13,881,316 (GRCm38)	V1022A	probably damaging	Het
Akap9	T	C	5: 4,001,406 (GRCm38)	V1391A	probably damaging	Het
Akip1	A	G	7: 109,711,775 (GRCm38)	Y174C	probably damaging	Het
Ap3b2	T	C	7: 81,464,150 (GRCm38)	T830A	unknown	Het
Aph1a	A	G	3: 95,895,564 (GRCm38)	T159A	probably damaging	Het
Ccdc146	T	C	5: 21,301,290 (GRCm38)	T718A	probably benign	Het
Cdk5r2	T	C	1: 74,855,822 (GRCm38)	L242P	probably damaging	Het
Cep97	T	A	16: 55,927,866 (GRCm38)	N67I	probably damaging	Het
Chic2	A	T	5: 75,011,479 (GRCm38)	W121R	possibly damaging	Het
Clock	A	G	5: 76,248,462 (GRCm38)	S147P	possibly damaging	Het
Cntnap5a	T	G	1: 116,089,210 (GRCm38)	S178A	probably benign	Het
Col11a2	C	A	17: 34,062,555 (GRCm38)		probably benign	Het
Col6a3	T	A	1: 90,830,214 (GRCm38)	H6L	probably damaging	Het
Cpne5	T	C	17: 29,204,693 (GRCm38)	N154D	probably benign	Het
Ctsz	T	G	2: 174,427,976 (GRCm38)	K273Q	probably benign	Het
Cybrd1	G	A	2: 71,129,760 (GRCm38)	V101M	probably benign	Het
Cyp2c23	T	A	19: 44,005,551 (GRCm38)	K459*	probably null	Het
Cyp4a31	A	T	4: 115,574,736 (GRCm38)	H419L	probably damaging	Het
D930020B18Rik	G	A	10: 121,641,974 (GRCm38)	V35M	probably damaging	Het
Dnah9	C	T	11: 66,037,490 (GRCm38)	V2118M	probably benign	Het
Doxl2	A	G	6: 48,975,620 (GRCm38)	I160V	probably benign	Het
Dtna	T	C	18: 23,597,560 (GRCm38)		probably null	Het
Ednra	C	T	8: 77,720,396 (GRCm38)	V18I	possibly damaging	Het
Elac1	T	C	18: 73,742,646 (GRCm38)	R105G	probably benign	Het
Exoc2	A	G	13: 30,822,661 (GRCm38)	S844P	probably benign	Het
Fam185a	A	T	5: 21,480,330 (GRCm38)		probably null	Het
Fam204a	A	G	19: 60,199,449 (GRCm38)	M233T	possibly damaging	Het
Fat1	T	A	8: 45,038,349 (GRCm38)	Y3816N	probably damaging	Het
Fat1	C	A	8: 44,953,304 (GRCm38)	H1031N	probably benign	Het
Fbxo38	C	T	18: 62,517,023 (GRCm38)	R621Q	probably benign	Het
Fhod3	C	A	18: 25,130,610 (GRCm38)	R1524S	probably damaging	Het
Fnip1	A	T	11: 54,487,735 (GRCm38)	R192W	probably damaging	Het
Frem3	T	A	8: 80,612,576 (GRCm38)	H499Q	probably damaging	Het
Gab2	C	T	7: 97,299,043 (GRCm38)	T280I	probably damaging	Het
Gdpgp1	A	G	7: 80,238,424 (GRCm38)	R68G	probably benign	Het
Gm10382	C	T	5: 125,389,560 (GRCm38)		probably benign	Het
Gm4858	T	A	3: 93,074,422 (GRCm38)	L249H	probably damaging	Het
Gmps	A	G	3: 64,001,517 (GRCm38)	H480R	probably benign	Het
Hecw1	G	A	13: 14,280,449 (GRCm38)	R674*	probably null	Het
Herc2	T	A	7: 56,157,509 (GRCm38)	F2478L	probably benign	Het
Homer2	C	T	7: 81,636,402 (GRCm38)	V21M	probably damaging	Het
Ifna9	A	G	4: 88,592,255 (GRCm38)	M44T	probably damaging	Het
Igfl3	A	G	7: 18,179,896 (GRCm38)	D57G	possibly damaging	Het
Jcad	T	C	18: 4,673,048 (GRCm38)	M270T	probably benign	Het
Kdm5b	T	C	1: 134,624,994 (GRCm38)	L1236P	probably damaging	Het
Kif14	T	A	1: 136,486,358 (GRCm38)	L724Q	probably damaging	Het
Lhb	T	C	7: 45,421,333 (GRCm38)	V45A	probably damaging	Het
Lhpp	A	G	7: 132,634,087 (GRCm38)	N134D	probably benign	Het
Mas1	T	C	17: 12,842,191 (GRCm38)	Y115C	probably damaging	Het
Mb21d1	T	C	9: 78,433,202 (GRCm38)	D416G	probably benign	Het
Mgam	A	T	6: 40,661,300 (GRCm38)	K395*	probably null	Het
Mms22l	A	G	4: 24,598,807 (GRCm38)	N1134S	probably damaging	Het
Mrc1	A	G	2: 14,325,381 (GRCm38)		probably null	Het
Mrgprg	G	A	7: 143,764,544 (GRCm38)	S277L	probably damaging	Het
Mrpl49	G	T	19: 6,056,980 (GRCm38)	P60T	possibly damaging	Het
Mrps10	G	A	17: 47,372,452 (GRCm38)	G104D	possibly damaging	Het
Msantd3	A	G	4: 48,552,771 (GRCm38)	Y120C	probably damaging	Het
N4bp2	C	T	5: 65,794,518 (GRCm38)		probably benign	Het
Nfic	T	A	10: 81,420,684 (GRCm38)	M71L	possibly damaging	Het
Ntn4	C	T	10: 93,707,353 (GRCm38)	R314W	probably damaging	Het
Olfr1112	A	G	2: 87,191,878 (GRCm38)	T64A	possibly damaging	Het
Olfr115	G	T	17: 37,609,912 (GRCm38)	P280T	probably damaging	Het
Olfr1202	T	A	2: 88,817,936 (GRCm38)	V255E	probably benign	Het
Olfr1234	A	G	2: 89,362,589 (GRCm38)	L280P	probably damaging	Het
Pak7	T	C	2: 136,085,588 (GRCm38)	I655V	possibly damaging	Het
Pip5k1c	A	G	10: 81,306,319 (GRCm38)	N121S	probably damaging	Het
Plce1	A	T	19: 38,760,077 (GRCm38)	I1737F	probably damaging	Het
Prrt1	T	C	17: 34,630,951 (GRCm38)	L113P	probably damaging	Het
Ptprq	T	A	10: 107,643,999 (GRCm38)	T1137S	probably benign	Het
Recql5	T	C	11: 115,923,309 (GRCm38)	I223V	probably benign	Het
Reg3g	A	T	6: 78,467,853 (GRCm38)	Y47*	probably null	Het
Rgs12	T	G	5: 34,965,821 (GRCm38)	M316R	probably damaging	Het
Ric1	T	C	19: 29,602,668 (GRCm38)	S1290P	probably benign	Het
Rpl36al	A	G	12: 69,182,923 (GRCm38)	C72R	probably damaging	Het
Rplp0	T	A	5: 115,563,315 (GRCm38)	F275L	possibly damaging	Het
Rpp30	G	A	19: 36,087,393 (GRCm38)	V89I	probably benign	Het
Ryr3	A	G	2: 112,709,137 (GRCm38)	F3253L	possibly damaging	Het
Serpina3n	A	T	12: 104,408,944 (GRCm38)	N92Y	probably benign	Het
Setd7	G	T	3: 51,542,831 (GRCm38)	T58N	probably benign	Het
Sh3tc2	T	A	18: 62,011,883 (GRCm38)	L1136Q	probably damaging	Het
Slc35b4	G	A	6: 34,158,505 (GRCm38)	Q291*	probably null	Het
Soga1	A	G	2: 157,040,261 (GRCm38)	C624R	possibly damaging	Het
Sort1	A	G	3: 108,340,695 (GRCm38)	N452S	probably benign	Het
Sympk	A	G	7: 19,029,145 (GRCm38)	I46V	probably benign	Het
Syngr2	T	C	11: 117,812,538 (GRCm38)	V60A	probably damaging	Het
Syt17	A	T	7: 118,408,118 (GRCm38)	F318I	probably benign	Het
Tgfb1	T	A	7: 25,692,466 (GRCm38)	L149M	probably damaging	Het
Ticam1	A	T	17: 56,271,897 (GRCm38)	M66K	probably benign	Het
Tmem131	G	T	1: 36,807,927 (GRCm38)	D1363E	probably benign	Het
Tns4	A	C	11: 99,080,100 (GRCm38)	D261E	probably damaging	Het
Trim30a	T	C	7: 104,429,210 (GRCm38)	N220D	probably benign	Het
Trmt10a	T	C	3: 138,156,720 (GRCm38)	L257P	probably damaging	Het
Troap	G	T	15: 99,075,352 (GRCm38)		probably benign	Het
Ttc6	T	C	12: 57,704,552 (GRCm38)		probably null	Het
Ttn	A	T	2: 76,811,243 (GRCm38)	L5176Q	possibly damaging	Het
Vav1	A	C	17: 57,324,750 (GRCm38)	K775T	probably damaging	Het
Vmn1r236	A	G	17: 21,287,411 (GRCm38)	K264E	possibly damaging	Het
Vmn1r84	A	G	7: 12,362,628 (GRCm38)	V46A	probably benign	Het
Wdr59	A	T	8: 111,459,017 (GRCm38)	W835R	probably damaging	Het
Zfp513	T	G	5: 31,200,423 (GRCm38)	K202T	probably damaging	Het
Zfp7	T	G	15: 76,891,777 (GRCm38)	I673S	probably benign	Het
Zmynd11	A	G	13: 9,698,701 (GRCm38)	I108T	possibly damaging	Het

Other mutations in Nbea

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00540:Nbea	APN	3	55,628,493 (GRCm38)	missense	probably damaging	1.00
IGL00541:Nbea	APN	3	55,968,089 (GRCm38)	missense	probably benign	0.02
IGL00584:Nbea	APN	3	56,082,448 (GRCm38)	missense	probably damaging	0.98
IGL00648:Nbea	APN	3	56,009,260 (GRCm38)	missense	probably damaging	0.98
IGL00785:Nbea	APN	3	55,955,393 (GRCm38)	missense	probably benign
IGL00899:Nbea	APN	3	55,642,845 (GRCm38)	missense	probably benign	0.32
IGL00955:Nbea	APN	3	56,005,472 (GRCm38)	missense	possibly damaging	0.45
IGL01296:Nbea	APN	3	56,031,536 (GRCm38)	missense	probably benign	0.04
IGL01299:Nbea	APN	3	55,690,894 (GRCm38)	missense	probably damaging	1.00
IGL01393:Nbea	APN	3	56,005,308 (GRCm38)	missense	probably benign	0.02
IGL01550:Nbea	APN	3	55,805,248 (GRCm38)	missense	possibly damaging	0.93
IGL02023:Nbea	APN	3	55,681,016 (GRCm38)	missense	probably damaging	1.00
IGL02034:Nbea	APN	3	55,968,156 (GRCm38)	missense	probably damaging	1.00
IGL02061:Nbea	APN	3	55,717,887 (GRCm38)	missense	possibly damaging	0.54
IGL02082:Nbea	APN	3	55,968,167 (GRCm38)	missense	possibly damaging	0.88
IGL02113:Nbea	APN	3	55,992,492 (GRCm38)	missense	probably benign
IGL02188:Nbea	APN	3	55,983,837 (GRCm38)	missense	probably benign	0.00
IGL02319:Nbea	APN	3	55,985,738 (GRCm38)	missense	probably damaging	1.00
IGL02406:Nbea	APN	3	56,086,266 (GRCm38)	missense	probably benign	0.02
IGL02494:Nbea	APN	3	55,805,351 (GRCm38)	missense	probably benign	0.02
IGL02550:Nbea	APN	3	56,019,414 (GRCm38)	missense	probably damaging	0.98
IGL02706:Nbea	APN	3	56,037,278 (GRCm38)	missense	probably damaging	1.00
IGL02718:Nbea	APN	3	55,632,062 (GRCm38)	nonsense	probably null
IGL02822:Nbea	APN	3	56,019,447 (GRCm38)	missense	possibly damaging	0.93
IGL02885:Nbea	APN	3	55,631,986 (GRCm38)	missense	probably benign	0.01
IGL03000:Nbea	APN	3	56,004,627 (GRCm38)	missense	possibly damaging	0.94
IGL03081:Nbea	APN	3	56,079,918 (GRCm38)	missense	probably damaging	1.00
IGL03091:Nbea	APN	3	56,085,304 (GRCm38)	missense	probably damaging	1.00
IGL03368:Nbea	APN	3	56,079,930 (GRCm38)	missense	probably damaging	0.98
Neches	UTSW	3	55,953,034 (GRCm38)	critical splice donor site	probably null
scotland	UTSW	3	55,626,908 (GRCm38)	missense	probably damaging	1.00
Wales	UTSW	3	56,091,119 (GRCm38)	missense	probably damaging	1.00
FR4340:Nbea	UTSW	3	56,009,212 (GRCm38)	critical splice donor site	probably benign
G4846:Nbea	UTSW	3	56,087,497 (GRCm38)	missense	probably damaging	0.98
IGL02835:Nbea	UTSW	3	55,717,869 (GRCm38)	missense	possibly damaging	0.88
LCD18:Nbea	UTSW	3	55,701,527 (GRCm38)	intron	probably benign
R0087:Nbea	UTSW	3	56,091,023 (GRCm38)	missense	possibly damaging	0.92
R0220:Nbea	UTSW	3	56,005,303 (GRCm38)	missense	probably benign	0.30
R0324:Nbea	UTSW	3	56,057,948 (GRCm38)	critical splice donor site	probably null
R0330:Nbea	UTSW	3	55,642,817 (GRCm38)	missense	probably benign	0.27
R0391:Nbea	UTSW	3	56,037,277 (GRCm38)	missense	probably damaging	1.00
R0394:Nbea	UTSW	3	56,029,907 (GRCm38)	missense	probably damaging	1.00
R0419:Nbea	UTSW	3	55,819,294 (GRCm38)	missense	probably benign	0.05
R0503:Nbea	UTSW	3	55,642,836 (GRCm38)	missense	possibly damaging	0.79
R0521:Nbea	UTSW	3	56,008,268 (GRCm38)	missense	probably damaging	1.00
R0595:Nbea	UTSW	3	55,628,496 (GRCm38)	missense	probably benign	0.18
R0894:Nbea	UTSW	3	56,009,340 (GRCm38)	missense	possibly damaging	0.89
R1072:Nbea	UTSW	3	56,086,196 (GRCm38)	missense	possibly damaging	0.94
R1125:Nbea	UTSW	3	55,857,006 (GRCm38)	nonsense	probably null
R1169:Nbea	UTSW	3	55,968,323 (GRCm38)	missense	probably benign	0.00
R1241:Nbea	UTSW	3	56,058,040 (GRCm38)	missense	probably damaging	1.00
R1269:Nbea	UTSW	3	56,004,781 (GRCm38)	missense	probably benign	0.05
R1406:Nbea	UTSW	3	56,037,281 (GRCm38)	missense	probably benign	0.00
R1406:Nbea	UTSW	3	56,037,281 (GRCm38)	missense	probably benign	0.00
R1457:Nbea	UTSW	3	56,085,327 (GRCm38)	missense	probably damaging	1.00
R1482:Nbea	UTSW	3	56,079,993 (GRCm38)	missense	probably damaging	1.00
R1483:Nbea	UTSW	3	56,002,790 (GRCm38)	missense	probably benign	0.25
R1502:Nbea	UTSW	3	56,004,889 (GRCm38)	missense	probably benign	0.03
R1544:Nbea	UTSW	3	56,058,827 (GRCm38)	missense	probably damaging	0.99
R1629:Nbea	UTSW	3	56,002,891 (GRCm38)	missense	possibly damaging	0.52
R1647:Nbea	UTSW	3	55,630,229 (GRCm38)	missense	probably damaging	0.97
R1663:Nbea	UTSW	3	55,645,986 (GRCm38)	missense	possibly damaging	0.95
R1722:Nbea	UTSW	3	55,665,695 (GRCm38)	missense	probably damaging	1.00
R1757:Nbea	UTSW	3	55,630,189 (GRCm38)	missense	possibly damaging	0.83
R1771:Nbea	UTSW	3	55,934,519 (GRCm38)	missense	probably benign	0.00
R1796:Nbea	UTSW	3	55,643,708 (GRCm38)	missense	possibly damaging	0.48
R1844:Nbea	UTSW	3	56,082,436 (GRCm38)	missense	probably damaging	0.97
R1938:Nbea	UTSW	3	56,085,322 (GRCm38)	missense	probably damaging	1.00
R1940:Nbea	UTSW	3	55,953,100 (GRCm38)	missense	possibly damaging	0.78
R2062:Nbea	UTSW	3	56,086,157 (GRCm38)	splice site	probably benign
R2066:Nbea	UTSW	3	55,968,146 (GRCm38)	missense	probably damaging	1.00
R2097:Nbea	UTSW	3	55,723,217 (GRCm38)	missense	probably damaging	0.96
R2181:Nbea	UTSW	3	56,029,939 (GRCm38)	missense	possibly damaging	0.92
R2274:Nbea	UTSW	3	55,988,085 (GRCm38)	splice site	probably null
R2345:Nbea	UTSW	3	56,085,279 (GRCm38)	missense	probably damaging	1.00
R2423:Nbea	UTSW	3	56,085,306 (GRCm38)	missense	probably damaging	1.00
R2434:Nbea	UTSW	3	55,647,460 (GRCm38)	missense	possibly damaging	0.91
R2880:Nbea	UTSW	3	55,647,358 (GRCm38)	missense	probably benign	0.04
R2881:Nbea	UTSW	3	55,647,358 (GRCm38)	missense	probably benign	0.04
R2940:Nbea	UTSW	3	55,934,624 (GRCm38)	missense	probably benign	0.24
R3500:Nbea	UTSW	3	55,681,010 (GRCm38)	missense	possibly damaging	0.88
R3765:Nbea	UTSW	3	56,005,549 (GRCm38)	missense	probably damaging	1.00
R3790:Nbea	UTSW	3	56,005,029 (GRCm38)	missense	probably benign
R3808:Nbea	UTSW	3	55,717,848 (GRCm38)	missense	probably benign	0.02
R3845:Nbea	UTSW	3	56,086,292 (GRCm38)	splice site	probably benign
R4182:Nbea	UTSW	3	56,008,427 (GRCm38)	missense	probably damaging	0.99
R4385:Nbea	UTSW	3	56,000,638 (GRCm38)	missense	possibly damaging	0.77
R4419:Nbea	UTSW	3	56,009,600 (GRCm38)	missense	probably damaging	1.00
R4426:Nbea	UTSW	3	56,082,379 (GRCm38)	missense	probably damaging	0.98
R4451:Nbea	UTSW	3	55,992,332 (GRCm38)	critical splice donor site	probably null
R4456:Nbea	UTSW	3	55,643,784 (GRCm38)	missense	probably benign	0.00
R4604:Nbea	UTSW	3	55,723,648 (GRCm38)	missense	probably benign	0.18
R4687:Nbea	UTSW	3	56,058,065 (GRCm38)	missense	probably damaging	1.00
R4758:Nbea	UTSW	3	56,005,403 (GRCm38)	missense	probably benign
R4840:Nbea	UTSW	3	55,710,670 (GRCm38)	missense	probably benign	0.37
R4888:Nbea	UTSW	3	56,005,355 (GRCm38)	missense	possibly damaging	0.61
R4954:Nbea	UTSW	3	56,035,958 (GRCm38)	missense	probably damaging	1.00
R4972:Nbea	UTSW	3	56,085,246 (GRCm38)	missense	probably damaging	0.99
R4980:Nbea	UTSW	3	55,953,045 (GRCm38)	missense	probably benign	0.00
R4980:Nbea	UTSW	3	55,647,351 (GRCm38)	splice site	probably null
R5104:Nbea	UTSW	3	56,079,927 (GRCm38)	missense	probably damaging	1.00
R5139:Nbea	UTSW	3	55,626,963 (GRCm38)	missense	possibly damaging	0.90
R5166:Nbea	UTSW	3	56,019,453 (GRCm38)	missense	probably damaging	1.00
R5347:Nbea	UTSW	3	56,040,876 (GRCm38)	missense	probably damaging	1.00
R5350:Nbea	UTSW	3	56,019,424 (GRCm38)	missense	probably damaging	1.00
R5418:Nbea	UTSW	3	55,645,989 (GRCm38)	missense	possibly damaging	0.86
R5586:Nbea	UTSW	3	55,631,971 (GRCm38)	missense	probably benign	0.08
R5627:Nbea	UTSW	3	55,992,345 (GRCm38)	missense	probably damaging	1.00
R5683:Nbea	UTSW	3	55,628,586 (GRCm38)	missense	possibly damaging	0.53
R5765:Nbea	UTSW	3	56,005,298 (GRCm38)	missense	probably benign	0.15
R5853:Nbea	UTSW	3	55,992,401 (GRCm38)	missense	probably damaging	1.00
R5858:Nbea	UTSW	3	55,953,034 (GRCm38)	critical splice donor site	probably null
R5955:Nbea	UTSW	3	55,680,983 (GRCm38)	missense	probably benign	0.00
R5976:Nbea	UTSW	3	55,853,847 (GRCm38)	missense	probably benign	0.30
R6039:Nbea	UTSW	3	56,005,117 (GRCm38)	missense	probably benign	0.00
R6039:Nbea	UTSW	3	56,005,117 (GRCm38)	missense	probably benign	0.00
R6043:Nbea	UTSW	3	55,786,475 (GRCm38)	missense	probably benign	0.32
R6122:Nbea	UTSW	3	56,029,896 (GRCm38)	missense	probably damaging	1.00
R6218:Nbea	UTSW	3	55,628,484 (GRCm38)	missense	probably damaging	0.97
R6331:Nbea	UTSW	3	56,000,616 (GRCm38)	missense	possibly damaging	0.94
R6334:Nbea	UTSW	3	56,037,149 (GRCm38)	missense	probably damaging	1.00
R6393:Nbea	UTSW	3	56,091,119 (GRCm38)	missense	probably damaging	1.00
R6411:Nbea	UTSW	3	55,805,357 (GRCm38)	missense	probably benign	0.01
R6457:Nbea	UTSW	3	56,000,569 (GRCm38)	missense	probably damaging	1.00
R6476:Nbea	UTSW	3	56,004,806 (GRCm38)	missense	probably benign	0.00
R6488:Nbea	UTSW	3	55,717,843 (GRCm38)	missense	probably damaging	0.99
R6700:Nbea	UTSW	3	56,082,448 (GRCm38)	missense	possibly damaging	0.89
R6702:Nbea	UTSW	3	56,005,502 (GRCm38)	missense	probably benign	0.06
R6752:Nbea	UTSW	3	56,037,219 (GRCm38)	missense	probably benign
R6752:Nbea	UTSW	3	55,968,309 (GRCm38)	missense	probably benign	0.02
R6804:Nbea	UTSW	3	56,087,453 (GRCm38)	missense	probably benign	0.37
R6901:Nbea	UTSW	3	56,019,415 (GRCm38)	missense	probably damaging	1.00
R6933:Nbea	UTSW	3	55,723,610 (GRCm38)	missense	possibly damaging	0.63
R7124:Nbea	UTSW	3	55,992,444 (GRCm38)	missense	probably damaging	1.00
R7211:Nbea	UTSW	3	56,004,901 (GRCm38)	missense	probably benign	0.05
R7308:Nbea	UTSW	3	56,091,031 (GRCm38)	missense	probably damaging	1.00
R7405:Nbea	UTSW	3	55,805,266 (GRCm38)	missense	possibly damaging	0.94
R7669:Nbea	UTSW	3	55,717,779 (GRCm38)	missense	probably damaging	1.00
R7762:Nbea	UTSW	3	55,649,705 (GRCm38)	missense	probably damaging	1.00
R7833:Nbea	UTSW	3	56,002,797 (GRCm38)	missense	probably damaging	1.00
R7885:Nbea	UTSW	3	55,665,689 (GRCm38)	missense	probably damaging	0.97
R7935:Nbea	UTSW	3	56,058,665 (GRCm38)	missense	probably damaging	1.00
R8050:Nbea	UTSW	3	55,987,981 (GRCm38)	missense	probably damaging	0.99
R8108:Nbea	UTSW	3	55,819,315 (GRCm38)	missense	probably benign	0.11
R8290:Nbea	UTSW	3	56,058,635 (GRCm38)	nonsense	probably null
R8314:Nbea	UTSW	3	56,009,251 (GRCm38)	missense	probably damaging	0.99
R8321:Nbea	UTSW	3	56,183,097 (GRCm38)	missense	possibly damaging	0.86
R8376:Nbea	UTSW	3	55,643,655 (GRCm38)	missense	possibly damaging	0.79
R8410:Nbea	UTSW	3	56,037,263 (GRCm38)	missense	probably damaging	1.00
R8556:Nbea	UTSW	3	55,647,386 (GRCm38)	missense	probably benign	0.25
R8753:Nbea	UTSW	3	55,626,908 (GRCm38)	missense	probably damaging	1.00
R8844:Nbea	UTSW	3	56,090,994 (GRCm38)	missense	probably damaging	0.97
R8884:Nbea	UTSW	3	55,805,299 (GRCm38)	missense	probably benign	0.00
R8886:Nbea	UTSW	3	56,058,727 (GRCm38)	missense	probably damaging	1.00
R8890:Nbea	UTSW	3	56,019,363 (GRCm38)	splice site	probably benign
R9004:Nbea	UTSW	3	56,002,938 (GRCm38)	missense	probably benign	0.01
R9022:Nbea	UTSW	3	55,643,689 (GRCm38)	missense	possibly damaging	0.79
R9080:Nbea	UTSW	3	56,005,095 (GRCm38)	nonsense	probably null
R9087:Nbea	UTSW	3	55,642,736 (GRCm38)	critical splice donor site	probably null
R9104:Nbea	UTSW	3	55,955,388 (GRCm38)	missense	probably benign
R9165:Nbea	UTSW	3	56,004,868 (GRCm38)	missense	probably benign	0.15
R9219:Nbea	UTSW	3	56,090,972 (GRCm38)	frame shift	probably null
R9221:Nbea	UTSW	3	56,090,972 (GRCm38)	frame shift	probably null
R9222:Nbea	UTSW	3	56,090,972 (GRCm38)	frame shift	probably null
R9260:Nbea	UTSW	3	55,983,812 (GRCm38)	missense	possibly damaging	0.50
R9263:Nbea	UTSW	3	56,090,972 (GRCm38)	frame shift	probably null
R9265:Nbea	UTSW	3	56,090,972 (GRCm38)	frame shift	probably null
R9294:Nbea	UTSW	3	56,091,092 (GRCm38)	missense	probably benign	0.00
R9360:Nbea	UTSW	3	56,035,898 (GRCm38)	missense	possibly damaging	0.96
R9387:Nbea	UTSW	3	55,991,039 (GRCm38)	missense	probably benign	0.12
R9428:Nbea	UTSW	3	56,090,972 (GRCm38)	frame shift	probably null
R9435:Nbea	UTSW	3	56,035,888 (GRCm38)	missense	possibly damaging	0.63
R9507:Nbea	UTSW	3	55,665,590 (GRCm38)	missense	probably damaging	1.00
R9514:Nbea	UTSW	3	56,029,945 (GRCm38)	missense	probably damaging	1.00
R9516:Nbea	UTSW	3	56,029,945 (GRCm38)	missense	probably damaging	1.00
R9674:Nbea	UTSW	3	56,058,762 (GRCm38)	missense	probably damaging	1.00
R9688:Nbea	UTSW	3	55,649,744 (GRCm38)	missense	probably benign	0.42
R9709:Nbea	UTSW	3	55,786,458 (GRCm38)	nonsense	probably null
RF051:Nbea	UTSW	3	56,009,212 (GRCm38)	critical splice donor site	probably benign
X0018:Nbea	UTSW	3	56,036,048 (GRCm38)	missense	probably benign	0.39
Z1088:Nbea	UTSW	3	55,723,163 (GRCm38)	missense	probably benign	0.34
Z1177:Nbea	UTSW	3	56,031,550 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ATTGTCTGAAAGGACCCTTGTGG -3'
(R):5'- CTGTCAGGCCCAAATTCTGAAGAG -3'

Sequencing Primer
(F):5'- GGAGACACTTACTGCTATTGGG -3'
(R):5'- GAAAAATCATGGCCATCTCGTAAG -3'

Posted On

2014-06-30