Mutagenetix > Incidental Mutation

Incidental Mutation 'R1873:Vmn2r107'

210979

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r107

Ensembl Gene

ENSMUSG00000056910

Gene Name

vomeronasal 2, receptor 107

Synonyms

V2r6

MMRRC Submission

039895-MU

Accession Numbers

Genbank: NM_001104569; MGI: 1316664

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R1873 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

20345425-20375772 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 20345578 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 52 (T52A)

Ref Sequence

ENSEMBL: ENSMUSP00000048706 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042090]

AlphaFold

E9PZJ7

Predicted Effect

probably benign
Transcript: ENSMUST00000042090
AA Change: T52A

PolyPhen 2 Score 0.105 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000048706
Gene: ENSMUSG00000056910
AA Change: T52A

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	466	3.6e-40	PFAM
Pfam:NCD3G	509	562	5.1e-21	PFAM
Pfam:7tm_3	593	830	8e-51	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 95.4%
20x: 92.9%

Validation Efficiency

98% (82/84)

Allele List at MGI

Other mutations in this stock

Total: 75 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca8b	T	A	11: 109,979,955	I124L	probably benign	Het
Abi3bp	A	G	16: 56,574,499	Y190C	probably damaging	Het
Adam34	A	C	8: 43,651,806	N267K	probably benign	Het
Anxa5	T	C	3: 36,449,402	D301G	probably damaging	Het
Atf7ip	G	T	6: 136,559,888	D40Y	probably damaging	Het
Cacna2d2	T	G	9: 107,513,872	M400R	probably damaging	Het
Cd96	C	A	16: 46,117,972	L43F	probably damaging	Het
Cep120	T	C	18: 53,738,488	E104G	probably damaging	Het
Cfap221	T	C	1: 119,953,659	I358V	probably benign	Het
Chil4	C	T	3: 106,206,098	E168K	probably benign	Het
Clca3a1	A	G	3: 144,746,829	V631A	probably damaging	Het
Cluh	C	T	11: 74,662,076	A649V	possibly damaging	Het
Commd9	A	G	2: 101,897,157	T99A	probably benign	Het
Csgalnact1	T	C	8: 68,401,384	N255S	probably benign	Het
Cyth3	T	A	5: 143,697,761	H138Q	possibly damaging	Het
Dnah7a	A	T	1: 53,456,532		probably benign	Het
Fbxl18	G	A	5: 142,886,223	A419V	probably damaging	Het
Fyco1	A	G	9: 123,823,238	V1135A	probably benign	Het
Glcci1	C	A	6: 8,537,837	H152N	probably benign	Het
Gm10477	T	A	X: 56,524,767	F9Y	probably damaging	Het
Gm4788	C	T	1: 139,774,660	E29K	probably damaging	Het
Gnrhr	A	G	5: 86,182,201	L320P	probably damaging	Het
Gorasp1	A	T	9: 119,930,240	S138T	probably benign	Het
Hars	C	A	18: 36,767,241	Q469H	probably damaging	Het
Homer2	T	C	7: 81,636,363	K34E	probably damaging	Het
Hscb	T	C	5: 110,830,957	I198V	probably benign	Het
Kat6b	T	C	14: 21,516,989	S39P	probably damaging	Het
Kcnk12	G	T	17: 87,746,071	Q388K	probably damaging	Het
Kcnq3	A	G	15: 66,002,255	I548T	probably benign	Het
Mark2	A	G	19: 7,284,515	Y351H	probably damaging	Het
Masp2	A	T	4: 148,614,495	I678F	probably damaging	Het
Mc4r	A	T	18: 66,859,460	I194N	probably damaging	Het
Ms4a6d	A	G	19: 11,601,859	S85P	probably damaging	Het
Mum1	T	A	10: 80,232,608	D195E	possibly damaging	Het
Myh4	T	A	11: 67,254,743	Y1351N	probably benign	Het
Myo16	A	G	8: 10,272,789	D73G	probably damaging	Het
Mzt1	C	T	14: 99,040,661		probably null	Het
Nalcn	G	A	14: 123,283,601	H1631Y	probably benign	Het
Ncf2	A	G	1: 152,825,910	N213S	probably benign	Het
Nf1	C	A	11: 79,547,161	T99K	probably damaging	Het
Nsf	T	C	11: 103,859,017	S547G	probably damaging	Het
Ntrk3	T	A	7: 78,462,839	I190F	probably benign	Het
Obsl1	T	C	1: 75,498,233	Y841C	probably damaging	Het
Ogdh	A	T	11: 6,340,438		probably benign	Het
Olfr1448	C	T	19: 12,919,488	V274M	probably damaging	Het
Olfr693	T	A	7: 106,678,484	M1L	probably damaging	Het
Otog	G	A	7: 46,269,343	V948I	probably damaging	Het
Plekhm1	T	C	11: 103,373,998	D880G	probably benign	Het
Pnliprp2	G	T	19: 58,763,389	V189L	probably benign	Het
Polg	A	G	7: 79,456,493	L678S	probably benign	Het
Ptprm	C	T	17: 66,688,355	V1293I	probably damaging	Het
Rhou	A	T	8: 123,661,251	R241W	probably damaging	Het
Rtn4	A	T	11: 29,736,437	N264I	probably damaging	Het
Sez6l	T	C	5: 112,473,410		probably benign	Het
Sost	T	C	11: 101,964,243	E80G	probably damaging	Het
Spag16	C	T	1: 69,896,585		probably benign	Het
Speer4f2	A	T	5: 17,374,449	N82I	probably damaging	Het
Spef2	C	T	15: 9,584,108	E1624K	probably damaging	Het
Taf1b	T	A	12: 24,556,669	L496Q	possibly damaging	Het
Tarbp1	A	G	8: 126,447,047	I976T	probably damaging	Het
Tex14	T	A	11: 87,499,605	V376D	probably damaging	Het
Timm21	G	C	18: 84,949,262	L130V	probably damaging	Het
Tm9sf1	T	C	14: 55,636,223	D606G	probably damaging	Het
Tmc2	A	C	2: 130,248,756	N674T	possibly damaging	Het
Top3a	C	A	11: 60,747,984	E562*	probably null	Het
Umodl1	A	T	17: 30,982,264	D389V	probably damaging	Het
Uso1	T	C	5: 92,192,859		probably benign	Het
Vmn1r205	A	G	13: 22,592,053	V293A	possibly damaging	Het
Vmn2r4	C	T	3: 64,391,058	V461I	possibly damaging	Het
Vmn2r99	A	T	17: 19,362,153	I7F	probably benign	Het
Vps11	A	G	9: 44,359,936	F80S	probably damaging	Het
Wdr43	A	G	17: 71,633,652	S258G	probably benign	Het
Zbtb24	A	G	10: 41,451,127	D3G	probably benign	Het
Zc3hav1	C	T	6: 38,332,757	V377I	possibly damaging	Het
Zfp668	T	C	7: 127,866,482		probably null	Het

Other mutations in Vmn2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01402:Vmn2r107	APN	17	20375747	missense	probably damaging	0.98
IGL01768:Vmn2r107	APN	17	20345606	missense	probably benign	0.32
IGL02086:Vmn2r107	APN	17	20357800	missense	probably benign	0.00
IGL02136:Vmn2r107	APN	17	20374906	missense	probably benign	0.02
IGL02266:Vmn2r107	APN	17	20356777	missense	probably damaging	1.00
IGL02285:Vmn2r107	APN	17	20375561	missense	probably damaging	1.00
IGL02724:Vmn2r107	APN	17	20356744	missense	possibly damaging	0.49
IGL02998:Vmn2r107	APN	17	20357755	missense	probably damaging	0.99
IGL03089:Vmn2r107	APN	17	20375712	missense	probably benign	0.05
IGL03284:Vmn2r107	APN	17	20356911	missense	probably benign	0.07
IGL03307:Vmn2r107	APN	17	20356776	missense	probably benign	0.09
IGL03399:Vmn2r107	APN	17	20357958	splice site	probably benign
3-1:Vmn2r107	UTSW	17	20345504	missense	probably benign
BB006:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
BB016:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R0285:Vmn2r107	UTSW	17	20345611	missense	probably benign	0.00
R0455:Vmn2r107	UTSW	17	20374823	splice site	probably benign
R0497:Vmn2r107	UTSW	17	20375132	missense	probably damaging	1.00
R0506:Vmn2r107	UTSW	17	20357759	missense	probably benign
R0621:Vmn2r107	UTSW	17	20374990	missense	probably benign	0.01
R0667:Vmn2r107	UTSW	17	20355654	missense	possibly damaging	0.91
R1118:Vmn2r107	UTSW	17	20356598	missense	probably benign	0.03
R1204:Vmn2r107	UTSW	17	20357769	missense	probably benign
R1237:Vmn2r107	UTSW	17	20356685	nonsense	probably null
R1485:Vmn2r107	UTSW	17	20374847	missense	possibly damaging	0.95
R1783:Vmn2r107	UTSW	17	20356513	missense	possibly damaging	0.51
R1974:Vmn2r107	UTSW	17	20355617	splice site	probably null
R2009:Vmn2r107	UTSW	17	20375467	missense	probably benign	0.01
R2029:Vmn2r107	UTSW	17	20375287	missense	probably benign	0.01
R2164:Vmn2r107	UTSW	17	20375642	missense	probably damaging	1.00
R2269:Vmn2r107	UTSW	17	20375555	missense	possibly damaging	0.58
R3087:Vmn2r107	UTSW	17	20360345	missense	probably benign	0.03
R3740:Vmn2r107	UTSW	17	20374889	missense	probably benign	0.00
R3961:Vmn2r107	UTSW	17	20375455	missense	probably damaging	1.00
R4031:Vmn2r107	UTSW	17	20375221	missense	probably benign	0.00
R4270:Vmn2r107	UTSW	17	20355779	missense	probably benign
R4963:Vmn2r107	UTSW	17	20375141	missense	probably damaging	1.00
R5121:Vmn2r107	UTSW	17	20355753	missense	probably benign	0.01
R5640:Vmn2r107	UTSW	17	20375164	missense	probably damaging	1.00
R6007:Vmn2r107	UTSW	17	20375054	missense	probably benign	0.19
R6238:Vmn2r107	UTSW	17	20345587	missense	probably benign	0.43
R6298:Vmn2r107	UTSW	17	20355782	missense	probably benign	0.00
R6467:Vmn2r107	UTSW	17	20375677	missense	probably damaging	0.99
R6726:Vmn2r107	UTSW	17	20375375	missense	probably damaging	0.96
R6782:Vmn2r107	UTSW	17	20356879	missense	probably damaging	1.00
R7299:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7301:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7375:Vmn2r107	UTSW	17	20355876	missense	probably benign
R7448:Vmn2r107	UTSW	17	20375732	missense	probably benign	0.00
R7495:Vmn2r107	UTSW	17	20375009	missense	possibly damaging	0.71
R7589:Vmn2r107	UTSW	17	20375372	missense	probably benign	0.05
R7594:Vmn2r107	UTSW	17	20360373	missense	probably benign	0.03
R7678:Vmn2r107	UTSW	17	20356639	missense	probably benign	0.01
R7929:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R7974:Vmn2r107	UTSW	17	20357008	missense	probably benign	0.00
R8040:Vmn2r107	UTSW	17	20375546	missense	probably damaging	1.00
R8263:Vmn2r107	UTSW	17	20360352	missense	probably damaging	1.00
R8426:Vmn2r107	UTSW	17	20356977	missense	possibly damaging	0.91
R9175:Vmn2r107	UTSW	17	20356789	missense	possibly damaging	0.79
R9537:Vmn2r107	UTSW	17	20374887	missense	probably benign	0.00
R9642:Vmn2r107	UTSW	17	20360399	missense	probably damaging	1.00
R9711:Vmn2r107	UTSW	17	20357000	missense	probably damaging	1.00
X0022:Vmn2r107	UTSW	17	20356968	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- AGACCAATGTGCTAATAGGATGTTC -3'
(R):5'- CCTCCTGAGTGTGGAATATAATCC -3'

Sequencing Primer
(F):5'- GGATGTTCTCCTGGATTTTTATCTTC -3'
(R):5'- GCTACACCCATTACGTCAT -3'

Posted On

2014-06-30