Incidental Mutation 'R1874:Cenpf'
| ID |
211004 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cenpf
|
| Ensembl Gene |
ENSMUSG00000026605 |
| Gene Name |
centromere protein F |
| Synonyms |
mitosin, 6530404A22Rik, Lek1 |
| MMRRC Submission |
039896-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.433)
|
| Stock # |
R1874 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
189640606-189688086 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 189683816 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 104
(L104P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129738
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165663]
[ENSMUST00000165962]
[ENSMUST00000171929]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165663
|
| SMART Domains |
Protein: ENSMUSP00000130308
Gene: ENSMUSG00000026605
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:CENP-F_N
|
1 |
65 |
8.7e-35 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000165962
AA Change: L104P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000132759
Gene: ENSMUSG00000026605
AA Change: L104P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:CENP-F_N
|
1 |
300 |
7.3e-135 |
PFAM |
|
low complexity region
|
332 |
347 |
N/A |
INTRINSIC |
|
low complexity region
|
361 |
379 |
N/A |
INTRINSIC |
|
low complexity region
|
527 |
540 |
N/A |
INTRINSIC |
|
low complexity region
|
572 |
592 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
737 |
759 |
3.18e-5 |
PROSPERO |
|
internal_repeat_1
|
751 |
773 |
3.18e-5 |
PROSPERO |
|
internal_repeat_2
|
789 |
804 |
5.94e-5 |
PROSPERO |
|
coiled coil region
|
812 |
864 |
N/A |
INTRINSIC |
|
coiled coil region
|
885 |
923 |
N/A |
INTRINSIC |
|
low complexity region
|
925 |
936 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000171929
AA Change: L104P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000129738
Gene: ENSMUSG00000026605
AA Change: L104P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:CENP-F_N
|
1 |
300 |
2.8e-144 |
PFAM |
|
low complexity region
|
349 |
364 |
N/A |
INTRINSIC |
|
low complexity region
|
378 |
396 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
609 |
N/A |
INTRINSIC |
|
internal_repeat_5
|
678 |
707 |
8.32e-5 |
PROSPERO |
|
internal_repeat_3
|
743 |
798 |
2.21e-5 |
PROSPERO |
|
internal_repeat_1
|
780 |
812 |
2.12e-7 |
PROSPERO |
|
coiled coil region
|
829 |
881 |
N/A |
INTRINSIC |
|
coiled coil region
|
902 |
1169 |
N/A |
INTRINSIC |
|
coiled coil region
|
1206 |
1364 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1381 |
1413 |
3.02e-6 |
PROSPERO |
|
internal_repeat_3
|
1412 |
1470 |
2.21e-5 |
PROSPERO |
|
low complexity region
|
1526 |
1542 |
N/A |
INTRINSIC |
|
coiled coil region
|
1560 |
1650 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1655 |
1687 |
3.02e-6 |
PROSPERO |
|
low complexity region
|
1744 |
1755 |
N/A |
INTRINSIC |
|
coiled coil region
|
1822 |
1852 |
N/A |
INTRINSIC |
|
Pfam:CENP-F_leu_zip
|
1893 |
2035 |
1.2e-14 |
PFAM |
|
Pfam:CENP-F_leu_zip
|
2131 |
2270 |
1.5e-47 |
PFAM |
|
Pfam:CENP-F_leu_zip
|
2313 |
2449 |
1e-46 |
PFAM |
|
low complexity region
|
2544 |
2555 |
N/A |
INTRINSIC |
|
low complexity region
|
2642 |
2654 |
N/A |
INTRINSIC |
|
low complexity region
|
2755 |
2769 |
N/A |
INTRINSIC |
|
internal_repeat_4
|
2778 |
2801 |
4.28e-5 |
PROSPERO |
|
low complexity region
|
2837 |
2847 |
N/A |
INTRINSIC |
|
Pfam:CENP-F_C_Rb_bdg
|
2850 |
2896 |
6.6e-29 |
PFAM |
|
internal_repeat_1
|
2935 |
2964 |
2.12e-7 |
PROSPERO |
|
internal_repeat_4
|
2946 |
2969 |
4.28e-5 |
PROSPERO |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193510
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000194165
|
| Meta Mutation Damage Score |
0.7743 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.8%
- 20x: 94.1%
|
| Validation Efficiency |
96% (105/109) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 104 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| AA986860 |
A |
G |
1: 130,742,691 (GRCm38) |
S217G |
probably benign |
Het |
| Adrb3 |
C |
A |
8: 27,227,563 (GRCm38) |
R286L |
probably damaging |
Het |
| Akap11 |
T |
A |
14: 78,511,866 (GRCm38) |
D1027V |
probably benign |
Het |
| Ank3 |
A |
T |
10: 69,898,083 (GRCm38) |
I726F |
probably damaging |
Het |
| Ankmy2 |
T |
A |
12: 36,165,931 (GRCm38) |
D43E |
possibly damaging |
Het |
| Ankrd34b |
A |
G |
13: 92,439,556 (GRCm38) |
D432G |
probably damaging |
Het |
| Ano3 |
A |
C |
2: 110,884,872 (GRCm38) |
S74A |
probably benign |
Het |
| B4galnt4 |
T |
A |
7: 141,070,526 (GRCm38) |
S769T |
probably damaging |
Het |
| Bicral |
T |
A |
17: 46,825,178 (GRCm38) |
T369S |
probably benign |
Het |
| Blm |
A |
G |
7: 80,497,418 (GRCm38) |
L738P |
probably damaging |
Het |
| Bpifb3 |
A |
G |
2: 153,925,840 (GRCm38) |
T278A |
probably benign |
Het |
| Bpifb5 |
A |
G |
2: 154,227,202 (GRCm38) |
|
probably benign |
Het |
| Brd8 |
G |
C |
18: 34,610,474 (GRCm38) |
P266R |
probably damaging |
Het |
| Btaf1 |
A |
T |
19: 36,980,583 (GRCm38) |
M587L |
probably benign |
Het |
| Casz1 |
C |
G |
4: 148,943,211 (GRCm38) |
T1015S |
probably damaging |
Het |
| Cdh23 |
A |
G |
10: 60,436,818 (GRCm38) |
I524T |
possibly damaging |
Het |
| Celsr3 |
T |
C |
9: 108,835,838 (GRCm38) |
V1825A |
probably benign |
Het |
| Clasp1 |
G |
T |
1: 118,600,585 (GRCm38) |
|
probably null |
Het |
| Coprs |
A |
G |
8: 13,885,112 (GRCm38) |
W148R |
probably damaging |
Het |
| Cpne1 |
A |
G |
2: 156,078,382 (GRCm38) |
S168P |
probably damaging |
Het |
| Cpxm2 |
T |
C |
7: 132,059,834 (GRCm38) |
Y408C |
probably damaging |
Het |
| Ctnna3 |
A |
G |
10: 63,504,107 (GRCm38) |
E24G |
possibly damaging |
Het |
| Cubn |
T |
A |
2: 13,323,002 (GRCm38) |
S2671C |
probably damaging |
Het |
| Cyp4f39 |
T |
A |
17: 32,483,324 (GRCm38) |
F265Y |
probably damaging |
Het |
| Dgkq |
C |
A |
5: 108,660,595 (GRCm38) |
R34L |
probably benign |
Het |
| Dnajc7 |
C |
T |
11: 100,599,313 (GRCm38) |
|
probably benign |
Het |
| Eml6 |
T |
G |
11: 29,831,136 (GRCm38) |
D632A |
probably damaging |
Het |
| Fbxl18 |
G |
A |
5: 142,886,223 (GRCm38) |
A419V |
probably damaging |
Het |
| Fbxw22 |
A |
T |
9: 109,385,111 (GRCm38) |
C212* |
probably null |
Het |
| Ffar2 |
A |
G |
7: 30,819,414 (GRCm38) |
|
probably null |
Het |
| Fga |
A |
T |
3: 83,032,721 (GRCm38) |
T561S |
probably damaging |
Het |
| Fry |
A |
G |
5: 150,345,921 (GRCm38) |
Y159C |
probably damaging |
Het |
| Gal3st1 |
A |
G |
11: 3,998,231 (GRCm38) |
Y146C |
probably damaging |
Het |
| Gapvd1 |
A |
T |
2: 34,706,021 (GRCm38) |
H788Q |
probably damaging |
Het |
| Gimap7 |
G |
A |
6: 48,723,515 (GRCm38) |
V12I |
possibly damaging |
Het |
| Gli2 |
C |
A |
1: 119,002,049 (GRCm38) |
A43S |
possibly damaging |
Het |
| Gm15446 |
T |
C |
5: 109,942,553 (GRCm38) |
F224L |
probably damaging |
Het |
| Gm21738 |
C |
T |
14: 19,418,824 (GRCm38) |
V35I |
possibly damaging |
Het |
| Grhl1 |
T |
C |
12: 24,586,156 (GRCm38) |
|
probably benign |
Het |
| Grk6 |
T |
C |
13: 55,450,273 (GRCm38) |
Y53H |
probably damaging |
Het |
| Hcar1 |
C |
T |
5: 123,879,265 (GRCm38) |
R121K |
probably damaging |
Het |
| Hmcn1 |
A |
C |
1: 150,720,695 (GRCm38) |
S1797A |
probably damaging |
Het |
| Hsd17b7 |
A |
T |
1: 169,955,993 (GRCm38) |
L282Q |
possibly damaging |
Het |
| Irs1 |
TTCTCTGAGTGGCCACAGCGTCT |
TTCT |
1: 82,289,853 (GRCm38) |
|
probably null |
Het |
| Kif1b |
C |
T |
4: 149,187,632 (GRCm38) |
V1571I |
probably benign |
Het |
| Lpl |
T |
A |
8: 68,896,619 (GRCm38) |
C266S |
probably damaging |
Het |
| Mag |
G |
A |
7: 30,909,051 (GRCm38) |
H213Y |
probably benign |
Het |
| Mansc4 |
T |
G |
6: 147,075,190 (GRCm38) |
R309S |
probably benign |
Het |
| Mlh3 |
A |
G |
12: 85,237,513 (GRCm38) |
|
probably null |
Het |
| Mndal |
G |
A |
1: 173,860,367 (GRCm38) |
|
probably benign |
Het |
| Mrgpra2b |
T |
A |
7: 47,463,994 (GRCm38) |
E330V |
probably damaging |
Het |
| Myh3 |
A |
G |
11: 67,093,179 (GRCm38) |
I990V |
probably benign |
Het |
| Myoz2 |
A |
T |
3: 123,026,116 (GRCm38) |
S65T |
probably damaging |
Het |
| Naa16 |
T |
C |
14: 79,355,743 (GRCm38) |
E463G |
possibly damaging |
Het |
| Nadsyn1 |
A |
G |
7: 143,797,844 (GRCm38) |
F684S |
probably damaging |
Het |
| Notch1 |
T |
C |
2: 26,481,579 (GRCm38) |
E286G |
possibly damaging |
Het |
| Nynrin |
A |
T |
14: 55,863,493 (GRCm38) |
I247L |
probably benign |
Het |
| Olfr136 |
C |
T |
17: 38,335,969 (GRCm38) |
P271S |
probably damaging |
Het |
| Olfr644 |
T |
C |
7: 104,068,129 (GRCm38) |
I301V |
probably null |
Het |
| Olfr981 |
T |
A |
9: 40,022,855 (GRCm38) |
I154N |
possibly damaging |
Het |
| Oprm1 |
A |
G |
10: 6,789,035 (GRCm38) |
H54R |
probably benign |
Het |
| P4hb |
C |
T |
11: 120,562,166 (GRCm38) |
D483N |
probably benign |
Het |
| Pak1 |
T |
C |
7: 97,871,580 (GRCm38) |
S149P |
probably benign |
Het |
| Pars2 |
T |
C |
4: 106,653,716 (GRCm38) |
F232L |
possibly damaging |
Het |
| Pih1d2 |
A |
G |
9: 50,620,945 (GRCm38) |
M88V |
possibly damaging |
Het |
| Pms1 |
A |
T |
1: 53,207,233 (GRCm38) |
N382K |
probably benign |
Het |
| Pnliprp2 |
G |
T |
19: 58,763,389 (GRCm38) |
V189L |
probably benign |
Het |
| Pole |
G |
A |
5: 110,323,664 (GRCm38) |
V1425M |
possibly damaging |
Het |
| Pot1b |
T |
A |
17: 55,654,805 (GRCm38) |
Q591L |
probably benign |
Het |
| Ppp1r9a |
C |
T |
6: 4,906,348 (GRCm38) |
T301M |
possibly damaging |
Het |
| Psg21 |
T |
C |
7: 18,650,816 (GRCm38) |
E335G |
probably benign |
Het |
| Ptpru |
T |
A |
4: 131,769,755 (GRCm38) |
M1416L |
probably benign |
Het |
| Pxn |
T |
C |
5: 115,544,990 (GRCm38) |
V117A |
probably damaging |
Het |
| Qsox1 |
C |
T |
1: 155,812,639 (GRCm38) |
R54H |
possibly damaging |
Het |
| Rad1 |
A |
G |
15: 10,488,006 (GRCm38) |
E42G |
probably damaging |
Het |
| Rpp14 |
A |
G |
14: 8,090,145 (GRCm38) |
Y23C |
probably benign |
Het |
| Sdk2 |
C |
T |
11: 113,834,956 (GRCm38) |
V1156I |
probably benign |
Het |
| Serpina3j |
G |
T |
12: 104,319,699 (GRCm38) |
R371L |
probably benign |
Het |
| Serpinb9d |
T |
A |
13: 33,197,963 (GRCm38) |
|
probably null |
Het |
| Sirt5 |
C |
T |
13: 43,370,791 (GRCm38) |
S13F |
possibly damaging |
Het |
| Slc6a7 |
T |
A |
18: 61,001,398 (GRCm38) |
|
probably benign |
Het |
| Slx4 |
A |
G |
16: 3,986,848 (GRCm38) |
S701P |
probably benign |
Het |
| Snx29 |
A |
G |
16: 11,367,681 (GRCm38) |
T43A |
probably benign |
Het |
| Speg |
T |
C |
1: 75,423,906 (GRCm38) |
V2570A |
probably benign |
Het |
| Srrm4 |
T |
A |
5: 116,453,506 (GRCm38) |
|
probably benign |
Het |
| Stk32a |
A |
G |
18: 43,261,316 (GRCm38) |
Y110C |
probably damaging |
Het |
| Tbc1d31 |
G |
A |
15: 57,916,110 (GRCm38) |
G73E |
probably benign |
Het |
| Thsd7a |
A |
T |
6: 12,555,435 (GRCm38) |
I150N |
possibly damaging |
Het |
| Tjp1 |
A |
T |
7: 65,319,253 (GRCm38) |
D699E |
probably damaging |
Het |
| Tmem143 |
A |
G |
7: 45,916,564 (GRCm38) |
D437G |
possibly damaging |
Het |
| Tmem45a2 |
A |
G |
16: 57,047,084 (GRCm38) |
Y85H |
possibly damaging |
Het |
| Tmem45b |
T |
A |
9: 31,429,087 (GRCm38) |
T7S |
probably damaging |
Het |
| Ube4b |
A |
G |
4: 149,347,971 (GRCm38) |
L832P |
probably damaging |
Het |
| Ugp2 |
G |
T |
11: 21,329,048 (GRCm38) |
F379L |
probably damaging |
Het |
| Ugt3a2 |
A |
T |
15: 9,365,351 (GRCm38) |
D350V |
probably damaging |
Het |
| Vmn2r8 |
T |
A |
5: 108,802,418 (GRCm38) |
T188S |
possibly damaging |
Het |
| Vwa7 |
C |
G |
17: 35,017,112 (GRCm38) |
P14R |
probably benign |
Het |
| Vwc2 |
C |
A |
11: 11,261,495 (GRCm38) |
T317K |
probably damaging |
Het |
| Vwf |
A |
T |
6: 125,628,372 (GRCm38) |
Q906L |
probably benign |
Het |
| Wdr49 |
A |
G |
3: 75,429,347 (GRCm38) |
V351A |
probably damaging |
Het |
| Wdr7 |
A |
G |
18: 63,728,504 (GRCm38) |
S196G |
probably benign |
Het |
| Xkr6 |
C |
A |
14: 63,798,296 (GRCm38) |
A26E |
unknown |
Het |
| Zcchc11 |
T |
A |
4: 108,550,725 (GRCm38) |
V1397D |
probably damaging |
Het |
| Zfp955b |
T |
C |
17: 33,305,453 (GRCm38) |
I47V |
probably benign |
Het |
|
| Other mutations in Cenpf |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00778:Cenpf
|
APN |
1 |
189,654,912 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01154:Cenpf
|
APN |
1 |
189,680,333 (GRCm38) |
missense |
probably benign |
0.19 |
|
IGL01434:Cenpf
|
APN |
1 |
189,657,868 (GRCm38) |
nonsense |
probably null |
|
|
IGL01461:Cenpf
|
APN |
1 |
189,657,096 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01615:Cenpf
|
APN |
1 |
189,653,184 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
IGL01720:Cenpf
|
APN |
1 |
189,651,215 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01720:Cenpf
|
APN |
1 |
189,682,386 (GRCm38) |
missense |
probably benign |
0.05 |
|
IGL01803:Cenpf
|
APN |
1 |
189,654,771 (GRCm38) |
nonsense |
probably null |
|
|
IGL02152:Cenpf
|
APN |
1 |
189,649,012 (GRCm38) |
missense |
probably benign |
|
|
IGL02222:Cenpf
|
APN |
1 |
189,654,444 (GRCm38) |
missense |
probably benign |
|
|
IGL02338:Cenpf
|
APN |
1 |
189,680,418 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02580:Cenpf
|
APN |
1 |
189,657,441 (GRCm38) |
missense |
probably benign |
0.20 |
|
IGL02629:Cenpf
|
APN |
1 |
189,652,334 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02650:Cenpf
|
APN |
1 |
189,652,473 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
IGL02660:Cenpf
|
APN |
1 |
189,654,782 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02703:Cenpf
|
APN |
1 |
189,659,758 (GRCm38) |
missense |
probably benign |
0.14 |
|
IGL02809:Cenpf
|
APN |
1 |
189,682,358 (GRCm38) |
splice site |
probably benign |
|
|
IGL02851:Cenpf
|
APN |
1 |
189,658,030 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02903:Cenpf
|
APN |
1 |
189,646,876 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03126:Cenpf
|
APN |
1 |
189,659,010 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03235:Cenpf
|
APN |
1 |
189,683,927 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03336:Cenpf
|
APN |
1 |
189,652,647 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03402:Cenpf
|
APN |
1 |
189,655,076 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02799:Cenpf
|
UTSW |
1 |
189,659,652 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0011:Cenpf
|
UTSW |
1 |
189,650,706 (GRCm38) |
missense |
probably benign |
0.05 |
|
R0129:Cenpf
|
UTSW |
1 |
189,659,650 (GRCm38) |
missense |
probably benign |
0.26 |
|
R0157:Cenpf
|
UTSW |
1 |
189,652,359 (GRCm38) |
missense |
probably benign |
0.07 |
|
R0270:Cenpf
|
UTSW |
1 |
189,650,714 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0607:Cenpf
|
UTSW |
1 |
189,682,463 (GRCm38) |
splice site |
probably null |
|
|
R0621:Cenpf
|
UTSW |
1 |
189,672,628 (GRCm38) |
missense |
probably benign |
|
|
R0639:Cenpf
|
UTSW |
1 |
189,658,062 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0653:Cenpf
|
UTSW |
1 |
189,659,986 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0718:Cenpf
|
UTSW |
1 |
189,653,984 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1157:Cenpf
|
UTSW |
1 |
189,658,453 (GRCm38) |
missense |
probably benign |
0.20 |
|
R1331:Cenpf
|
UTSW |
1 |
189,642,801 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1463:Cenpf
|
UTSW |
1 |
189,654,739 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1514:Cenpf
|
UTSW |
1 |
189,679,141 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R1529:Cenpf
|
UTSW |
1 |
189,660,038 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1574:Cenpf
|
UTSW |
1 |
189,652,713 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1574:Cenpf
|
UTSW |
1 |
189,652,713 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1662:Cenpf
|
UTSW |
1 |
189,657,771 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1671:Cenpf
|
UTSW |
1 |
189,679,144 (GRCm38) |
splice site |
probably null |
|
|
R1725:Cenpf
|
UTSW |
1 |
189,680,479 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1743:Cenpf
|
UTSW |
1 |
189,654,263 (GRCm38) |
missense |
probably benign |
0.19 |
|
R1884:Cenpf
|
UTSW |
1 |
189,646,849 (GRCm38) |
missense |
probably benign |
|
|
R1980:Cenpf
|
UTSW |
1 |
189,653,915 (GRCm38) |
missense |
probably benign |
0.04 |
|
R2074:Cenpf
|
UTSW |
1 |
189,656,901 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2096:Cenpf
|
UTSW |
1 |
189,653,459 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R2109:Cenpf
|
UTSW |
1 |
189,679,067 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2113:Cenpf
|
UTSW |
1 |
189,679,102 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R2134:Cenpf
|
UTSW |
1 |
189,658,642 (GRCm38) |
missense |
probably benign |
0.03 |
|
R2209:Cenpf
|
UTSW |
1 |
189,652,598 (GRCm38) |
missense |
probably benign |
0.04 |
|
R2875:Cenpf
|
UTSW |
1 |
189,658,644 (GRCm38) |
missense |
probably benign |
0.11 |
|
R2876:Cenpf
|
UTSW |
1 |
189,658,644 (GRCm38) |
missense |
probably benign |
0.11 |
|
R3433:Cenpf
|
UTSW |
1 |
189,659,949 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3709:Cenpf
|
UTSW |
1 |
189,648,812 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R3786:Cenpf
|
UTSW |
1 |
189,658,337 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4014:Cenpf
|
UTSW |
1 |
189,653,159 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4108:Cenpf
|
UTSW |
1 |
189,683,868 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4119:Cenpf
|
UTSW |
1 |
189,653,045 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4177:Cenpf
|
UTSW |
1 |
189,668,619 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R4422:Cenpf
|
UTSW |
1 |
189,658,350 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4546:Cenpf
|
UTSW |
1 |
189,654,650 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4592:Cenpf
|
UTSW |
1 |
189,679,033 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4643:Cenpf
|
UTSW |
1 |
189,659,589 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4650:Cenpf
|
UTSW |
1 |
189,660,038 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4801:Cenpf
|
UTSW |
1 |
189,651,220 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4802:Cenpf
|
UTSW |
1 |
189,651,220 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4817:Cenpf
|
UTSW |
1 |
189,682,369 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R4871:Cenpf
|
UTSW |
1 |
189,658,531 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5037:Cenpf
|
UTSW |
1 |
189,683,846 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5106:Cenpf
|
UTSW |
1 |
189,683,808 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5208:Cenpf
|
UTSW |
1 |
189,671,046 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5213:Cenpf
|
UTSW |
1 |
189,654,980 (GRCm38) |
missense |
probably benign |
0.04 |
|
R5237:Cenpf
|
UTSW |
1 |
189,659,533 (GRCm38) |
missense |
probably benign |
0.28 |
|
R5255:Cenpf
|
UTSW |
1 |
189,672,627 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R5378:Cenpf
|
UTSW |
1 |
189,653,466 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R5468:Cenpf
|
UTSW |
1 |
189,652,371 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5510:Cenpf
|
UTSW |
1 |
189,682,903 (GRCm38) |
missense |
probably benign |
0.14 |
|
R5616:Cenpf
|
UTSW |
1 |
189,657,286 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5652:Cenpf
|
UTSW |
1 |
189,657,082 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5735:Cenpf
|
UTSW |
1 |
189,654,363 (GRCm38) |
missense |
probably benign |
0.10 |
|
R5841:Cenpf
|
UTSW |
1 |
189,657,444 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R5943:Cenpf
|
UTSW |
1 |
189,659,969 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R6082:Cenpf
|
UTSW |
1 |
189,658,104 (GRCm38) |
missense |
probably benign |
0.11 |
|
R6108:Cenpf
|
UTSW |
1 |
189,662,013 (GRCm38) |
missense |
probably benign |
0.03 |
|
R6269:Cenpf
|
UTSW |
1 |
189,659,920 (GRCm38) |
missense |
probably benign |
0.37 |
|
R6284:Cenpf
|
UTSW |
1 |
189,652,742 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6425:Cenpf
|
UTSW |
1 |
189,659,898 (GRCm38) |
missense |
probably benign |
0.09 |
|
R6587:Cenpf
|
UTSW |
1 |
189,658,374 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6747:Cenpf
|
UTSW |
1 |
189,652,854 (GRCm38) |
missense |
probably benign |
0.15 |
|
R6811:Cenpf
|
UTSW |
1 |
189,654,542 (GRCm38) |
missense |
probably benign |
0.06 |
|
R6834:Cenpf
|
UTSW |
1 |
189,659,446 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6951:Cenpf
|
UTSW |
1 |
189,653,792 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7095:Cenpf
|
UTSW |
1 |
189,659,176 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7128:Cenpf
|
UTSW |
1 |
189,684,991 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7185:Cenpf
|
UTSW |
1 |
189,653,489 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7292:Cenpf
|
UTSW |
1 |
189,650,694 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7353:Cenpf
|
UTSW |
1 |
189,654,138 (GRCm38) |
nonsense |
probably null |
|
|
R7402:Cenpf
|
UTSW |
1 |
189,659,378 (GRCm38) |
nonsense |
probably null |
|
|
R7460:Cenpf
|
UTSW |
1 |
189,654,050 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7484:Cenpf
|
UTSW |
1 |
189,656,821 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7574:Cenpf
|
UTSW |
1 |
189,658,667 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7691:Cenpf
|
UTSW |
1 |
189,658,207 (GRCm38) |
nonsense |
probably null |
|
|
R7698:Cenpf
|
UTSW |
1 |
189,662,072 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7901:Cenpf
|
UTSW |
1 |
189,657,248 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7941:Cenpf
|
UTSW |
1 |
189,657,286 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8007:Cenpf
|
UTSW |
1 |
189,646,947 (GRCm38) |
missense |
|
|
|
R8194:Cenpf
|
UTSW |
1 |
189,682,403 (GRCm38) |
missense |
probably benign |
0.06 |
|
R8420:Cenpf
|
UTSW |
1 |
189,672,585 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8429:Cenpf
|
UTSW |
1 |
189,657,307 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R8477:Cenpf
|
UTSW |
1 |
189,653,188 (GRCm38) |
missense |
probably benign |
|
|
R8492:Cenpf
|
UTSW |
1 |
189,658,729 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8510:Cenpf
|
UTSW |
1 |
189,650,706 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8686:Cenpf
|
UTSW |
1 |
189,659,604 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8696:Cenpf
|
UTSW |
1 |
189,657,997 (GRCm38) |
missense |
probably benign |
0.20 |
|
R8855:Cenpf
|
UTSW |
1 |
189,653,233 (GRCm38) |
missense |
probably benign |
0.11 |
|
R8901:Cenpf
|
UTSW |
1 |
189,662,051 (GRCm38) |
missense |
probably benign |
0.30 |
|
R8958:Cenpf
|
UTSW |
1 |
189,653,153 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R9109:Cenpf
|
UTSW |
1 |
189,659,374 (GRCm38) |
missense |
probably benign |
0.06 |
|
R9135:Cenpf
|
UTSW |
1 |
189,672,549 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9136:Cenpf
|
UTSW |
1 |
189,671,155 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9198:Cenpf
|
UTSW |
1 |
189,656,790 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9240:Cenpf
|
UTSW |
1 |
189,656,970 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9303:Cenpf
|
UTSW |
1 |
189,660,074 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R9305:Cenpf
|
UTSW |
1 |
189,660,074 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R9354:Cenpf
|
UTSW |
1 |
189,646,917 (GRCm38) |
missense |
|
|
|
R9502:Cenpf
|
UTSW |
1 |
189,656,781 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9619:Cenpf
|
UTSW |
1 |
189,653,768 (GRCm38) |
missense |
probably benign |
0.01 |
|
RF006:Cenpf
|
UTSW |
1 |
189,657,386 (GRCm38) |
missense |
probably damaging |
1.00 |
|
X0025:Cenpf
|
UTSW |
1 |
189,653,874 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
X0066:Cenpf
|
UTSW |
1 |
189,657,929 (GRCm38) |
missense |
probably benign |
0.23 |
|
Z1088:Cenpf
|
UTSW |
1 |
189,652,931 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Cenpf
|
UTSW |
1 |
189,659,472 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGCACTGTACACTGAGACC -3'
(R):5'- TCTCAGAAAAGTTAGAGCCAGGC -3'
Sequencing Primer
(F):5'- GGCACTGTACACTGAGACCCTTAG -3'
(R):5'- AGAGCCAGGCTTATATGTGATAC -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation