Incidental Mutation 'R1875:Psg23'
ID 211140
Institutional Source Beutler Lab
Gene Symbol Psg23
Ensembl Gene ENSMUSG00000074359
Gene Name pregnancy-specific beta-1-glycoprotein 23
Synonyms 1620401C02Rik
MMRRC Submission 039897-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1875 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 18340268-18350426 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 18344375 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 360 (T360I)
Ref Sequence ENSEMBL: ENSMUSP00000056586 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057810]
AlphaFold Q9D2U0
Predicted Effect probably benign
Transcript: ENSMUST00000057810
AA Change: T360I

PolyPhen 2 Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000056586
Gene: ENSMUSG00000074359
AA Change: T360I

DomainStartEndE-ValueType
IG 39 138 2.03e-4 SMART
IG 159 260 4.16e-1 SMART
IG 276 375 1.25e-4 SMART
IGc2 393 457 4.7e-9 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 95.1%
  • 20x: 92.1%
Validation Efficiency 98% (85/87)
MGI Phenotype PHENOTYPE: Mice homozygous for this spontaneous mutation display no phenotypic abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 A T 7: 119,847,190 (GRCm39) M685L possibly damaging Het
Abi3bp A G 16: 56,394,862 (GRCm39) Y190C probably damaging Het
Adam26a C A 8: 44,022,888 (GRCm39) V201L probably benign Het
Adamts20 G T 15: 94,229,277 (GRCm39) D947E probably benign Het
Ankrd26 A G 6: 118,517,410 (GRCm39) probably null Het
Apol11a C A 15: 77,397,766 (GRCm39) T39N possibly damaging Het
Arhgef38 T A 3: 132,839,501 (GRCm39) probably null Het
Armh4 T C 14: 49,919,815 (GRCm39) D772G probably damaging Het
Atp11b T C 3: 35,893,296 (GRCm39) L883P probably damaging Het
Btnl10 T A 11: 58,814,586 (GRCm39) I422N probably damaging Het
C2cd3 A G 7: 100,056,232 (GRCm39) K547E possibly damaging Het
Cdh2 T A 18: 16,757,934 (GRCm39) L549F probably benign Het
Celsr3 T C 9: 108,713,037 (GRCm39) V1825A probably benign Het
Cfap221 T C 1: 119,881,389 (GRCm39) I358V probably benign Het
Cimap2 G A 4: 106,470,453 (GRCm39) probably benign Het
Csmd1 T C 8: 15,979,101 (GRCm39) K2828E probably damaging Het
Ddah2 T C 17: 35,279,821 (GRCm39) F137S probably damaging Het
Ddx21 A G 10: 62,429,847 (GRCm39) I299T probably damaging Het
Dnah7a A T 1: 53,495,691 (GRCm39) probably benign Het
Elmod1 A G 9: 53,843,151 (GRCm39) I9T probably benign Het
Epha2 A G 4: 141,036,290 (GRCm39) E242G probably benign Het
Erbb3 T C 10: 128,410,335 (GRCm39) H641R possibly damaging Het
Fbxl18 G A 5: 142,871,978 (GRCm39) A419V probably damaging Het
Fli1 T C 9: 32,335,209 (GRCm39) M408V probably benign Het
Fmo4 T C 1: 162,631,187 (GRCm39) N260S possibly damaging Het
Fry A G 5: 150,249,597 (GRCm39) E136G probably damaging Het
Gm10477 T A X: 55,570,127 (GRCm39) F9Y probably damaging Het
Gm8258 A G 5: 104,924,320 (GRCm39) noncoding transcript Het
Gpr68 T A 12: 100,845,049 (GRCm39) D165V probably damaging Het
Htt T A 5: 34,951,456 (GRCm39) M139K probably benign Het
Jup A G 11: 100,263,120 (GRCm39) probably null Het
Kifc5b G A 17: 27,136,264 (GRCm39) probably null Het
Krba1 T A 6: 48,390,983 (GRCm39) probably null Het
Lamp1 G A 8: 13,217,257 (GRCm39) G89R probably damaging Het
Lrrc17 C T 5: 21,765,650 (GRCm39) S44F possibly damaging Het
Mdga1 T C 17: 30,071,581 (GRCm39) T347A probably damaging Het
Mical3 A T 6: 121,019,025 (GRCm39) W66R probably damaging Het
Mpl A G 4: 118,314,026 (GRCm39) Y73H probably benign Het
Mterf1b T A 5: 4,247,364 (GRCm39) I335N possibly damaging Het
Mylk3 A G 8: 86,079,494 (GRCm39) I388T probably damaging Het
Myo15a C T 11: 60,398,354 (GRCm39) R2775W probably damaging Het
Myoz2 A T 3: 122,819,765 (GRCm39) S65T probably damaging Het
Ndrg1 T C 15: 66,802,940 (GRCm39) T137A possibly damaging Het
Neil3 G T 8: 54,052,454 (GRCm39) N381K probably damaging Het
Obsl1 T C 1: 75,474,877 (GRCm39) Y841C probably damaging Het
Or2b4 A G 17: 38,115,996 (GRCm39) probably benign Het
Or6b6 G A 7: 106,571,389 (GRCm39) S54F possibly damaging Het
Otogl T C 10: 107,735,451 (GRCm39) D111G probably damaging Het
Parp10 T C 15: 76,127,051 (GRCm39) E103G probably damaging Het
Pars2 T C 4: 106,510,913 (GRCm39) F232L possibly damaging Het
Pcdh18 A T 3: 49,709,154 (GRCm39) F720L probably damaging Het
Phf3 T C 1: 30,869,704 (GRCm39) E448G possibly damaging Het
Pigc A G 1: 161,798,516 (GRCm39) Y166C probably damaging Het
Pik3c2a A T 7: 116,017,206 (GRCm39) S184T probably benign Het
Pkd1l1 A G 11: 8,794,670 (GRCm39) probably benign Het
Plch2 G A 4: 155,082,965 (GRCm39) S485F probably damaging Het
Plxnd1 G T 6: 115,955,045 (GRCm39) probably null Het
Pnliprp2 G T 19: 58,751,821 (GRCm39) V189L probably benign Het
Prl8a2 T C 13: 27,535,037 (GRCm39) V103A probably benign Het
Rad51c A T 11: 87,279,469 (GRCm39) I323N probably damaging Het
Rsbn1l C T 5: 21,156,696 (GRCm39) E30K probably benign Het
Serpina3c C A 12: 104,118,145 (GRCm39) L64F probably damaging Het
Shroom1 A G 11: 53,356,502 (GRCm39) D392G probably damaging Het
Slc26a5 T A 5: 22,020,725 (GRCm39) I540L probably benign Het
Slc37a4 A G 9: 44,312,808 (GRCm39) T321A probably damaging Het
Slc41a2 A G 10: 83,091,949 (GRCm39) L438S probably damaging Het
Spef2 C T 15: 9,584,194 (GRCm39) E1624K probably damaging Het
Spef2 C T 15: 9,597,487 (GRCm39) G1390R possibly damaging Het
Spmap2l A T 5: 77,202,431 (GRCm39) K284M probably benign Het
Synj2 G T 17: 6,078,825 (GRCm39) A740S possibly damaging Het
Tigd4 A C 3: 84,502,394 (GRCm39) D437A probably benign Het
Timm21 G C 18: 84,967,387 (GRCm39) L130V probably damaging Het
Tmem106a CAGCTCAACACGACGGTA CAGCTCAACACGACGGTAAGCTCAACACGACGGTA 11: 101,477,204 (GRCm39) probably benign Het
Tmem131l A T 3: 83,812,383 (GRCm39) C1313* probably null Het
Tmem86b A T 7: 4,632,698 (GRCm39) I47N possibly damaging Het
Tspan13 T C 12: 36,070,550 (GRCm39) probably null Het
Vps54 A G 11: 21,250,251 (GRCm39) T396A probably benign Het
Zfp106 A T 2: 120,344,096 (GRCm39) probably null Het
Zfp668 T C 7: 127,465,654 (GRCm39) probably null Het
Zfp809 A T 9: 22,150,027 (GRCm39) R175* probably null Het
Other mutations in Psg23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00814:Psg23 APN 7 18,348,608 (GRCm39) nonsense probably null
IGL01309:Psg23 APN 7 18,348,465 (GRCm39) missense probably damaging 1.00
IGL01736:Psg23 APN 7 18,346,122 (GRCm39) missense possibly damaging 0.76
IGL02142:Psg23 APN 7 18,344,345 (GRCm39) missense probably benign 0.01
IGL02728:Psg23 APN 7 18,340,853 (GRCm39) missense probably benign 0.02
IGL03080:Psg23 APN 7 18,340,910 (GRCm39) missense probably damaging 1.00
IGL03130:Psg23 APN 7 18,344,341 (GRCm39) missense probably benign 0.25
R0113:Psg23 UTSW 7 18,345,927 (GRCm39) missense probably benign 0.31
R0137:Psg23 UTSW 7 18,348,558 (GRCm39) missense probably benign 0.00
R0544:Psg23 UTSW 7 18,348,607 (GRCm39) missense probably damaging 1.00
R1368:Psg23 UTSW 7 18,348,645 (GRCm39) missense probably benign 0.13
R1840:Psg23 UTSW 7 18,344,363 (GRCm39) missense possibly damaging 0.67
R1869:Psg23 UTSW 7 18,348,543 (GRCm39) missense probably benign 0.09
R2041:Psg23 UTSW 7 18,348,703 (GRCm39) missense possibly damaging 0.78
R2096:Psg23 UTSW 7 18,348,668 (GRCm39) missense probably damaging 1.00
R3110:Psg23 UTSW 7 18,344,369 (GRCm39) missense possibly damaging 0.72
R3112:Psg23 UTSW 7 18,344,369 (GRCm39) missense possibly damaging 0.72
R3790:Psg23 UTSW 7 18,346,126 (GRCm39) missense probably benign 0.00
R3892:Psg23 UTSW 7 18,345,966 (GRCm39) missense probably damaging 1.00
R4074:Psg23 UTSW 7 18,341,043 (GRCm39) missense possibly damaging 0.66
R4200:Psg23 UTSW 7 18,345,990 (GRCm39) missense probably damaging 1.00
R4865:Psg23 UTSW 7 18,346,039 (GRCm39) missense probably benign 0.14
R5337:Psg23 UTSW 7 18,345,997 (GRCm39) missense probably benign 0.00
R6016:Psg23 UTSW 7 18,346,112 (GRCm39) missense probably benign 0.00
R6951:Psg23 UTSW 7 18,348,636 (GRCm39) missense probably damaging 1.00
R7033:Psg23 UTSW 7 18,348,669 (GRCm39) missense possibly damaging 0.82
R7212:Psg23 UTSW 7 18,341,064 (GRCm39) missense probably benign 0.00
R7427:Psg23 UTSW 7 18,345,908 (GRCm39) splice site probably null
R7527:Psg23 UTSW 7 18,348,699 (GRCm39) missense probably damaging 1.00
R7814:Psg23 UTSW 7 18,340,839 (GRCm39) makesense probably null
R7864:Psg23 UTSW 7 18,344,435 (GRCm39) missense possibly damaging 0.87
R7897:Psg23 UTSW 7 18,341,108 (GRCm39) missense possibly damaging 0.83
R8155:Psg23 UTSW 7 18,346,179 (GRCm39) missense probably damaging 1.00
R8358:Psg23 UTSW 7 18,348,522 (GRCm39) missense probably benign 0.00
R9032:Psg23 UTSW 7 18,348,660 (GRCm39) missense possibly damaging 0.83
R9085:Psg23 UTSW 7 18,348,660 (GRCm39) missense possibly damaging 0.83
R9365:Psg23 UTSW 7 18,344,393 (GRCm39) missense probably damaging 1.00
R9577:Psg23 UTSW 7 18,346,067 (GRCm39) missense probably benign 0.00
R9688:Psg23 UTSW 7 18,344,547 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTAATGCTGTTGGACCACC -3'
(R):5'- AGATCTGCAAACCTTTTCCTGG -3'

Sequencing Primer
(F):5'- CCATGTATGCCCTGCAGTAAGTG -3'
(R):5'- GCAAACCTTTTCCTGGTACAAGGG -3'
Posted On 2014-06-30