Incidental Mutation 'R1876:Tigd4'
ID 211206
Institutional Source Beutler Lab
Gene Symbol Tigd4
Ensembl Gene ENSMUSG00000047819
Gene Name tigger transposable element derived 4
Synonyms C130063O11Rik, Tigd4
MMRRC Submission 039898-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.161) question?
Stock # R1876 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 84500881-84504339 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 84501242 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 53 (L53*)
Ref Sequence ENSEMBL: ENSMUSP00000052320 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062623] [ENSMUST00000154148]
AlphaFold Q8BUZ3
Predicted Effect probably null
Transcript: ENSMUST00000062623
AA Change: L53*
SMART Domains Protein: ENSMUSP00000052320
Gene: ENSMUSG00000047819
AA Change: L53*

DomainStartEndE-ValueType
Pfam:CENP-B_N 15 67 9e-14 PFAM
CENPB 81 146 5.52e-16 SMART
Pfam:DDE_1 211 375 4.9e-39 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000154148
SMART Domains Protein: ENSMUSP00000116393
Gene: ENSMUSG00000102805

DomainStartEndE-ValueType
Arfaptin 1 227 7.15e-121 SMART
Meta Mutation Damage Score 0.9711 question?
Coding Region Coverage
  • 1x: 97.3%
  • 3x: 96.7%
  • 10x: 95.1%
  • 20x: 92.2%
Validation Efficiency 99% (82/83)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh C A 5: 77,025,396 (GRCm39) C961F probably damaging Het
Abca16 A C 7: 120,032,608 (GRCm39) D209A probably damaging Het
Adamts14 T C 10: 61,036,151 (GRCm39) I1047V probably benign Het
Ak1 A G 2: 32,520,282 (GRCm39) K27E probably damaging Het
Akap9 T A 5: 4,011,809 (GRCm39) D837E probably benign Het
Arfgef3 T C 10: 18,473,104 (GRCm39) Y1653C probably damaging Het
Atad2 T G 15: 57,970,264 (GRCm39) I446L probably benign Het
Atp8b3 T G 10: 80,365,912 (GRCm39) T313P possibly damaging Het
Btg4 T C 9: 51,028,489 (GRCm39) L72S probably damaging Het
Canx A G 11: 50,195,186 (GRCm39) I294T probably damaging Het
Casp1 G A 9: 5,303,663 (GRCm39) E250K probably benign Het
Chchd10 T A 10: 75,772,166 (GRCm39) S46T probably benign Het
Col12a1 G T 9: 79,585,563 (GRCm39) Y1271* probably null Het
Col3a1 G A 1: 45,381,395 (GRCm39) probably null Het
Ctc1 A T 11: 68,922,390 (GRCm39) T872S probably benign Het
Cx3cl1 T C 8: 95,507,048 (GRCm39) F351S probably damaging Het
Cyb5r4 T A 9: 86,937,867 (GRCm39) H295Q probably damaging Het
Cyp2j7 T C 4: 96,105,656 (GRCm39) T285A probably benign Het
Dip2a G A 10: 76,153,925 (GRCm39) T135M probably damaging Het
Eif1ad18 T G 12: 88,050,810 (GRCm39) I115S probably damaging Het
Fgf10 A G 13: 118,925,695 (GRCm39) E158G probably damaging Het
Ftcd G T 10: 76,417,403 (GRCm39) A281S probably benign Het
Gpat4 A T 8: 23,669,486 (GRCm39) M333K possibly damaging Het
Gpcpd1 A G 2: 132,376,673 (GRCm39) L541P probably damaging Het
Grk5 T C 19: 61,071,663 (GRCm39) Y408H probably damaging Het
Hcrtr2 A G 9: 76,153,627 (GRCm39) probably null Het
Hsd17b13 T A 5: 104,116,633 (GRCm39) N127I probably damaging Het
Hspa4 T G 11: 53,174,983 (GRCm39) D158A probably benign Het
Ice2 G A 9: 69,322,857 (GRCm39) A451T possibly damaging Het
Inpp5e A T 2: 26,298,169 (GRCm39) I144K possibly damaging Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lrrc49 T C 9: 60,495,060 (GRCm39) I652V possibly damaging Het
Man1a A T 10: 53,795,268 (GRCm39) W571R probably damaging Het
Mecom A G 3: 30,047,807 (GRCm39) S32P probably damaging Het
Mrpl40 A G 16: 18,691,224 (GRCm39) I162T probably benign Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Mtmr12 T C 15: 12,257,716 (GRCm39) W265R probably damaging Het
Mup21 C T 4: 62,067,663 (GRCm39) V79I probably benign Het
Myh11 G A 16: 14,086,967 (GRCm39) probably benign Het
Myom3 T A 4: 135,506,711 (GRCm39) F495I probably benign Het
Ncoa7 A T 10: 30,574,122 (GRCm39) probably benign Het
Nisch T C 14: 30,895,594 (GRCm39) Y45C probably damaging Het
Nkain2 T A 10: 32,766,435 (GRCm39) probably benign Het
Or1ak2 A T 2: 36,827,775 (GRCm39) I215F possibly damaging Het
Or4k1 A G 14: 50,377,629 (GRCm39) S156P probably damaging Het
Pdcl A C 2: 37,245,708 (GRCm39) H98Q probably damaging Het
Pink1 A G 4: 138,043,013 (GRCm39) V427A probably damaging Het
Plce1 T C 19: 38,769,067 (GRCm39) S2242P probably damaging Het
Plrg1 C A 3: 82,976,375 (GRCm39) probably benign Het
Plxnc1 A G 10: 94,702,803 (GRCm39) F586S possibly damaging Het
Pnpla7 G A 2: 24,930,985 (GRCm39) V867M possibly damaging Het
Ppfia3 T A 7: 45,001,631 (GRCm39) D427V possibly damaging Het
Ppp6r3 A T 19: 3,521,971 (GRCm39) probably benign Het
Pros1 A T 16: 62,723,881 (GRCm39) S210C probably damaging Het
Ptk2b A G 14: 66,395,841 (GRCm39) S839P probably benign Het
Ptpre T C 7: 135,280,046 (GRCm39) V570A possibly damaging Het
Rbm48 C T 5: 3,645,259 (GRCm39) A142T probably damaging Het
Safb2 T C 17: 56,883,909 (GRCm39) probably null Het
Scnn1a A G 6: 125,315,801 (GRCm39) E384G probably benign Het
Sec23ip A G 7: 128,354,575 (GRCm39) Y277C probably benign Het
Slc25a29 G A 12: 108,793,637 (GRCm39) T42M probably damaging Het
Slc6a4 A T 11: 76,905,990 (GRCm39) T264S probably benign Het
Srgap3 A G 6: 112,752,527 (GRCm39) M319T probably damaging Het
Strn4 T A 7: 16,572,207 (GRCm39) I640N probably damaging Het
Tacc2 A G 7: 130,225,475 (GRCm39) D739G probably benign Het
Tlr6 T A 5: 65,112,763 (GRCm39) D48V probably damaging Het
Tmem125 T C 4: 118,399,101 (GRCm39) D110G probably damaging Het
Tmem198 A G 1: 75,461,567 (GRCm39) D341G probably damaging Het
Tnfaip3 A G 10: 18,880,682 (GRCm39) F462L possibly damaging Het
Tnrc6a CTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTT CTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTT 7: 122,761,669 (GRCm39) probably benign Het
Ush2a T A 1: 188,410,486 (GRCm39) I2378N possibly damaging Het
Usp47 A G 7: 111,654,127 (GRCm39) T108A probably damaging Het
Vmn1r236 T A 17: 21,506,900 (GRCm39) I6K probably benign Het
Vmn2r65 A T 7: 84,595,505 (GRCm39) V393D probably damaging Het
Other mutations in Tigd4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01791:Tigd4 APN 3 84,502,052 (GRCm39) missense probably damaging 1.00
R0080:Tigd4 UTSW 3 84,501,452 (GRCm39) missense probably benign 0.19
R0320:Tigd4 UTSW 3 84,502,481 (GRCm39) missense probably benign
R0347:Tigd4 UTSW 3 84,501,167 (GRCm39) missense probably damaging 1.00
R1875:Tigd4 UTSW 3 84,502,394 (GRCm39) missense probably benign 0.00
R2142:Tigd4 UTSW 3 84,501,670 (GRCm39) missense possibly damaging 0.95
R2258:Tigd4 UTSW 3 84,501,600 (GRCm39) missense probably benign 0.00
R2519:Tigd4 UTSW 3 84,501,221 (GRCm39) missense probably damaging 1.00
R2866:Tigd4 UTSW 3 84,501,259 (GRCm39) missense possibly damaging 0.48
R2867:Tigd4 UTSW 3 84,501,259 (GRCm39) missense possibly damaging 0.48
R2867:Tigd4 UTSW 3 84,501,259 (GRCm39) missense possibly damaging 0.48
R3974:Tigd4 UTSW 3 84,502,585 (GRCm39) missense possibly damaging 0.82
R4094:Tigd4 UTSW 3 84,501,947 (GRCm39) missense probably damaging 1.00
R4967:Tigd4 UTSW 3 84,502,460 (GRCm39) missense probably benign 0.03
R5155:Tigd4 UTSW 3 84,501,970 (GRCm39) missense possibly damaging 0.96
R5878:Tigd4 UTSW 3 84,501,749 (GRCm39) missense probably benign 0.09
R6174:Tigd4 UTSW 3 84,502,574 (GRCm39) missense probably benign 0.02
R6960:Tigd4 UTSW 3 84,501,423 (GRCm39) missense probably damaging 1.00
R7414:Tigd4 UTSW 3 84,501,128 (GRCm39) missense probably benign 0.37
R7445:Tigd4 UTSW 3 84,502,471 (GRCm39) missense probably benign 0.01
R7696:Tigd4 UTSW 3 84,502,224 (GRCm39) missense possibly damaging 0.89
R7810:Tigd4 UTSW 3 84,502,310 (GRCm39) missense possibly damaging 0.49
R8016:Tigd4 UTSW 3 84,501,971 (GRCm39) missense possibly damaging 0.46
R8489:Tigd4 UTSW 3 84,502,526 (GRCm39) missense probably benign
R8745:Tigd4 UTSW 3 84,501,874 (GRCm39) missense probably benign 0.03
R8872:Tigd4 UTSW 3 84,501,547 (GRCm39) missense probably benign
X0023:Tigd4 UTSW 3 84,501,164 (GRCm39) missense probably damaging 1.00
X0064:Tigd4 UTSW 3 84,501,785 (GRCm39) missense probably damaging 1.00
Z1176:Tigd4 UTSW 3 84,501,696 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGATTACGGAAACTTACACCAGGAG -3'
(R):5'- GCTTTTAGACGCAACATCGGG -3'

Sequencing Primer
(F):5'- AAGGTCTGCACAAGCCG -3'
(R):5'- GCAACATCGGGCCATTAACTG -3'
Posted On 2014-06-30