Incidental Mutation 'R1891:Lrrk1'
| ID |
211491 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrrk1
|
| Ensembl Gene |
ENSMUSG00000015133 |
| Gene Name |
leucine-rich repeat kinase 1 |
| Synonyms |
D130026O16Rik, C230002E15Rik |
| MMRRC Submission |
039911-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1891 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
65908493-66038089 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 65929048 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Phenylalanine
at position 1195
(L1195F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000015277
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000015277]
[ENSMUST00000145954]
|
| AlphaFold |
Q3UHC2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000015277
AA Change: L1195F
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000015277
Gene: ENSMUSG00000015133
AA Change: L1195F
| Domain | Start | End | E-Value | Type |
|---|
|
ANK
|
86 |
116 |
9.33e2 |
SMART |
|
ANK
|
119 |
148 |
1.14e2 |
SMART |
|
ANK
|
152 |
182 |
8.36e1 |
SMART |
|
ANK
|
193 |
223 |
2.6e1 |
SMART |
|
LRR
|
278 |
300 |
2.84e2 |
SMART |
|
LRR
|
301 |
325 |
7.79e0 |
SMART |
|
LRR
|
328 |
351 |
3.27e1 |
SMART |
|
LRR_TYP
|
379 |
401 |
2.53e-2 |
SMART |
|
LRR
|
403 |
427 |
5.89e1 |
SMART |
|
LRR
|
472 |
493 |
5.27e1 |
SMART |
|
LRR
|
548 |
569 |
2.92e2 |
SMART |
|
LRR
|
570 |
594 |
5.88e0 |
SMART |
|
Pfam:Arf
|
625 |
786 |
2e-8 |
PFAM |
|
Pfam:Roc
|
640 |
761 |
3.1e-24 |
PFAM |
|
Pfam:Ras
|
640 |
782 |
2.2e-7 |
PFAM |
|
Pfam:COR
|
844 |
1046 |
4.7e-26 |
PFAM |
|
low complexity region
|
1109 |
1119 |
N/A |
INTRINSIC |
|
low complexity region
|
1209 |
1222 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
1243 |
1521 |
7.8e-40 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1244 |
1520 |
9.4e-39 |
PFAM |
|
low complexity region
|
1642 |
1654 |
N/A |
INTRINSIC |
|
low complexity region
|
1839 |
1846 |
N/A |
INTRINSIC |
|
low complexity region
|
1852 |
1871 |
N/A |
INTRINSIC |
|
low complexity region
|
1957 |
1970 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000145954
AA Change: L110F
PolyPhen 2
Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000114938
Gene: ENSMUSG00000015133
AA Change: L110F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
124 |
137 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
158 |
435 |
6.6e-46 |
PFAM |
|
Pfam:Pkinase_Tyr
|
159 |
435 |
5.8e-40 |
PFAM |
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.4%
- 20x: 92.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice homozygous for another knock-out allele exhibit severe osteopetrosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca7 |
T |
C |
10: 79,840,874 (GRCm39) |
I921T |
possibly damaging |
Het |
| Abca8a |
T |
C |
11: 109,982,433 (GRCm39) |
K3R |
probably benign |
Het |
| Adgrl3 |
A |
T |
5: 81,659,891 (GRCm39) |
D152V |
probably damaging |
Het |
| Akap6 |
A |
T |
12: 53,188,958 (GRCm39) |
D2124V |
possibly damaging |
Het |
| Akt1 |
A |
G |
12: 112,626,009 (GRCm39) |
F88L |
probably damaging |
Het |
| Ankrd24 |
T |
C |
10: 81,479,342 (GRCm39) |
|
probably benign |
Het |
| Arid4b |
T |
A |
13: 14,310,821 (GRCm39) |
N141K |
possibly damaging |
Het |
| Cacna1c |
C |
A |
6: 118,753,480 (GRCm39) |
D219Y |
probably damaging |
Het |
| Ccdc113 |
A |
G |
8: 96,267,544 (GRCm39) |
K170E |
probably damaging |
Het |
| Ceacam9 |
A |
G |
7: 16,457,880 (GRCm39) |
E136G |
probably damaging |
Het |
| Cfap43 |
A |
G |
19: 47,802,380 (GRCm39) |
L333P |
probably damaging |
Het |
| Chl1 |
A |
G |
6: 103,691,544 (GRCm39) |
D1062G |
possibly damaging |
Het |
| Cimip4 |
T |
A |
15: 78,262,952 (GRCm39) |
D234V |
probably damaging |
Het |
| Ckb |
TCCACCACCA |
TCCACCA |
12: 111,636,079 (GRCm39) |
|
probably benign |
Het |
| Clpp |
T |
A |
17: 57,298,307 (GRCm39) |
V91E |
probably damaging |
Het |
| Cndp1 |
A |
T |
18: 84,637,758 (GRCm39) |
H325Q |
probably null |
Het |
| Cngb3 |
A |
G |
4: 19,366,446 (GRCm39) |
N169S |
probably benign |
Het |
| Cog6 |
A |
C |
3: 52,890,601 (GRCm39) |
I613R |
probably benign |
Het |
| Creb3l1 |
A |
G |
2: 91,817,385 (GRCm39) |
L376P |
probably damaging |
Het |
| Cry2 |
A |
T |
2: 92,243,985 (GRCm39) |
V396D |
possibly damaging |
Het |
| Cxxc5 |
A |
G |
18: 35,992,318 (GRCm39) |
M240V |
possibly damaging |
Het |
| Defa28 |
G |
A |
8: 22,073,801 (GRCm39) |
C68Y |
probably damaging |
Het |
| Ecd |
A |
G |
14: 20,388,227 (GRCm39) |
I187T |
probably damaging |
Het |
| Erg28 |
A |
G |
12: 85,862,962 (GRCm39) |
S117P |
probably benign |
Het |
| Ergic2 |
A |
T |
6: 148,084,577 (GRCm39) |
C319S |
probably damaging |
Het |
| Ess2 |
C |
T |
16: 17,725,644 (GRCm39) |
W183* |
probably null |
Het |
| Evc2 |
A |
C |
5: 37,549,423 (GRCm39) |
D773A |
probably damaging |
Het |
| Fam151b |
T |
A |
13: 92,586,678 (GRCm39) |
T252S |
probably benign |
Het |
| Fbxo28 |
A |
T |
1: 182,145,389 (GRCm39) |
M233K |
probably benign |
Het |
| Fbxw26 |
T |
G |
9: 109,551,232 (GRCm39) |
D355A |
probably benign |
Het |
| Gm4884 |
G |
C |
7: 40,692,539 (GRCm39) |
E169D |
possibly damaging |
Het |
| Hk2 |
C |
T |
6: 82,726,264 (GRCm39) |
R94Q |
probably benign |
Het |
| Hps4 |
G |
A |
5: 112,517,422 (GRCm39) |
|
probably null |
Het |
| Hspg2 |
T |
A |
4: 137,292,801 (GRCm39) |
D4126E |
probably damaging |
Het |
| Kif13a |
T |
C |
13: 47,082,695 (GRCm39) |
E48G |
possibly damaging |
Het |
| Krt31 |
T |
A |
11: 99,938,634 (GRCm39) |
N320Y |
probably damaging |
Het |
| Lca5 |
T |
C |
9: 83,277,661 (GRCm39) |
Y561C |
probably damaging |
Het |
| Ly6g6d |
A |
C |
17: 35,293,269 (GRCm39) |
Y25* |
probably null |
Het |
| Map3k13 |
T |
G |
16: 21,729,836 (GRCm39) |
M489R |
probably damaging |
Het |
| Mcm6 |
C |
T |
1: 128,263,547 (GRCm39) |
R658H |
probably damaging |
Het |
| Mecp2 |
C |
T |
X: 73,080,781 (GRCm39) |
A79T |
probably damaging |
Het |
| Mitf |
A |
G |
6: 97,918,237 (GRCm39) |
T94A |
probably benign |
Het |
| Mpo |
T |
A |
11: 87,692,106 (GRCm39) |
L513* |
probably null |
Het |
| Mst1r |
T |
A |
9: 107,790,661 (GRCm39) |
N722K |
probably damaging |
Het |
| Mthfd1l |
T |
A |
10: 3,982,284 (GRCm39) |
L497* |
probably null |
Het |
| Mtus1 |
C |
T |
8: 41,537,362 (GRCm39) |
S118N |
probably damaging |
Het |
| Mybbp1a |
C |
T |
11: 72,336,863 (GRCm39) |
T565I |
probably benign |
Het |
| Naip2 |
C |
T |
13: 100,291,395 (GRCm39) |
R1181K |
probably benign |
Het |
| Nbas |
T |
C |
12: 13,440,973 (GRCm39) |
M1101T |
possibly damaging |
Het |
| Odad3 |
G |
T |
9: 21,906,677 (GRCm39) |
|
probably null |
Het |
| Or2y1b |
T |
C |
11: 49,208,684 (GRCm39) |
F104L |
probably benign |
Het |
| Or4f60 |
A |
T |
2: 111,902,739 (GRCm39) |
L63Q |
probably damaging |
Het |
| Or52l1 |
A |
T |
7: 104,829,754 (GRCm39) |
Y270* |
probably null |
Het |
| Or5ae1 |
T |
A |
7: 84,565,461 (GRCm39) |
V158D |
possibly damaging |
Het |
| Or6c33 |
T |
C |
10: 129,853,439 (GRCm39) |
S70P |
probably damaging |
Het |
| Or7a40 |
T |
A |
16: 16,491,441 (GRCm39) |
I135F |
probably damaging |
Het |
| Or7g20 |
T |
C |
9: 18,947,274 (GRCm39) |
L285S |
probably damaging |
Het |
| Or8b12b |
T |
A |
9: 37,684,163 (GRCm39) |
D69E |
possibly damaging |
Het |
| Oxct2b |
A |
G |
4: 123,010,938 (GRCm39) |
D286G |
probably benign |
Het |
| Pax5 |
A |
T |
4: 44,691,859 (GRCm39) |
V129E |
probably damaging |
Het |
| Pax7 |
G |
A |
4: 139,511,937 (GRCm39) |
R215C |
probably damaging |
Het |
| Pcdh7 |
A |
T |
5: 57,878,217 (GRCm39) |
I591F |
probably damaging |
Het |
| Pcdhb22 |
T |
C |
18: 37,652,357 (GRCm39) |
V275A |
probably damaging |
Het |
| Pkp3 |
C |
T |
7: 140,663,969 (GRCm39) |
|
probably null |
Het |
| Plekhb1 |
A |
G |
7: 100,304,599 (GRCm39) |
L35P |
probably damaging |
Het |
| Pole |
T |
A |
5: 110,480,408 (GRCm39) |
F1993Y |
probably damaging |
Het |
| Pramel28 |
A |
T |
4: 143,693,235 (GRCm39) |
V81E |
probably damaging |
Het |
| Prdx1 |
T |
C |
4: 116,556,451 (GRCm39) |
*200R |
probably null |
Het |
| Prkdc |
C |
A |
16: 15,543,300 (GRCm39) |
T1777N |
probably benign |
Het |
| Prss59 |
A |
T |
6: 40,902,967 (GRCm39) |
M135K |
possibly damaging |
Het |
| Ptpn14 |
G |
A |
1: 189,530,850 (GRCm39) |
V106M |
probably damaging |
Het |
| Ptpn23 |
T |
C |
9: 110,222,868 (GRCm39) |
E63G |
possibly damaging |
Het |
| Qser1 |
A |
C |
2: 104,620,444 (GRCm39) |
S123A |
probably benign |
Het |
| Rbm11 |
A |
G |
16: 75,397,675 (GRCm39) |
N202D |
possibly damaging |
Het |
| Robo3 |
T |
A |
9: 37,339,351 (GRCm39) |
Y212F |
probably damaging |
Het |
| Sde2 |
G |
A |
1: 180,687,573 (GRCm39) |
S153N |
probably benign |
Het |
| Serpinb1c |
T |
A |
13: 33,068,235 (GRCm39) |
D179V |
probably benign |
Het |
| Skint6 |
T |
C |
4: 112,703,893 (GRCm39) |
D994G |
possibly damaging |
Het |
| Sorbs1 |
A |
G |
19: 40,381,904 (GRCm39) |
S46P |
probably damaging |
Het |
| St8sia4 |
T |
C |
1: 95,519,433 (GRCm39) |
T352A |
possibly damaging |
Het |
| Stab1 |
C |
A |
14: 30,863,287 (GRCm39) |
R2133L |
probably benign |
Het |
| Stk11ip |
T |
C |
1: 75,509,060 (GRCm39) |
C730R |
probably benign |
Het |
| Tedc2 |
C |
A |
17: 24,435,292 (GRCm39) |
E366* |
probably null |
Het |
| Tedc2 |
T |
A |
17: 24,435,291 (GRCm39) |
E366V |
probably damaging |
Het |
| Tle4 |
A |
T |
19: 14,522,150 (GRCm39) |
|
probably null |
Het |
| Tmem200a |
T |
A |
10: 25,869,970 (GRCm39) |
N100Y |
probably damaging |
Het |
| Tnnt2 |
A |
T |
1: 135,768,597 (GRCm39) |
|
probably null |
Het |
| Ttn |
T |
A |
2: 76,706,302 (GRCm39) |
|
probably benign |
Het |
| Ubac1 |
A |
G |
2: 25,904,974 (GRCm39) |
V88A |
probably benign |
Het |
| Urgcp |
T |
C |
11: 5,666,910 (GRCm39) |
E476G |
probably benign |
Het |
| Vmn1r201 |
G |
A |
13: 22,659,425 (GRCm39) |
R213H |
probably benign |
Het |
| Vmn2r84 |
C |
T |
10: 130,221,938 (GRCm39) |
V761M |
possibly damaging |
Het |
| Vwde |
A |
T |
6: 13,187,454 (GRCm39) |
Y678N |
probably damaging |
Het |
| Wnk2 |
C |
A |
13: 49,206,200 (GRCm39) |
E1865* |
probably null |
Het |
| Zc3h3 |
A |
C |
15: 75,628,780 (GRCm39) |
M838R |
possibly damaging |
Het |
| Zfp959 |
T |
A |
17: 56,204,604 (GRCm39) |
C211S |
probably damaging |
Het |
|
| Other mutations in Lrrk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01365:Lrrk1
|
APN |
7 |
65,937,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01511:Lrrk1
|
APN |
7 |
65,915,198 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02337:Lrrk1
|
APN |
7 |
65,929,164 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02636:Lrrk1
|
APN |
7 |
65,958,407 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02679:Lrrk1
|
APN |
7 |
65,924,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02711:Lrrk1
|
APN |
7 |
65,980,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02742:Lrrk1
|
APN |
7 |
65,958,439 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02878:Lrrk1
|
APN |
7 |
65,912,311 (GRCm39) |
missense |
probably benign |
|
|
IGL03135:Lrrk1
|
APN |
7 |
65,912,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03191:Lrrk1
|
APN |
7 |
65,909,707 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03198:Lrrk1
|
APN |
7 |
65,956,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
combustion
|
UTSW |
7 |
65,912,413 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
fluorine
|
UTSW |
7 |
65,952,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
halide
|
UTSW |
7 |
65,915,222 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
Heiland
|
UTSW |
7 |
65,912,481 (GRCm39) |
missense |
probably damaging |
0.96 |
|
liebster
|
UTSW |
7 |
65,944,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
magi
|
UTSW |
7 |
65,931,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
oxidation
|
UTSW |
7 |
65,929,120 (GRCm39) |
missense |
probably benign |
0.00 |
|
phlogiston
|
UTSW |
7 |
65,928,268 (GRCm39) |
splice site |
probably benign |
|
|
Savior
|
UTSW |
7 |
65,912,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
wenig
|
UTSW |
7 |
65,922,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
65,942,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
65,942,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0276:Lrrk1
|
UTSW |
7 |
65,946,011 (GRCm39) |
splice site |
probably benign |
|
|
R0505:Lrrk1
|
UTSW |
7 |
65,940,656 (GRCm39) |
splice site |
probably null |
|
|
R0609:Lrrk1
|
UTSW |
7 |
65,916,363 (GRCm39) |
splice site |
probably null |
|
|
R0650:Lrrk1
|
UTSW |
7 |
65,942,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0676:Lrrk1
|
UTSW |
7 |
65,944,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1157:Lrrk1
|
UTSW |
7 |
65,912,031 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1435:Lrrk1
|
UTSW |
7 |
65,922,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
65,909,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
65,909,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1498:Lrrk1
|
UTSW |
7 |
65,952,419 (GRCm39) |
nonsense |
probably null |
|
|
R1620:Lrrk1
|
UTSW |
7 |
66,031,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1884:Lrrk1
|
UTSW |
7 |
65,912,185 (GRCm39) |
missense |
probably benign |
|
|
R1989:Lrrk1
|
UTSW |
7 |
65,931,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2107:Lrrk1
|
UTSW |
7 |
65,929,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2140:Lrrk1
|
UTSW |
7 |
65,980,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2144:Lrrk1
|
UTSW |
7 |
65,945,911 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2147:Lrrk1
|
UTSW |
7 |
65,935,159 (GRCm39) |
splice site |
probably null |
|
|
R3176:Lrrk1
|
UTSW |
7 |
65,955,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R3276:Lrrk1
|
UTSW |
7 |
65,955,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R3886:Lrrk1
|
UTSW |
7 |
65,942,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3893:Lrrk1
|
UTSW |
7 |
65,928,268 (GRCm39) |
splice site |
probably benign |
|
|
R3906:Lrrk1
|
UTSW |
7 |
65,944,651 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R4259:Lrrk1
|
UTSW |
7 |
65,980,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4649:Lrrk1
|
UTSW |
7 |
65,922,801 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4653:Lrrk1
|
UTSW |
7 |
65,922,801 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4672:Lrrk1
|
UTSW |
7 |
65,929,120 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4693:Lrrk1
|
UTSW |
7 |
65,912,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4729:Lrrk1
|
UTSW |
7 |
65,912,041 (GRCm39) |
missense |
probably benign |
|
|
R4737:Lrrk1
|
UTSW |
7 |
65,956,621 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4795:Lrrk1
|
UTSW |
7 |
65,912,413 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4911:Lrrk1
|
UTSW |
7 |
65,945,202 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5002:Lrrk1
|
UTSW |
7 |
65,982,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5254:Lrrk1
|
UTSW |
7 |
65,956,855 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5407:Lrrk1
|
UTSW |
7 |
65,920,545 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5482:Lrrk1
|
UTSW |
7 |
65,980,418 (GRCm39) |
missense |
probably benign |
|
|
R5600:Lrrk1
|
UTSW |
7 |
65,956,963 (GRCm39) |
missense |
probably benign |
0.31 |
|
R5615:Lrrk1
|
UTSW |
7 |
65,937,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6041:Lrrk1
|
UTSW |
7 |
65,911,881 (GRCm39) |
missense |
probably benign |
|
|
R6211:Lrrk1
|
UTSW |
7 |
65,952,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6271:Lrrk1
|
UTSW |
7 |
65,956,851 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6276:Lrrk1
|
UTSW |
7 |
65,956,587 (GRCm39) |
splice site |
probably null |
|
|
R6447:Lrrk1
|
UTSW |
7 |
65,952,476 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6478:Lrrk1
|
UTSW |
7 |
65,912,481 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6615:Lrrk1
|
UTSW |
7 |
65,931,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6745:Lrrk1
|
UTSW |
7 |
65,922,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6836:Lrrk1
|
UTSW |
7 |
65,992,527 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6995:Lrrk1
|
UTSW |
7 |
65,942,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7107:Lrrk1
|
UTSW |
7 |
65,937,191 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7137:Lrrk1
|
UTSW |
7 |
65,935,027 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7203:Lrrk1
|
UTSW |
7 |
65,920,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7224:Lrrk1
|
UTSW |
7 |
65,982,134 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7239:Lrrk1
|
UTSW |
7 |
65,911,903 (GRCm39) |
missense |
probably benign |
|
|
R7440:Lrrk1
|
UTSW |
7 |
65,940,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7515:Lrrk1
|
UTSW |
7 |
65,912,310 (GRCm39) |
missense |
probably benign |
|
|
R7593:Lrrk1
|
UTSW |
7 |
65,958,439 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7728:Lrrk1
|
UTSW |
7 |
65,912,463 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7984:Lrrk1
|
UTSW |
7 |
65,950,477 (GRCm39) |
splice site |
probably null |
|
|
R7993:Lrrk1
|
UTSW |
7 |
65,912,202 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8009:Lrrk1
|
UTSW |
7 |
65,915,222 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8037:Lrrk1
|
UTSW |
7 |
65,935,089 (GRCm39) |
missense |
probably benign |
|
|
R8101:Lrrk1
|
UTSW |
7 |
65,992,530 (GRCm39) |
missense |
probably benign |
|
|
R8116:Lrrk1
|
UTSW |
7 |
65,912,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8126:Lrrk1
|
UTSW |
7 |
65,942,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8278:Lrrk1
|
UTSW |
7 |
65,928,432 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8559:Lrrk1
|
UTSW |
7 |
65,932,075 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R8669:Lrrk1
|
UTSW |
7 |
65,912,344 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8690:Lrrk1
|
UTSW |
7 |
65,952,477 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8955:Lrrk1
|
UTSW |
7 |
65,919,573 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9135:Lrrk1
|
UTSW |
7 |
65,928,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9380:Lrrk1
|
UTSW |
7 |
65,928,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9625:Lrrk1
|
UTSW |
7 |
65,909,666 (GRCm39) |
makesense |
probably null |
|
|
R9721:Lrrk1
|
UTSW |
7 |
65,924,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF018:Lrrk1
|
UTSW |
7 |
66,031,250 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTCTGTCACCCCATGGTTAC -3'
(R):5'- AGGGTACTGCTCAGAACACC -3'
Sequencing Primer
(F):5'- CCCATGGTTACAGCGCTAAG -3'
(R):5'- TACTGCTCAGAACACCCACGG -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation