Incidental Mutation 'R1892:Insrr'
| ID |
211578 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Insrr
|
| Ensembl Gene |
ENSMUSG00000005640 |
| Gene Name |
insulin receptor-related receptor |
| Synonyms |
|
| MMRRC Submission |
039912-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.285)
|
| Stock # |
R1892 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
87704258-87723408 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 87721184 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 1112
(V1112M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000103208
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000029711]
[ENSMUST00000029714]
[ENSMUST00000090981]
[ENSMUST00000107582]
|
| AlphaFold |
Q9WTL4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000029711
AA Change: V1112M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000029711
Gene: ENSMUSG00000005640
AA Change: V1112M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
47 |
159 |
1.8e-25 |
PFAM |
|
FU
|
225 |
268 |
9.54e-11 |
SMART |
|
Pfam:Recep_L_domain
|
346 |
460 |
3.8e-28 |
PFAM |
|
FN3
|
483 |
586 |
9.19e-1 |
SMART |
|
FN3
|
605 |
798 |
6.45e-5 |
SMART |
|
FN3
|
816 |
899 |
6.35e-4 |
SMART |
|
TyrKc
|
979 |
1246 |
4.61e-128 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000029714
|
| SMART Domains |
Protein: ENSMUSP00000029714
Gene: ENSMUSG00000028073
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
78 |
N/A |
INTRINSIC |
|
EGF
|
102 |
130 |
3.82e-2 |
SMART |
|
EGF_like
|
132 |
173 |
2.92e1 |
SMART |
|
EGF_like
|
146 |
185 |
1.92e0 |
SMART |
|
EGF_like
|
189 |
246 |
1.99e0 |
SMART |
|
EGF
|
217 |
258 |
1.04e1 |
SMART |
|
EGF_Lam
|
274 |
313 |
1.21e-4 |
SMART |
|
EGF
|
312 |
344 |
4.03e-1 |
SMART |
|
EGF_Lam
|
361 |
402 |
1.33e-1 |
SMART |
|
EGF
|
401 |
433 |
1.18e-2 |
SMART |
|
EGF_like
|
449 |
488 |
1.72e0 |
SMART |
|
EGF
|
487 |
519 |
6.92e0 |
SMART |
|
EGF_Lam
|
535 |
574 |
2.08e-3 |
SMART |
|
EGF
|
573 |
605 |
5.49e-3 |
SMART |
|
EGF_Lam
|
620 |
660 |
1.58e-3 |
SMART |
|
EGF
|
659 |
691 |
3.1e-2 |
SMART |
|
EGF
|
702 |
734 |
2.53e1 |
SMART |
|
transmembrane domain
|
754 |
776 |
N/A |
INTRINSIC |
|
low complexity region
|
809 |
822 |
N/A |
INTRINSIC |
|
low complexity region
|
829 |
835 |
N/A |
INTRINSIC |
|
low complexity region
|
954 |
971 |
N/A |
INTRINSIC |
|
low complexity region
|
993 |
1002 |
N/A |
INTRINSIC |
|
low complexity region
|
1019 |
1031 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000090981
|
| SMART Domains |
Protein: ENSMUSP00000088503
Gene: ENSMUSG00000028073
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
78 |
N/A |
INTRINSIC |
|
EGF
|
102 |
130 |
3.82e-2 |
SMART |
|
EGF_like
|
132 |
173 |
2.92e1 |
SMART |
|
EGF_like
|
146 |
185 |
1.92e0 |
SMART |
|
EGF_like
|
189 |
246 |
1.99e0 |
SMART |
|
EGF
|
217 |
258 |
1.04e1 |
SMART |
|
EGF_Lam
|
274 |
313 |
1.21e-4 |
SMART |
|
EGF
|
312 |
344 |
4.03e-1 |
SMART |
|
EGF_Lam
|
361 |
402 |
1.33e-1 |
SMART |
|
EGF
|
401 |
433 |
1.18e-2 |
SMART |
|
EGF_like
|
449 |
488 |
1.72e0 |
SMART |
|
EGF
|
487 |
519 |
6.92e0 |
SMART |
|
EGF_Lam
|
535 |
574 |
2.08e-3 |
SMART |
|
EGF
|
573 |
605 |
5.49e-3 |
SMART |
|
EGF_Lam
|
620 |
660 |
1.58e-3 |
SMART |
|
EGF
|
659 |
691 |
3.1e-2 |
SMART |
|
EGF
|
702 |
734 |
2.53e1 |
SMART |
|
transmembrane domain
|
754 |
776 |
N/A |
INTRINSIC |
|
low complexity region
|
809 |
822 |
N/A |
INTRINSIC |
|
low complexity region
|
829 |
835 |
N/A |
INTRINSIC |
|
low complexity region
|
954 |
971 |
N/A |
INTRINSIC |
|
low complexity region
|
993 |
1002 |
N/A |
INTRINSIC |
|
low complexity region
|
1019 |
1031 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000107582
AA Change: V1112M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000103208
Gene: ENSMUSG00000005640
AA Change: V1112M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
47 |
159 |
7.7e-25 |
PFAM |
|
FU
|
225 |
268 |
9.54e-11 |
SMART |
|
Pfam:Recep_L_domain
|
346 |
460 |
1.6e-28 |
PFAM |
|
FN3
|
483 |
586 |
9.19e-1 |
SMART |
|
FN3
|
605 |
798 |
6.45e-5 |
SMART |
|
FN3
|
816 |
899 |
6.35e-4 |
SMART |
|
TyrKc
|
979 |
1246 |
4.61e-128 |
SMART |
|
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.4%
- 20x: 93.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a targeted null mutation exhibit no anomalies in pancreatic islet morphology, beta-cell mass or pancreatic secretory function. This mutation in combination with Insr mutant mice does not affect the diabetes predisposition of Insr mutant mice. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca14 |
G |
A |
7: 119,815,561 (GRCm39) |
A270T |
probably benign |
Het |
| Abcb7 |
A |
T |
X: 103,386,142 (GRCm39) |
H97Q |
probably damaging |
Het |
| Adat3 |
T |
C |
10: 80,442,249 (GRCm39) |
L29P |
probably damaging |
Het |
| AI987944 |
A |
T |
7: 41,024,020 (GRCm39) |
C320S |
probably damaging |
Het |
| Asic4 |
C |
T |
1: 75,446,126 (GRCm39) |
R285W |
probably damaging |
Het |
| Asic5 |
A |
T |
3: 81,928,293 (GRCm39) |
I419L |
probably damaging |
Het |
| Batf |
A |
G |
12: 85,736,102 (GRCm39) |
K42E |
probably damaging |
Het |
| Bcar3 |
A |
G |
3: 122,301,785 (GRCm39) |
N160S |
probably benign |
Het |
| Bco2 |
C |
A |
9: 50,461,863 (GRCm39) |
G47V |
probably damaging |
Het |
| Bicc1 |
T |
G |
10: 70,794,614 (GRCm39) |
K181T |
probably damaging |
Het |
| Brinp2 |
A |
G |
1: 158,082,542 (GRCm39) |
|
probably null |
Het |
| Cacng8 |
A |
G |
7: 3,463,568 (GRCm39) |
D240G |
possibly damaging |
Het |
| Calca |
A |
G |
7: 114,232,962 (GRCm39) |
Y96H |
probably damaging |
Het |
| Cdh1 |
A |
T |
8: 107,390,882 (GRCm39) |
K666I |
possibly damaging |
Het |
| Cdh16 |
A |
T |
8: 105,344,631 (GRCm39) |
I500N |
possibly damaging |
Het |
| Chst14 |
A |
G |
2: 118,757,830 (GRCm39) |
Y208C |
probably damaging |
Het |
| Chst9 |
T |
C |
18: 15,586,017 (GRCm39) |
H182R |
probably damaging |
Het |
| Clk2 |
A |
G |
3: 89,082,502 (GRCm39) |
I367M |
possibly damaging |
Het |
| Cobl |
G |
C |
11: 12,203,258 (GRCm39) |
S1066W |
probably damaging |
Het |
| Ctcfl |
A |
G |
2: 172,960,478 (GRCm39) |
V35A |
probably benign |
Het |
| Dchs1 |
G |
T |
7: 105,413,363 (GRCm39) |
H1151N |
probably benign |
Het |
| Dennd1c |
T |
C |
17: 57,374,083 (GRCm39) |
T529A |
probably benign |
Het |
| Dnah11 |
A |
T |
12: 118,070,209 (GRCm39) |
V1532D |
possibly damaging |
Het |
| Dync1h1 |
A |
G |
12: 110,612,738 (GRCm39) |
Y2871C |
probably damaging |
Het |
| Dytn |
T |
C |
1: 63,716,420 (GRCm39) |
E51G |
probably benign |
Het |
| Esd |
C |
T |
14: 74,987,113 (GRCm39) |
A266V |
probably damaging |
Het |
| Gli1 |
T |
C |
10: 127,165,975 (GRCm39) |
M1093V |
possibly damaging |
Het |
| Gm15446 |
A |
G |
5: 110,091,253 (GRCm39) |
K502E |
probably damaging |
Het |
| Gm4076 |
T |
A |
13: 85,275,447 (GRCm39) |
|
noncoding transcript |
Het |
| Gm9830 |
A |
G |
9: 44,375,825 (GRCm39) |
|
noncoding transcript |
Het |
| Gm9938 |
G |
A |
19: 23,701,955 (GRCm39) |
|
probably benign |
Het |
| Grhl1 |
G |
A |
12: 24,634,909 (GRCm39) |
R245H |
probably damaging |
Het |
| Hnrnpul1 |
A |
T |
7: 25,426,191 (GRCm39) |
D553E |
probably benign |
Het |
| Hpn |
G |
A |
7: 30,798,468 (GRCm39) |
Q415* |
probably null |
Het |
| Hsd11b1 |
T |
G |
1: 192,906,068 (GRCm39) |
M175L |
probably benign |
Het |
| Htra1 |
G |
A |
7: 130,586,799 (GRCm39) |
V461I |
possibly damaging |
Het |
| Il1rl2 |
A |
G |
1: 40,366,694 (GRCm39) |
H76R |
probably damaging |
Het |
| Ints9 |
T |
C |
14: 65,257,872 (GRCm39) |
S351P |
probably benign |
Het |
| Itgav |
T |
A |
2: 83,601,680 (GRCm39) |
N350K |
probably damaging |
Het |
| Kdm4d |
C |
A |
9: 14,375,613 (GRCm39) |
V82L |
probably benign |
Het |
| Klc1 |
T |
C |
12: 111,748,261 (GRCm39) |
|
probably null |
Het |
| Kmt5c |
T |
A |
7: 4,745,714 (GRCm39) |
C69* |
probably null |
Het |
| Lgals3 |
T |
G |
14: 47,622,164 (GRCm39) |
N193K |
possibly damaging |
Het |
| Morc2b |
T |
A |
17: 33,354,748 (GRCm39) |
D1008V |
probably damaging |
Het |
| Mpg |
C |
T |
11: 32,181,720 (GRCm39) |
Q243* |
probably null |
Het |
| Muc15 |
C |
T |
2: 110,567,697 (GRCm39) |
R281* |
probably null |
Het |
| Ncstn |
CAGCTCCACGAAG |
CAG |
1: 171,899,038 (GRCm39) |
|
probably null |
Het |
| Nek5 |
A |
G |
8: 22,597,745 (GRCm39) |
M278T |
probably benign |
Het |
| Npas2 |
A |
G |
1: 39,384,503 (GRCm39) |
T599A |
probably benign |
Het |
| Nrf1 |
A |
G |
6: 30,144,787 (GRCm39) |
D519G |
probably null |
Het |
| Nup43 |
A |
G |
10: 7,549,373 (GRCm39) |
H176R |
probably damaging |
Het |
| Nxpe2 |
T |
C |
9: 48,237,914 (GRCm39) |
T114A |
probably damaging |
Het |
| Or10j3 |
T |
C |
1: 173,031,795 (GRCm39) |
Y291H |
probably damaging |
Het |
| Or5p72 |
A |
T |
7: 108,022,147 (GRCm39) |
Y123F |
possibly damaging |
Het |
| Or6c75 |
A |
C |
10: 129,336,902 (GRCm39) |
I50L |
probably benign |
Het |
| Perm1 |
C |
T |
4: 156,302,340 (GRCm39) |
R295C |
probably benign |
Het |
| Pik3ip1 |
G |
T |
11: 3,283,304 (GRCm39) |
A135S |
probably damaging |
Het |
| Pira13 |
A |
C |
7: 3,827,573 (GRCm39) |
C195G |
probably benign |
Het |
| Ppp4c |
A |
G |
7: 126,385,452 (GRCm39) |
V119A |
probably damaging |
Het |
| Prepl |
A |
G |
17: 85,395,878 (GRCm39) |
Y35H |
possibly damaging |
Het |
| Ptpn13 |
A |
G |
5: 103,649,545 (GRCm39) |
Y316C |
possibly damaging |
Het |
| Pxk |
C |
T |
14: 8,151,507 (GRCm38) |
R441* |
probably null |
Het |
| Ranbp2 |
T |
C |
10: 58,299,921 (GRCm39) |
V491A |
probably benign |
Het |
| Ranbp9 |
C |
A |
13: 43,569,933 (GRCm39) |
C495F |
possibly damaging |
Het |
| Rfx8 |
A |
T |
1: 39,709,746 (GRCm39) |
|
probably null |
Het |
| Rnf111 |
T |
A |
9: 70,383,656 (GRCm39) |
K92N |
probably damaging |
Het |
| Rtn1 |
A |
G |
12: 72,259,337 (GRCm39) |
I772T |
probably damaging |
Het |
| Ryr2 |
T |
A |
13: 11,673,844 (GRCm39) |
K72* |
probably null |
Het |
| Sergef |
A |
T |
7: 46,264,040 (GRCm39) |
|
probably null |
Het |
| Sez6l |
T |
C |
5: 112,620,665 (GRCm39) |
N305S |
probably damaging |
Het |
| Slc40a1 |
A |
T |
1: 45,950,302 (GRCm39) |
C383* |
probably null |
Het |
| Stab2 |
C |
T |
10: 86,773,913 (GRCm39) |
C806Y |
probably damaging |
Het |
| Stard9 |
A |
G |
2: 120,524,189 (GRCm39) |
T795A |
probably benign |
Het |
| Stk31 |
T |
C |
6: 49,415,408 (GRCm39) |
I536T |
probably damaging |
Het |
| Stox1 |
T |
A |
10: 62,501,178 (GRCm39) |
T461S |
possibly damaging |
Het |
| Suv39h2 |
T |
C |
2: 3,460,805 (GRCm39) |
Y219C |
probably damaging |
Het |
| Tap1 |
T |
G |
17: 34,413,915 (GRCm39) |
D643E |
probably damaging |
Het |
| Tbc1d2b |
T |
A |
9: 90,100,996 (GRCm39) |
I665F |
probably damaging |
Het |
| Tdrd6 |
T |
C |
17: 43,935,696 (GRCm39) |
N1784S |
probably benign |
Het |
| Tmem14c |
T |
C |
13: 41,174,633 (GRCm39) |
F81L |
possibly damaging |
Het |
| Tnrc6c |
A |
G |
11: 117,605,188 (GRCm39) |
N108D |
probably benign |
Het |
| Tox3 |
A |
T |
8: 90,996,869 (GRCm39) |
N131K |
probably benign |
Het |
| Tspear |
T |
A |
10: 77,706,308 (GRCm39) |
D359E |
probably benign |
Het |
| Ttc9 |
A |
G |
12: 81,678,551 (GRCm39) |
I125V |
probably benign |
Het |
| Ttn |
A |
T |
2: 76,728,531 (GRCm39) |
|
probably benign |
Het |
| Ubn2 |
C |
T |
6: 38,468,226 (GRCm39) |
S980F |
probably damaging |
Het |
| Vcf1 |
G |
T |
11: 113,554,212 (GRCm39) |
P161H |
probably damaging |
Het |
| Zfp362 |
T |
A |
4: 128,684,057 (GRCm39) |
T30S |
probably benign |
Het |
| Zfp385c |
A |
C |
11: 100,528,630 (GRCm39) |
H32Q |
probably damaging |
Het |
| Zfp870 |
A |
T |
17: 33,102,863 (GRCm39) |
H156Q |
possibly damaging |
Het |
| Zfp873 |
T |
C |
10: 81,897,080 (GRCm39) |
C641R |
probably damaging |
Het |
| Zfp950 |
A |
T |
19: 61,107,549 (GRCm39) |
H511Q |
probably benign |
Het |
|
| Other mutations in Insrr |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00718:Insrr
|
APN |
3 |
87,720,981 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL00801:Insrr
|
APN |
3 |
87,721,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01628:Insrr
|
APN |
3 |
87,708,099 (GRCm39) |
nonsense |
probably null |
|
|
IGL01755:Insrr
|
APN |
3 |
87,721,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02100:Insrr
|
APN |
3 |
87,718,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02261:Insrr
|
APN |
3 |
87,708,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02366:Insrr
|
APN |
3 |
87,717,216 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02387:Insrr
|
APN |
3 |
87,720,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02478:Insrr
|
APN |
3 |
87,716,719 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL02550:Insrr
|
APN |
3 |
87,711,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02555:Insrr
|
APN |
3 |
87,721,124 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02673:Insrr
|
APN |
3 |
87,720,368 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02724:Insrr
|
APN |
3 |
87,716,879 (GRCm39) |
missense |
probably benign |
0.31 |
|
IGL02798:Insrr
|
APN |
3 |
87,717,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02969:Insrr
|
APN |
3 |
87,721,498 (GRCm39) |
nonsense |
probably null |
|
|
IGL03073:Insrr
|
APN |
3 |
87,717,245 (GRCm39) |
splice site |
probably benign |
|
|
IGL03178:Insrr
|
APN |
3 |
87,709,848 (GRCm39) |
splice site |
probably null |
|
|
IGL03389:Insrr
|
APN |
3 |
87,716,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03399:Insrr
|
APN |
3 |
87,716,638 (GRCm39) |
missense |
probably null |
0.99 |
|
IGL02799:Insrr
|
UTSW |
3 |
87,720,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0011:Insrr
|
UTSW |
3 |
87,716,923 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0053:Insrr
|
UTSW |
3 |
87,707,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0053:Insrr
|
UTSW |
3 |
87,707,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0357:Insrr
|
UTSW |
3 |
87,715,953 (GRCm39) |
splice site |
probably null |
|
|
R0501:Insrr
|
UTSW |
3 |
87,717,991 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0504:Insrr
|
UTSW |
3 |
87,720,463 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0522:Insrr
|
UTSW |
3 |
87,708,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0555:Insrr
|
UTSW |
3 |
87,721,744 (GRCm39) |
splice site |
probably benign |
|
|
R0558:Insrr
|
UTSW |
3 |
87,718,288 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0599:Insrr
|
UTSW |
3 |
87,720,440 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1312:Insrr
|
UTSW |
3 |
87,707,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1694:Insrr
|
UTSW |
3 |
87,711,369 (GRCm39) |
missense |
probably benign |
|
|
R1785:Insrr
|
UTSW |
3 |
87,717,879 (GRCm39) |
splice site |
probably null |
|
|
R1786:Insrr
|
UTSW |
3 |
87,717,879 (GRCm39) |
splice site |
probably null |
|
|
R1950:Insrr
|
UTSW |
3 |
87,721,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2080:Insrr
|
UTSW |
3 |
87,721,598 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R2094:Insrr
|
UTSW |
3 |
87,710,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2130:Insrr
|
UTSW |
3 |
87,717,879 (GRCm39) |
splice site |
probably null |
|
|
R2131:Insrr
|
UTSW |
3 |
87,717,879 (GRCm39) |
splice site |
probably null |
|
|
R2133:Insrr
|
UTSW |
3 |
87,717,879 (GRCm39) |
splice site |
probably null |
|
|
R2220:Insrr
|
UTSW |
3 |
87,716,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2259:Insrr
|
UTSW |
3 |
87,707,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2404:Insrr
|
UTSW |
3 |
87,709,974 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4027:Insrr
|
UTSW |
3 |
87,716,906 (GRCm39) |
missense |
probably benign |
|
|
R4042:Insrr
|
UTSW |
3 |
87,721,134 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4510:Insrr
|
UTSW |
3 |
87,715,978 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4511:Insrr
|
UTSW |
3 |
87,715,978 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4571:Insrr
|
UTSW |
3 |
87,708,194 (GRCm39) |
missense |
probably benign |
|
|
R4870:Insrr
|
UTSW |
3 |
87,718,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5057:Insrr
|
UTSW |
3 |
87,722,572 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5393:Insrr
|
UTSW |
3 |
87,718,007 (GRCm39) |
splice site |
probably null |
|
|
R5685:Insrr
|
UTSW |
3 |
87,707,803 (GRCm39) |
splice site |
probably null |
|
|
R6039:Insrr
|
UTSW |
3 |
87,716,608 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6039:Insrr
|
UTSW |
3 |
87,716,608 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6047:Insrr
|
UTSW |
3 |
87,711,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6276:Insrr
|
UTSW |
3 |
87,707,826 (GRCm39) |
nonsense |
probably null |
|
|
R6298:Insrr
|
UTSW |
3 |
87,720,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6726:Insrr
|
UTSW |
3 |
87,720,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6727:Insrr
|
UTSW |
3 |
87,720,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6728:Insrr
|
UTSW |
3 |
87,720,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6796:Insrr
|
UTSW |
3 |
87,720,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7041:Insrr
|
UTSW |
3 |
87,722,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7169:Insrr
|
UTSW |
3 |
87,715,901 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7270:Insrr
|
UTSW |
3 |
87,710,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7340:Insrr
|
UTSW |
3 |
87,721,623 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7398:Insrr
|
UTSW |
3 |
87,716,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7473:Insrr
|
UTSW |
3 |
87,711,838 (GRCm39) |
splice site |
probably null |
|
|
R7815:Insrr
|
UTSW |
3 |
87,716,002 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8159:Insrr
|
UTSW |
3 |
87,707,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8289:Insrr
|
UTSW |
3 |
87,721,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8309:Insrr
|
UTSW |
3 |
87,717,749 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8312:Insrr
|
UTSW |
3 |
87,707,791 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8445:Insrr
|
UTSW |
3 |
87,720,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8917:Insrr
|
UTSW |
3 |
87,718,276 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8960:Insrr
|
UTSW |
3 |
87,720,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8989:Insrr
|
UTSW |
3 |
87,722,664 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9015:Insrr
|
UTSW |
3 |
87,720,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9202:Insrr
|
UTSW |
3 |
87,720,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9251:Insrr
|
UTSW |
3 |
87,717,391 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9327:Insrr
|
UTSW |
3 |
87,721,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9646:Insrr
|
UTSW |
3 |
87,721,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF022:Insrr
|
UTSW |
3 |
87,711,792 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
Z1177:Insrr
|
UTSW |
3 |
87,708,134 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Z1192:Insrr
|
UTSW |
3 |
87,709,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATCTCTGAGACCTGAGGCAGAG -3'
(R):5'- TTCAGGACTTGGGGACTTGC -3'
Sequencing Primer
(F):5'- AAGACCCTGAGCCGTGTGATG -3'
(R):5'- ACTTGGGGACTTGCCTGAC -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation