Incidental Mutation 'R1893:Cr2'
| ID |
211671 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cr2
|
| Ensembl Gene |
ENSMUSG00000026616 |
| Gene Name |
complement receptor 2 |
| Synonyms |
C3DR, CD21, Cr-2, Cr1, Cr-1, CD35 |
| MMRRC Submission |
039913-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.142)
|
| Stock # |
R1893 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
194819119-194859024 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 194837495 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Arginine
at position 1201
(H1201R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000147804
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000082321]
[ENSMUST00000193356]
[ENSMUST00000193801]
[ENSMUST00000195120]
[ENSMUST00000210219]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000082321
AA Change: H825R
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000080938
Gene: ENSMUSG00000026616
AA Change: H825R
| Domain | Start | End | E-Value | Type |
|---|
|
CCP
|
23 |
82 |
1.01e-11 |
SMART |
|
CCP
|
91 |
147 |
9.1e-14 |
SMART |
|
CCP
|
155 |
211 |
1.9e-16 |
SMART |
|
CCP
|
216 |
272 |
1.6e-9 |
SMART |
|
CCP
|
277 |
343 |
1.01e-11 |
SMART |
|
CCP
|
352 |
407 |
1.2e-13 |
SMART |
|
CCP
|
411 |
467 |
2.34e-16 |
SMART |
|
CCP
|
472 |
523 |
1.24e0 |
SMART |
|
CCP
|
528 |
594 |
4.48e-13 |
SMART |
|
CCP
|
603 |
658 |
1.95e-13 |
SMART |
|
CCP
|
718 |
778 |
1.75e-15 |
SMART |
|
CCP
|
787 |
842 |
2.06e-12 |
SMART |
|
CCP
|
850 |
906 |
7.92e-14 |
SMART |
|
CCP
|
911 |
967 |
1.29e-13 |
SMART |
|
transmembrane domain
|
975 |
997 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000192604
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193356
AA Change: H528R
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000141706
Gene: ENSMUSG00000026616
AA Change: H528R
| Domain | Start | End | E-Value | Type |
|---|
|
CCP
|
1 |
46 |
1.2e-1 |
SMART |
|
CCP
|
55 |
110 |
5.9e-16 |
SMART |
|
CCP
|
114 |
170 |
1.1e-18 |
SMART |
|
CCP
|
175 |
226 |
6.1e-3 |
SMART |
|
CCP
|
231 |
297 |
2.2e-15 |
SMART |
|
CCP
|
306 |
361 |
9.4e-16 |
SMART |
|
CCP
|
421 |
481 |
8.3e-18 |
SMART |
|
CCP
|
490 |
545 |
1e-14 |
SMART |
|
CCP
|
553 |
609 |
4e-16 |
SMART |
|
CCP
|
614 |
670 |
6.2e-16 |
SMART |
|
transmembrane domain
|
678 |
700 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193436
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193801
|
| SMART Domains |
Protein: ENSMUSP00000141276
Gene: ENSMUSG00000026616
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195120
AA Change: H825R
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000141538
Gene: ENSMUSG00000026616
AA Change: H825R
| Domain | Start | End | E-Value | Type |
|---|
|
CCP
|
23 |
82 |
4.9e-14 |
SMART |
|
CCP
|
91 |
147 |
4.5e-16 |
SMART |
|
CCP
|
155 |
211 |
9.1e-19 |
SMART |
|
CCP
|
216 |
272 |
8e-12 |
SMART |
|
CCP
|
277 |
343 |
5e-14 |
SMART |
|
CCP
|
352 |
407 |
5.9e-16 |
SMART |
|
CCP
|
411 |
467 |
1.1e-18 |
SMART |
|
CCP
|
472 |
523 |
6.1e-3 |
SMART |
|
CCP
|
528 |
594 |
2.2e-15 |
SMART |
|
CCP
|
603 |
658 |
9.4e-16 |
SMART |
|
CCP
|
718 |
778 |
8.3e-18 |
SMART |
|
CCP
|
787 |
842 |
1e-14 |
SMART |
|
CCP
|
850 |
906 |
4e-16 |
SMART |
|
CCP
|
911 |
967 |
6.2e-16 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000195737
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000210219
AA Change: H1201R
PolyPhen 2
Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.4%
- 20x: 93.0%
|
| Validation Efficiency |
99% (99/100) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired humoral immune responses to T cell-dependent antigens, with limited affinity maturation, and reduced memory B cell and germinal center formation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2210408I21Rik |
T |
C |
13: 77,415,928 (GRCm39) |
Y674H |
possibly damaging |
Het |
| Aars2 |
G |
A |
17: 45,825,725 (GRCm39) |
R347Q |
probably benign |
Het |
| Abca15 |
A |
T |
7: 119,939,776 (GRCm39) |
M293L |
possibly damaging |
Het |
| Abcb7 |
A |
T |
X: 103,386,142 (GRCm39) |
H97Q |
probably damaging |
Het |
| Aldh1l2 |
G |
T |
10: 83,328,400 (GRCm39) |
N772K |
probably damaging |
Het |
| Ascc2 |
T |
A |
11: 4,622,305 (GRCm39) |
L457Q |
probably benign |
Het |
| Aspm |
T |
A |
1: 139,407,605 (GRCm39) |
I2164N |
probably damaging |
Het |
| Cabs1 |
A |
G |
5: 88,127,894 (GRCm39) |
T182A |
probably benign |
Het |
| Carmil1 |
T |
C |
13: 24,208,446 (GRCm39) |
E833G |
possibly damaging |
Het |
| Ccdc102a |
G |
A |
8: 95,640,171 (GRCm39) |
T41M |
probably damaging |
Het |
| Cimap1c |
A |
G |
9: 56,756,498 (GRCm39) |
Y173H |
probably benign |
Het |
| Clec2h |
T |
C |
6: 128,647,795 (GRCm39) |
V48A |
probably benign |
Het |
| Cpb2 |
G |
A |
14: 75,493,403 (GRCm39) |
V27I |
probably benign |
Het |
| Cyp2d9 |
T |
C |
15: 82,336,807 (GRCm39) |
V52A |
probably damaging |
Het |
| Cyp4a12a |
C |
A |
4: 115,183,864 (GRCm39) |
N223K |
probably benign |
Het |
| Cyp7b1 |
G |
A |
3: 18,150,731 (GRCm39) |
S336L |
possibly damaging |
Het |
| Dnah10 |
T |
C |
5: 124,831,381 (GRCm39) |
V803A |
probably benign |
Het |
| Dnah17 |
T |
A |
11: 117,957,794 (GRCm39) |
T2745S |
probably benign |
Het |
| Ep300 |
T |
A |
15: 81,515,847 (GRCm39) |
|
probably benign |
Het |
| Epha3 |
A |
G |
16: 63,388,762 (GRCm39) |
S829P |
probably damaging |
Het |
| Fads3 |
C |
A |
19: 10,033,868 (GRCm39) |
H418N |
probably benign |
Het |
| Fat1 |
T |
C |
8: 45,476,893 (GRCm39) |
S1980P |
probably damaging |
Het |
| Fgf20 |
T |
C |
8: 40,732,844 (GRCm39) |
E198G |
possibly damaging |
Het |
| Fgl2 |
G |
A |
5: 21,580,669 (GRCm39) |
R337H |
probably benign |
Het |
| Gbp2 |
G |
T |
3: 142,335,933 (GRCm39) |
|
probably benign |
Het |
| Gja10 |
G |
A |
4: 32,601,541 (GRCm39) |
S281L |
probably benign |
Het |
| Gm5422 |
G |
A |
10: 31,125,609 (GRCm39) |
|
noncoding transcript |
Het |
| Gmpr |
T |
A |
13: 45,674,423 (GRCm39) |
D129E |
possibly damaging |
Het |
| Gtf3c4 |
C |
T |
2: 28,724,374 (GRCm39) |
V453I |
possibly damaging |
Het |
| Heatr6 |
T |
C |
11: 83,648,140 (GRCm39) |
V111A |
probably benign |
Het |
| Hipk3 |
G |
A |
2: 104,263,601 (GRCm39) |
R905W |
probably damaging |
Het |
| Hpn |
T |
A |
7: 30,798,773 (GRCm39) |
D103V |
probably damaging |
Het |
| Ipcef1 |
G |
A |
10: 6,850,680 (GRCm39) |
R304W |
probably damaging |
Het |
| Iqcb1 |
A |
G |
16: 36,652,245 (GRCm39) |
D52G |
probably damaging |
Het |
| Klhdc7b |
C |
T |
15: 89,271,898 (GRCm39) |
|
probably null |
Het |
| Klhl1 |
A |
T |
14: 96,477,642 (GRCm39) |
|
probably null |
Het |
| Lrrn1 |
A |
T |
6: 107,545,083 (GRCm39) |
I294F |
possibly damaging |
Het |
| Map3k1 |
A |
T |
13: 111,904,567 (GRCm39) |
F406I |
possibly damaging |
Het |
| Map4k4 |
T |
A |
1: 40,040,717 (GRCm39) |
V579E |
probably benign |
Het |
| Mapre2 |
A |
G |
18: 23,986,774 (GRCm39) |
K62R |
probably damaging |
Het |
| Mdga1 |
A |
T |
17: 30,068,200 (GRCm39) |
Y305N |
probably damaging |
Het |
| Mgl2 |
T |
A |
11: 70,024,993 (GRCm39) |
|
probably null |
Het |
| Mnx1 |
C |
T |
5: 29,682,828 (GRCm39) |
G149D |
unknown |
Het |
| Mtbp |
T |
A |
15: 55,421,064 (GRCm39) |
S17T |
probably benign |
Het |
| Neu3 |
T |
C |
7: 99,472,627 (GRCm39) |
T37A |
possibly damaging |
Het |
| Nr1i3 |
T |
C |
1: 171,044,792 (GRCm39) |
|
probably null |
Het |
| Or10al2 |
A |
T |
17: 37,983,747 (GRCm39) |
K278* |
probably null |
Het |
| Or10g6 |
A |
T |
9: 39,934,270 (GRCm39) |
I194F |
possibly damaging |
Het |
| Or6ae1 |
T |
C |
7: 139,742,734 (GRCm39) |
N43S |
probably damaging |
Het |
| Or9s18 |
T |
A |
13: 65,300,806 (GRCm39) |
M256K |
possibly damaging |
Het |
| Osr2 |
A |
G |
15: 35,300,608 (GRCm39) |
T55A |
possibly damaging |
Het |
| Palld |
A |
G |
8: 61,969,655 (GRCm39) |
V981A |
probably damaging |
Het |
| Pbx1 |
A |
T |
1: 168,030,979 (GRCm39) |
M213K |
possibly damaging |
Het |
| Pcdhb12 |
C |
A |
18: 37,570,136 (GRCm39) |
H427Q |
probably benign |
Het |
| Perm1 |
C |
T |
4: 156,302,340 (GRCm39) |
R295C |
probably benign |
Het |
| Phaf1 |
G |
T |
8: 105,973,133 (GRCm39) |
V248F |
probably damaging |
Het |
| Polm |
T |
C |
11: 5,785,574 (GRCm39) |
T162A |
possibly damaging |
Het |
| Prox1 |
A |
G |
1: 189,892,715 (GRCm39) |
|
probably benign |
Het |
| Ptpn7 |
A |
T |
1: 135,062,641 (GRCm39) |
T127S |
probably benign |
Het |
| Pxk |
C |
T |
14: 8,151,507 (GRCm38) |
R441* |
probably null |
Het |
| Rab21 |
T |
C |
10: 115,126,805 (GRCm39) |
T181A |
probably benign |
Het |
| Rab38 |
A |
T |
7: 88,139,924 (GRCm39) |
T198S |
probably benign |
Het |
| Rnase4 |
C |
G |
14: 51,342,395 (GRCm39) |
Q40E |
possibly damaging |
Het |
| Rnf213 |
T |
A |
11: 119,307,274 (GRCm39) |
W645R |
probably damaging |
Het |
| Rnf8 |
A |
G |
17: 29,840,524 (GRCm39) |
I51M |
probably damaging |
Het |
| Sbpl |
T |
A |
17: 24,172,241 (GRCm39) |
D226V |
unknown |
Het |
| Sdf4 |
T |
G |
4: 156,085,205 (GRCm39) |
I180S |
probably benign |
Het |
| Simc1 |
A |
G |
13: 54,687,528 (GRCm39) |
K99R |
probably damaging |
Het |
| Slc2a4 |
T |
C |
11: 69,837,398 (GRCm39) |
Q49R |
probably damaging |
Het |
| Slco1a4 |
T |
C |
6: 141,780,342 (GRCm39) |
|
probably null |
Het |
| Slco5a1 |
C |
A |
1: 12,964,696 (GRCm39) |
C527F |
probably damaging |
Het |
| Sox6 |
T |
A |
7: 115,143,803 (GRCm39) |
N405I |
probably benign |
Het |
| Sphkap |
G |
A |
1: 83,256,687 (GRCm39) |
P354L |
probably benign |
Het |
| Spi1 |
A |
G |
2: 90,944,702 (GRCm39) |
D149G |
probably benign |
Het |
| Sptan1 |
T |
A |
2: 29,910,472 (GRCm39) |
D1812E |
probably damaging |
Het |
| Sub1 |
A |
T |
15: 11,991,130 (GRCm39) |
V37E |
possibly damaging |
Het |
| Sult2a6 |
T |
C |
7: 13,959,814 (GRCm39) |
T240A |
probably benign |
Het |
| Tacc2 |
A |
G |
7: 130,227,055 (GRCm39) |
S1247G |
probably benign |
Het |
| Taf4 |
T |
C |
2: 179,574,823 (GRCm39) |
D594G |
probably damaging |
Het |
| Tap1 |
T |
G |
17: 34,413,915 (GRCm39) |
D643E |
probably damaging |
Het |
| Ticam1 |
T |
C |
17: 56,578,894 (GRCm39) |
N67S |
probably benign |
Het |
| Tlr6 |
A |
G |
5: 65,110,556 (GRCm39) |
F784L |
probably damaging |
Het |
| Tmprss15 |
A |
G |
16: 78,868,306 (GRCm39) |
V202A |
probably benign |
Het |
| Trp53bp2 |
T |
C |
1: 182,259,193 (GRCm39) |
V82A |
probably benign |
Het |
| Ube2o |
C |
T |
11: 116,439,661 (GRCm39) |
V170I |
possibly damaging |
Het |
| Ube2q2l |
A |
G |
6: 136,378,825 (GRCm39) |
S2P |
possibly damaging |
Het |
| Vmn1r177 |
G |
A |
7: 23,565,573 (GRCm39) |
T101I |
probably benign |
Het |
| Vmn2r68 |
A |
T |
7: 84,883,867 (GRCm39) |
Y79* |
probably null |
Het |
| Wdr35 |
A |
C |
12: 9,035,994 (GRCm39) |
Y255S |
probably benign |
Het |
| Zfp507 |
A |
T |
7: 35,502,052 (GRCm39) |
|
probably benign |
Het |
| Zfp688 |
G |
A |
7: 127,018,409 (GRCm39) |
R239C |
probably damaging |
Het |
| Zfp74 |
T |
A |
7: 29,635,470 (GRCm39) |
|
probably null |
Het |
| Zfp932 |
A |
G |
5: 110,157,069 (GRCm39) |
N223D |
possibly damaging |
Het |
|
| Other mutations in Cr2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00587:Cr2
|
APN |
1 |
194,836,559 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
IGL01326:Cr2
|
APN |
1 |
194,823,529 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL01358:Cr2
|
APN |
1 |
194,842,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01410:Cr2
|
APN |
1 |
194,845,542 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01468:Cr2
|
APN |
1 |
194,850,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01608:Cr2
|
APN |
1 |
194,837,528 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL01810:Cr2
|
APN |
1 |
194,841,903 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01843:Cr2
|
APN |
1 |
194,833,222 (GRCm39) |
splice site |
probably benign |
|
|
IGL02332:Cr2
|
APN |
1 |
194,842,630 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02934:Cr2
|
APN |
1 |
194,836,633 (GRCm39) |
splice site |
probably benign |
|
|
IGL02938:Cr2
|
APN |
1 |
194,848,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03149:Cr2
|
APN |
1 |
194,848,674 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03327:Cr2
|
APN |
1 |
194,852,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03346:Cr2
|
APN |
1 |
194,852,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Pillar
|
UTSW |
1 |
194,838,196 (GRCm39) |
nonsense |
probably null |
|
|
PIT4354001:Cr2
|
UTSW |
1 |
194,848,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4418001:Cr2
|
UTSW |
1 |
194,839,760 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0128:Cr2
|
UTSW |
1 |
194,848,539 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0130:Cr2
|
UTSW |
1 |
194,848,539 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0380:Cr2
|
UTSW |
1 |
194,839,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0538:Cr2
|
UTSW |
1 |
194,842,667 (GRCm39) |
splice site |
probably benign |
|
|
R0605:Cr2
|
UTSW |
1 |
194,845,904 (GRCm39) |
splice site |
probably benign |
|
|
R0626:Cr2
|
UTSW |
1 |
194,853,419 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1135:Cr2
|
UTSW |
1 |
194,839,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1396:Cr2
|
UTSW |
1 |
194,851,561 (GRCm39) |
splice site |
probably null |
|
|
R1422:Cr2
|
UTSW |
1 |
194,853,433 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1467:Cr2
|
UTSW |
1 |
194,839,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Cr2
|
UTSW |
1 |
194,839,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1511:Cr2
|
UTSW |
1 |
194,837,580 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1572:Cr2
|
UTSW |
1 |
194,845,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1714:Cr2
|
UTSW |
1 |
194,833,994 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1748:Cr2
|
UTSW |
1 |
194,838,213 (GRCm39) |
nonsense |
probably null |
|
|
R1761:Cr2
|
UTSW |
1 |
194,837,431 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1824:Cr2
|
UTSW |
1 |
194,839,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1990:Cr2
|
UTSW |
1 |
194,836,458 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1991:Cr2
|
UTSW |
1 |
194,836,458 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1992:Cr2
|
UTSW |
1 |
194,836,458 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2191:Cr2
|
UTSW |
1 |
194,845,689 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2276:Cr2
|
UTSW |
1 |
194,839,676 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2277:Cr2
|
UTSW |
1 |
194,839,676 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3548:Cr2
|
UTSW |
1 |
194,838,196 (GRCm39) |
nonsense |
probably null |
|
|
R3743:Cr2
|
UTSW |
1 |
194,832,274 (GRCm39) |
splice site |
probably benign |
|
|
R3941:Cr2
|
UTSW |
1 |
194,848,122 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3963:Cr2
|
UTSW |
1 |
194,842,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4211:Cr2
|
UTSW |
1 |
194,838,636 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4484:Cr2
|
UTSW |
1 |
194,836,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4546:Cr2
|
UTSW |
1 |
194,853,349 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4791:Cr2
|
UTSW |
1 |
194,838,243 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Cr2
|
UTSW |
1 |
194,845,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4802:Cr2
|
UTSW |
1 |
194,845,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4874:Cr2
|
UTSW |
1 |
194,858,878 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4885:Cr2
|
UTSW |
1 |
194,841,039 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4889:Cr2
|
UTSW |
1 |
194,858,893 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R5154:Cr2
|
UTSW |
1 |
194,841,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5574:Cr2
|
UTSW |
1 |
194,823,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5594:Cr2
|
UTSW |
1 |
194,839,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5645:Cr2
|
UTSW |
1 |
194,836,581 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5700:Cr2
|
UTSW |
1 |
194,842,065 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5929:Cr2
|
UTSW |
1 |
194,853,419 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6237:Cr2
|
UTSW |
1 |
194,839,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6299:Cr2
|
UTSW |
1 |
194,850,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6368:Cr2
|
UTSW |
1 |
194,850,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6406:Cr2
|
UTSW |
1 |
194,852,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6618:Cr2
|
UTSW |
1 |
194,839,687 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6684:Cr2
|
UTSW |
1 |
194,853,329 (GRCm39) |
nonsense |
probably null |
|
|
R6720:Cr2
|
UTSW |
1 |
194,837,508 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6866:Cr2
|
UTSW |
1 |
194,833,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6915:Cr2
|
UTSW |
1 |
194,853,454 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7057:Cr2
|
UTSW |
1 |
194,833,918 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7117:Cr2
|
UTSW |
1 |
194,842,909 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7200:Cr2
|
UTSW |
1 |
194,845,557 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7209:Cr2
|
UTSW |
1 |
194,851,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7350:Cr2
|
UTSW |
1 |
194,837,594 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7414:Cr2
|
UTSW |
1 |
194,832,344 (GRCm39) |
missense |
probably benign |
|
|
R7453:Cr2
|
UTSW |
1 |
194,847,565 (GRCm39) |
splice site |
probably null |
|
|
R7479:Cr2
|
UTSW |
1 |
194,840,718 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7480:Cr2
|
UTSW |
1 |
194,836,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7570:Cr2
|
UTSW |
1 |
194,851,648 (GRCm39) |
nonsense |
probably null |
|
|
R7666:Cr2
|
UTSW |
1 |
194,836,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7921:Cr2
|
UTSW |
1 |
194,833,975 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7923:Cr2
|
UTSW |
1 |
194,850,995 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8396:Cr2
|
UTSW |
1 |
194,840,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8503:Cr2
|
UTSW |
1 |
194,845,850 (GRCm39) |
missense |
probably benign |
|
|
R8517:Cr2
|
UTSW |
1 |
194,838,207 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8773:Cr2
|
UTSW |
1 |
194,840,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8849:Cr2
|
UTSW |
1 |
194,839,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Cr2
|
UTSW |
1 |
194,851,581 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8938:Cr2
|
UTSW |
1 |
194,853,424 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9027:Cr2
|
UTSW |
1 |
194,834,029 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9045:Cr2
|
UTSW |
1 |
194,837,680 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9116:Cr2
|
UTSW |
1 |
194,840,977 (GRCm39) |
nonsense |
probably null |
|
|
R9137:Cr2
|
UTSW |
1 |
194,850,640 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9476:Cr2
|
UTSW |
1 |
194,840,416 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9497:Cr2
|
UTSW |
1 |
194,850,743 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9510:Cr2
|
UTSW |
1 |
194,840,416 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9752:Cr2
|
UTSW |
1 |
194,823,575 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9799:Cr2
|
UTSW |
1 |
194,842,988 (GRCm39) |
missense |
probably benign |
0.02 |
|
X0028:Cr2
|
UTSW |
1 |
194,832,290 (GRCm39) |
missense |
probably benign |
0.09 |
|
X0066:Cr2
|
UTSW |
1 |
194,848,629 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Cr2
|
UTSW |
1 |
194,836,461 (GRCm39) |
missense |
probably benign |
0.23 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATCACCATTTCAGGTAATCTTGCTC -3'
(R):5'- TCATGGCTCTTGGAGTGGAC -3'
Sequencing Primer
(F):5'- TCAGGTAATCTTGCTCTATAGAAAGG -3'
(R):5'- TGGACCTCCACCACAATGCTTAC -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation