Incidental Mutation 'R1893:Fads3'
ID 211762
Institutional Source Beutler Lab
Gene Symbol Fads3
Ensembl Gene ENSMUSG00000024664
Gene Name fatty acid desaturase 3
Synonyms
MMRRC Submission 039913-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1893 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 10018933-10037474 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 10033868 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Asparagine at position 418 (H418N)
Ref Sequence ENSEMBL: ENSMUSP00000111659 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115995]
AlphaFold Q9JJE7
Predicted Effect probably benign
Transcript: ENSMUST00000115995
AA Change: H418N

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000111659
Gene: ENSMUSG00000024664
AA Change: H418N

DomainStartEndE-ValueType
low complexity region 2 25 N/A INTRINSIC
Cyt-b5 27 101 6.21e-16 SMART
Pfam:FA_desaturase 162 423 4.1e-35 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 95.4%
  • 20x: 93.0%
Validation Efficiency 99% (99/100)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous knockout affects highly unsaturated fatty acid levels in the liver and brain. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 93 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik T C 13: 77,415,928 (GRCm39) Y674H possibly damaging Het
Aars2 G A 17: 45,825,725 (GRCm39) R347Q probably benign Het
Abca15 A T 7: 119,939,776 (GRCm39) M293L possibly damaging Het
Abcb7 A T X: 103,386,142 (GRCm39) H97Q probably damaging Het
Aldh1l2 G T 10: 83,328,400 (GRCm39) N772K probably damaging Het
Ascc2 T A 11: 4,622,305 (GRCm39) L457Q probably benign Het
Aspm T A 1: 139,407,605 (GRCm39) I2164N probably damaging Het
Cabs1 A G 5: 88,127,894 (GRCm39) T182A probably benign Het
Carmil1 T C 13: 24,208,446 (GRCm39) E833G possibly damaging Het
Ccdc102a G A 8: 95,640,171 (GRCm39) T41M probably damaging Het
Cimap1c A G 9: 56,756,498 (GRCm39) Y173H probably benign Het
Clec2h T C 6: 128,647,795 (GRCm39) V48A probably benign Het
Cpb2 G A 14: 75,493,403 (GRCm39) V27I probably benign Het
Cr2 T C 1: 194,837,495 (GRCm39) H1201R probably benign Het
Cyp2d9 T C 15: 82,336,807 (GRCm39) V52A probably damaging Het
Cyp4a12a C A 4: 115,183,864 (GRCm39) N223K probably benign Het
Cyp7b1 G A 3: 18,150,731 (GRCm39) S336L possibly damaging Het
Dnah10 T C 5: 124,831,381 (GRCm39) V803A probably benign Het
Dnah17 T A 11: 117,957,794 (GRCm39) T2745S probably benign Het
Ep300 T A 15: 81,515,847 (GRCm39) probably benign Het
Epha3 A G 16: 63,388,762 (GRCm39) S829P probably damaging Het
Fat1 T C 8: 45,476,893 (GRCm39) S1980P probably damaging Het
Fgf20 T C 8: 40,732,844 (GRCm39) E198G possibly damaging Het
Fgl2 G A 5: 21,580,669 (GRCm39) R337H probably benign Het
Gbp2 G T 3: 142,335,933 (GRCm39) probably benign Het
Gja10 G A 4: 32,601,541 (GRCm39) S281L probably benign Het
Gm5422 G A 10: 31,125,609 (GRCm39) noncoding transcript Het
Gmpr T A 13: 45,674,423 (GRCm39) D129E possibly damaging Het
Gtf3c4 C T 2: 28,724,374 (GRCm39) V453I possibly damaging Het
Heatr6 T C 11: 83,648,140 (GRCm39) V111A probably benign Het
Hipk3 G A 2: 104,263,601 (GRCm39) R905W probably damaging Het
Hpn T A 7: 30,798,773 (GRCm39) D103V probably damaging Het
Ipcef1 G A 10: 6,850,680 (GRCm39) R304W probably damaging Het
Iqcb1 A G 16: 36,652,245 (GRCm39) D52G probably damaging Het
Klhdc7b C T 15: 89,271,898 (GRCm39) probably null Het
Klhl1 A T 14: 96,477,642 (GRCm39) probably null Het
Lrrn1 A T 6: 107,545,083 (GRCm39) I294F possibly damaging Het
Map3k1 A T 13: 111,904,567 (GRCm39) F406I possibly damaging Het
Map4k4 T A 1: 40,040,717 (GRCm39) V579E probably benign Het
Mapre2 A G 18: 23,986,774 (GRCm39) K62R probably damaging Het
Mdga1 A T 17: 30,068,200 (GRCm39) Y305N probably damaging Het
Mgl2 T A 11: 70,024,993 (GRCm39) probably null Het
Mnx1 C T 5: 29,682,828 (GRCm39) G149D unknown Het
Mtbp T A 15: 55,421,064 (GRCm39) S17T probably benign Het
Neu3 T C 7: 99,472,627 (GRCm39) T37A possibly damaging Het
Nr1i3 T C 1: 171,044,792 (GRCm39) probably null Het
Or10al2 A T 17: 37,983,747 (GRCm39) K278* probably null Het
Or10g6 A T 9: 39,934,270 (GRCm39) I194F possibly damaging Het
Or6ae1 T C 7: 139,742,734 (GRCm39) N43S probably damaging Het
Or9s18 T A 13: 65,300,806 (GRCm39) M256K possibly damaging Het
Osr2 A G 15: 35,300,608 (GRCm39) T55A possibly damaging Het
Palld A G 8: 61,969,655 (GRCm39) V981A probably damaging Het
Pbx1 A T 1: 168,030,979 (GRCm39) M213K possibly damaging Het
Pcdhb12 C A 18: 37,570,136 (GRCm39) H427Q probably benign Het
Perm1 C T 4: 156,302,340 (GRCm39) R295C probably benign Het
Phaf1 G T 8: 105,973,133 (GRCm39) V248F probably damaging Het
Polm T C 11: 5,785,574 (GRCm39) T162A possibly damaging Het
Prox1 A G 1: 189,892,715 (GRCm39) probably benign Het
Ptpn7 A T 1: 135,062,641 (GRCm39) T127S probably benign Het
Pxk C T 14: 8,151,507 (GRCm38) R441* probably null Het
Rab21 T C 10: 115,126,805 (GRCm39) T181A probably benign Het
Rab38 A T 7: 88,139,924 (GRCm39) T198S probably benign Het
Rnase4 C G 14: 51,342,395 (GRCm39) Q40E possibly damaging Het
Rnf213 T A 11: 119,307,274 (GRCm39) W645R probably damaging Het
Rnf8 A G 17: 29,840,524 (GRCm39) I51M probably damaging Het
Sbpl T A 17: 24,172,241 (GRCm39) D226V unknown Het
Sdf4 T G 4: 156,085,205 (GRCm39) I180S probably benign Het
Simc1 A G 13: 54,687,528 (GRCm39) K99R probably damaging Het
Slc2a4 T C 11: 69,837,398 (GRCm39) Q49R probably damaging Het
Slco1a4 T C 6: 141,780,342 (GRCm39) probably null Het
Slco5a1 C A 1: 12,964,696 (GRCm39) C527F probably damaging Het
Sox6 T A 7: 115,143,803 (GRCm39) N405I probably benign Het
Sphkap G A 1: 83,256,687 (GRCm39) P354L probably benign Het
Spi1 A G 2: 90,944,702 (GRCm39) D149G probably benign Het
Sptan1 T A 2: 29,910,472 (GRCm39) D1812E probably damaging Het
Sub1 A T 15: 11,991,130 (GRCm39) V37E possibly damaging Het
Sult2a6 T C 7: 13,959,814 (GRCm39) T240A probably benign Het
Tacc2 A G 7: 130,227,055 (GRCm39) S1247G probably benign Het
Taf4 T C 2: 179,574,823 (GRCm39) D594G probably damaging Het
Tap1 T G 17: 34,413,915 (GRCm39) D643E probably damaging Het
Ticam1 T C 17: 56,578,894 (GRCm39) N67S probably benign Het
Tlr6 A G 5: 65,110,556 (GRCm39) F784L probably damaging Het
Tmprss15 A G 16: 78,868,306 (GRCm39) V202A probably benign Het
Trp53bp2 T C 1: 182,259,193 (GRCm39) V82A probably benign Het
Ube2o C T 11: 116,439,661 (GRCm39) V170I possibly damaging Het
Ube2q2l A G 6: 136,378,825 (GRCm39) S2P possibly damaging Het
Vmn1r177 G A 7: 23,565,573 (GRCm39) T101I probably benign Het
Vmn2r68 A T 7: 84,883,867 (GRCm39) Y79* probably null Het
Wdr35 A C 12: 9,035,994 (GRCm39) Y255S probably benign Het
Zfp507 A T 7: 35,502,052 (GRCm39) probably benign Het
Zfp688 G A 7: 127,018,409 (GRCm39) R239C probably damaging Het
Zfp74 T A 7: 29,635,470 (GRCm39) probably null Het
Zfp932 A G 5: 110,157,069 (GRCm39) N223D possibly damaging Het
Other mutations in Fads3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Fads3 APN 19 10,029,663 (GRCm39) missense probably null 0.98
IGL00422:Fads3 APN 19 10,033,045 (GRCm39) missense possibly damaging 0.80
IGL01081:Fads3 APN 19 10,030,366 (GRCm39) missense probably benign 0.00
IGL02454:Fads3 APN 19 10,032,483 (GRCm39) missense probably damaging 0.97
IGL02477:Fads3 APN 19 10,033,806 (GRCm39) missense probably damaging 1.00
R0611:Fads3 UTSW 19 10,019,200 (GRCm39) missense probably damaging 1.00
R1169:Fads3 UTSW 19 10,031,463 (GRCm39) missense possibly damaging 0.82
R1400:Fads3 UTSW 19 10,033,664 (GRCm39) splice site probably null
R2508:Fads3 UTSW 19 10,033,818 (GRCm39) missense probably damaging 1.00
R3151:Fads3 UTSW 19 10,035,262 (GRCm39) missense probably benign 0.01
R4543:Fads3 UTSW 19 10,019,175 (GRCm39) missense possibly damaging 0.60
R4766:Fads3 UTSW 19 10,033,384 (GRCm39) missense possibly damaging 0.94
R4823:Fads3 UTSW 19 10,019,252 (GRCm39) missense probably damaging 0.98
R5117:Fads3 UTSW 19 10,019,322 (GRCm39) critical splice donor site probably null
R5846:Fads3 UTSW 19 10,030,397 (GRCm39) missense probably null 1.00
R6117:Fads3 UTSW 19 10,031,631 (GRCm39) missense probably damaging 1.00
R6225:Fads3 UTSW 19 10,019,202 (GRCm39) missense probably benign 0.25
R9024:Fads3 UTSW 19 10,033,839 (GRCm39) missense probably damaging 1.00
X0027:Fads3 UTSW 19 10,031,614 (GRCm39) missense probably damaging 1.00
Z1176:Fads3 UTSW 19 10,019,171 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- GATTGAGCACCAGTGAGTGTG -3'
(R):5'- TGGCTAATCAGGAAAGCTCTAGG -3'

Sequencing Primer
(F):5'- CTTGCTGGGTGAGACCAAAGC -3'
(R):5'- AAGCTCTAGGAAGTCAGTTCTTAGG -3'
Posted On 2014-06-30