Mutagenetix > Incidental Mutations

Incidental Mutation 'R1896:Vmn1r158'

211982

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r158

Ensembl Gene

ENSMUSG00000094700

Gene Name

vomeronasal 1 receptor 158

Synonyms

Gm16455

MMRRC Submission

039916-MU

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.426) question?

Stock #

R1896 (G1)

Quality Score

196

Status

Not validated

Chromosome

Chromosomal Location

22789859-22790782 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 22790718 bp

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Tyrosine at position 22 (C22Y)

Ref Sequence

ENSEMBL: ENSMUSP00000133990 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000174643]

Predicted Effect

probably damaging
Transcript: ENSMUST00000174643
AA Change: C22Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000133990
Gene: ENSMUSG00000094700
AA Change: C22Y

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	298	2.9e-15	PFAM
Pfam:7tm_1	39	290	5.5e-9	PFAM
Pfam:V1R	41	298	3.2e-17	PFAM

Coding Region Coverage

1x: 97.3%
3x: 96.7%
10x: 94.9%
20x: 91.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110008F13Rik	C	T	2: 156,865,332	P64S	probably damaging	Het
1810046K07Rik	A	G	9: 51,291,798	S19P	probably damaging	Het
4932438A13Rik	C	T	3: 36,908,231	Q494*	probably null	Het
Abo	C	A	2: 26,843,597	D199Y	probably damaging	Het
Acvr1c	A	C	2: 58,280,294	V277G	probably damaging	Het
Adam23	G	A	1: 63,545,572	A380T	probably benign	Het
Art2b	A	G	7: 101,580,029	V221A	probably benign	Het
Bcam	A	G	7: 19,766,715	S153P	probably damaging	Het
C1qtnf1	G	T	11: 118,443,757	G21V	probably damaging	Het
Car13	T	C	3: 14,645,175	I59T	probably benign	Het
Cep97	T	C	16: 55,927,744	N108D	probably damaging	Het
Cog3	T	A	14: 75,742,344	E182D	probably benign	Het
Endou	A	G	15: 97,712,992	Y404H	probably damaging	Het
F12	T	C	13: 55,420,727	Y373C	probably damaging	Het
Fam221b	T	C	4: 43,660,375	T405A	probably damaging	Het
Fetub	A	G	16: 22,932,295	R131G	probably damaging	Het
Foxp2	A	T	6: 15,379,768		probably benign	Het
Ggt5	T	C	10: 75,604,726	V227A	probably damaging	Het
Gipr	A	G	7: 19,164,071	S79P	probably benign	Het
Gm11639	A	G	11: 104,720,688	K452R	probably benign	Het
Gm13089	C	G	4: 143,698,144	G243A	probably benign	Het
Gphn	A	G	12: 78,412,354	D72G	possibly damaging	Het
Gzmk	A	G	13: 113,172,893	S208P	probably damaging	Het
Itpkc	T	C	7: 27,208,380	D633G	probably damaging	Het
Jarid2	T	C	13: 44,884,882		probably null	Het
Kif21b	C	A	1: 136,147,845	R237S	possibly damaging	Het
Lama1	G	A	17: 67,791,223	R1805H	probably benign	Het
Lpin3	C	T	2: 160,905,298	P815S	probably damaging	Het
Lrp1	T	A	10: 127,559,998	I2468F	possibly damaging	Het
Nav1	T	C	1: 135,460,737	N1118S	probably benign	Het
Ncoa3	T	A	2: 166,048,464	I90N	probably benign	Het
Notch3	T	C	17: 32,143,428	T1408A	probably benign	Het
Nwd2	A	G	5: 63,805,410	D779G	probably benign	Het
Obox6	A	T	7: 15,834,845	H35Q	possibly damaging	Het
Pkd1l3	C	A	8: 109,624,199	P559T	possibly damaging	Het
Prex1	T	A	2: 166,586,654	I716F	probably benign	Het
Psap	C	T	10: 60,295,046	Q219*	probably null	Het
Shisa5	T	A	9: 109,056,040	I126N	probably damaging	Het
Slc11a1	T	C	1: 74,375,772	L21P	probably benign	Het
Slc4a4	A	G	5: 89,046,308	T172A	probably damaging	Het
Sned1	C	T	1: 93,265,047	P352L	probably benign	Het
Sox4	T	C	13: 28,952,144	Y293C	probably damaging	Het
Srgap3	T	A	6: 112,738,997	H654L	probably benign	Het
Stra6	A	T	9: 58,151,883	M510L	probably benign	Het
Syna	C	A	5: 134,559,152	M314I	probably benign	Het
Taf5l	A	G	8: 124,003,413	L144P	probably damaging	Het
Tll2	A	G	19: 41,113,059	F379L	probably benign	Het
Traf3ip3	A	G	1: 193,175,734	V492A	probably benign	Het
Uba2	A	G	7: 34,151,030	F364S	probably damaging	Het
Unc50	T	A	1: 37,437,242	L161Q	probably damaging	Het
Ush2a	T	C	1: 188,550,009	V1907A	probably benign	Het
Uso1	A	T	5: 92,201,133		probably null	Het
Utf1	C	A	7: 139,944,300	L143I	probably damaging	Het
Vmn1r36	T	A	6: 66,716,772	M40L	probably benign	Het
Vmn2r43	A	G	7: 8,255,056	V386A	possibly damaging	Het
Vps9d1	C	A	8: 123,247,039	R335L	probably damaging	Het
Zbtb26	A	G	2: 37,436,335	S230P	possibly damaging	Het
Zfp74	A	T	7: 29,935,144	C380S	probably damaging	Het
Zfyve1	A	C	12: 83,555,614	V469G	probably damaging	Het

Other mutations in Vmn1r158

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01147:Vmn1r158	APN	7	22790779	missense	probably benign	0.01
R1173:Vmn1r158	UTSW	7	22790445	missense	probably benign	0.19
R1574:Vmn1r158	UTSW	7	22790347	missense	probably damaging	1.00
R1574:Vmn1r158	UTSW	7	22790347	missense	probably damaging	1.00
R1725:Vmn1r158	UTSW	7	22790647	missense	probably benign	0.08
R1777:Vmn1r158	UTSW	7	22790430	missense	probably damaging	1.00
R1813:Vmn1r158	UTSW	7	22790718	missense	probably damaging	1.00
R2077:Vmn1r158	UTSW	7	22790390	missense	probably benign	0.03
R3749:Vmn1r158	UTSW	7	22790214	missense	probably damaging	1.00
R4872:Vmn1r158	UTSW	7	22790754	missense	possibly damaging	0.94
R5238:Vmn1r158	UTSW	7	22790374	missense	probably benign
R6500:Vmn1r158	UTSW	7	22790653	missense	possibly damaging	0.89
R6511:Vmn1r158	UTSW	7	22790691	missense	probably benign	0.00
R6581:Vmn1r158	UTSW	7	22790040	missense	possibly damaging	0.69
R6751:Vmn1r158	UTSW	7	22789881	missense	probably damaging	0.96
R7168:Vmn1r158	UTSW	7	22790676	missense	possibly damaging	0.82
R7337:Vmn1r158	UTSW	7	22790224	missense	probably benign	0.00
R7747:Vmn1r158	UTSW	7	22790300	missense	probably benign	0.15
R7902:Vmn1r158	UTSW	7	22790008	missense	possibly damaging	0.67
R8328:Vmn1r158	UTSW	7	22790062	missense	probably damaging	1.00
R8400:Vmn1r158	UTSW	7	22789880	nonsense	probably null
Z1177:Vmn1r158	UTSW	7	22790458	missense	possibly damaging	0.46

Predicted Primers

PCR Primer
(F):5'- TGGGAGCAAAAGCCATCATG -3'
(R):5'- TCCCTGCAATTTACCTGTAATGTG -3'

Sequencing Primer
(F):5'- GAGCAAAAGCCATCATGTTGTTTGG -3'
(R):5'- CCACAGAGAGTAGTGTCCTA -3'

Posted On

2014-06-30