Incidental Mutation 'R1897:Greb1l'
ID 212088
Institutional Source Beutler Lab
Gene Symbol Greb1l
Ensembl Gene ENSMUSG00000042942
Gene Name growth regulation by estrogen in breast cancer-like
Synonyms AK220484, mKIAA4095
MMRRC Submission 039917-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1897 (G1)
Quality Score 225
Status Validated
Chromosome 18
Chromosomal Location 10325177-10562934 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 10498992 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 292 (S292P)
Ref Sequence ENSEMBL: ENSMUSP00000049003 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048977] [ENSMUST00000172532]
AlphaFold B9EJV3
Predicted Effect probably benign
Transcript: ENSMUST00000048977
AA Change: S292P

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000049003
Gene: ENSMUSG00000042942
AA Change: S292P

DomainStartEndE-ValueType
Pfam:GREB1 1 1172 N/A PFAM
Pfam:GREB1 1154 1913 N/A PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000172532
AA Change: S292P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000134090
Gene: ENSMUSG00000042942
AA Change: S292P

DomainStartEndE-ValueType
low complexity region 83 100 N/A INTRINSIC
low complexity region 282 301 N/A INTRINSIC
low complexity region 606 617 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173356
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224958
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 95.3%
  • 20x: 92.8%
Validation Efficiency 99% (72/73)
Allele List at MGI

All alleles(5) : Targeted, other(2) Gene trapped(3)

Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acbd6 A G 1: 155,558,818 (GRCm38) S61G probably damaging Het
Acot12 A G 13: 91,784,397 (GRCm38) N504S probably benign Het
Adcy3 C T 12: 4,173,450 (GRCm38) probably benign Het
Adcyap1r1 A T 6: 55,479,194 (GRCm38) H168L probably damaging Het
Adgrd1 A G 5: 129,129,001 (GRCm38) E213G probably benign Het
Aldh1l2 G T 10: 83,502,525 (GRCm38) T510K probably damaging Het
Apol7e A T 15: 77,717,894 (GRCm38) M231L probably benign Het
Asb1 C A 1: 91,546,925 (GRCm38) probably null Het
Atf7ip2 C T 16: 10,211,084 (GRCm38) P160L probably damaging Het
Atp8a1 A G 5: 67,738,429 (GRCm38) L554P probably damaging Het
Ccdc18 A T 5: 108,196,042 (GRCm38) M884L probably benign Het
Ccdc93 A G 1: 121,491,212 (GRCm38) I499V probably benign Het
Ccl20 A G 1: 83,117,895 (GRCm38) D60G probably damaging Het
Cdhr3 T C 12: 33,045,193 (GRCm38) T626A possibly damaging Het
Cep250 A G 2: 155,976,095 (GRCm38) E789G probably damaging Het
Cmpk2 T C 12: 26,474,047 (GRCm38) L281P probably damaging Het
Col6a6 A T 9: 105,785,744 (GRCm38) M198K possibly damaging Het
Crocc G A 4: 141,018,736 (GRCm38) R1691C probably damaging Het
Csf1 C T 3: 107,748,279 (GRCm38) V90M probably damaging Het
Cul2 T G 18: 3,414,164 (GRCm38) M86R probably benign Het
Dbndd2 T C 2: 164,488,664 (GRCm38) F79S probably damaging Het
Dkk1 G T 19: 30,549,278 (GRCm38) N34K possibly damaging Het
Dnah6 T A 6: 73,181,762 (GRCm38) L619F probably benign Het
Eif2b5 T C 16: 20,507,037 (GRCm38) V588A probably damaging Het
Elf3 A T 1: 135,257,137 (GRCm38) Y104N probably damaging Het
Fahd2a T C 2: 127,436,610 (GRCm38) D272G probably damaging Het
Fbxw15 A T 9: 109,558,203 (GRCm38) C188* probably null Het
Fbxw8 T C 5: 118,128,876 (GRCm38) Y174C probably benign Het
Gnl1 C A 17: 35,988,692 (GRCm38) P585Q possibly damaging Het
Gsk3b G A 16: 38,217,084 (GRCm38) probably null Het
Hcls1 C T 16: 36,962,643 (GRCm38) P452L probably damaging Het
Hdlbp A T 1: 93,422,285 (GRCm38) probably benign Het
Hecw1 A G 13: 14,377,940 (GRCm38) S25P probably damaging Het
Hells T C 19: 38,940,484 (GRCm38) V100A probably benign Het
Isl1 C T 13: 116,303,330 (GRCm38) E161K probably benign Het
Klra9 G T 6: 130,185,592 (GRCm38) N160K possibly damaging Het
Lama4 T C 10: 39,060,186 (GRCm38) V619A probably damaging Het
Mpc1 G A 17: 8,296,878 (GRCm38) R134Q possibly damaging Het
Myo5c A T 9: 75,292,241 (GRCm38) N1377I probably benign Het
Myrf T C 19: 10,218,232 (GRCm38) I607V probably benign Het
Olfr123 T G 17: 37,796,184 (GRCm38) S247A probably benign Het
Olfr968 A T 9: 39,772,065 (GRCm38) I245K probably damaging Het
Pik3c2b A G 1: 133,066,916 (GRCm38) D206G possibly damaging Het
Pipox A G 11: 77,882,742 (GRCm38) Y228H probably damaging Het
Pitrm1 T A 13: 6,560,095 (GRCm38) V401D possibly damaging Het
Plod1 C T 4: 147,926,200 (GRCm38) E265K probably damaging Het
Ptpn21 A T 12: 98,680,405 (GRCm38) probably null Het
Qars C T 9: 108,514,083 (GRCm38) Q7* probably null Het
Rpap2 T A 5: 107,633,095 (GRCm38) V479E possibly damaging Het
Rsf1 G A 7: 97,579,910 (GRCm38) probably benign Het
Rusc2 A G 4: 43,421,749 (GRCm38) Y723C probably damaging Het
Ryr2 A T 13: 11,750,932 (GRCm38) M1306K probably benign Het
Sesn3 A C 9: 14,308,645 (GRCm38) Y110S probably damaging Het
Sgce C T 6: 4,691,511 (GRCm38) V319I probably benign Het
Slc15a5 G T 6: 138,079,764 (GRCm38) F51L possibly damaging Het
Slit2 T A 5: 48,238,423 (GRCm38) C723S probably damaging Het
Sncaip A G 18: 52,894,790 (GRCm38) probably null Het
Snx2 T A 18: 53,197,878 (GRCm38) D138E probably damaging Het
Spef2 A T 15: 9,729,654 (GRCm38) L126* probably null Het
Stam T C 2: 14,129,026 (GRCm38) S195P probably damaging Het
Strn T C 17: 78,682,842 (GRCm38) I82V probably benign Het
Synj2 T A 17: 6,022,137 (GRCm38) C202* probably null Het
Tecpr2 A G 12: 110,933,247 (GRCm38) D683G probably benign Het
Tfec A G 6: 16,835,308 (GRCm38) V157A probably damaging Het
Tff1 T G 17: 31,164,938 (GRCm38) Q28P probably benign Het
Vmn2r86 A G 10: 130,452,445 (GRCm38) Y396H probably damaging Het
Vmn2r87 A T 10: 130,471,960 (GRCm38) M803K probably damaging Het
Vmn2r90 A G 17: 17,733,304 (GRCm38) K577E probably damaging Het
Vrk1 T C 12: 106,036,540 (GRCm38) probably benign Het
Wdr20 A G 12: 110,793,723 (GRCm38) T348A probably benign Het
Other mutations in Greb1l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00485:Greb1l APN 18 10,555,962 (GRCm38) missense possibly damaging 0.90
IGL01554:Greb1l APN 18 10,522,144 (GRCm38) missense probably benign 0.01
IGL01563:Greb1l APN 18 10,469,399 (GRCm38) missense probably damaging 0.99
IGL01944:Greb1l APN 18 10,557,280 (GRCm38) missense possibly damaging 0.91
IGL02110:Greb1l APN 18 10,515,271 (GRCm38) missense probably damaging 1.00
IGL02249:Greb1l APN 18 10,532,961 (GRCm38) missense probably damaging 1.00
IGL02318:Greb1l APN 18 10,469,388 (GRCm38) missense possibly damaging 0.91
IGL02340:Greb1l APN 18 10,515,200 (GRCm38) missense probably damaging 0.99
IGL02516:Greb1l APN 18 10,537,064 (GRCm38) missense probably benign 0.31
IGL02566:Greb1l APN 18 10,503,299 (GRCm38) missense probably damaging 0.99
IGL02583:Greb1l APN 18 10,542,362 (GRCm38) missense probably damaging 1.00
IGL02838:Greb1l APN 18 10,560,430 (GRCm38) missense probably damaging 1.00
A4554:Greb1l UTSW 18 10,532,862 (GRCm38) missense possibly damaging 0.58
PIT4453001:Greb1l UTSW 18 10,533,032 (GRCm38) missense probably benign 0.08
PIT4453001:Greb1l UTSW 18 10,533,031 (GRCm38) missense probably damaging 0.98
R0099:Greb1l UTSW 18 10,509,158 (GRCm38) missense probably damaging 1.00
R0226:Greb1l UTSW 18 10,522,076 (GRCm38) intron probably benign
R0234:Greb1l UTSW 18 10,560,331 (GRCm38) missense probably damaging 1.00
R0234:Greb1l UTSW 18 10,560,331 (GRCm38) missense probably damaging 1.00
R0239:Greb1l UTSW 18 10,458,567 (GRCm38) splice site probably benign
R0316:Greb1l UTSW 18 10,547,420 (GRCm38) missense probably damaging 1.00
R0369:Greb1l UTSW 18 10,469,375 (GRCm38) missense possibly damaging 0.80
R0394:Greb1l UTSW 18 10,523,374 (GRCm38) missense probably damaging 0.99
R0478:Greb1l UTSW 18 10,509,281 (GRCm38) missense probably damaging 1.00
R0555:Greb1l UTSW 18 10,458,781 (GRCm38) splice site probably benign
R0671:Greb1l UTSW 18 10,474,303 (GRCm38) missense probably damaging 1.00
R1282:Greb1l UTSW 18 10,547,289 (GRCm38) missense probably benign 0.13
R1574:Greb1l UTSW 18 10,554,997 (GRCm38) missense possibly damaging 0.95
R1574:Greb1l UTSW 18 10,554,997 (GRCm38) missense possibly damaging 0.95
R1607:Greb1l UTSW 18 10,529,703 (GRCm38) missense possibly damaging 0.85
R1666:Greb1l UTSW 18 10,529,708 (GRCm38) critical splice donor site probably null
R1666:Greb1l UTSW 18 10,501,080 (GRCm38) critical splice donor site probably null
R1720:Greb1l UTSW 18 10,553,848 (GRCm38) missense probably benign 0.19
R1808:Greb1l UTSW 18 10,542,143 (GRCm38) missense probably benign
R1829:Greb1l UTSW 18 10,509,314 (GRCm38) missense probably damaging 1.00
R1967:Greb1l UTSW 18 10,501,049 (GRCm38) missense possibly damaging 0.91
R2025:Greb1l UTSW 18 10,515,221 (GRCm38) missense possibly damaging 0.71
R2086:Greb1l UTSW 18 10,523,281 (GRCm38) missense probably damaging 1.00
R2125:Greb1l UTSW 18 10,511,422 (GRCm38) missense probably damaging 0.98
R2139:Greb1l UTSW 18 10,555,011 (GRCm38) missense probably damaging 1.00
R2255:Greb1l UTSW 18 10,554,857 (GRCm38) missense probably damaging 1.00
R2256:Greb1l UTSW 18 10,503,307 (GRCm38) missense possibly damaging 0.91
R2257:Greb1l UTSW 18 10,503,307 (GRCm38) missense possibly damaging 0.91
R2880:Greb1l UTSW 18 10,547,288 (GRCm38) missense possibly damaging 0.93
R3623:Greb1l UTSW 18 10,542,380 (GRCm38) missense probably damaging 0.99
R3778:Greb1l UTSW 18 10,469,444 (GRCm38) missense possibly damaging 0.60
R3975:Greb1l UTSW 18 10,522,247 (GRCm38) missense possibly damaging 0.71
R4038:Greb1l UTSW 18 10,515,209 (GRCm38) missense possibly damaging 0.93
R4062:Greb1l UTSW 18 10,522,150 (GRCm38) missense probably damaging 0.99
R4134:Greb1l UTSW 18 10,529,708 (GRCm38) critical splice donor site probably null
R4342:Greb1l UTSW 18 10,544,561 (GRCm38) missense probably benign 0.12
R4409:Greb1l UTSW 18 10,503,182 (GRCm38) missense possibly damaging 0.70
R4600:Greb1l UTSW 18 10,553,705 (GRCm38) missense probably damaging 1.00
R4618:Greb1l UTSW 18 10,498,965 (GRCm38) missense probably benign 0.00
R4683:Greb1l UTSW 18 10,529,563 (GRCm38) splice site probably null
R4686:Greb1l UTSW 18 10,522,112 (GRCm38) missense probably damaging 0.98
R4707:Greb1l UTSW 18 10,532,922 (GRCm38) missense probably benign 0.02
R4780:Greb1l UTSW 18 10,541,792 (GRCm38) missense probably benign 0.00
R4819:Greb1l UTSW 18 10,458,358 (GRCm38) missense probably damaging 1.00
R4925:Greb1l UTSW 18 10,547,447 (GRCm38) missense possibly damaging 0.79
R4960:Greb1l UTSW 18 10,547,306 (GRCm38) missense probably damaging 0.99
R5150:Greb1l UTSW 18 10,555,950 (GRCm38) frame shift probably null
R5154:Greb1l UTSW 18 10,458,312 (GRCm38) missense probably benign 0.02
R5269:Greb1l UTSW 18 10,511,409 (GRCm38) missense probably benign
R5290:Greb1l UTSW 18 10,542,427 (GRCm38) missense probably damaging 1.00
R5310:Greb1l UTSW 18 10,542,427 (GRCm38) missense probably damaging 1.00
R5328:Greb1l UTSW 18 10,553,720 (GRCm38) missense probably damaging 1.00
R5337:Greb1l UTSW 18 10,509,143 (GRCm38) missense probably damaging 1.00
R5393:Greb1l UTSW 18 10,458,312 (GRCm38) missense probably benign 0.02
R5402:Greb1l UTSW 18 10,537,169 (GRCm38) missense probably benign 0.26
R5718:Greb1l UTSW 18 10,542,427 (GRCm38) missense probably damaging 1.00
R5719:Greb1l UTSW 18 10,542,427 (GRCm38) missense probably damaging 1.00
R5720:Greb1l UTSW 18 10,542,427 (GRCm38) missense probably damaging 1.00
R5721:Greb1l UTSW 18 10,542,427 (GRCm38) missense probably damaging 1.00
R5902:Greb1l UTSW 18 10,538,302 (GRCm38) missense probably benign 0.00
R5993:Greb1l UTSW 18 10,544,455 (GRCm38) missense probably benign 0.10
R6035:Greb1l UTSW 18 10,501,025 (GRCm38) missense possibly damaging 0.91
R6035:Greb1l UTSW 18 10,501,025 (GRCm38) missense possibly damaging 0.91
R6045:Greb1l UTSW 18 10,547,068 (GRCm38) missense probably damaging 1.00
R6063:Greb1l UTSW 18 10,557,340 (GRCm38) missense probably damaging 1.00
R6297:Greb1l UTSW 18 10,469,494 (GRCm38) missense probably damaging 1.00
R6405:Greb1l UTSW 18 10,501,076 (GRCm38) missense probably benign 0.30
R6552:Greb1l UTSW 18 10,541,814 (GRCm38) missense probably benign 0.00
R6572:Greb1l UTSW 18 10,522,131 (GRCm38) missense probably benign 0.07
R6575:Greb1l UTSW 18 10,547,347 (GRCm38) missense possibly damaging 0.88
R6922:Greb1l UTSW 18 10,547,482 (GRCm38) missense possibly damaging 0.88
R6957:Greb1l UTSW 18 10,558,786 (GRCm38) missense probably benign 0.23
R6962:Greb1l UTSW 18 10,547,327 (GRCm38) missense probably damaging 1.00
R7012:Greb1l UTSW 18 10,529,707 (GRCm38) critical splice donor site probably null
R7179:Greb1l UTSW 18 10,544,576 (GRCm38) missense probably benign 0.00
R7251:Greb1l UTSW 18 10,515,319 (GRCm38) missense probably damaging 1.00
R7275:Greb1l UTSW 18 10,544,561 (GRCm38) missense probably benign 0.12
R7301:Greb1l UTSW 18 10,544,970 (GRCm38) missense probably damaging 1.00
R7307:Greb1l UTSW 18 10,538,142 (GRCm38) missense probably damaging 0.99
R7455:Greb1l UTSW 18 10,554,915 (GRCm38) missense probably damaging 1.00
R7832:Greb1l UTSW 18 10,542,056 (GRCm38) missense probably benign 0.38
R7934:Greb1l UTSW 18 10,474,371 (GRCm38) nonsense probably null
R8137:Greb1l UTSW 18 10,474,357 (GRCm38) missense possibly damaging 0.77
R8138:Greb1l UTSW 18 10,533,060 (GRCm38) missense probably benign 0.13
R8208:Greb1l UTSW 18 10,510,703 (GRCm38) missense probably damaging 1.00
R8227:Greb1l UTSW 18 10,515,371 (GRCm38) missense probably damaging 1.00
R8312:Greb1l UTSW 18 10,511,587 (GRCm38) intron probably benign
R8331:Greb1l UTSW 18 10,458,706 (GRCm38) missense possibly damaging 0.96
R8364:Greb1l UTSW 18 10,529,687 (GRCm38) missense possibly damaging 0.85
R8389:Greb1l UTSW 18 10,529,613 (GRCm38) missense probably benign 0.00
R8695:Greb1l UTSW 18 10,544,450 (GRCm38) missense probably benign 0.01
R8795:Greb1l UTSW 18 10,553,739 (GRCm38) missense probably damaging 0.98
R8836:Greb1l UTSW 18 10,509,257 (GRCm38) missense probably benign 0.30
R8862:Greb1l UTSW 18 10,555,042 (GRCm38) missense possibly damaging 0.90
R8872:Greb1l UTSW 18 10,529,684 (GRCm38) missense probably benign 0.18
R8874:Greb1l UTSW 18 10,544,896 (GRCm38) missense probably benign 0.01
R8886:Greb1l UTSW 18 10,553,843 (GRCm38) missense probably benign 0.21
R8921:Greb1l UTSW 18 10,541,825 (GRCm38) missense probably benign 0.01
R8997:Greb1l UTSW 18 10,510,747 (GRCm38) missense probably damaging 1.00
R9015:Greb1l UTSW 18 10,541,675 (GRCm38) missense probably benign 0.00
R9018:Greb1l UTSW 18 10,542,004 (GRCm38) missense possibly damaging 0.76
R9074:Greb1l UTSW 18 10,558,795 (GRCm38) missense probably damaging 1.00
R9074:Greb1l UTSW 18 10,532,797 (GRCm38) missense probably damaging 1.00
R9117:Greb1l UTSW 18 10,542,422 (GRCm38) missense probably benign 0.31
R9189:Greb1l UTSW 18 10,499,983 (GRCm38) missense probably benign
R9332:Greb1l UTSW 18 10,532,796 (GRCm38) missense possibly damaging 0.92
R9367:Greb1l UTSW 18 10,522,130 (GRCm38) missense probably benign 0.00
R9497:Greb1l UTSW 18 10,458,600 (GRCm38) missense probably benign 0.00
R9796:Greb1l UTSW 18 10,538,233 (GRCm38) missense possibly damaging 0.69
Z1176:Greb1l UTSW 18 10,515,305 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGGTTTTATGCAACTAGGCTG -3'
(R):5'- CCGGGTTCATTGAGAGATTCTG -3'

Sequencing Primer
(F):5'- ATGCAACTAGGCTGTCCTATCTG -3'
(R):5'- CTGTTTCTAAGGATAATGTAGAGGGC -3'
Posted On 2014-06-30