Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00229:Hdac10'

2123

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Hdac10

Ensembl Gene

ENSMUSG00000062906

Gene Name

histone deacetylase 10

Synonyms

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00229

Quality Score

Status

Chromosome

Chromosomal Location

89123307-89128700 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 89128442 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 3 (T3A)

Ref Sequence

ENSEMBL: ENSMUSP00000104971 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000082197] [ENSMUST00000088827] [ENSMUST00000109347]

AlphaFold

Q6P3E7

Predicted Effect

probably damaging
Transcript: ENSMUST00000082197
AA Change: T3A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000080832
Gene: ENSMUSG00000062906
AA Change: T3A

Domain	Start	End	E-Value	Type
Pfam:Hist_deacetyl	13	322	2.1e-85	PFAM
low complexity region	478	489	N/A	INTRINSIC
low complexity region	583	595	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000088827

SMART Domains

Protein: ENSMUSP00000086207
Gene: ENSMUSG00000022610

Domain	Start	End	E-Value	Type
S_TKc	27	311	1.63e-96	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000109347
AA Change: T3A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000104971
Gene: ENSMUSG00000062906
AA Change: T3A

Domain	Start	End	E-Value	Type
Pfam:Hist_deacetyl	13	251	6.1e-66	PFAM
low complexity region	270	282	N/A	INTRINSIC
low complexity region	398	409	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128908

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129398

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134111

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138245

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000143465

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153195

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000230266

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000230352

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000230509

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231014

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231056

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010111I01Rik	A	G	13: 63,199,500		probably benign	Het
9030624J02Rik	T	A	7: 118,804,191		probably benign	Het
Abca4	A	G	3: 122,170,954	T929A	probably damaging	Het
Adam6b	G	A	12: 113,491,393	R610H	probably damaging	Het
Adamts12	T	A	15: 11,311,599	M1314K	probably benign	Het
Alg6	T	A	4: 99,753,054	F152I	probably damaging	Het
Arid5b	A	G	10: 68,128,975	S289P	probably damaging	Het
Axin1	T	C	17: 26,194,072	F780L	probably damaging	Het
C87499	A	G	4: 88,629,053	I214T	probably damaging	Het
C9	C	T	15: 6,483,231	S278L	possibly damaging	Het
Calr4	A	T	4: 109,244,115	I65F	probably damaging	Het
Cdh23	A	G	10: 60,523,548	V260A	probably benign	Het
Ddx25	T	C	9: 35,543,595		probably benign	Het
Dppa4	A	G	16: 48,291,083	T92A	possibly damaging	Het
Ercc5	T	C	1: 44,163,898	Y232H	probably damaging	Het
Exoc4	A	G	6: 33,918,399		probably null	Het
Fam149a	A	G	8: 45,351,786	V253A	probably damaging	Het
Fam209	C	T	2: 172,474,182	T159I	probably damaging	Het
Gcfc2	A	T	6: 81,936,015	N265I	probably damaging	Het
Glud1	T	C	14: 34,336,130	V366A	probably benign	Het
Ifnar1	T	C	16: 91,489,782	S54P	probably damaging	Het
Itpr2	T	C	6: 146,144,185	Y2561C	probably damaging	Het
Klhl30	A	G	1: 91,354,157	E160G	possibly damaging	Het
Kmt2d	A	T	15: 98,862,333	S1015T	unknown	Het
Lactb2	A	G	1: 13,660,374	M26T	probably damaging	Het
Lactbl1	A	T	4: 136,631,051	D111V	probably damaging	Het
Lig4	T	C	8: 9,972,775	Y335C	probably damaging	Het
Lrrc8e	T	A	8: 4,235,921	D715E	probably benign	Het
Med6	A	T	12: 81,579,574	V142D	possibly damaging	Het
Men1	G	A	19: 6,337,207		probably null	Het
Mettl13	A	G	1: 162,535,865	V600A	possibly damaging	Het
Mpdz	A	T	4: 81,310,224	C1314*	probably null	Het
Nbeal2	A	G	9: 110,635,869	V1009A	probably damaging	Het
Nmur2	A	G	11: 56,040,777	L36P	probably damaging	Het
Nudt2	T	A	4: 41,480,474	L119Q	probably damaging	Het
Olfr1472	T	C	19: 13,453,840	M226V	possibly damaging	Het
Osbpl3	C	T	6: 50,323,068	E519K	probably damaging	Het
Pak6	A	T	2: 118,689,845	T106S	possibly damaging	Het
Pggt1b	T	G	18: 46,280,719	Q34P	probably benign	Het
Phactr4	T	C	4: 132,370,992	T322A	possibly damaging	Het
Plekhj1	T	C	10: 80,796,602		probably null	Het
Pnpt1	T	C	11: 29,154,217		probably null	Het
Prr14l	T	C	5: 32,830,676	I492V	probably benign	Het
Ranbp2	C	A	10: 58,477,256	A1266E	probably damaging	Het
Riok3	G	A	18: 12,137,020	D140N	probably damaging	Het
Rsph4a	G	A	10: 33,914,343	E643K	probably damaging	Het
Scara3	T	G	14: 65,933,121	E103A	probably benign	Het
Sgk3	T	C	1: 9,868,384	V33A	probably damaging	Het
Slc38a4	A	G	15: 96,999,494	F480S	probably damaging	Het
Slc44a1	G	A	4: 53,543,571	V372M	probably damaging	Het
Slc9a2	A	G	1: 40,767,737	Y728C	probably benign	Het
Sox4	C	A	13: 28,952,973	G17W	probably damaging	Het
Spidr	A	T	16: 15,895,578	L847Q	probably damaging	Het
Sptb	A	G	12: 76,620,753	S857P	probably benign	Het
Syde1	A	G	10: 78,585,809	V636A	probably damaging	Het
Syna	A	G	5: 134,559,717	L126P	possibly damaging	Het
Taar2	A	G	10: 23,941,368	T269A	possibly damaging	Het
Tapbp	C	T	17: 33,925,704	T258I	probably damaging	Het
Tcf20	T	A	15: 82,857,142	Q36L	possibly damaging	Het
Tmem131l	A	T	3: 83,942,500	M260K	probably damaging	Het
Tnc	T	A	4: 64,016,824		probably benign	Het
Ugp2	T	A	11: 21,354,345	E27D	probably benign	Het
Wdr27	A	T	17: 14,928,310	C140*	probably null	Het
Wnt2b	T	C	3: 104,953,133	T153A	possibly damaging	Het
Xirp2	A	T	2: 67,513,375	T1987S	probably benign	Het
Zfp36l1	C	A	12: 80,110,464	G48C	probably damaging	Het
Zfp474	A	T	18: 52,638,493	I73F	possibly damaging	Het
Zfp790	T	A	7: 29,828,563	F224L	probably benign	Het

Other mutations in Hdac10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01063:Hdac10	APN	15	89123868	missense	possibly damaging	0.68
IGL01577:Hdac10	APN	15	89126213	missense	possibly damaging	0.90
IGL01690:Hdac10	APN	15	89125991	missense	probably benign	0.00
IGL01724:Hdac10	APN	15	89124709	unclassified	probably benign
IGL01866:Hdac10	APN	15	89124533	missense	probably damaging	1.00
IGL01989:Hdac10	APN	15	89125343	missense	probably damaging	1.00
IGL01995:Hdac10	APN	15	89127598	missense	probably damaging	1.00
IGL02256:Hdac10	APN	15	89125894	unclassified	probably benign
IGL02668:Hdac10	APN	15	89125644	missense	probably benign	0.10
R0240:Hdac10	UTSW	15	89125882	missense	possibly damaging	0.65
R0240:Hdac10	UTSW	15	89125882	missense	possibly damaging	0.65
R0454:Hdac10	UTSW	15	89125758	splice site	probably null
R0723:Hdac10	UTSW	15	89126418	missense	probably damaging	1.00
R0924:Hdac10	UTSW	15	89125862	missense	probably benign
R1553:Hdac10	UTSW	15	89125515	missense	possibly damaging	0.51
R1608:Hdac10	UTSW	15	89125318	missense	probably benign	0.04
R1619:Hdac10	UTSW	15	89126675	missense	probably damaging	1.00
R1715:Hdac10	UTSW	15	89126709	splice site	probably null
R2284:Hdac10	UTSW	15	89127404	missense	probably benign	0.00
R2872:Hdac10	UTSW	15	89125856	missense	possibly damaging	0.46
R2872:Hdac10	UTSW	15	89125856	missense	possibly damaging	0.46
R3688:Hdac10	UTSW	15	89123564	critical splice donor site	probably null
R4283:Hdac10	UTSW	15	89125623	missense	possibly damaging	0.94
R4604:Hdac10	UTSW	15	89125397	critical splice acceptor site	probably null
R4654:Hdac10	UTSW	15	89126833	unclassified	probably benign
R4898:Hdac10	UTSW	15	89128447	start codon destroyed	probably null	1.00
R4998:Hdac10	UTSW	15	89123940	missense	possibly damaging	0.94
R5393:Hdac10	UTSW	15	89126684	missense	probably damaging	1.00
R5769:Hdac10	UTSW	15	89123616	missense	probably benign	0.00
R5785:Hdac10	UTSW	15	89126945	missense	probably benign
R6992:Hdac10	UTSW	15	89125331	missense	probably benign	0.01
R7149:Hdac10	UTSW	15	89127449	missense	probably damaging	1.00
R7237:Hdac10	UTSW	15	89125377	missense	probably benign
R7276:Hdac10	UTSW	15	89128285	missense	probably benign	0.01
R7395:Hdac10	UTSW	15	89128284	missense	probably benign	0.14
R9294:Hdac10	UTSW	15	89126277	missense	probably damaging	1.00

Posted On

2011-12-09