Mutagenetix > Incidental Mutation

Incidental Mutation 'R1902:Casz1'

212311

Institutional Source

Beutler Lab

Gene Symbol

Casz1

Ensembl Gene

ENSMUSG00000028977

Gene Name

castor zinc finger 1

Synonyms

D4Ertd432e, 2410019P08Rik, Cst, castor

MMRRC Submission

039922-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1902 (G1)

Quality Score

120

Status

Not validated

Chromosome

Chromosomal Location

148804429-148954889 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 148936195 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 479 (I479T)

Ref Sequence

ENSEMBL: ENSMUSP00000092035 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094464] [ENSMUST00000122222] [ENSMUST00000139806] [ENSMUST00000147270]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000094464
AA Change: I479T

PolyPhen 2 Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000092035
Gene: ENSMUSG00000028977
AA Change: I479T

Domain	Start	End	E-Value	Type
low complexity region	403	420	N/A	INTRINSIC
ZnF_C2H2	489	514	5.34e0	SMART
ZnF_C2H2	550	574	8.09e-1	SMART
ZnF_C2H2	609	633	9.3e-1	SMART
low complexity region	643	658	N/A	INTRINSIC
ZnF_C2H2	667	691	1.1e-2	SMART
low complexity region	698	711	N/A	INTRINSIC
low complexity region	728	766	N/A	INTRINSIC
low complexity region	796	807	N/A	INTRINSIC
low complexity region	810	834	N/A	INTRINSIC
low complexity region	875	890	N/A	INTRINSIC
low complexity region	951	957	N/A	INTRINSIC
ZnF_C2H2	1031	1055	2.29e1	SMART
low complexity region	1080	1091	N/A	INTRINSIC
low complexity region	1105	1115	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000122222
AA Change: I479T

PolyPhen 2 Score 0.039 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000112978
Gene: ENSMUSG00000028977
AA Change: I479T

Domain	Start	End	E-Value	Type
low complexity region	403	420	N/A	INTRINSIC
ZnF_C2H2	489	514	5.34e0	SMART
ZnF_C2H2	550	574	8.09e-1	SMART
ZnF_C2H2	609	633	9.3e-1	SMART
low complexity region	643	658	N/A	INTRINSIC
ZnF_C2H2	667	691	1.1e-2	SMART
low complexity region	698	711	N/A	INTRINSIC
low complexity region	728	766	N/A	INTRINSIC
low complexity region	796	807	N/A	INTRINSIC
low complexity region	810	834	N/A	INTRINSIC
low complexity region	875	890	N/A	INTRINSIC
low complexity region	951	957	N/A	INTRINSIC
ZnF_C2H2	1031	1055	2.29e1	SMART
low complexity region	1080	1091	N/A	INTRINSIC
low complexity region	1105	1115	N/A	INTRINSIC
ZnF_C2H2	1182	1206	1.59e1	SMART
ZnF_C2H2	1242	1266	2.47e1	SMART
ZnF_C2H2	1300	1324	3.47e0	SMART
ZnF_C2H2	1457	1481	7.89e0	SMART
ZnF_C2H2	1515	1537	3.21e1	SMART
ZnF_C2H2	1571	1595	3.99e0	SMART
low complexity region	1632	1649	N/A	INTRINSIC
SCOP:d1qbkb_	1675	1742	2e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000139806
AA Change: I193T

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000120307
Gene: ENSMUSG00000028977
AA Change: I193T

Domain	Start	End	E-Value	Type
low complexity region	117	134	N/A	INTRINSIC
ZnF_C2H2	203	228	5.34e0	SMART
ZnF_C2H2	264	288	8.09e-1	SMART
ZnF_C2H2	323	347	9.3e-1	SMART
low complexity region	357	372	N/A	INTRINSIC
ZnF_C2H2	381	405	1.1e-2	SMART
low complexity region	412	425	N/A	INTRINSIC
low complexity region	442	480	N/A	INTRINSIC
low complexity region	510	521	N/A	INTRINSIC
low complexity region	524	548	N/A	INTRINSIC
low complexity region	589	604	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000147270

Coding Region Coverage

1x: 97.3%
3x: 96.7%
10x: 94.9%
20x: 91.7%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a zinc finger transcription factor. The encoded protein may function as a tumor suppressor, and single nucleotide polymorphisms in this gene are associated with blood pressure variation. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete lethality throughout fetal growth and development and abnormal heart development associated with edema, decreased fetal cardiomyocyte proliferation, myocardium hypoplasia, ventricular septal defect, and altered heart shape and Z line formation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 128 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5730507C01Rik	C	T	12: 18,534,003 (GRCm38)	Q355*	probably null	Het
Acacb	A	T	5: 114,165,734 (GRCm38)	R73*	probably null	Het
Adra1a	T	C	14: 66,638,235 (GRCm38)	S220P	probably benign	Het
Ano2	A	T	6: 125,872,684 (GRCm38)	E126D	probably damaging	Het
Anpep	C	T	7: 79,838,256 (GRCm38)	E518K	probably benign	Het
Arhgap45	C	A	10: 80,025,466 (GRCm38)	Q488K	probably damaging	Het
Arhgef7	C	A	8: 11,808,713 (GRCm38)		probably null	Het
Atxn7l3b	A	G	10: 112,928,673 (GRCm38)	I17T	probably benign	Het
BC003331	T	A	1: 150,388,609 (GRCm38)		probably null	Het
Bpifb9a	A	T	2: 154,261,991 (GRCm38)	N118I	probably benign	Het
Btbd9	A	T	17: 30,530,228 (GRCm38)	D37E	probably damaging	Het
C8a	T	C	4: 104,856,601 (GRCm38)		probably null	Het
Capn13	G	A	17: 73,326,361 (GRCm38)	S535F	probably damaging	Het
Carns1	G	T	19: 4,166,338 (GRCm38)	P615Q	probably damaging	Het
Ccdc88a	G	T	11: 29,461,788 (GRCm38)	M532I	probably benign	Het
Cdc42bpb	T	G	12: 111,326,016 (GRCm38)	S362R	probably damaging	Het
Ceacam11	A	T	7: 17,975,327 (GRCm38)	H150L	probably benign	Het
Cfap44	A	C	16: 44,422,374 (GRCm38)	T714P	probably benign	Het
Cnot1	T	C	8: 95,743,121 (GRCm38)	I1369V	possibly damaging	Het
Cpeb1	T	C	7: 81,372,119 (GRCm38)	D92G	probably benign	Het
Cped1	T	A	6: 22,120,981 (GRCm38)		probably null	Het
Csf1r	A	G	18: 61,130,141 (GRCm38)	T896A	probably damaging	Het
Csf3r	T	C	4: 126,042,918 (GRCm38)	F658S	probably damaging	Het
Cts6	A	T	13: 61,201,515 (GRCm38)	Y126*	probably null	Het
Cul7	T	C	17: 46,655,740 (GRCm38)	L365P	probably damaging	Het
Cxcl5	T	C	5: 90,759,785 (GRCm38)	V72A	probably damaging	Het
Cyp4v3	T	A	8: 45,306,952 (GRCm38)	H521L	probably benign	Het
Dct	T	C	14: 118,034,278 (GRCm38)	N380S	probably benign	Het
Dnah1	T	C	14: 31,319,759 (GRCm38)	D85G	probably damaging	Het
Dnah7a	T	C	1: 53,535,478 (GRCm38)	D1709G	probably damaging	Het
Dnaic1	A	T	4: 41,625,319 (GRCm38)	K428*	probably null	Het
Dsc1	A	T	18: 20,095,988 (GRCm38)	V415D	probably damaging	Het
E2f8	T	C	7: 48,871,172 (GRCm38)	H467R	probably benign	Het
Eddm3b	T	A	14: 51,116,864 (GRCm38)	I103N	probably damaging	Het
Fam71b	A	T	11: 46,407,011 (GRCm38)	T381S	probably benign	Het
Gal3st2c	T	G	1: 94,008,889 (GRCm38)	N185K	probably damaging	Het
Ganc	T	C	2: 120,446,482 (GRCm38)	L675P	probably damaging	Het
Gdf9	G	A	11: 53,436,953 (GRCm38)	M245I	probably benign	Het
Gm21886	G	A	18: 80,089,418 (GRCm38)	T175I	probably damaging	Het
Gria2	A	G	3: 80,722,108 (GRCm38)	L269P	probably damaging	Het
Grm8	T	C	6: 27,429,482 (GRCm38)	Y471C	probably damaging	Het
Gucy2g	T	A	19: 55,210,237 (GRCm38)	T825S	probably benign	Het
H2-Bl	A	T	17: 36,083,953 (GRCm38)	M16K	probably damaging	Het
Iffo2	T	C	4: 139,607,701 (GRCm38)	S124P	probably damaging	Het
Igf1r	T	C	7: 68,201,249 (GRCm38)	Y931H	possibly damaging	Het
Il22ra1	A	T	4: 135,750,908 (GRCm38)	Q430L	probably damaging	Het
Il23r	A	C	6: 67,423,734 (GRCm38)	D537E	probably benign	Het
Ip6k1	G	A	9: 108,040,996 (GRCm38)	E77K	possibly damaging	Het
Itgb4	T	C	11: 115,980,738 (GRCm38)	V179A	probably damaging	Het
Itpr2	T	A	6: 146,229,703 (GRCm38)	H1968L	probably damaging	Het
Kdm4a	A	G	4: 118,160,399 (GRCm38)	V490A	probably benign	Het
Kif13a	A	T	13: 46,788,162 (GRCm38)	D946E	probably benign	Het
Klhl22	T	A	16: 17,771,787 (GRCm38)	I104N	probably damaging	Het
Klk6	A	C	7: 43,826,057 (GRCm38)	M1L	probably benign	Het
Krt78	A	T	15: 101,946,963 (GRCm38)	C804*	probably null	Het
Larp7	A	T	3: 127,540,578 (GRCm38)	N533K	probably damaging	Het
Lrit3	T	C	3: 129,791,246 (GRCm38)	T288A	probably benign	Het
Lrp11	T	A	10: 7,623,780 (GRCm38)	L245Q	probably damaging	Het
Lrp1b	T	C	2: 40,860,661 (GRCm38)	S2964G	probably damaging	Het
Lrrc66	C	T	5: 73,607,622 (GRCm38)	V693M	probably damaging	Het
Macf1	T	A	4: 123,471,165 (GRCm38)	M3268L	probably benign	Het
Mad1l1	A	G	5: 140,303,688 (GRCm38)	S161P	possibly damaging	Het
Mettl25	A	G	10: 105,826,087 (GRCm38)	S341P	probably damaging	Het
Morc3	A	G	16: 93,870,497 (GRCm38)	T588A	probably damaging	Het
Mospd3	A	G	5: 137,600,415 (GRCm38)	S21P	probably damaging	Het
Mrpl57	T	A	14: 57,826,729 (GRCm38)	F71L	probably damaging	Het
Mtbp	T	C	15: 55,606,715 (GRCm38)	L594S	probably damaging	Het
Mthfd2	T	C	6: 83,306,731 (GRCm38)	N323S	probably damaging	Het
Muc5b	G	T	7: 141,864,105 (GRCm38)	S3596I	possibly damaging	Het
Mug1	A	G	6: 121,881,821 (GRCm38)	D1166G	probably benign	Het
Nav1	T	G	1: 135,472,410 (GRCm38)	N474T	probably benign	Het
Ncoa1	A	T	12: 4,339,049 (GRCm38)	D75E	possibly damaging	Het
Ncor1	A	C	11: 62,338,158 (GRCm38)	I958S	probably damaging	Het
Nefm	T	C	14: 68,124,114 (GRCm38)	S234G	probably benign	Het
Nlrp4c	T	C	7: 6,065,819 (GRCm38)	S240P	probably damaging	Het
Nox3	C	T	17: 3,670,017 (GRCm38)	V298M	probably damaging	Het
Ntn4	A	G	10: 93,707,372 (GRCm38)	D320G	possibly damaging	Het
Nudt13	C	G	14: 20,310,641 (GRCm38)	T174R	probably damaging	Het
Olfr1002	T	C	2: 85,647,857 (GRCm38)	S155G	possibly damaging	Het
Olfr119	T	A	17: 37,701,421 (GRCm38)	H250Q	probably damaging	Het
Olfr1245	A	T	2: 89,575,603 (GRCm38)	L41Q	possibly damaging	Het
Olfr1512	T	G	14: 52,372,717 (GRCm38)	Q112P	possibly damaging	Het
Olfr209	A	T	16: 59,362,163 (GRCm38)	D18E	probably benign	Het
Olfr355	T	C	2: 36,927,185 (GRCm38)	I310V	probably benign	Het
Olfr430	T	C	1: 174,070,126 (GRCm38)	V276A	probably damaging	Het
Olfr437	T	A	6: 43,167,723 (GRCm38)		probably null	Het
Olfr812	G	T	10: 129,842,506 (GRCm38)	P179T	probably benign	Het
Olfr967	T	C	9: 39,750,806 (GRCm38)	V140A	probably benign	Het
Opn1sw	T	A	6: 29,379,804 (GRCm38)	N144Y	possibly damaging	Het
Osbpl5	T	C	7: 143,703,181 (GRCm38)	D404G	possibly damaging	Het
Parp14	C	T	16: 35,853,518 (GRCm38)		probably null	Het
Pde3a	C	A	6: 141,498,770 (GRCm38)	N1101K	probably benign	Het
Plcb1	G	A	2: 134,813,613 (GRCm38)	V38I	possibly damaging	Het
Plec	T	A	15: 76,175,551 (GRCm38)	E3417D	probably damaging	Het
Ppfibp2	C	T	7: 107,746,378 (GRCm38)	P869L	probably damaging	Het
Ppp1r12a	T	A	10: 108,198,891 (GRCm38)	I99N	probably damaging	Het
Pramel5	G	A	4: 144,273,863 (GRCm38)	Q48*	probably null	Het
Prr13	C	A	15: 102,460,698 (GRCm38)		probably benign	Het
Psg22	T	A	7: 18,724,438 (GRCm38)	Y312*	probably null	Het
Ptchd4	A	T	17: 42,503,616 (GRCm38)	I803L	probably benign	Het
Rasa4	A	G	5: 136,091,238 (GRCm38)	D56G	probably benign	Het
Rif1	T	A	2: 52,116,673 (GRCm38)	N2206K	possibly damaging	Het
Robo1	A	G	16: 72,960,204 (GRCm38)	Q351R	probably null	Het
Samd4	T	C	14: 47,074,128 (GRCm38)	F81S	probably damaging	Het
Sh3pxd2b	T	C	11: 32,423,559 (GRCm38)	*909Q	probably null	Het
Slc25a45	A	G	19: 5,884,522 (GRCm38)	R173G	probably damaging	Het
Smarca1	G	A	X: 47,849,963 (GRCm38)	Q723*	probably null	Het
Smoc1	T	C	12: 81,104,671 (GRCm38)	I54T	probably benign	Het
Spef2	G	T	15: 9,607,377 (GRCm38)	R1319S	probably damaging	Het
Steap3	T	G	1: 120,241,734 (GRCm38)	I240L	probably benign	Het
Stmn4	C	T	14: 66,355,609 (GRCm38)	L13F	probably damaging	Het
Stxbp5	C	A	10: 9,812,298 (GRCm38)	V420F	possibly damaging	Het
Syt3	T	C	7: 44,390,516 (GRCm38)	S58P	possibly damaging	Het
Tas2r125	T	C	6: 132,910,176 (GRCm38)	F176L	probably benign	Het
Tbc1d19	T	A	5: 53,829,353 (GRCm38)	C35S	probably benign	Het
Tcaf3	T	C	6: 42,593,552 (GRCm38)	E422G	possibly damaging	Het
Tekt4	T	A	17: 25,471,858 (GRCm38)	F46Y	possibly damaging	Het
Tnfaip3	T	C	10: 19,008,189 (GRCm38)	K148E	probably benign	Het
Trrap	T	G	5: 144,816,053 (GRCm38)	I1813R	probably damaging	Het
Ttc29	A	G	8: 78,251,732 (GRCm38)	E137G	probably benign	Het
Tubgcp6	C	A	15: 89,116,241 (GRCm38)	R307L	possibly damaging	Het
Tyro3	T	C	2: 119,801,695 (GRCm38)	I81T	possibly damaging	Het
Upp2	T	G	2: 58,771,452 (GRCm38)	M71R	probably damaging	Het
Utp20	G	T	10: 88,753,026 (GRCm38)	T2427K	probably benign	Het
Vcl	T	A	14: 20,982,699 (GRCm38)	L122Q	probably damaging	Het
Vmn1r213	A	C	13: 23,012,306 (GRCm38)	N353T	possibly damaging	Het
Vwa5b2	G	T	16: 20,604,832 (GRCm38)	S1165I	possibly damaging	Het
Zfp869	T	C	8: 69,707,438 (GRCm38)	K162E	probably benign	Het

Other mutations in Casz1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00914:Casz1	APN	4	148,929,371 (GRCm38)	missense	probably damaging	1.00
IGL02137:Casz1	APN	4	148,933,468 (GRCm38)	missense	possibly damaging	0.71
IGL02176:Casz1	APN	4	148,934,619 (GRCm38)	missense	probably damaging	1.00
IGL02629:Casz1	APN	4	148,944,391 (GRCm38)	missense	probably benign	0.01
IGL02871:Casz1	APN	4	148,944,319 (GRCm38)	missense	possibly damaging	0.93
FR4340:Casz1	UTSW	4	148,952,302 (GRCm38)	small deletion	probably benign
G1Funyon:Casz1	UTSW	4	148,946,043 (GRCm38)	missense	probably damaging	0.98
H8562:Casz1	UTSW	4	148,933,451 (GRCm38)	missense	probably damaging	1.00
R0090:Casz1	UTSW	4	148,933,411 (GRCm38)	missense	probably benign	0.00
R0389:Casz1	UTSW	4	148,948,911 (GRCm38)	missense	possibly damaging	0.83
R0443:Casz1	UTSW	4	148,948,911 (GRCm38)	missense	possibly damaging	0.83
R0550:Casz1	UTSW	4	148,952,284 (GRCm38)	small deletion	probably benign
R0597:Casz1	UTSW	4	148,944,394 (GRCm38)	missense	probably benign	0.00
R1117:Casz1	UTSW	4	148,934,595 (GRCm38)	missense	probably damaging	1.00
R1476:Casz1	UTSW	4	148,946,171 (GRCm38)	missense	probably benign	0.05
R1540:Casz1	UTSW	4	148,942,900 (GRCm38)	unclassified	probably benign
R1610:Casz1	UTSW	4	148,929,087 (GRCm38)	missense	possibly damaging	0.54
R1764:Casz1	UTSW	4	148,942,900 (GRCm38)	unclassified	probably benign
R1779:Casz1	UTSW	4	148,932,937 (GRCm38)	missense	probably benign	0.00
R1874:Casz1	UTSW	4	148,943,211 (GRCm38)	missense	probably damaging	0.99
R1914:Casz1	UTSW	4	148,932,958 (GRCm38)	missense	probably damaging	1.00
R2126:Casz1	UTSW	4	148,946,064 (GRCm38)	missense	probably damaging	0.99
R2261:Casz1	UTSW	4	148,929,099 (GRCm38)	missense	probably damaging	0.96
R2262:Casz1	UTSW	4	148,929,099 (GRCm38)	missense	probably damaging	0.96
R3874:Casz1	UTSW	4	148,939,589 (GRCm38)	intron	probably benign
R4019:Casz1	UTSW	4	148,932,878 (GRCm38)	missense	probably benign	0.00
R4355:Casz1	UTSW	4	148,952,335 (GRCm38)	missense	unknown
R4420:Casz1	UTSW	4	148,948,918 (GRCm38)	missense	possibly damaging	0.90
R4610:Casz1	UTSW	4	148,933,267 (GRCm38)	missense	probably damaging	1.00
R4632:Casz1	UTSW	4	148,951,855 (GRCm38)	missense	possibly damaging	0.71
R4762:Casz1	UTSW	4	148,938,981 (GRCm38)	missense	probably damaging	1.00
R4824:Casz1	UTSW	4	148,944,571 (GRCm38)	missense	probably damaging	1.00
R4907:Casz1	UTSW	4	148,944,541 (GRCm38)	missense	probably damaging	1.00
R5628:Casz1	UTSW	4	148,946,096 (GRCm38)	missense	probably damaging	1.00
R5736:Casz1	UTSW	4	148,929,410 (GRCm38)	missense	probably benign	0.00
R5929:Casz1	UTSW	4	148,938,969 (GRCm38)	missense	probably damaging	1.00
R5929:Casz1	UTSW	4	148,938,696 (GRCm38)	missense	probably damaging	1.00
R5932:Casz1	UTSW	4	148,939,113 (GRCm38)	missense	possibly damaging	0.52
R6016:Casz1	UTSW	4	148,934,584 (GRCm38)	missense	probably damaging	1.00
R6019:Casz1	UTSW	4	148,947,038 (GRCm38)	missense	probably damaging	0.99
R6139:Casz1	UTSW	4	148,951,697 (GRCm38)	missense	probably damaging	1.00
R6223:Casz1	UTSW	4	148,933,383 (GRCm38)	missense	probably damaging	1.00
R6239:Casz1	UTSW	4	148,938,277 (GRCm38)	missense	probably damaging	1.00
R6323:Casz1	UTSW	4	148,941,704 (GRCm38)	missense	possibly damaging	0.89
R6354:Casz1	UTSW	4	148,952,542 (GRCm38)	missense	unknown
R6454:Casz1	UTSW	4	148,951,495 (GRCm38)	missense	probably damaging	0.99
R6479:Casz1	UTSW	4	148,937,078 (GRCm38)	missense	probably damaging	1.00
R6529:Casz1	UTSW	4	148,938,189 (GRCm38)	missense	probably damaging	1.00
R6772:Casz1	UTSW	4	148,943,206 (GRCm38)	missense	probably damaging	1.00
R7000:Casz1	UTSW	4	148,929,236 (GRCm38)	missense	probably damaging	1.00
R7152:Casz1	UTSW	4	148,901,291 (GRCm38)	start gained	probably benign
R7324:Casz1	UTSW	4	148,947,033 (GRCm38)	missense	probably damaging	0.99
R7339:Casz1	UTSW	4	148,951,745 (GRCm38)	missense	probably damaging	1.00
R7388:Casz1	UTSW	4	148,952,393 (GRCm38)	missense	unknown
R7480:Casz1	UTSW	4	148,944,586 (GRCm38)	missense	probably damaging	0.99
R7719:Casz1	UTSW	4	148,944,524 (GRCm38)	missense	probably damaging	0.99
R7789:Casz1	UTSW	4	148,929,406 (GRCm38)	missense	probably benign
R7801:Casz1	UTSW	4	148,938,249 (GRCm38)	missense	probably damaging	0.99
R7815:Casz1	UTSW	4	148,929,305 (GRCm38)	missense	possibly damaging	0.89
R7818:Casz1	UTSW	4	148,946,076 (GRCm38)	missense	probably damaging	1.00
R7938:Casz1	UTSW	4	148,944,486 (GRCm38)	missense	probably benign	0.05
R8045:Casz1	UTSW	4	148,932,779 (GRCm38)	missense	probably damaging	1.00
R8134:Casz1	UTSW	4	148,943,035 (GRCm38)	missense	probably damaging	1.00
R8165:Casz1	UTSW	4	148,944,431 (GRCm38)	missense	probably damaging	1.00
R8301:Casz1	UTSW	4	148,946,043 (GRCm38)	missense	probably damaging	0.98
R8419:Casz1	UTSW	4	148,948,583 (GRCm38)	missense	probably benign	0.29
R9047:Casz1	UTSW	4	148,939,040 (GRCm38)	missense	probably damaging	1.00
R9420:Casz1	UTSW	4	148,938,863 (GRCm38)	missense	probably damaging	0.99
R9584:Casz1	UTSW	4	148,901,247 (GRCm38)	start gained	probably benign
RF001:Casz1	UTSW	4	148,952,304 (GRCm38)	small deletion	probably benign
RF063:Casz1	UTSW	4	148,952,304 (GRCm38)	small deletion	probably benign
X0018:Casz1	UTSW	4	148,939,008 (GRCm38)	missense	probably damaging	1.00
X0064:Casz1	UTSW	4	148,932,952 (GRCm38)	missense	probably damaging	0.99
Z1088:Casz1	UTSW	4	148,944,359 (GRCm38)	missense	probably benign
Z1176:Casz1	UTSW	4	148,944,359 (GRCm38)	missense	probably benign
Z1177:Casz1	UTSW	4	148,944,359 (GRCm38)	missense	probably benign
Z1177:Casz1	UTSW	4	148,933,306 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTTGCTCTGGCTTTTCAGAC -3'
(R):5'- TGGCTGATGCAGACCCTATTG -3'

Sequencing Primer
(F):5'- GCTCTGGCTTTTCAGACTTTGC -3'
(R):5'- GGTTGCTTGTCTGTTTATCCATGTC -3'

Posted On

2014-06-30