Mutagenetix > Incidental Mutation

Incidental Mutation 'R1902:Mug1'

212329

Institutional Source

Beutler Lab

Gene Symbol

Mug1

Ensembl Gene

ENSMUSG00000059908

Gene Name

murinoglobulin 1

Synonyms

MMRRC Submission

039922-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1902 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

121838541-121889057 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 121881821 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 1166 (D1166G)

Ref Sequence

ENSEMBL: ENSMUSP00000032228 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032228]

AlphaFold

P28665

Predicted Effect

probably benign
Transcript: ENSMUST00000032228
AA Change: D1166G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000032228
Gene: ENSMUSG00000059908
AA Change: D1166G

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:A2M_N	128	221	5e-21	PFAM
A2M_N_2	449	599	2.55e-41	SMART
A2M	740	830	5.43e-36	SMART
Pfam:Thiol-ester_cl	963	992	1e-18	PFAM
Pfam:A2M_comp	1012	1268	5.4e-94	PFAM
A2M_recep	1378	1465	4.14e-41	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148563

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000204210

Coding Region Coverage

1x: 97.3%
3x: 96.7%
10x: 94.9%
20x: 91.7%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile and phenotypically normal under standard conditions but show increased mortality in response to diet-induced acute pancreatitis along with hepatic cell necrosis and inflammatory infiltration, andincreased plasma amylase and lipase levels. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 128 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5730507C01Rik	C	T	12: 18,534,003	Q355*	probably null	Het
Acacb	A	T	5: 114,165,734	R73*	probably null	Het
Adra1a	T	C	14: 66,638,235	S220P	probably benign	Het
Ano2	A	T	6: 125,872,684	E126D	probably damaging	Het
Anpep	C	T	7: 79,838,256	E518K	probably benign	Het
Arhgap45	C	A	10: 80,025,466	Q488K	probably damaging	Het
Arhgef7	C	A	8: 11,808,713		probably null	Het
Atxn7l3b	A	G	10: 112,928,673	I17T	probably benign	Het
BC003331	T	A	1: 150,388,609		probably null	Het
Bpifb9a	A	T	2: 154,261,991	N118I	probably benign	Het
Btbd9	A	T	17: 30,530,228	D37E	probably damaging	Het
C8a	T	C	4: 104,856,601		probably null	Het
Capn13	G	A	17: 73,326,361	S535F	probably damaging	Het
Carns1	G	T	19: 4,166,338	P615Q	probably damaging	Het
Casz1	T	C	4: 148,936,195	I479T	possibly damaging	Het
Ccdc88a	G	T	11: 29,461,788	M532I	probably benign	Het
Cdc42bpb	T	G	12: 111,326,016	S362R	probably damaging	Het
Ceacam11	A	T	7: 17,975,327	H150L	probably benign	Het
Cfap44	A	C	16: 44,422,374	T714P	probably benign	Het
Cnot1	T	C	8: 95,743,121	I1369V	possibly damaging	Het
Cpeb1	T	C	7: 81,372,119	D92G	probably benign	Het
Cped1	T	A	6: 22,120,981		probably null	Het
Csf1r	A	G	18: 61,130,141	T896A	probably damaging	Het
Csf3r	T	C	4: 126,042,918	F658S	probably damaging	Het
Cts6	A	T	13: 61,201,515	Y126*	probably null	Het
Cul7	T	C	17: 46,655,740	L365P	probably damaging	Het
Cxcl5	T	C	5: 90,759,785	V72A	probably damaging	Het
Cyp4v3	T	A	8: 45,306,952	H521L	probably benign	Het
Dct	T	C	14: 118,034,278	N380S	probably benign	Het
Dnah1	T	C	14: 31,319,759	D85G	probably damaging	Het
Dnah7a	T	C	1: 53,535,478	D1709G	probably damaging	Het
Dnaic1	A	T	4: 41,625,319	K428*	probably null	Het
Dsc1	A	T	18: 20,095,988	V415D	probably damaging	Het
E2f8	T	C	7: 48,871,172	H467R	probably benign	Het
Eddm3b	T	A	14: 51,116,864	I103N	probably damaging	Het
Fam71b	A	T	11: 46,407,011	T381S	probably benign	Het
Gal3st2c	T	G	1: 94,008,889	N185K	probably damaging	Het
Ganc	T	C	2: 120,446,482	L675P	probably damaging	Het
Gdf9	G	A	11: 53,436,953	M245I	probably benign	Het
Gm21886	G	A	18: 80,089,418	T175I	probably damaging	Het
Gria2	A	G	3: 80,722,108	L269P	probably damaging	Het
Grm8	T	C	6: 27,429,482	Y471C	probably damaging	Het
Gucy2g	T	A	19: 55,210,237	T825S	probably benign	Het
H2-Bl	A	T	17: 36,083,953	M16K	probably damaging	Het
Iffo2	T	C	4: 139,607,701	S124P	probably damaging	Het
Igf1r	T	C	7: 68,201,249	Y931H	possibly damaging	Het
Il22ra1	A	T	4: 135,750,908	Q430L	probably damaging	Het
Il23r	A	C	6: 67,423,734	D537E	probably benign	Het
Ip6k1	G	A	9: 108,040,996	E77K	possibly damaging	Het
Itgb4	T	C	11: 115,980,738	V179A	probably damaging	Het
Itpr2	T	A	6: 146,229,703	H1968L	probably damaging	Het
Kdm4a	A	G	4: 118,160,399	V490A	probably benign	Het
Kif13a	A	T	13: 46,788,162	D946E	probably benign	Het
Klhl22	T	A	16: 17,771,787	I104N	probably damaging	Het
Klk6	A	C	7: 43,826,057	M1L	probably benign	Het
Krt78	A	T	15: 101,946,963	C804*	probably null	Het
Larp7	A	T	3: 127,540,578	N533K	probably damaging	Het
Lrit3	T	C	3: 129,791,246	T288A	probably benign	Het
Lrp11	T	A	10: 7,623,780	L245Q	probably damaging	Het
Lrp1b	T	C	2: 40,860,661	S2964G	probably damaging	Het
Lrrc66	C	T	5: 73,607,622	V693M	probably damaging	Het
Macf1	T	A	4: 123,471,165	M3268L	probably benign	Het
Mad1l1	A	G	5: 140,303,688	S161P	possibly damaging	Het
Mettl25	A	G	10: 105,826,087	S341P	probably damaging	Het
Morc3	A	G	16: 93,870,497	T588A	probably damaging	Het
Mospd3	A	G	5: 137,600,415	S21P	probably damaging	Het
Mrpl57	T	A	14: 57,826,729	F71L	probably damaging	Het
Mtbp	T	C	15: 55,606,715	L594S	probably damaging	Het
Mthfd2	T	C	6: 83,306,731	N323S	probably damaging	Het
Muc5b	G	T	7: 141,864,105	S3596I	possibly damaging	Het
Nav1	T	G	1: 135,472,410	N474T	probably benign	Het
Ncoa1	A	T	12: 4,339,049	D75E	possibly damaging	Het
Ncor1	A	C	11: 62,338,158	I958S	probably damaging	Het
Nefm	T	C	14: 68,124,114	S234G	probably benign	Het
Nlrp4c	T	C	7: 6,065,819	S240P	probably damaging	Het
Nox3	C	T	17: 3,670,017	V298M	probably damaging	Het
Ntn4	A	G	10: 93,707,372	D320G	possibly damaging	Het
Nudt13	C	G	14: 20,310,641	T174R	probably damaging	Het
Olfr1002	T	C	2: 85,647,857	S155G	possibly damaging	Het
Olfr119	T	A	17: 37,701,421	H250Q	probably damaging	Het
Olfr1245	A	T	2: 89,575,603	L41Q	possibly damaging	Het
Olfr1512	T	G	14: 52,372,717	Q112P	possibly damaging	Het
Olfr209	A	T	16: 59,362,163	D18E	probably benign	Het
Olfr355	T	C	2: 36,927,185	I310V	probably benign	Het
Olfr430	T	C	1: 174,070,126	V276A	probably damaging	Het
Olfr437	T	A	6: 43,167,723		probably null	Het
Olfr812	G	T	10: 129,842,506	P179T	probably benign	Het
Olfr967	T	C	9: 39,750,806	V140A	probably benign	Het
Opn1sw	T	A	6: 29,379,804	N144Y	possibly damaging	Het
Osbpl5	T	C	7: 143,703,181	D404G	possibly damaging	Het
Parp14	C	T	16: 35,853,518		probably null	Het
Pde3a	C	A	6: 141,498,770	N1101K	probably benign	Het
Plcb1	G	A	2: 134,813,613	V38I	possibly damaging	Het
Plec	T	A	15: 76,175,551	E3417D	probably damaging	Het
Ppfibp2	C	T	7: 107,746,378	P869L	probably damaging	Het
Ppp1r12a	T	A	10: 108,198,891	I99N	probably damaging	Het
Pramel5	G	A	4: 144,273,863	Q48*	probably null	Het
Prr13	C	A	15: 102,460,698		probably benign	Het
Psg22	T	A	7: 18,724,438	Y312*	probably null	Het
Ptchd4	A	T	17: 42,503,616	I803L	probably benign	Het
Rasa4	A	G	5: 136,091,238	D56G	probably benign	Het
Rif1	T	A	2: 52,116,673	N2206K	possibly damaging	Het
Robo1	A	G	16: 72,960,204	Q351R	probably null	Het
Samd4	T	C	14: 47,074,128	F81S	probably damaging	Het
Sh3pxd2b	T	C	11: 32,423,559	*909Q	probably null	Het
Slc25a45	A	G	19: 5,884,522	R173G	probably damaging	Het
Smarca1	G	A	X: 47,849,963	Q723*	probably null	Het
Smoc1	T	C	12: 81,104,671	I54T	probably benign	Het
Spef2	G	T	15: 9,607,377	R1319S	probably damaging	Het
Steap3	T	G	1: 120,241,734	I240L	probably benign	Het
Stmn4	C	T	14: 66,355,609	L13F	probably damaging	Het
Stxbp5	C	A	10: 9,812,298	V420F	possibly damaging	Het
Syt3	T	C	7: 44,390,516	S58P	possibly damaging	Het
Tas2r125	T	C	6: 132,910,176	F176L	probably benign	Het
Tbc1d19	T	A	5: 53,829,353	C35S	probably benign	Het
Tcaf3	T	C	6: 42,593,552	E422G	possibly damaging	Het
Tekt4	T	A	17: 25,471,858	F46Y	possibly damaging	Het
Tnfaip3	T	C	10: 19,008,189	K148E	probably benign	Het
Trrap	T	G	5: 144,816,053	I1813R	probably damaging	Het
Ttc29	A	G	8: 78,251,732	E137G	probably benign	Het
Tubgcp6	C	A	15: 89,116,241	R307L	possibly damaging	Het
Tyro3	T	C	2: 119,801,695	I81T	possibly damaging	Het
Upp2	T	G	2: 58,771,452	M71R	probably damaging	Het
Utp20	G	T	10: 88,753,026	T2427K	probably benign	Het
Vcl	T	A	14: 20,982,699	L122Q	probably damaging	Het
Vmn1r213	A	C	13: 23,012,306	N353T	possibly damaging	Het
Vwa5b2	G	T	16: 20,604,832	S1165I	possibly damaging	Het
Zfp869	T	C	8: 69,707,438	K162E	probably benign	Het

Other mutations in Mug1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00158:Mug1	APN	6	121865809	missense	probably damaging	1.00
IGL00485:Mug1	APN	6	121887416	missense	probably benign	0.17
IGL00816:Mug1	APN	6	121882638	missense	probably damaging	0.99
IGL01140:Mug1	APN	6	121882734	missense	probably benign	0.01
IGL01141:Mug1	APN	6	121870499	missense	probably benign	0.08
IGL01384:Mug1	APN	6	121849474	splice site	probably benign
IGL01659:Mug1	APN	6	121870660	splice site	probably benign
IGL02049:Mug1	APN	6	121871336	missense	probably benign
IGL02151:Mug1	APN	6	121884690	critical splice donor site	probably null
IGL02315:Mug1	APN	6	121840167	missense	probably benign
IGL02629:Mug1	APN	6	121840065	missense	possibly damaging	0.62
IGL02642:Mug1	APN	6	121882585	missense	probably benign	0.14
IGL02807:Mug1	APN	6	121886572	missense	probably damaging	0.96
IGL02932:Mug1	APN	6	121887427	missense	probably benign	0.35
IGL03232:Mug1	APN	6	121878535	missense	probably benign	0.00
R1462_Mug1_304	UTSW	6	121882629	missense	probably benign	0.41
R2341_Mug1_749	UTSW	6	121884629	missense	probably benign	0.06
R4261_Mug1_652	UTSW	6	121873734	missense	probably benign
R6173_mug1_139	UTSW	6	121863793	missense	probably damaging	0.99
IGL03050:Mug1	UTSW	6	121880571	missense	possibly damaging	0.90
R0101:Mug1	UTSW	6	121884247	missense	possibly damaging	0.59
R0194:Mug1	UTSW	6	121840107	missense	probably damaging	0.98
R0196:Mug1	UTSW	6	121838725	critical splice donor site	probably null
R0325:Mug1	UTSW	6	121849842	missense	probably benign
R0332:Mug1	UTSW	6	121849897	splice site	probably null
R0377:Mug1	UTSW	6	121857361	missense	probably benign	0.02
R0393:Mug1	UTSW	6	121849850	missense	possibly damaging	0.64
R0414:Mug1	UTSW	6	121856554	missense	probably benign	0.00
R0457:Mug1	UTSW	6	121861555	missense	probably benign	0.06
R0479:Mug1	UTSW	6	121840227	missense	probably benign
R0519:Mug1	UTSW	6	121851424	missense	possibly damaging	0.83
R0535:Mug1	UTSW	6	121851454	missense	probably benign
R0745:Mug1	UTSW	6	121887427	missense	probably benign	0.35
R0939:Mug1	UTSW	6	121884349	missense	possibly damaging	0.95
R0975:Mug1	UTSW	6	121878539	missense	probably damaging	0.99
R1033:Mug1	UTSW	6	121880551	missense	probably damaging	0.99
R1086:Mug1	UTSW	6	121885854	missense	probably damaging	1.00
R1116:Mug1	UTSW	6	121870645	missense	probably benign
R1131:Mug1	UTSW	6	121861185	missense	probably benign	0.18
R1249:Mug1	UTSW	6	121849461	missense	probably benign	0.07
R1364:Mug1	UTSW	6	121881713	missense	probably damaging	1.00
R1418:Mug1	UTSW	6	121838676	missense	probably benign	0.00
R1462:Mug1	UTSW	6	121882629	missense	probably benign	0.41
R1462:Mug1	UTSW	6	121882629	missense	probably benign	0.41
R1494:Mug1	UTSW	6	121879300	missense	probably damaging	1.00
R1639:Mug1	UTSW	6	121880571	missense	probably damaging	1.00
R1901:Mug1	UTSW	6	121881821	missense	probably benign
R2087:Mug1	UTSW	6	121856291	missense	probably benign	0.00
R2168:Mug1	UTSW	6	121870499	missense	probably benign	0.08
R2249:Mug1	UTSW	6	121870510	missense	probably benign
R2341:Mug1	UTSW	6	121884629	missense	probably benign	0.06
R2888:Mug1	UTSW	6	121881843	missense	probably benign	0.44
R2892:Mug1	UTSW	6	121840070	missense	possibly damaging	0.91
R3703:Mug1	UTSW	6	121888556	splice site	probably benign
R3789:Mug1	UTSW	6	121884628	missense	probably benign	0.03
R3790:Mug1	UTSW	6	121884628	missense	probably benign	0.03
R3950:Mug1	UTSW	6	121878530	missense	probably damaging	1.00
R4261:Mug1	UTSW	6	121873734	missense	probably benign
R4402:Mug1	UTSW	6	121879352	missense	probably damaging	1.00
R4589:Mug1	UTSW	6	121857351	missense	probably benign	0.19
R4707:Mug1	UTSW	6	121884641	missense	probably damaging	1.00
R4766:Mug1	UTSW	6	121884254	missense	probably benign	0.01
R4840:Mug1	UTSW	6	121885854	missense	probably damaging	1.00
R4984:Mug1	UTSW	6	121838617	utr 5 prime	probably benign
R4999:Mug1	UTSW	6	121878943	nonsense	probably null
R5198:Mug1	UTSW	6	121874562	missense	probably damaging	1.00
R5220:Mug1	UTSW	6	121861133	missense	probably benign	0.03
R5253:Mug1	UTSW	6	121888913	missense	probably benign	0.03
R5273:Mug1	UTSW	6	121873789	missense	probably damaging	0.99
R5285:Mug1	UTSW	6	121841107	missense	probably benign	0.45
R5387:Mug1	UTSW	6	121884394	missense	probably damaging	0.99
R5560:Mug1	UTSW	6	121861073	missense	probably damaging	0.96
R5652:Mug1	UTSW	6	121840181	missense	probably benign
R5704:Mug1	UTSW	6	121851433	missense	possibly damaging	0.63
R5732:Mug1	UTSW	6	121878493	missense	probably benign	0.00
R6053:Mug1	UTSW	6	121865738	missense	probably benign	0.00
R6173:Mug1	UTSW	6	121863793	missense	probably damaging	0.99
R6578:Mug1	UTSW	6	121887452	missense	probably benign	0.00
R6647:Mug1	UTSW	6	121840241	missense	probably benign	0.02
R6681:Mug1	UTSW	6	121838724	missense	possibly damaging	0.75
R6925:Mug1	UTSW	6	121881787	missense	probably damaging	1.00
R7014:Mug1	UTSW	6	121861125	missense	probably benign	0.22
R7031:Mug1	UTSW	6	121838714	missense	probably benign	0.00
R7034:Mug1	UTSW	6	121873644	missense	probably benign	0.00
R7156:Mug1	UTSW	6	121880905	missense	probably damaging	1.00
R7156:Mug1	UTSW	6	121884343	missense	probably damaging	1.00
R7179:Mug1	UTSW	6	121857420	missense	probably benign	0.00
R7211:Mug1	UTSW	6	121880539	missense	possibly damaging	0.52
R7318:Mug1	UTSW	6	121870652	critical splice donor site	probably null
R7462:Mug1	UTSW	6	121875440	missense	probably benign	0.00
R7479:Mug1	UTSW	6	121878508	missense	possibly damaging	0.83
R7588:Mug1	UTSW	6	121875517	missense	probably damaging	1.00
R7611:Mug1	UTSW	6	121875428	critical splice acceptor site	probably null
R7659:Mug1	UTSW	6	121861220	missense	possibly damaging	0.95
R7660:Mug1	UTSW	6	121861220	missense	possibly damaging	0.95
R7661:Mug1	UTSW	6	121861220	missense	possibly damaging	0.95
R7663:Mug1	UTSW	6	121861220	missense	possibly damaging	0.95
R7664:Mug1	UTSW	6	121861220	missense	possibly damaging	0.95
R7666:Mug1	UTSW	6	121861220	missense	possibly damaging	0.95
R7788:Mug1	UTSW	6	121861220	missense	possibly damaging	0.95
R7789:Mug1	UTSW	6	121861220	missense	possibly damaging	0.95
R7794:Mug1	UTSW	6	121856288	missense	possibly damaging	0.93
R7809:Mug1	UTSW	6	121878985	missense	possibly damaging	0.79
R7836:Mug1	UTSW	6	121870652	critical splice donor site	probably null
R7867:Mug1	UTSW	6	121873634	missense	probably benign
R7904:Mug1	UTSW	6	121851465	missense	probably benign
R7937:Mug1	UTSW	6	121861169	missense	probably benign	0.00
R7981:Mug1	UTSW	6	121881764	missense	probably damaging	1.00
R7999:Mug1	UTSW	6	121880896	missense	possibly damaging	0.90
R8070:Mug1	UTSW	6	121875879	missense	probably benign	0.26
R8071:Mug1	UTSW	6	121873672	missense	probably benign
R8151:Mug1	UTSW	6	121841158	missense	probably benign	0.01
R8491:Mug1	UTSW	6	121882729	missense	probably damaging	1.00
R8714:Mug1	UTSW	6	121882722	missense	probably benign	0.01
R8734:Mug1	UTSW	6	121871381	missense	probably benign	0.00
R8738:Mug1	UTSW	6	121840249	splice site	probably benign
R8807:Mug1	UTSW	6	121874475	missense	probably benign	0.27
R8931:Mug1	UTSW	6	121884337	missense	probably benign
R8940:Mug1	UTSW	6	121881683	missense
R9156:Mug1	UTSW	6	121874431	missense	probably damaging	0.99
R9314:Mug1	UTSW	6	121857337	missense	probably damaging	0.97
R9315:Mug1	UTSW	6	121873771	missense	possibly damaging	0.95
R9330:Mug1	UTSW	6	121882764	missense	probably benign	0.14
R9334:Mug1	UTSW	6	121861531	missense	probably benign	0.01
R9357:Mug1	UTSW	6	121875491	missense	probably benign	0.02
R9515:Mug1	UTSW	6	121884676	missense	probably damaging	1.00
R9549:Mug1	UTSW	6	121881803	missense	probably damaging	1.00
R9564:Mug1	UTSW	6	121884628	missense	probably benign	0.03
R9663:Mug1	UTSW	6	121880504	missense	probably benign	0.08
R9663:Mug1	UTSW	6	121882740	missense	probably benign	0.03
R9681:Mug1	UTSW	6	121856295	missense	probably benign	0.01
R9777:Mug1	UTSW	6	121880905	missense	probably damaging	1.00
RF017:Mug1	UTSW	6	121884574	missense	probably damaging	1.00
X0064:Mug1	UTSW	6	121861215	missense	possibly damaging	0.48
Z1176:Mug1	UTSW	6	121841294	missense	probably benign	0.32
Z1176:Mug1	UTSW	6	121880493	missense	probably damaging	1.00
Z1177:Mug1	UTSW	6	121863808	missense	probably damaging	0.99
Z1177:Mug1	UTSW	6	121879299	critical splice acceptor site	probably null
Z1177:Mug1	UTSW	6	121886568	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- AAGCCTCCATATTTGTCCCAG -3'
(R):5'- AGACTCATTTCTTCATGGGGC -3'

Sequencing Primer
(F):5'- ATATTTGTCCCAGGATCTGCTAGGAC -3'
(R):5'- CATTTCTTCATGGGGCAGTCCAAG -3'

Posted On

2014-06-30