Mutagenetix > Incidental Mutation

Incidental Mutation 'R1917:Lrba'

212589

Institutional Source

Beutler Lab

Gene Symbol

Lrba

Ensembl Gene

ENSMUSG00000028080

Gene Name

LPS-responsive beige-like anchor

Synonyms

Lba, D3Ertd775e

MMRRC Submission

039935-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1917 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

86224680-86782692 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 86664501 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Arginine at position 275 (G275R)

Ref Sequence

ENSEMBL: ENSMUSP00000141734 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000107635] [ENSMUST00000192145] [ENSMUST00000194759] [ENSMUST00000195524]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000107635
AA Change: G2371R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000103261
Gene: ENSMUSG00000028080
AA Change: G2371R

Domain	Start	End	E-Value	Type
low complexity region	12	31	N/A	INTRINSIC
Pfam:Laminin_G_3	211	377	4.6e-13	PFAM
Pfam:DUF4704	446	717	2.5e-109	PFAM
coiled coil region	1019	1037	N/A	INTRINSIC
low complexity region	1073	1089	N/A	INTRINSIC
low complexity region	1100	1113	N/A	INTRINSIC
low complexity region	1585	1600	N/A	INTRINSIC
low complexity region	1614	1630	N/A	INTRINSIC
low complexity region	1698	1713	N/A	INTRINSIC
low complexity region	1738	1757	N/A	INTRINSIC
low complexity region	1848	1861	N/A	INTRINSIC
Pfam:DUF1088	1882	2049	7e-88	PFAM
Pfam:PH_BEACH	2075	2172	9.1e-31	PFAM
Beach	2203	2480	2.87e-207	SMART
WD40	2578	2615	7.4e0	SMART
WD40	2618	2661	1.72e0	SMART
WD40	2677	2716	3.99e-1	SMART
WD40	2760	2798	1.79e-1	SMART
WD40	2801	2840	4.28e0	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000192145
AA Change: G2371R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000142179
Gene: ENSMUSG00000028080
AA Change: G2371R

Domain	Start	End	E-Value	Type
low complexity region	12	31	N/A	INTRINSIC
Pfam:Laminin_G_3	205	377	7.4e-18	PFAM
coiled coil region	1019	1037	N/A	INTRINSIC
low complexity region	1073	1089	N/A	INTRINSIC
low complexity region	1100	1113	N/A	INTRINSIC
low complexity region	1585	1600	N/A	INTRINSIC
low complexity region	1614	1630	N/A	INTRINSIC
low complexity region	1698	1713	N/A	INTRINSIC
low complexity region	1738	1757	N/A	INTRINSIC
low complexity region	1848	1861	N/A	INTRINSIC
Pfam:DUF1088	1882	2050	1.5e-92	PFAM
Pfam:PH_BEACH	2068	2172	7.5e-32	PFAM
Beach	2203	2480	2.87e-207	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000194759
AA Change: G2371R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000142043
Gene: ENSMUSG00000028080
AA Change: G2371R

Domain	Start	End	E-Value	Type
low complexity region	12	31	N/A	INTRINSIC
Pfam:Laminin_G_3	205	377	8.1e-18	PFAM
coiled coil region	1019	1037	N/A	INTRINSIC
low complexity region	1073	1089	N/A	INTRINSIC
low complexity region	1100	1113	N/A	INTRINSIC
low complexity region	1585	1600	N/A	INTRINSIC
low complexity region	1614	1630	N/A	INTRINSIC
low complexity region	1698	1713	N/A	INTRINSIC
low complexity region	1738	1757	N/A	INTRINSIC
low complexity region	1848	1861	N/A	INTRINSIC
Pfam:DUF1088	1882	2050	1.6e-92	PFAM
Pfam:PH_BEACH	2068	2172	8.3e-32	PFAM
Beach	2203	2480	2.87e-207	SMART
WD40	2578	2615	7.4e0	SMART
WD40	2618	2661	1.72e0	SMART
WD40	2677	2716	3.99e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000195524
AA Change: G275R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000141734
Gene: ENSMUSG00000028080
AA Change: G275R

Domain	Start	End	E-Value	Type
Pfam:PH_BEACH	3	76	3.6e-20	PFAM
Beach	107	384	2.87e-207	SMART
WD40	482	519	7.4e0	SMART
WD40	522	565	1.72e0	SMART
WD40	581	620	3.99e-1	SMART
WD40	664	702	1.79e-1	SMART
WD40	705	744	4.28e0	SMART

Meta Mutation Damage Score

0.9456

Coding Region Coverage

1x: 97.5%
3x: 97.0%
10x: 95.8%
20x: 93.6%

Validation Efficiency

100% (83/83)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased numbers of myeloid-derived suppressor cells and regulatory T cells, abnormal NK cell physiology, impaired rejection of allogeneic, xenogeneic and missing self bone-marrow grafts, and resistance to acute graft vs host disease. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 81 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931440F15Rik	A	G	11: 29,824,039 (GRCm38)	S473P	probably benign	Het
Abca8a	A	G	11: 110,091,515 (GRCm38)		probably benign	Het
Adgre5	A	G	8: 83,729,109 (GRCm38)	V190A	probably damaging	Het
Akap6	A	G	12: 53,104,612 (GRCm38)	N1153S	probably benign	Het
Aldh1a7	G	A	19: 20,727,455 (GRCm38)	H20Y	probably benign	Het
B430306N03Rik	A	G	17: 48,324,148 (GRCm38)	E278G	probably benign	Het
Cacna1b	C	A	2: 24,616,879 (GRCm38)	R72L	probably null	Het
Cc2d2a	C	G	5: 43,706,222 (GRCm38)	S675R	probably damaging	Het
Ccdc88b	T	A	19: 6,849,226 (GRCm38)	E1040D	probably damaging	Het
Cmtm7	A	G	9: 114,763,364 (GRCm38)	V55A	probably damaging	Het
Coq4	A	C	2: 29,789,926 (GRCm38)	T77P	probably damaging	Het
Cyp2j11	C	A	4: 96,339,974 (GRCm38)	W136L	probably damaging	Het
Dctn2	T	A	10: 127,275,049 (GRCm38)	Y86*	probably null	Het
Ddx56	A	G	11: 6,263,937 (GRCm38)		probably null	Het
Dopey2	T	C	16: 93,716,262 (GRCm38)	S30P	probably damaging	Het
Ep400	T	C	5: 110,703,575 (GRCm38)	K1347R	unknown	Het
Fat3	T	A	9: 15,997,057 (GRCm38)	T2550S	possibly damaging	Het
Fcrla	G	T	1: 170,927,526 (GRCm38)	C5*	probably null	Het
Fermt1	T	A	2: 132,922,842 (GRCm38)	D365V	probably damaging	Het
Fhod3	A	G	18: 24,989,965 (GRCm38)		probably benign	Het
Fhod3	A	G	18: 25,085,601 (GRCm38)	D807G	probably benign	Het
Fnip1	C	T	11: 54,480,684 (GRCm38)	T177I	probably damaging	Het
Gart	T	C	16: 91,628,149 (GRCm38)	Y662C	probably damaging	Het
Gda	A	T	19: 21,397,640 (GRCm38)		probably benign	Het
Gk	A	G	X: 85,760,580 (GRCm38)	I85T	probably damaging	Het
Gm12169	A	G	11: 46,528,531 (GRCm38)	D58G	possibly damaging	Het
Gm14548	C	T	7: 3,897,638 (GRCm38)	V38M	probably damaging	Het
Gm3476	A	G	14: 6,118,358 (GRCm38)	L255P	possibly damaging	Het
Gm9966	T	C	7: 95,958,477 (GRCm38)	C2R	unknown	Het
Gnpda1	T	C	18: 38,333,190 (GRCm38)		probably null	Het
Gtf2h4	G	A	17: 35,670,198 (GRCm38)	L246F	possibly damaging	Het
Hao1	A	T	2: 134,523,060 (GRCm38)	S216T	probably benign	Het
Hnrnpr	C	A	4: 136,332,488 (GRCm38)	S301*	probably null	Het
Hsd3b2	A	G	3: 98,712,026 (GRCm38)	I201T	probably benign	Het
Jade2	T	C	11: 51,818,538 (GRCm38)	E548G	possibly damaging	Het
Katnbl1	T	C	2: 112,409,179 (GRCm38)	I241T	probably benign	Het
Keap1	G	T	9: 21,233,806 (GRCm38)	Q299K	probably benign	Het
Kif1a	T	C	1: 93,019,031 (GRCm38)	I1650V	possibly damaging	Het
Map3k9	C	A	12: 81,780,790 (GRCm38)	E29*	probably null	Het
Mat1a	G	A	14: 41,121,437 (GRCm38)	V307I	probably damaging	Het
Mcm2	A	T	6: 88,891,803 (GRCm38)	M324K	possibly damaging	Het
Metap1d	T	C	2: 71,511,527 (GRCm38)	V155A	probably damaging	Het
Mtbp	A	G	15: 55,564,677 (GRCm38)		probably benign	Het
Myh14	T	C	7: 44,657,925 (GRCm38)	T231A	probably benign	Het
Mylk4	A	T	13: 32,724,853 (GRCm38)	D90E	probably benign	Het
Myo15b	T	A	11: 115,882,254 (GRCm38)	I1837K	possibly damaging	Het
Myo3a	T	A	2: 22,291,922 (GRCm38)	H242Q	probably damaging	Het
Nxn	A	G	11: 76,261,672 (GRCm38)		probably benign	Het
Olfr791	T	A	10: 129,527,049 (GRCm38)	V274D	probably damaging	Het
Pak3	C	A	X: 143,791,302 (GRCm38)	A553E	possibly damaging	Het
Pdia2	T	A	17: 26,198,105 (GRCm38)	T122S	possibly damaging	Het
Plod2	A	G	9: 92,581,257 (GRCm38)	T132A	probably benign	Het
Ptprz1	T	A	6: 23,035,040 (GRCm38)		probably benign	Het
Rad54b	A	C	4: 11,601,693 (GRCm38)	N416T	probably damaging	Het
Recql4	A	T	15: 76,703,837 (GRCm38)	Y1142*	probably null	Het
Rnf216	A	G	5: 142,992,806 (GRCm38)	V859A	probably benign	Het
Scnm1	G	T	3: 95,130,273 (GRCm38)	P161T	possibly damaging	Het
Serpinb6b	A	G	13: 32,978,240 (GRCm38)	I222V	probably benign	Het
Serpinf1	A	G	11: 75,411,007 (GRCm38)	I274T	possibly damaging	Het
Slc28a1	T	C	7: 81,169,586 (GRCm38)	F641L	probably benign	Het
Slc8a2	A	G	7: 16,152,920 (GRCm38)	I657V	probably benign	Het
Smchd1	A	G	17: 71,407,237 (GRCm38)	I877T	possibly damaging	Het
Spata31	T	C	13: 64,920,865 (GRCm38)	Y276H	possibly damaging	Het
Spire2	A	G	8: 123,363,071 (GRCm38)	D447G	probably benign	Het
Stk3	G	A	15: 35,073,217 (GRCm38)	T119I	probably damaging	Het
Stxbp5	C	A	10: 9,812,298 (GRCm38)	V420F	possibly damaging	Het
Sult2a5	T	C	7: 13,670,684 (GRCm38)	F282S	probably damaging	Het
Syk	A	T	13: 52,622,708 (GRCm38)	D248V	probably damaging	Het
Thoc6	C	T	17: 23,669,390 (GRCm38)		probably benign	Het
Tll2	T	A	19: 41,128,497 (GRCm38)	D293V	possibly damaging	Het
Umodl1	G	A	17: 30,984,043 (GRCm38)	V457M	probably damaging	Het
Usp19	T	A	9: 108,499,325 (GRCm38)	C689*	probably null	Het
Usp24	T	G	4: 106,410,286 (GRCm38)	V1955G	probably damaging	Het
Vmn1r226	T	C	17: 20,687,580 (GRCm38)	S25P	probably damaging	Het
Vmn2r69	C	T	7: 85,411,683 (GRCm38)	C231Y	probably damaging	Het
Wdr73	C	T	7: 80,893,333 (GRCm38)	D176N	probably benign	Het
Wnt7b	T	A	15: 85,559,080 (GRCm38)	I41F	probably damaging	Het
Zfhx3	T	C	8: 108,956,248 (GRCm38)	S3440P	unknown	Het
Zfp52	T	G	17: 21,560,164 (GRCm38)	N91K	probably benign	Het
Zfp930	C	A	8: 69,228,705 (GRCm38)	Q350K	probably benign	Het
Zfp949	T	C	9: 88,570,062 (GRCm38)	S562P	probably damaging	Het

Other mutations in Lrba

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00420:Lrba	APN	3	86,359,782 (GRCm38)	missense	probably benign	0.00
IGL00788:Lrba	APN	3	86,327,685 (GRCm38)	missense	probably damaging	0.97
IGL01139:Lrba	APN	3	86,642,662 (GRCm38)	missense	possibly damaging	0.88
IGL01302:Lrba	APN	3	86,295,400 (GRCm38)	missense	probably damaging	1.00
IGL01612:Lrba	APN	3	86,776,177 (GRCm38)	missense	possibly damaging	0.89
IGL01718:Lrba	APN	3	86,351,248 (GRCm38)	missense	probably damaging	1.00
IGL01719:Lrba	APN	3	86,327,596 (GRCm38)	splice site	probably benign
IGL01730:Lrba	APN	3	86,741,424 (GRCm38)	missense	possibly damaging	0.89
IGL01735:Lrba	APN	3	86,327,661 (GRCm38)	missense	probably benign	0.28
IGL01875:Lrba	APN	3	86,310,047 (GRCm38)	missense	probably damaging	1.00
IGL01884:Lrba	APN	3	86,310,412 (GRCm38)	missense	possibly damaging	0.86
IGL02264:Lrba	APN	3	86,780,262 (GRCm38)	missense	probably damaging	0.99
IGL02638:Lrba	APN	3	86,325,073 (GRCm38)	missense	probably damaging	0.97
IGL02647:Lrba	APN	3	86,359,731 (GRCm38)	missense	probably benign	0.00
IGL02664:Lrba	APN	3	86,325,731 (GRCm38)	missense	possibly damaging	0.84
IGL02728:Lrba	APN	3	86,776,049 (GRCm38)	missense	probably damaging	0.99
IGL02730:Lrba	APN	3	86,328,199 (GRCm38)	missense	probably damaging	1.00
IGL02883:Lrba	APN	3	86,445,413 (GRCm38)	missense	probably damaging	0.99
IGL02883:Lrba	APN	3	86,354,206 (GRCm38)	missense	probably damaging	1.00
IGL02948:Lrba	APN	3	86,310,384 (GRCm38)	splice site	probably null
IGL03090:Lrba	APN	3	86,773,141 (GRCm38)	missense	probably benign	0.01
molasses	UTSW	3	86,354,307 (GRCm38)	critical splice donor site	probably null
oscar	UTSW	3	86,350,304 (GRCm38)	nonsense	probably null
oscar2	UTSW	3	86,664,458 (GRCm38)	nonsense	probably null
P0023:Lrba	UTSW	3	86,417,935 (GRCm38)	missense	probably damaging	1.00
PIT4802001:Lrba	UTSW	3	86,664,494 (GRCm38)	nonsense	probably null
R0077:Lrba	UTSW	3	86,542,688 (GRCm38)	missense	probably damaging	0.99
R0189:Lrba	UTSW	3	86,368,509 (GRCm38)	missense	probably damaging	1.00
R0217:Lrba	UTSW	3	86,642,722 (GRCm38)	missense	probably damaging	1.00
R0349:Lrba	UTSW	3	86,540,005 (GRCm38)	missense	probably damaging	1.00
R0396:Lrba	UTSW	3	86,295,179 (GRCm38)	missense	probably damaging	1.00
R0417:Lrba	UTSW	3	86,715,654 (GRCm38)	missense	probably damaging	1.00
R0536:Lrba	UTSW	3	86,715,532 (GRCm38)	missense	probably damaging	1.00
R0712:Lrba	UTSW	3	86,297,990 (GRCm38)	nonsense	probably null
R0722:Lrba	UTSW	3	86,605,989 (GRCm38)	critical splice donor site	probably null
R0828:Lrba	UTSW	3	86,608,370 (GRCm38)	splice site	probably null
R0927:Lrba	UTSW	3	86,780,233 (GRCm38)	missense	probably damaging	1.00
R1120:Lrba	UTSW	3	86,295,192 (GRCm38)	missense	probably damaging	1.00
R1141:Lrba	UTSW	3	86,619,558 (GRCm38)	missense	probably damaging	1.00
R1276:Lrba	UTSW	3	86,664,526 (GRCm38)	missense	probably damaging	1.00
R1449:Lrba	UTSW	3	86,354,278 (GRCm38)	missense	probably damaging	1.00
R1470:Lrba	UTSW	3	86,737,142 (GRCm38)	missense	probably damaging	1.00
R1470:Lrba	UTSW	3	86,737,142 (GRCm38)	missense	probably damaging	1.00
R1474:Lrba	UTSW	3	86,780,266 (GRCm38)	splice site	probably benign
R1558:Lrba	UTSW	3	86,351,315 (GRCm38)	missense	probably damaging	1.00
R1596:Lrba	UTSW	3	86,350,304 (GRCm38)	nonsense	probably null
R1652:Lrba	UTSW	3	86,539,938 (GRCm38)	missense	probably damaging	1.00
R1800:Lrba	UTSW	3	86,351,868 (GRCm38)	missense	probably benign	0.00
R1819:Lrba	UTSW	3	86,542,634 (GRCm38)	missense	possibly damaging	0.80
R1862:Lrba	UTSW	3	86,773,203 (GRCm38)	critical splice donor site	probably null
R1965:Lrba	UTSW	3	86,605,868 (GRCm38)	critical splice acceptor site	probably null
R1966:Lrba	UTSW	3	86,605,868 (GRCm38)	critical splice acceptor site	probably null
R1969:Lrba	UTSW	3	86,608,389 (GRCm38)	missense	probably damaging	0.99
R2011:Lrba	UTSW	3	86,310,017 (GRCm38)	missense	probably damaging	0.99
R2179:Lrba	UTSW	3	86,354,281 (GRCm38)	missense	probably damaging	1.00
R2186:Lrba	UTSW	3	86,304,336 (GRCm38)	missense	probably damaging	1.00
R2281:Lrba	UTSW	3	86,776,103 (GRCm38)	missense	possibly damaging	0.46
R2359:Lrba	UTSW	3	86,348,750 (GRCm38)	missense	probably benign	0.01
R2412:Lrba	UTSW	3	86,327,700 (GRCm38)	missense	probably damaging	1.00
R2496:Lrba	UTSW	3	86,532,087 (GRCm38)	missense	probably damaging	1.00
R3153:Lrba	UTSW	3	86,285,219 (GRCm38)	missense	probably damaging	0.99
R3708:Lrba	UTSW	3	86,285,024 (GRCm38)	missense	possibly damaging	0.80
R3746:Lrba	UTSW	3	86,375,953 (GRCm38)	missense	probably damaging	1.00
R3747:Lrba	UTSW	3	86,375,953 (GRCm38)	missense	probably damaging	1.00
R3748:Lrba	UTSW	3	86,375,953 (GRCm38)	missense	probably damaging	1.00
R3749:Lrba	UTSW	3	86,375,953 (GRCm38)	missense	probably damaging	1.00
R3750:Lrba	UTSW	3	86,375,953 (GRCm38)	missense	probably damaging	1.00
R3758:Lrba	UTSW	3	86,776,049 (GRCm38)	missense	probably damaging	0.99
R3975:Lrba	UTSW	3	86,351,255 (GRCm38)	missense	probably damaging	1.00
R4210:Lrba	UTSW	3	86,360,126 (GRCm38)	missense	probably damaging	1.00
R4258:Lrba	UTSW	3	86,445,349 (GRCm38)	missense	probably damaging	1.00
R4657:Lrba	UTSW	3	86,737,164 (GRCm38)	missense	probably damaging	1.00
R4713:Lrba	UTSW	3	86,359,868 (GRCm38)	missense	probably benign	0.13
R4716:Lrba	UTSW	3	86,642,714 (GRCm38)	missense	probably damaging	0.99
R4811:Lrba	UTSW	3	86,776,141 (GRCm38)	missense	probably damaging	1.00
R4827:Lrba	UTSW	3	86,360,150 (GRCm38)	missense	possibly damaging	0.85
R4840:Lrba	UTSW	3	86,619,509 (GRCm38)	critical splice acceptor site	probably null
R4920:Lrba	UTSW	3	86,664,458 (GRCm38)	nonsense	probably null
R4948:Lrba	UTSW	3	86,285,028 (GRCm38)	missense	probably damaging	1.00
R4970:Lrba	UTSW	3	86,225,371 (GRCm38)	missense	probably benign	0.23
R4985:Lrba	UTSW	3	86,327,436 (GRCm38)	splice site	probably null
R4993:Lrba	UTSW	3	86,360,037 (GRCm38)	missense	probably damaging	1.00
R5107:Lrba	UTSW	3	86,359,779 (GRCm38)	missense	possibly damaging	0.47
R5112:Lrba	UTSW	3	86,225,371 (GRCm38)	missense	probably benign	0.23
R5122:Lrba	UTSW	3	86,349,154 (GRCm38)	nonsense	probably null
R5155:Lrba	UTSW	3	86,351,300 (GRCm38)	missense	probably benign	0.25
R5194:Lrba	UTSW	3	86,328,219 (GRCm38)	missense	probably damaging	1.00
R5280:Lrba	UTSW	3	86,325,022 (GRCm38)	missense	possibly damaging	0.94
R5445:Lrba	UTSW	3	86,368,595 (GRCm38)	missense	probably benign
R5469:Lrba	UTSW	3	86,542,641 (GRCm38)	missense	probably damaging	1.00
R5513:Lrba	UTSW	3	86,542,641 (GRCm38)	missense	probably damaging	1.00
R5578:Lrba	UTSW	3	86,757,507 (GRCm38)	missense	probably benign	0.27
R5740:Lrba	UTSW	3	86,328,342 (GRCm38)	missense	probably damaging	1.00
R5868:Lrba	UTSW	3	86,319,604 (GRCm38)	missense	probably damaging	1.00
R6104:Lrba	UTSW	3	86,353,792 (GRCm38)	missense	probably damaging	1.00
R6166:Lrba	UTSW	3	86,354,307 (GRCm38)	critical splice donor site	probably null
R6279:Lrba	UTSW	3	86,348,864 (GRCm38)	missense	probably benign	0.26
R6330:Lrba	UTSW	3	86,348,357 (GRCm38)	missense	probably benign	0.07
R6367:Lrba	UTSW	3	86,368,562 (GRCm38)	missense	probably benign	0.42
R6571:Lrba	UTSW	3	86,360,060 (GRCm38)	missense	probably damaging	1.00
R6584:Lrba	UTSW	3	86,664,576 (GRCm38)	missense	probably damaging	1.00
R6698:Lrba	UTSW	3	86,304,425 (GRCm38)	missense	probably damaging	0.99
R6763:Lrba	UTSW	3	86,354,263 (GRCm38)	missense	probably damaging	1.00
R6834:Lrba	UTSW	3	86,350,286 (GRCm38)	missense	probably benign	0.00
R6951:Lrba	UTSW	3	86,745,873 (GRCm38)	missense	probably benign	0.01
R6969:Lrba	UTSW	3	86,619,590 (GRCm38)	missense	probably benign	0.21
R7045:Lrba	UTSW	3	86,285,091 (GRCm38)	missense	probably benign	0.03
R7133:Lrba	UTSW	3	86,394,931 (GRCm38)	splice site	probably null
R7182:Lrba	UTSW	3	86,741,458 (GRCm38)	frame shift	probably null
R7214:Lrba	UTSW	3	86,328,326 (GRCm38)	missense	probably damaging	1.00
R7224:Lrba	UTSW	3	86,395,246 (GRCm38)	missense	probably damaging	1.00
R7243:Lrba	UTSW	3	86,751,516 (GRCm38)	splice site	probably null
R7350:Lrba	UTSW	3	86,351,902 (GRCm38)	missense	probably damaging	0.96
R7380:Lrba	UTSW	3	86,325,074 (GRCm38)	missense	probably damaging	1.00
R7492:Lrba	UTSW	3	86,664,528 (GRCm38)	missense	probably damaging	1.00
R7651:Lrba	UTSW	3	86,741,466 (GRCm38)	nonsense	probably null
R7729:Lrba	UTSW	3	86,318,167 (GRCm38)	missense	probably damaging	1.00
R7754:Lrba	UTSW	3	86,445,397 (GRCm38)	missense	probably damaging	1.00
R7762:Lrba	UTSW	3	86,532,201 (GRCm38)	missense	probably damaging	0.99
R7855:Lrba	UTSW	3	86,315,430 (GRCm38)	missense	possibly damaging	0.94
R7867:Lrba	UTSW	3	86,368,589 (GRCm38)	missense	probably damaging	1.00
R7912:Lrba	UTSW	3	86,715,565 (GRCm38)	missense	probably damaging	1.00
R7995:Lrba	UTSW	3	86,619,551 (GRCm38)	missense	probably damaging	1.00
R8013:Lrba	UTSW	3	86,417,971 (GRCm38)	missense	probably damaging	1.00
R8014:Lrba	UTSW	3	86,417,971 (GRCm38)	missense	probably damaging	1.00
R8024:Lrba	UTSW	3	86,295,401 (GRCm38)	nonsense	probably null
R8027:Lrba	UTSW	3	86,417,912 (GRCm38)	missense	probably benign	0.05
R8090:Lrba	UTSW	3	86,348,489 (GRCm38)	missense	probably benign
R8111:Lrba	UTSW	3	86,327,705 (GRCm38)	missense	probably damaging	1.00
R8118:Lrba	UTSW	3	86,354,226 (GRCm38)	missense	probably benign
R8204:Lrba	UTSW	3	86,315,403 (GRCm38)	missense	possibly damaging	0.95
R8239:Lrba	UTSW	3	86,542,575 (GRCm38)	missense	probably damaging	1.00
R8509:Lrba	UTSW	3	86,348,176 (GRCm38)	missense	probably benign	0.04
R8532:Lrba	UTSW	3	86,757,483 (GRCm38)	missense	probably damaging	1.00
R8726:Lrba	UTSW	3	86,353,755 (GRCm38)	missense	probably benign
R8744:Lrba	UTSW	3	86,304,333 (GRCm38)	missense	probably benign	0.08
R8782:Lrba	UTSW	3	86,642,669 (GRCm38)	missense	probably benign	0.00
R8784:Lrba	UTSW	3	86,375,928 (GRCm38)	missense	probably damaging	1.00
R8922:Lrba	UTSW	3	86,356,666 (GRCm38)	missense	probably damaging	1.00
R8964:Lrba	UTSW	3	86,351,245 (GRCm38)	missense	probably benign	0.22
R8971:Lrba	UTSW	3	86,615,081 (GRCm38)	missense	probably benign	0.00
R9046:Lrba	UTSW	3	86,395,236 (GRCm38)	missense	possibly damaging	0.94
R9155:Lrba	UTSW	3	86,295,201 (GRCm38)	missense	probably damaging	1.00
R9236:Lrba	UTSW	3	86,353,759 (GRCm38)	missense	probably benign	0.05
R9266:Lrba	UTSW	3	86,291,467 (GRCm38)	missense	probably benign	0.08
R9297:Lrba	UTSW	3	86,373,566 (GRCm38)	missense	probably damaging	1.00
R9404:Lrba	UTSW	3	86,297,917 (GRCm38)	missense	probably damaging	0.99
R9617:Lrba	UTSW	3	86,359,862 (GRCm38)	missense	probably benign
R9640:Lrba	UTSW	3	86,619,568 (GRCm38)	nonsense	probably null
R9779:Lrba	UTSW	3	86,325,771 (GRCm38)	missense	probably damaging	1.00
X0065:Lrba	UTSW	3	86,325,089 (GRCm38)	missense	possibly damaging	0.95
X0065:Lrba	UTSW	3	86,297,899 (GRCm38)	missense	probably damaging	1.00
Z1176:Lrba	UTSW	3	86,751,532 (GRCm38)	missense	possibly damaging	0.85
Z1176:Lrba	UTSW	3	86,715,538 (GRCm38)	missense	probably benign	0.31
Z1177:Lrba	UTSW	3	86,540,049 (GRCm38)	missense	probably null	1.00

Predicted Primers

PCR Primer
(F):5'- TAAGATGCTGGGTACATTTTCCTC -3'
(R):5'- CAGCTAAGCACTGTACAGAAAG -3'

Sequencing Primer
(F):5'- GCTGGGTACATTTTCCTCTAAACAG -3'
(R):5'- GAAAGGCAGGGGTTAATGTTTTAC -3'

Posted On

2014-07-14