Incidental Mutation 'R1919:Cux1'
| ID |
212835 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cux1
|
| Ensembl Gene |
ENSMUSG00000029705 |
| Gene Name |
cut-like homeobox 1 |
| Synonyms |
Cux-1, Cutl1, CDP, Cux |
| MMRRC Submission |
039937-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.861)
|
| Stock # |
R1919 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
136248135-136567490 bp(-) (GRCm38) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to A
at 136363319 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 194
(Q194*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134819
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000004097]
[ENSMUST00000175918]
[ENSMUST00000175975]
[ENSMUST00000175998]
[ENSMUST00000176172]
[ENSMUST00000176216]
[ENSMUST00000176423]
[ENSMUST00000176745]
[ENSMUST00000176778]
[ENSMUST00000177297]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000004097
AA Change: Q194*
|
| SMART Domains |
Protein: ENSMUSP00000004097
Gene: ENSMUSG00000029705
AA Change: Q194*
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
low complexity region
|
425 |
436 |
N/A |
INTRINSIC |
|
CUT
|
452 |
538 |
5.06e-39 |
SMART |
|
low complexity region
|
602 |
608 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
642 |
N/A |
INTRINSIC |
|
CUT
|
841 |
929 |
3.31e-43 |
SMART |
|
low complexity region
|
956 |
972 |
N/A |
INTRINSIC |
|
low complexity region
|
990 |
1011 |
N/A |
INTRINSIC |
|
CUT
|
1024 |
1110 |
3.78e-38 |
SMART |
|
HOX
|
1150 |
1212 |
6.32e-15 |
SMART |
|
low complexity region
|
1224 |
1239 |
N/A |
INTRINSIC |
|
low complexity region
|
1317 |
1379 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148082
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000175918
AA Change: Q157*
|
| SMART Domains |
Protein: ENSMUSP00000135606
Gene: ENSMUSG00000029705
AA Change: Q157*
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
73 |
328 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000175975
AA Change: Q194*
|
| SMART Domains |
Protein: ENSMUSP00000135223
Gene: ENSMUSG00000029705
AA Change: Q194*
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
235 |
251 |
N/A |
INTRINSIC |
|
low complexity region
|
277 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
331 |
342 |
N/A |
INTRINSIC |
|
CUT
|
358 |
444 |
5.06e-39 |
SMART |
|
low complexity region
|
508 |
514 |
N/A |
INTRINSIC |
|
low complexity region
|
526 |
548 |
N/A |
INTRINSIC |
|
CUT
|
747 |
835 |
3.31e-43 |
SMART |
|
low complexity region
|
862 |
878 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
917 |
N/A |
INTRINSIC |
|
CUT
|
930 |
1016 |
3.78e-38 |
SMART |
|
HOX
|
1056 |
1118 |
6.32e-15 |
SMART |
|
low complexity region
|
1130 |
1145 |
N/A |
INTRINSIC |
|
low complexity region
|
1223 |
1285 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175998
|
| SMART Domains |
Protein: ENSMUSP00000135816
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
coiled coil region
|
76 |
148 |
N/A |
INTRINSIC |
|
Pfam:CASP_C
|
204 |
430 |
8.6e-72 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000176172
AA Change: Q183*
|
| SMART Domains |
Protein: ENSMUSP00000135086
Gene: ENSMUSG00000029705
AA Change: Q183*
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
99 |
354 |
N/A |
INTRINSIC |
|
low complexity region
|
420 |
436 |
N/A |
INTRINSIC |
|
low complexity region
|
462 |
474 |
N/A |
INTRINSIC |
|
low complexity region
|
516 |
527 |
N/A |
INTRINSIC |
|
CUT
|
543 |
629 |
5.06e-39 |
SMART |
|
low complexity region
|
693 |
699 |
N/A |
INTRINSIC |
|
low complexity region
|
711 |
733 |
N/A |
INTRINSIC |
|
CUT
|
932 |
1020 |
3.31e-43 |
SMART |
|
low complexity region
|
1047 |
1063 |
N/A |
INTRINSIC |
|
low complexity region
|
1081 |
1102 |
N/A |
INTRINSIC |
|
CUT
|
1115 |
1201 |
3.78e-38 |
SMART |
|
HOX
|
1241 |
1303 |
6.32e-15 |
SMART |
|
low complexity region
|
1315 |
1330 |
N/A |
INTRINSIC |
|
low complexity region
|
1408 |
1470 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000176216
AA Change: Q194*
|
| SMART Domains |
Protein: ENSMUSP00000135054
Gene: ENSMUSG00000029705
AA Change: Q194*
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
369 |
390 |
9.35e-5 |
PROSPERO |
|
Pfam:CASP_C
|
421 |
647 |
1.2e-71 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176423
|
| SMART Domains |
Protein: ENSMUSP00000135036
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
coiled coil region
|
76 |
148 |
N/A |
INTRINSIC |
|
low complexity region
|
217 |
226 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000176486
AA Change: Q56*
|
| SMART Domains |
Protein: ENSMUSP00000135370
Gene: ENSMUSG00000029705
AA Change: Q56*
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
363 |
N/A |
INTRINSIC |
|
low complexity region
|
429 |
445 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
483 |
N/A |
INTRINSIC |
|
low complexity region
|
525 |
536 |
N/A |
INTRINSIC |
|
CUT
|
552 |
638 |
5.06e-39 |
SMART |
|
Blast:CUT
|
641 |
840 |
3e-50 |
BLAST |
|
CUT
|
919 |
1007 |
3.31e-43 |
SMART |
|
low complexity region
|
1034 |
1050 |
N/A |
INTRINSIC |
|
low complexity region
|
1068 |
1089 |
N/A |
INTRINSIC |
|
CUT
|
1102 |
1188 |
3.78e-38 |
SMART |
|
HOX
|
1228 |
1290 |
6.32e-15 |
SMART |
|
low complexity region
|
1302 |
1317 |
N/A |
INTRINSIC |
|
low complexity region
|
1395 |
1457 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176501
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000176745
AA Change: Q194*
|
| SMART Domains |
Protein: ENSMUSP00000135512
Gene: ENSMUSG00000029705
AA Change: Q194*
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
363 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
367 |
388 |
8.95e-5 |
PROSPERO |
|
Pfam:CASP_C
|
419 |
645 |
1.2e-71 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000176778
AA Change: Q279*
|
| SMART Domains |
Protein: ENSMUSP00000135892
Gene: ENSMUSG00000029705
AA Change: Q279*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
86 |
N/A |
INTRINSIC |
|
coiled coil region
|
195 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
519 |
N/A |
INTRINSIC |
|
CUT
|
535 |
621 |
5.06e-39 |
SMART |
|
low complexity region
|
685 |
691 |
N/A |
INTRINSIC |
|
low complexity region
|
703 |
725 |
N/A |
INTRINSIC |
|
CUT
|
924 |
1012 |
3.31e-43 |
SMART |
|
low complexity region
|
1039 |
1055 |
N/A |
INTRINSIC |
|
low complexity region
|
1073 |
1094 |
N/A |
INTRINSIC |
|
CUT
|
1107 |
1193 |
3.78e-38 |
SMART |
|
HOX
|
1233 |
1295 |
6.32e-15 |
SMART |
|
low complexity region
|
1307 |
1322 |
N/A |
INTRINSIC |
|
low complexity region
|
1400 |
1462 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000177297
AA Change: Q194*
|
| SMART Domains |
Protein: ENSMUSP00000134819
Gene: ENSMUSG00000029705
AA Change: Q194*
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
369 |
390 |
8.99e-6 |
PROSPERO |
|
Pfam:CASP_C
|
422 |
527 |
1.8e-17 |
PFAM |
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.7%
- 20x: 93.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygotes for a targeted null mutation exhibit delayed lung development and neonatal mortality. Survivors show growth retardation and hair defects. Homozygotes for a partially deleted protein have curly hair, and females tend to lose their litters. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
A |
G |
3: 138,067,270 |
E740G |
probably damaging |
Het |
| 4930474N05Rik |
G |
T |
14: 36,095,457 |
V105F |
possibly damaging |
Het |
| 4932438A13Rik |
A |
G |
3: 37,006,983 |
|
probably null |
Het |
| Actr10 |
A |
G |
12: 70,942,330 |
I74M |
probably benign |
Het |
| Aen |
T |
C |
7: 78,905,912 |
Y108H |
probably damaging |
Het |
| Afm |
A |
T |
5: 90,524,920 |
K205* |
probably null |
Het |
| Ankrd27 |
T |
A |
7: 35,632,985 |
S846T |
probably benign |
Het |
| Ano3 |
A |
G |
2: 110,885,007 |
S29P |
probably benign |
Het |
| Apaf1 |
C |
T |
10: 91,077,614 |
W138* |
probably null |
Het |
| Arfgef1 |
C |
T |
1: 10,199,878 |
A349T |
probably benign |
Het |
| Arhgef4 |
A |
G |
1: 34,811,140 |
Q1798R |
probably damaging |
Het |
| Astn1 |
G |
A |
1: 158,509,971 |
V416I |
probably damaging |
Het |
| Atxn2l |
G |
A |
7: 126,493,168 |
T70I |
probably damaging |
Het |
| Auh |
G |
A |
13: 52,835,496 |
P308L |
probably benign |
Het |
| Bspry |
T |
A |
4: 62,494,797 |
C256S |
probably damaging |
Het |
| C3 |
C |
A |
17: 57,220,135 |
W771C |
probably damaging |
Het |
| Camkv |
A |
G |
9: 107,947,088 |
D233G |
possibly damaging |
Het |
| Catsperd |
T |
A |
17: 56,635,548 |
V109E |
probably damaging |
Het |
| Cd101 |
A |
G |
3: 101,018,917 |
L162P |
probably damaging |
Het |
| Cdr2l |
A |
G |
11: 115,392,777 |
T154A |
probably damaging |
Het |
| Clca3a2 |
G |
C |
3: 144,810,696 |
Q380E |
probably benign |
Het |
| Col6a3 |
T |
C |
1: 90,822,359 |
N251S |
possibly damaging |
Het |
| Cttnbp2nl |
A |
G |
3: 105,011,278 |
V82A |
possibly damaging |
Het |
| Daam2 |
T |
C |
17: 49,485,457 |
E361G |
probably benign |
Het |
| Dcaf17 |
A |
T |
2: 71,078,172 |
|
probably null |
Het |
| Dnaic1 |
T |
C |
4: 41,570,020 |
|
probably null |
Het |
| Eml5 |
T |
C |
12: 98,798,839 |
Y1617C |
probably damaging |
Het |
| Epb41l4b |
T |
C |
4: 57,040,993 |
E490G |
probably damaging |
Het |
| Epha7 |
T |
C |
4: 28,963,969 |
M988T |
possibly damaging |
Het |
| Fancm |
T |
C |
12: 65,105,520 |
C917R |
possibly damaging |
Het |
| Fnip1 |
C |
T |
11: 54,480,684 |
T177I |
probably damaging |
Het |
| Gm12169 |
A |
G |
11: 46,528,531 |
D58G |
possibly damaging |
Het |
| Gm3604 |
G |
T |
13: 62,369,942 |
H201N |
probably benign |
Het |
| Gnpda1 |
T |
C |
18: 38,333,190 |
|
probably null |
Het |
| Gpatch8 |
A |
G |
11: 102,508,142 |
|
probably null |
Het |
| H2-M3 |
T |
C |
17: 37,271,189 |
Y179H |
possibly damaging |
Het |
| H2-Q10 |
C |
A |
17: 35,470,488 |
S62R |
probably damaging |
Het |
| Hipk2 |
G |
A |
6: 38,818,984 |
R117* |
probably null |
Het |
| Hrg |
A |
T |
16: 22,954,457 |
Q113H |
probably damaging |
Het |
| Kcnj16 |
T |
C |
11: 111,024,953 |
V147A |
possibly damaging |
Het |
| Kif1a |
T |
C |
1: 93,019,031 |
I1650V |
possibly damaging |
Het |
| Kmt2a |
C |
T |
9: 44,820,345 |
|
probably benign |
Het |
| Krt90 |
A |
T |
15: 101,557,230 |
Y319N |
probably damaging |
Het |
| Lipo4 |
T |
C |
19: 33,499,271 |
N359S |
possibly damaging |
Het |
| Lrp1b |
G |
T |
2: 41,728,729 |
T225K |
probably benign |
Het |
| Map1a |
C |
T |
2: 121,307,012 |
P2532S |
probably damaging |
Het |
| Mmrn2 |
A |
G |
14: 34,397,643 |
D193G |
probably benign |
Het |
| Mpped2 |
T |
A |
2: 106,867,032 |
I284N |
probably damaging |
Het |
| Msh6 |
A |
G |
17: 87,985,125 |
H436R |
probably benign |
Het |
| Mterf3 |
A |
T |
13: 66,930,062 |
S48T |
probably damaging |
Het |
| Muc5b |
T |
C |
7: 141,846,031 |
F414L |
unknown |
Het |
| Mylk4 |
A |
T |
13: 32,724,853 |
D90E |
probably benign |
Het |
| Nploc4 |
A |
G |
11: 120,404,229 |
Y420H |
probably damaging |
Het |
| Npr2 |
T |
A |
4: 43,640,578 |
Y344N |
probably damaging |
Het |
| Nsun5 |
A |
G |
5: 135,375,598 |
T397A |
probably benign |
Het |
| Ntsr2 |
A |
T |
12: 16,654,110 |
Q204L |
probably damaging |
Het |
| Nwd2 |
T |
A |
5: 63,806,180 |
Y1036N |
probably damaging |
Het |
| Oacyl |
T |
C |
18: 65,710,547 |
V105A |
possibly damaging |
Het |
| Olfr791 |
T |
A |
10: 129,527,049 |
V274D |
probably damaging |
Het |
| Parp3 |
T |
A |
9: 106,475,117 |
Q70L |
possibly damaging |
Het |
| Parp4 |
T |
C |
14: 56,624,017 |
S936P |
probably damaging |
Het |
| Pdzd3 |
T |
C |
9: 44,250,303 |
D93G |
possibly damaging |
Het |
| Phkb |
A |
G |
8: 85,922,161 |
E202G |
probably benign |
Het |
| Pink1 |
T |
C |
4: 138,314,020 |
N530S |
probably benign |
Het |
| Pou3f2 |
T |
C |
4: 22,487,119 |
D338G |
probably damaging |
Het |
| Prss8 |
G |
T |
7: 127,929,858 |
L9I |
probably benign |
Het |
| Ptpn22 |
G |
A |
3: 103,876,738 |
|
probably null |
Het |
| Rad54b |
A |
C |
4: 11,601,693 |
N416T |
probably damaging |
Het |
| Rasef |
A |
G |
4: 73,744,114 |
S200P |
possibly damaging |
Het |
| Rb1 |
T |
A |
14: 73,212,990 |
K645* |
probably null |
Het |
| Robo2 |
C |
T |
16: 73,899,154 |
G1367D |
probably benign |
Het |
| Rp1 |
A |
G |
1: 4,352,671 |
V52A |
probably damaging |
Het |
| Samd13 |
T |
C |
3: 146,662,712 |
T23A |
probably benign |
Het |
| Scn7a |
T |
C |
2: 66,699,973 |
H676R |
probably damaging |
Het |
| Serpinb6b |
A |
G |
13: 32,978,240 |
I222V |
probably benign |
Het |
| Slc2a8 |
T |
C |
2: 32,980,079 |
Y150C |
probably damaging |
Het |
| Slc7a6os |
C |
A |
8: 106,210,564 |
R88L |
probably damaging |
Het |
| Slc8a2 |
A |
G |
7: 16,152,920 |
I657V |
probably benign |
Het |
| Slit2 |
C |
A |
5: 48,191,016 |
|
probably benign |
Het |
| Spire2 |
A |
G |
8: 123,363,071 |
D447G |
probably benign |
Het |
| Sptlc3 |
A |
G |
2: 139,566,675 |
N237D |
possibly damaging |
Het |
| Stk3 |
G |
A |
15: 35,073,217 |
T119I |
probably damaging |
Het |
| Suv39h2 |
G |
A |
2: 3,464,316 |
T334I |
probably damaging |
Het |
| Syt5 |
G |
T |
7: 4,540,279 |
T327N |
probably damaging |
Het |
| Tcof1 |
T |
C |
18: 60,816,084 |
D1253G |
possibly damaging |
Het |
| Tnks |
A |
T |
8: 34,875,232 |
V388D |
probably damaging |
Het |
| Ugt2b1 |
T |
C |
5: 86,926,000 |
T167A |
probably benign |
Het |
| Usp40 |
G |
A |
1: 87,995,842 |
R236C |
possibly damaging |
Het |
| Utrn |
T |
C |
10: 12,455,480 |
D2904G |
probably benign |
Het |
| Vmn1r226 |
T |
C |
17: 20,687,580 |
S25P |
probably damaging |
Het |
| Vmn2r23 |
T |
C |
6: 123,713,010 |
S282P |
possibly damaging |
Het |
| Vps45 |
T |
C |
3: 96,046,440 |
E200G |
probably benign |
Het |
| Wnt7b |
T |
A |
15: 85,559,080 |
I41F |
probably damaging |
Het |
| Zmym6 |
T |
A |
4: 127,103,414 |
N275K |
probably damaging |
Het |
|
| Other mutations in Cux1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00846:Cux1
|
APN |
5 |
136,326,796 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00966:Cux1
|
APN |
5 |
136,311,491 (GRCm38) |
intron |
probably benign |
|
|
IGL01129:Cux1
|
APN |
5 |
136,304,718 (GRCm38) |
intron |
probably benign |
|
|
IGL01885:Cux1
|
APN |
5 |
136,308,447 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
IGL01947:Cux1
|
APN |
5 |
136,275,125 (GRCm38) |
missense |
probably benign |
0.04 |
|
IGL02259:Cux1
|
APN |
5 |
136,326,833 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02666:Cux1
|
APN |
5 |
136,275,315 (GRCm38) |
nonsense |
probably null |
|
|
IGL02826:Cux1
|
APN |
5 |
136,308,003 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03014:Cux1
|
UTSW |
5 |
136,565,525 (GRCm38) |
intron |
probably benign |
|
|
R0047:Cux1
|
UTSW |
5 |
136,363,253 (GRCm38) |
splice site |
probably benign |
|
|
R0047:Cux1
|
UTSW |
5 |
136,363,253 (GRCm38) |
splice site |
probably benign |
|
|
R0057:Cux1
|
UTSW |
5 |
136,256,282 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0149:Cux1
|
UTSW |
5 |
136,279,497 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0295:Cux1
|
UTSW |
5 |
136,313,212 (GRCm38) |
missense |
probably benign |
0.04 |
|
R0361:Cux1
|
UTSW |
5 |
136,279,497 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0533:Cux1
|
UTSW |
5 |
136,307,859 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0630:Cux1
|
UTSW |
5 |
136,286,835 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0801:Cux1
|
UTSW |
5 |
136,326,929 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R0884:Cux1
|
UTSW |
5 |
136,307,835 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0976:Cux1
|
UTSW |
5 |
136,313,290 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1073:Cux1
|
UTSW |
5 |
136,252,541 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1222:Cux1
|
UTSW |
5 |
136,275,149 (GRCm38) |
missense |
probably benign |
0.18 |
|
R1518:Cux1
|
UTSW |
5 |
136,308,279 (GRCm38) |
missense |
probably benign |
0.29 |
|
R1686:Cux1
|
UTSW |
5 |
136,275,381 (GRCm38) |
nonsense |
probably null |
|
|
R1687:Cux1
|
UTSW |
5 |
136,312,669 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1758:Cux1
|
UTSW |
5 |
136,392,322 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1797:Cux1
|
UTSW |
5 |
136,275,315 (GRCm38) |
missense |
probably benign |
0.22 |
|
R2051:Cux1
|
UTSW |
5 |
136,332,658 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2339:Cux1
|
UTSW |
5 |
136,287,008 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3438:Cux1
|
UTSW |
5 |
136,311,560 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3713:Cux1
|
UTSW |
5 |
136,565,543 (GRCm38) |
intron |
probably benign |
|
|
R3800:Cux1
|
UTSW |
5 |
136,316,033 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3964:Cux1
|
UTSW |
5 |
136,282,942 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4135:Cux1
|
UTSW |
5 |
136,307,896 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4198:Cux1
|
UTSW |
5 |
136,286,848 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4467:Cux1
|
UTSW |
5 |
136,312,722 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4498:Cux1
|
UTSW |
5 |
136,312,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4622:Cux1
|
UTSW |
5 |
136,308,300 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4623:Cux1
|
UTSW |
5 |
136,308,300 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4651:Cux1
|
UTSW |
5 |
136,567,229 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4652:Cux1
|
UTSW |
5 |
136,567,229 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4658:Cux1
|
UTSW |
5 |
136,250,594 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R4665:Cux1
|
UTSW |
5 |
136,286,799 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4704:Cux1
|
UTSW |
5 |
136,249,201 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4867:Cux1
|
UTSW |
5 |
136,274,961 (GRCm38) |
intron |
probably benign |
|
|
R4965:Cux1
|
UTSW |
5 |
136,311,556 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R5090:Cux1
|
UTSW |
5 |
136,313,200 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R5155:Cux1
|
UTSW |
5 |
136,565,441 (GRCm38) |
intron |
probably benign |
|
|
R5226:Cux1
|
UTSW |
5 |
136,370,173 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5252:Cux1
|
UTSW |
5 |
136,308,297 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5266:Cux1
|
UTSW |
5 |
136,312,694 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5399:Cux1
|
UTSW |
5 |
136,252,604 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R5509:Cux1
|
UTSW |
5 |
136,275,317 (GRCm38) |
missense |
probably benign |
0.13 |
|
R5609:Cux1
|
UTSW |
5 |
136,392,320 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5681:Cux1
|
UTSW |
5 |
136,308,184 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5993:Cux1
|
UTSW |
5 |
136,363,271 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6049:Cux1
|
UTSW |
5 |
136,332,710 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6290:Cux1
|
UTSW |
5 |
136,311,558 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6310:Cux1
|
UTSW |
5 |
136,275,164 (GRCm38) |
missense |
probably benign |
0.10 |
|
R6351:Cux1
|
UTSW |
5 |
136,309,792 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6531:Cux1
|
UTSW |
5 |
136,275,119 (GRCm38) |
missense |
probably benign |
0.03 |
|
R6590:Cux1
|
UTSW |
5 |
136,340,117 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6663:Cux1
|
UTSW |
5 |
136,485,847 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6690:Cux1
|
UTSW |
5 |
136,340,117 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6777:Cux1
|
UTSW |
5 |
136,565,568 (GRCm38) |
intron |
probably benign |
|
|
R6786:Cux1
|
UTSW |
5 |
136,567,231 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6817:Cux1
|
UTSW |
5 |
136,373,173 (GRCm38) |
splice site |
probably null |
|
|
R6989:Cux1
|
UTSW |
5 |
136,279,648 (GRCm38) |
nonsense |
probably null |
|
|
R7011:Cux1
|
UTSW |
5 |
136,360,033 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7167:Cux1
|
UTSW |
5 |
136,310,041 (GRCm38) |
splice site |
probably null |
|
|
R7699:Cux1
|
UTSW |
5 |
136,485,739 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7861:Cux1
|
UTSW |
5 |
136,252,604 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R7876:Cux1
|
UTSW |
5 |
136,363,307 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7916:Cux1
|
UTSW |
5 |
136,282,961 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8023:Cux1
|
UTSW |
5 |
136,373,397 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8154:Cux1
|
UTSW |
5 |
136,252,580 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8267:Cux1
|
UTSW |
5 |
136,282,999 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8289:Cux1
|
UTSW |
5 |
136,308,504 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8305:Cux1
|
UTSW |
5 |
136,360,009 (GRCm38) |
missense |
probably benign |
0.02 |
|
R8319:Cux1
|
UTSW |
5 |
136,565,397 (GRCm38) |
missense |
probably benign |
0.02 |
|
R8405:Cux1
|
UTSW |
5 |
136,275,387 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R8483:Cux1
|
UTSW |
5 |
136,275,090 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R8506:Cux1
|
UTSW |
5 |
136,308,504 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8671:Cux1
|
UTSW |
5 |
136,250,600 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8680:Cux1
|
UTSW |
5 |
136,307,856 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R8737:Cux1
|
UTSW |
5 |
136,282,942 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8738:Cux1
|
UTSW |
5 |
136,373,366 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8793:Cux1
|
UTSW |
5 |
136,565,685 (GRCm38) |
missense |
unknown |
|
|
R8897:Cux1
|
UTSW |
5 |
136,286,769 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8926:Cux1
|
UTSW |
5 |
136,309,550 (GRCm38) |
intron |
probably benign |
|
|
R8954:Cux1
|
UTSW |
5 |
136,373,349 (GRCm38) |
nonsense |
probably null |
|
|
R9092:Cux1
|
UTSW |
5 |
136,485,817 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9205:Cux1
|
UTSW |
5 |
136,370,135 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9550:Cux1
|
UTSW |
5 |
136,311,533 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9578:Cux1
|
UTSW |
5 |
136,254,065 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9682:Cux1
|
UTSW |
5 |
136,308,262 (GRCm38) |
missense |
probably benign |
|
|
R9701:Cux1
|
UTSW |
5 |
136,314,315 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9712:Cux1
|
UTSW |
5 |
136,309,819 (GRCm38) |
missense |
probably benign |
0.35 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGACTAATGCAGCCAGGTAGAG -3'
(R):5'- AAGCTGCACTGTAAGGCTGC -3'
Sequencing Primer
(F):5'- GCCTGGGACACAAGCTTCAATTG -3'
(R):5'- CACACAGCCTATCTCAGTAG -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation