Mutagenetix > Incidental Mutation

Incidental Mutation 'R1919:Muc5b'

212845

Institutional Source

Beutler Lab

Gene Symbol

Muc5b

Ensembl Gene

ENSMUSG00000066108

Gene Name

mucin 5, subtype B, tracheobronchial

Synonyms

MUC5, MUC9, 2300002I04Rik

MMRRC Submission

039937-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.169) question?

Stock #

R1919 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

141839070-141873084 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 141846031 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 414 (F414L)

Ref Sequence

ENSEMBL: ENSMUSP00000128276 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165147]

AlphaFold

no structure available at present

Predicted Effect

unknown
Transcript: ENSMUST00000165147
AA Change: F414L

SMART Domains

Protein: ENSMUSP00000128276
Gene: ENSMUSG00000066108
AA Change: F414L

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
VWD	73	228	1.12e-25	SMART
C8	267	330	7.26e-8	SMART
Pfam:TIL	333	389	1.1e-13	PFAM
VWC	391	459	1.35e-1	SMART
VWD	418	582	2.87e-37	SMART
C8	619	693	2.53e-30	SMART
Pfam:TIL	699	756	2.6e-10	PFAM
VWC	758	823	1.26e0	SMART
VWC	861	930	1.58e-7	SMART
VWD	888	1048	3e-40	SMART
C8	1084	1158	3.75e-33	SMART
low complexity region	1314	1328	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1345	1432	6.7e-27	PFAM
low complexity region	1447	1468	N/A	INTRINSIC
low complexity region	1498	1517	N/A	INTRINSIC
low complexity region	1543	1558	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1574	1663	2.1e-26	PFAM
low complexity region	1678	1693	N/A	INTRINSIC
low complexity region	1728	1745	N/A	INTRINSIC
low complexity region	1778	1831	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1870	1959	2.7e-26	PFAM
low complexity region	1967	1990	N/A	INTRINSIC
low complexity region	2024	2041	N/A	INTRINSIC
low complexity region	2074	2127	N/A	INTRINSIC
Pfam:Mucin2_WxxW	2184	2273	2.1e-26	PFAM
low complexity region	2281	2304	N/A	INTRINSIC
low complexity region	2338	2355	N/A	INTRINSIC
low complexity region	2388	2441	N/A	INTRINSIC
Pfam:Mucin2_WxxW	2498	2587	2.1e-26	PFAM
low complexity region	2596	2618	N/A	INTRINSIC
low complexity region	2623	2654	N/A	INTRINSIC
low complexity region	2660	2681	N/A	INTRINSIC
Pfam:Mucin2_WxxW	2687	2776	3.8e-25	PFAM
low complexity region	2781	2796	N/A	INTRINSIC
low complexity region	2958	3009	N/A	INTRINSIC
Pfam:Mucin2_WxxW	3066	3155	2.6e-26	PFAM
low complexity region	3220	3237	N/A	INTRINSIC
low complexity region	3270	3317	N/A	INTRINSIC
Pfam:Mucin2_WxxW	3380	3469	3.4e-26	PFAM
low complexity region	3509	3529	N/A	INTRINSIC
low complexity region	3546	3562	N/A	INTRINSIC
low complexity region	3568	3591	N/A	INTRINSIC
Pfam:Mucin2_WxxW	3624	3713	2.6e-27	PFAM
Pfam:Mucin2_WxxW	3778	3867	3.2e-24	PFAM
low complexity region	3883	3900	N/A	INTRINSIC
low complexity region	3910	3934	N/A	INTRINSIC
low complexity region	3959	3976	N/A	INTRINSIC
low complexity region	4033	4053	N/A	INTRINSIC
VWD	4111	4283	6.75e-34	SMART
C8	4336	4403	4.26e-14	SMART
VWC	4461	4530	7.06e-5	SMART
VWC	4570	4631	6.53e-9	SMART
CT	4708	4790	2.93e-26	SMART

Coding Region Coverage

1x: 97.5%
3x: 97.0%
10x: 95.7%
20x: 93.3%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]
PHENOTYPE: Mice homozygous for a knock-out allele accumulate materials in the upper and lower airways leading to chronic infection and inflammation that does not resolve and results in premature death. Macrophage function is impaired. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 94 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110002E22Rik	A	G	3: 138,067,270	E740G	probably damaging	Het
4930474N05Rik	G	T	14: 36,095,457	V105F	possibly damaging	Het
4932438A13Rik	A	G	3: 37,006,983		probably null	Het
Actr10	A	G	12: 70,942,330	I74M	probably benign	Het
Aen	T	C	7: 78,905,912	Y108H	probably damaging	Het
Afm	A	T	5: 90,524,920	K205*	probably null	Het
Ankrd27	T	A	7: 35,632,985	S846T	probably benign	Het
Ano3	A	G	2: 110,885,007	S29P	probably benign	Het
Apaf1	C	T	10: 91,077,614	W138*	probably null	Het
Arfgef1	C	T	1: 10,199,878	A349T	probably benign	Het
Arhgef4	A	G	1: 34,811,140	Q1798R	probably damaging	Het
Astn1	G	A	1: 158,509,971	V416I	probably damaging	Het
Atxn2l	G	A	7: 126,493,168	T70I	probably damaging	Het
Auh	G	A	13: 52,835,496	P308L	probably benign	Het
Bspry	T	A	4: 62,494,797	C256S	probably damaging	Het
C3	C	A	17: 57,220,135	W771C	probably damaging	Het
Camkv	A	G	9: 107,947,088	D233G	possibly damaging	Het
Catsperd	T	A	17: 56,635,548	V109E	probably damaging	Het
Cd101	A	G	3: 101,018,917	L162P	probably damaging	Het
Cdr2l	A	G	11: 115,392,777	T154A	probably damaging	Het
Clca3a2	G	C	3: 144,810,696	Q380E	probably benign	Het
Col6a3	T	C	1: 90,822,359	N251S	possibly damaging	Het
Cttnbp2nl	A	G	3: 105,011,278	V82A	possibly damaging	Het
Cux1	G	A	5: 136,363,319	Q194*	probably null	Het
Daam2	T	C	17: 49,485,457	E361G	probably benign	Het
Dcaf17	A	T	2: 71,078,172		probably null	Het
Dnaic1	T	C	4: 41,570,020		probably null	Het
Eml5	T	C	12: 98,798,839	Y1617C	probably damaging	Het
Epb41l4b	T	C	4: 57,040,993	E490G	probably damaging	Het
Epha7	T	C	4: 28,963,969	M988T	possibly damaging	Het
Fancm	T	C	12: 65,105,520	C917R	possibly damaging	Het
Fnip1	C	T	11: 54,480,684	T177I	probably damaging	Het
Gm12169	A	G	11: 46,528,531	D58G	possibly damaging	Het
Gm3604	G	T	13: 62,369,942	H201N	probably benign	Het
Gnpda1	T	C	18: 38,333,190		probably null	Het
Gpatch8	A	G	11: 102,508,142		probably null	Het
H2-M3	T	C	17: 37,271,189	Y179H	possibly damaging	Het
H2-Q10	C	A	17: 35,470,488	S62R	probably damaging	Het
Hipk2	G	A	6: 38,818,984	R117*	probably null	Het
Hrg	A	T	16: 22,954,457	Q113H	probably damaging	Het
Kcnj16	T	C	11: 111,024,953	V147A	possibly damaging	Het
Kif1a	T	C	1: 93,019,031	I1650V	possibly damaging	Het
Kmt2a	C	T	9: 44,820,345		probably benign	Het
Krt90	A	T	15: 101,557,230	Y319N	probably damaging	Het
Lipo4	T	C	19: 33,499,271	N359S	possibly damaging	Het
Lrp1b	G	T	2: 41,728,729	T225K	probably benign	Het
Map1a	C	T	2: 121,307,012	P2532S	probably damaging	Het
Mmrn2	A	G	14: 34,397,643	D193G	probably benign	Het
Mpped2	T	A	2: 106,867,032	I284N	probably damaging	Het
Msh6	A	G	17: 87,985,125	H436R	probably benign	Het
Mterf3	A	T	13: 66,930,062	S48T	probably damaging	Het
Mylk4	A	T	13: 32,724,853	D90E	probably benign	Het
Nploc4	A	G	11: 120,404,229	Y420H	probably damaging	Het
Npr2	T	A	4: 43,640,578	Y344N	probably damaging	Het
Nsun5	A	G	5: 135,375,598	T397A	probably benign	Het
Ntsr2	A	T	12: 16,654,110	Q204L	probably damaging	Het
Nwd2	T	A	5: 63,806,180	Y1036N	probably damaging	Het
Oacyl	T	C	18: 65,710,547	V105A	possibly damaging	Het
Olfr791	T	A	10: 129,527,049	V274D	probably damaging	Het
Parp3	T	A	9: 106,475,117	Q70L	possibly damaging	Het
Parp4	T	C	14: 56,624,017	S936P	probably damaging	Het
Pdzd3	T	C	9: 44,250,303	D93G	possibly damaging	Het
Phkb	A	G	8: 85,922,161	E202G	probably benign	Het
Pink1	T	C	4: 138,314,020	N530S	probably benign	Het
Pou3f2	T	C	4: 22,487,119	D338G	probably damaging	Het
Prss8	G	T	7: 127,929,858	L9I	probably benign	Het
Ptpn22	G	A	3: 103,876,738		probably null	Het
Rad54b	A	C	4: 11,601,693	N416T	probably damaging	Het
Rasef	A	G	4: 73,744,114	S200P	possibly damaging	Het
Rb1	T	A	14: 73,212,990	K645*	probably null	Het
Robo2	C	T	16: 73,899,154	G1367D	probably benign	Het
Rp1	A	G	1: 4,352,671	V52A	probably damaging	Het
Samd13	T	C	3: 146,662,712	T23A	probably benign	Het
Scn7a	T	C	2: 66,699,973	H676R	probably damaging	Het
Serpinb6b	A	G	13: 32,978,240	I222V	probably benign	Het
Slc2a8	T	C	2: 32,980,079	Y150C	probably damaging	Het
Slc7a6os	C	A	8: 106,210,564	R88L	probably damaging	Het
Slc8a2	A	G	7: 16,152,920	I657V	probably benign	Het
Slit2	C	A	5: 48,191,016		probably benign	Het
Spire2	A	G	8: 123,363,071	D447G	probably benign	Het
Sptlc3	A	G	2: 139,566,675	N237D	possibly damaging	Het
Stk3	G	A	15: 35,073,217	T119I	probably damaging	Het
Suv39h2	G	A	2: 3,464,316	T334I	probably damaging	Het
Syt5	G	T	7: 4,540,279	T327N	probably damaging	Het
Tcof1	T	C	18: 60,816,084	D1253G	possibly damaging	Het
Tnks	A	T	8: 34,875,232	V388D	probably damaging	Het
Ugt2b1	T	C	5: 86,926,000	T167A	probably benign	Het
Usp40	G	A	1: 87,995,842	R236C	possibly damaging	Het
Utrn	T	C	10: 12,455,480	D2904G	probably benign	Het
Vmn1r226	T	C	17: 20,687,580	S25P	probably damaging	Het
Vmn2r23	T	C	6: 123,713,010	S282P	possibly damaging	Het
Vps45	T	C	3: 96,046,440	E200G	probably benign	Het
Wnt7b	T	A	15: 85,559,080	I41F	probably damaging	Het
Zmym6	T	A	4: 127,103,414	N275K	probably damaging	Het

Other mutations in Muc5b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00586:Muc5b	APN	7	141,841,392 (GRCm38)	missense	unknown
IGL00677:Muc5b	APN	7	141,857,894 (GRCm38)	nonsense	probably null
IGL00740:Muc5b	APN	7	141,855,598 (GRCm38)	missense	unknown
IGL01084:Muc5b	APN	7	141,843,449 (GRCm38)	splice site	probably benign
IGL01384:Muc5b	APN	7	141,846,818 (GRCm38)	missense	unknown
IGL01447:Muc5b	APN	7	141,863,094 (GRCm38)	missense	probably benign	0.01
IGL01510:Muc5b	APN	7	141,859,061 (GRCm38)	missense	unknown
IGL01532:Muc5b	APN	7	141,870,006 (GRCm38)	missense	possibly damaging	0.96
IGL01556:Muc5b	APN	7	141,863,240 (GRCm38)	missense	probably benign	0.01
IGL01608:Muc5b	APN	7	141,846,437 (GRCm38)	missense	unknown
IGL01884:Muc5b	APN	7	141,868,083 (GRCm38)	splice site	probably benign
IGL01943:Muc5b	APN	7	141,861,497 (GRCm38)	missense	possibly damaging	0.71
IGL02039:Muc5b	APN	7	141,871,164 (GRCm38)	missense	possibly damaging	0.96
IGL02089:Muc5b	APN	7	141,863,250 (GRCm38)	missense	probably benign	0.04
IGL02110:Muc5b	APN	7	141,847,716 (GRCm38)	nonsense	probably null
IGL02123:Muc5b	APN	7	141,863,757 (GRCm38)	missense	possibly damaging	0.68
IGL02124:Muc5b	APN	7	141,855,632 (GRCm38)	missense	unknown
IGL02141:Muc5b	APN	7	141,853,367 (GRCm38)	missense	unknown
IGL02409:Muc5b	APN	7	141,861,338 (GRCm38)	missense	possibly damaging	0.53
IGL02448:Muc5b	APN	7	141,868,489 (GRCm38)	missense	possibly damaging	0.53
IGL02503:Muc5b	APN	7	141,867,667 (GRCm38)	missense	probably benign	0.33
IGL02504:Muc5b	APN	7	141,846,440 (GRCm38)	missense	unknown
IGL02528:Muc5b	APN	7	141,864,017 (GRCm38)	missense	probably benign	0.01
IGL02534:Muc5b	APN	7	141,844,719 (GRCm38)	missense	unknown
IGL02565:Muc5b	APN	7	141,857,867 (GRCm38)	missense	unknown
IGL02630:Muc5b	APN	7	141,863,231 (GRCm38)	missense	probably benign	0.03
IGL02881:Muc5b	APN	7	141,857,712 (GRCm38)	missense	unknown
IGL02963:Muc5b	APN	7	141,864,264 (GRCm38)	missense	probably damaging	1.00
IGL03003:Muc5b	APN	7	141,863,614 (GRCm38)	missense	probably benign	0.03
IGL03013:Muc5b	APN	7	141,863,928 (GRCm38)	missense	possibly damaging	0.68
IGL03102:Muc5b	APN	7	141,863,069 (GRCm38)	missense	probably benign	0.35
IGL03114:Muc5b	APN	7	141,858,819 (GRCm38)	nonsense	probably null
IGL03150:Muc5b	APN	7	141,865,509 (GRCm38)	missense	possibly damaging	0.53
IGL03185:Muc5b	APN	7	141,862,822 (GRCm38)	missense	possibly damaging	0.83
IGL03299:Muc5b	APN	7	141,841,380 (GRCm38)	missense	unknown
IGL03336:Muc5b	APN	7	141,864,363 (GRCm38)	missense	probably damaging	1.00
IGL03370:Muc5b	APN	7	141,864,777 (GRCm38)	missense	probably benign	0.34
IGL03375:Muc5b	APN	7	141,861,962 (GRCm38)	missense	possibly damaging	0.53
IGL03393:Muc5b	APN	7	141,864,138 (GRCm38)	missense	probably benign	0.21
profligate	UTSW	7	141,857,822 (GRCm38)	nonsense	probably null
wasteful	UTSW	7	141,858,161 (GRCm38)	missense	unknown
R0045:Muc5b	UTSW	7	141,856,818 (GRCm38)	missense	unknown
R0256:Muc5b	UTSW	7	141,843,258 (GRCm38)	missense	unknown
R0256:Muc5b	UTSW	7	141,841,395 (GRCm38)	missense	unknown
R0321:Muc5b	UTSW	7	141,862,235 (GRCm38)	missense	probably benign	0.19
R0391:Muc5b	UTSW	7	141,865,082 (GRCm38)	missense	possibly damaging	0.73
R0458:Muc5b	UTSW	7	141,864,972 (GRCm38)	missense	probably benign	0.20
R0491:Muc5b	UTSW	7	141,862,015 (GRCm38)	missense	probably benign	0.01
R0543:Muc5b	UTSW	7	141,851,785 (GRCm38)	missense	unknown
R0583:Muc5b	UTSW	7	141,856,698 (GRCm38)	nonsense	probably null
R0611:Muc5b	UTSW	7	141,862,436 (GRCm38)	missense	probably benign	0.18
R0625:Muc5b	UTSW	7	141,846,427 (GRCm38)	missense	unknown
R0655:Muc5b	UTSW	7	141,863,942 (GRCm38)	missense	probably benign	0.01
R0845:Muc5b	UTSW	7	141,850,446 (GRCm38)	splice site	probably null
R0863:Muc5b	UTSW	7	141,867,717 (GRCm38)	missense	probably benign	0.18
R0965:Muc5b	UTSW	7	141,863,802 (GRCm38)	missense	possibly damaging	0.92
R0988:Muc5b	UTSW	7	141,871,795 (GRCm38)	missense	probably benign	0.03
R1140:Muc5b	UTSW	7	141,858,996 (GRCm38)	missense	unknown
R1209:Muc5b	UTSW	7	141,857,910 (GRCm38)	missense	unknown
R1333:Muc5b	UTSW	7	141,868,407 (GRCm38)	missense	possibly damaging	0.53
R1337:Muc5b	UTSW	7	141,858,624 (GRCm38)	missense	unknown
R1385:Muc5b	UTSW	7	141,862,137 (GRCm38)	missense	probably benign	0.00
R1463:Muc5b	UTSW	7	141,859,080 (GRCm38)	missense	unknown
R1471:Muc5b	UTSW	7	141,843,234 (GRCm38)	missense	unknown
R1617:Muc5b	UTSW	7	141,863,524 (GRCm38)	nonsense	probably null
R1736:Muc5b	UTSW	7	141,859,107 (GRCm38)	missense	unknown
R1752:Muc5b	UTSW	7	141,867,751 (GRCm38)	missense	possibly damaging	0.96
R1804:Muc5b	UTSW	7	141,863,780 (GRCm38)	missense	possibly damaging	0.68
R1806:Muc5b	UTSW	7	141,865,493 (GRCm38)	missense	possibly damaging	0.68
R1895:Muc5b	UTSW	7	141,857,645 (GRCm38)	missense	unknown
R1902:Muc5b	UTSW	7	141,864,105 (GRCm38)	missense	possibly damaging	0.77
R1924:Muc5b	UTSW	7	141,868,223 (GRCm38)	missense	possibly damaging	0.53
R1942:Muc5b	UTSW	7	141,857,684 (GRCm38)	missense	unknown
R1959:Muc5b	UTSW	7	141,862,637 (GRCm38)	missense	possibly damaging	0.86
R1960:Muc5b	UTSW	7	141,862,637 (GRCm38)	missense	possibly damaging	0.86
R1976:Muc5b	UTSW	7	141,863,154 (GRCm38)	missense	probably benign	0.01
R2080:Muc5b	UTSW	7	141,869,754 (GRCm38)	missense	probably benign	0.33
R2178:Muc5b	UTSW	7	141,864,116 (GRCm38)	missense	possibly damaging	0.58
R2184:Muc5b	UTSW	7	141,858,864 (GRCm38)	nonsense	probably null
R2229:Muc5b	UTSW	7	141,861,644 (GRCm38)	missense	possibly damaging	0.71
R2237:Muc5b	UTSW	7	141,862,089 (GRCm38)	missense	probably benign	0.00
R2509:Muc5b	UTSW	7	141,859,061 (GRCm38)	missense	unknown
R2510:Muc5b	UTSW	7	141,859,061 (GRCm38)	missense	unknown
R2512:Muc5b	UTSW	7	141,859,076 (GRCm38)	missense	unknown
R2888:Muc5b	UTSW	7	141,861,554 (GRCm38)	missense	probably damaging	0.98
R3054:Muc5b	UTSW	7	141,864,041 (GRCm38)	missense	probably damaging	0.97
R3055:Muc5b	UTSW	7	141,864,041 (GRCm38)	missense	probably damaging	0.97
R3108:Muc5b	UTSW	7	141,858,759 (GRCm38)	missense	unknown
R3109:Muc5b	UTSW	7	141,858,759 (GRCm38)	missense	unknown
R3113:Muc5b	UTSW	7	141,846,134 (GRCm38)	missense	unknown
R3551:Muc5b	UTSW	7	141,861,335 (GRCm38)	missense	possibly damaging	0.53
R3552:Muc5b	UTSW	7	141,867,705 (GRCm38)	missense	probably benign	0.18
R3552:Muc5b	UTSW	7	141,861,335 (GRCm38)	missense	possibly damaging	0.53
R3622:Muc5b	UTSW	7	141,851,858 (GRCm38)	splice site	probably benign
R3700:Muc5b	UTSW	7	141,847,249 (GRCm38)	missense	unknown
R3734:Muc5b	UTSW	7	141,859,037 (GRCm38)	nonsense	probably null
R3785:Muc5b	UTSW	7	141,865,116 (GRCm38)	missense	possibly damaging	0.86
R3786:Muc5b	UTSW	7	141,865,116 (GRCm38)	missense	possibly damaging	0.86
R3788:Muc5b	UTSW	7	141,863,834 (GRCm38)	missense	possibly damaging	0.68
R3810:Muc5b	UTSW	7	141,864,126 (GRCm38)	missense	possibly damaging	0.58
R3834:Muc5b	UTSW	7	141,859,181 (GRCm38)	missense	unknown
R3835:Muc5b	UTSW	7	141,859,181 (GRCm38)	missense	unknown
R3850:Muc5b	UTSW	7	141,862,638 (GRCm38)	missense	possibly damaging	0.95
R3877:Muc5b	UTSW	7	141,857,552 (GRCm38)	missense	unknown
R3909:Muc5b	UTSW	7	141,849,498 (GRCm38)	missense	unknown
R3964:Muc5b	UTSW	7	141,866,968 (GRCm38)	missense	possibly damaging	0.73
R4014:Muc5b	UTSW	7	141,863,630 (GRCm38)	missense	probably benign	0.40
R4015:Muc5b	UTSW	7	141,863,630 (GRCm38)	missense	probably benign	0.40
R4017:Muc5b	UTSW	7	141,863,630 (GRCm38)	missense	probably benign	0.40
R4042:Muc5b	UTSW	7	141,864,887 (GRCm38)	missense	possibly damaging	0.92
R4200:Muc5b	UTSW	7	141,858,925 (GRCm38)	nonsense	probably null
R4230:Muc5b	UTSW	7	141,863,522 (GRCm38)	missense	probably benign	0.03
R4400:Muc5b	UTSW	7	141,861,387 (GRCm38)	missense	possibly damaging	0.92
R4455:Muc5b	UTSW	7	141,858,818 (GRCm38)	missense	unknown
R4484:Muc5b	UTSW	7	141,868,450 (GRCm38)	missense	possibly damaging	0.73
R4630:Muc5b	UTSW	7	141,857,984 (GRCm38)	missense	unknown
R4646:Muc5b	UTSW	7	141,862,640 (GRCm38)	missense	probably benign	0.34
R4658:Muc5b	UTSW	7	141,841,398 (GRCm38)	missense	unknown
R4667:Muc5b	UTSW	7	141,842,379 (GRCm38)	missense	unknown
R4690:Muc5b	UTSW	7	141,842,294 (GRCm38)	missense	unknown
R4697:Muc5b	UTSW	7	141,857,361 (GRCm38)	missense	unknown
R4711:Muc5b	UTSW	7	141,846,033 (GRCm38)	missense	unknown
R4713:Muc5b	UTSW	7	141,849,079 (GRCm38)	nonsense	probably null
R4749:Muc5b	UTSW	7	141,861,448 (GRCm38)	nonsense	probably null
R4753:Muc5b	UTSW	7	141,856,853 (GRCm38)	missense	unknown
R4782:Muc5b	UTSW	7	141,847,716 (GRCm38)	nonsense	probably null
R4795:Muc5b	UTSW	7	141,849,567 (GRCm38)	missense	unknown
R4796:Muc5b	UTSW	7	141,864,246 (GRCm38)	missense	possibly damaging	0.52
R4799:Muc5b	UTSW	7	141,847,716 (GRCm38)	nonsense	probably null
R4824:Muc5b	UTSW	7	141,864,185 (GRCm38)	missense	probably damaging	1.00
R4825:Muc5b	UTSW	7	141,868,465 (GRCm38)	missense	possibly damaging	0.96
R5068:Muc5b	UTSW	7	141,858,608 (GRCm38)	missense	unknown
R5073:Muc5b	UTSW	7	141,859,262 (GRCm38)	missense	unknown
R5074:Muc5b	UTSW	7	141,859,262 (GRCm38)	missense	unknown
R5107:Muc5b	UTSW	7	141,855,531 (GRCm38)	missense	unknown
R5152:Muc5b	UTSW	7	141,865,531 (GRCm38)	missense	possibly damaging	0.53
R5183:Muc5b	UTSW	7	141,850,810 (GRCm38)	missense	unknown
R5191:Muc5b	UTSW	7	141,858,539 (GRCm38)	missense	unknown
R5254:Muc5b	UTSW	7	141,864,540 (GRCm38)	missense	probably benign	0.09
R5320:Muc5b	UTSW	7	141,859,001 (GRCm38)	missense	unknown
R5352:Muc5b	UTSW	7	141,864,558 (GRCm38)	missense	possibly damaging	0.66
R5378:Muc5b	UTSW	7	141,862,203 (GRCm38)	missense	unknown
R5417:Muc5b	UTSW	7	141,858,044 (GRCm38)	missense	unknown
R5548:Muc5b	UTSW	7	141,863,942 (GRCm38)	missense	probably benign	0.01
R5551:Muc5b	UTSW	7	141,868,503 (GRCm38)	missense	possibly damaging	0.73
R5562:Muc5b	UTSW	7	141,847,238 (GRCm38)	missense	unknown
R5580:Muc5b	UTSW	7	141,861,347 (GRCm38)	missense	possibly damaging	0.53
R5629:Muc5b	UTSW	7	141,861,299 (GRCm38)	missense	possibly damaging	0.73
R5758:Muc5b	UTSW	7	141,858,983 (GRCm38)	missense	unknown
R5783:Muc5b	UTSW	7	141,858,428 (GRCm38)	nonsense	probably null
R5795:Muc5b	UTSW	7	141,871,741 (GRCm38)	missense	possibly damaging	0.96
R5796:Muc5b	UTSW	7	141,857,396 (GRCm38)	missense	unknown
R5797:Muc5b	UTSW	7	141,851,582 (GRCm38)	missense	unknown
R5806:Muc5b	UTSW	7	141,862,835 (GRCm38)	missense	possibly damaging	0.68
R5888:Muc5b	UTSW	7	141,858,421 (GRCm38)	missense	unknown
R5910:Muc5b	UTSW	7	141,861,311 (GRCm38)	missense	possibly damaging	0.53
R5956:Muc5b	UTSW	7	141,864,173 (GRCm38)	missense	probably damaging	0.99
R5970:Muc5b	UTSW	7	141,856,712 (GRCm38)	missense	unknown
R5990:Muc5b	UTSW	7	141,858,161 (GRCm38)	missense	unknown
R5999:Muc5b	UTSW	7	141,857,379 (GRCm38)	missense	unknown
R6001:Muc5b	UTSW	7	141,872,381 (GRCm38)	missense	possibly damaging	0.72
R6053:Muc5b	UTSW	7	141,864,708 (GRCm38)	missense	probably benign	0.07
R6073:Muc5b	UTSW	7	141,858,288 (GRCm38)	missense	unknown
R6073:Muc5b	UTSW	7	141,849,060 (GRCm38)	missense	unknown
R6112:Muc5b	UTSW	7	141,863,305 (GRCm38)	missense	probably benign	0.01
R6153:Muc5b	UTSW	7	141,861,444 (GRCm38)	missense	possibly damaging	0.71
R6164:Muc5b	UTSW	7	141,863,345 (GRCm38)	missense	possibly damaging	0.73
R6172:Muc5b	UTSW	7	141,858,776 (GRCm38)	missense	unknown
R6178:Muc5b	UTSW	7	141,856,342 (GRCm38)	missense	probably null
R6196:Muc5b	UTSW	7	141,851,596 (GRCm38)	missense	unknown
R6213:Muc5b	UTSW	7	141,867,619 (GRCm38)	missense	possibly damaging	0.92
R6213:Muc5b	UTSW	7	141,862,166 (GRCm38)	missense	probably benign	0.00
R6344:Muc5b	UTSW	7	141,862,971 (GRCm38)	missense	possibly damaging	0.62
R6400:Muc5b	UTSW	7	141,858,665 (GRCm38)	missense	unknown
R6414:Muc5b	UTSW	7	141,859,097 (GRCm38)	missense	unknown
R6521:Muc5b	UTSW	7	141,859,171 (GRCm38)	nonsense	probably null
R6658:Muc5b	UTSW	7	141,868,507 (GRCm38)	critical splice donor site	probably null
R6717:Muc5b	UTSW	7	141,857,822 (GRCm38)	nonsense	probably null
R6737:Muc5b	UTSW	7	141,857,499 (GRCm38)	missense	unknown
R6763:Muc5b	UTSW	7	141,862,284 (GRCm38)	missense	probably benign	0.01
R6817:Muc5b	UTSW	7	141,862,913 (GRCm38)	missense	probably benign	0.06
R6819:Muc5b	UTSW	7	141,858,863 (GRCm38)	missense	unknown
R6916:Muc5b	UTSW	7	141,864,717 (GRCm38)	missense	possibly damaging	0.71
R7030:Muc5b	UTSW	7	141,842,455 (GRCm38)	missense	unknown
R7116:Muc5b	UTSW	7	141,863,750 (GRCm38)	missense	probably benign	0.10
R7134:Muc5b	UTSW	7	141,857,654 (GRCm38)	missense	unknown
R7146:Muc5b	UTSW	7	141,863,967 (GRCm38)	missense	possibly damaging	0.96
R7168:Muc5b	UTSW	7	141,864,017 (GRCm38)	missense	probably benign	0.01
R7182:Muc5b	UTSW	7	141,842,645 (GRCm38)	missense	unknown
R7189:Muc5b	UTSW	7	141,861,061 (GRCm38)	nonsense	probably null
R7207:Muc5b	UTSW	7	141,862,865 (GRCm38)	missense	probably benign	0.01
R7232:Muc5b	UTSW	7	141,866,129 (GRCm38)	missense	possibly damaging	0.53
R7260:Muc5b	UTSW	7	141,842,648 (GRCm38)	missense	unknown
R7269:Muc5b	UTSW	7	141,857,535 (GRCm38)	missense	unknown
R7273:Muc5b	UTSW	7	141,851,570 (GRCm38)	missense	unknown
R7278:Muc5b	UTSW	7	141,857,502 (GRCm38)	missense	unknown
R7307:Muc5b	UTSW	7	141,842,294 (GRCm38)	missense	unknown
R7323:Muc5b	UTSW	7	141,858,707 (GRCm38)	missense	unknown
R7374:Muc5b	UTSW	7	141,863,126 (GRCm38)	missense	probably benign	0.10
R7376:Muc5b	UTSW	7	141,872,550 (GRCm38)	missense	possibly damaging	0.53
R7382:Muc5b	UTSW	7	141,858,948 (GRCm38)	missense	unknown
R7481:Muc5b	UTSW	7	141,861,171 (GRCm38)	missense	unknown
R7497:Muc5b	UTSW	7	141,861,513 (GRCm38)	missense	possibly damaging	0.92
R7554:Muc5b	UTSW	7	141,858,776 (GRCm38)	missense	unknown
R7571:Muc5b	UTSW	7	141,847,249 (GRCm38)	missense	unknown
R7598:Muc5b	UTSW	7	141,859,262 (GRCm38)	missense	unknown
R7609:Muc5b	UTSW	7	141,861,729 (GRCm38)	missense	possibly damaging	0.86
R7615:Muc5b	UTSW	7	141,864,892 (GRCm38)	nonsense	probably null
R7618:Muc5b	UTSW	7	141,867,597 (GRCm38)	missense	probably benign	0.01
R7651:Muc5b	UTSW	7	141,864,023 (GRCm38)	missense	possibly damaging	0.75
R7692:Muc5b	UTSW	7	141,853,229 (GRCm38)	missense	unknown
R7731:Muc5b	UTSW	7	141,857,305 (GRCm38)	critical splice acceptor site	probably null
R7746:Muc5b	UTSW	7	141,862,239 (GRCm38)	missense	probably benign	0.10
R7748:Muc5b	UTSW	7	141,847,805 (GRCm38)	missense	unknown
R7774:Muc5b	UTSW	7	141,842,379 (GRCm38)	missense	unknown
R7783:Muc5b	UTSW	7	141,857,341 (GRCm38)	missense	unknown
R7834:Muc5b	UTSW	7	141,859,070 (GRCm38)	missense	unknown
R7872:Muc5b	UTSW	7	141,846,113 (GRCm38)	missense	unknown
R7935:Muc5b	UTSW	7	141,846,832 (GRCm38)	missense	unknown
R8026:Muc5b	UTSW	7	141,863,636 (GRCm38)	missense	probably benign	0.03
R8036:Muc5b	UTSW	7	141,867,741 (GRCm38)	missense	possibly damaging	0.73
R8081:Muc5b	UTSW	7	141,864,006 (GRCm38)	missense	possibly damaging	0.88
R8096:Muc5b	UTSW	7	141,849,555 (GRCm38)	missense	unknown
R8101:Muc5b	UTSW	7	141,865,175 (GRCm38)	missense	possibly damaging	0.53
R8112:Muc5b	UTSW	7	141,862,028 (GRCm38)	missense	possibly damaging	0.53
R8131:Muc5b	UTSW	7	141,842,409 (GRCm38)	missense	unknown
R8170:Muc5b	UTSW	7	141,861,000 (GRCm38)	missense	unknown
R8171:Muc5b	UTSW	7	141,861,000 (GRCm38)	missense	unknown
R8191:Muc5b	UTSW	7	141,867,684 (GRCm38)	missense	probably benign	0.18
R8237:Muc5b	UTSW	7	141,857,960 (GRCm38)	missense	unknown
R8342:Muc5b	UTSW	7	141,860,865 (GRCm38)	missense	unknown
R8343:Muc5b	UTSW	7	141,864,161 (GRCm38)	missense	probably benign	0.28
R8389:Muc5b	UTSW	7	141,861,779 (GRCm38)	missense	possibly damaging	0.53
R8396:Muc5b	UTSW	7	141,851,815 (GRCm38)	missense	unknown
R8733:Muc5b	UTSW	7	141,863,795 (GRCm38)	missense	possibly damaging	0.68
R8774:Muc5b	UTSW	7	141,865,094 (GRCm38)	missense	probably benign	0.18
R8774-TAIL:Muc5b	UTSW	7	141,865,094 (GRCm38)	missense	probably benign	0.18
R8833:Muc5b	UTSW	7	141,858,368 (GRCm38)	missense	unknown
R8884:Muc5b	UTSW	7	141,849,419 (GRCm38)	missense	unknown
R8907:Muc5b	UTSW	7	141,864,138 (GRCm38)	missense	probably benign	0.21
R8944:Muc5b	UTSW	7	141,867,378 (GRCm38)	missense
R9025:Muc5b	UTSW	7	141,872,472 (GRCm38)	missense	probably damaging	0.98
R9044:Muc5b	UTSW	7	141,858,058 (GRCm38)	missense	unknown
R9117:Muc5b	UTSW	7	141,869,333 (GRCm38)	missense	possibly damaging	0.73
R9145:Muc5b	UTSW	7	141,857,613 (GRCm38)	missense	unknown
R9154:Muc5b	UTSW	7	141,864,237 (GRCm38)	missense	probably damaging	0.98
R9177:Muc5b	UTSW	7	141,845,338 (GRCm38)	missense	unknown
R9190:Muc5b	UTSW	7	141,858,202 (GRCm38)	missense	unknown
R9204:Muc5b	UTSW	7	141,856,392 (GRCm38)	missense	unknown
R9260:Muc5b	UTSW	7	141,851,518 (GRCm38)	missense	unknown
R9331:Muc5b	UTSW	7	141,857,738 (GRCm38)	missense	unknown
R9366:Muc5b	UTSW	7	141,863,304 (GRCm38)	missense	probably benign	0.01
R9402:Muc5b	UTSW	7	141,845,414 (GRCm38)	missense	unknown
R9462:Muc5b	UTSW	7	141,861,479 (GRCm38)	missense
R9463:Muc5b	UTSW	7	141,851,766 (GRCm38)	missense	unknown
R9490:Muc5b	UTSW	7	141,871,760 (GRCm38)	missense	probably benign	0.33
R9523:Muc5b	UTSW	7	141,842,379 (GRCm38)	missense	unknown
R9548:Muc5b	UTSW	7	141,867,911 (GRCm38)	missense	possibly damaging	0.52
R9591:Muc5b	UTSW	7	141,858,779 (GRCm38)	missense	unknown
R9602:Muc5b	UTSW	7	141,863,474 (GRCm38)	missense	probably benign	0.11
R9664:Muc5b	UTSW	7	141,855,542 (GRCm38)	missense	unknown
R9703:Muc5b	UTSW	7	141,871,798 (GRCm38)	missense	possibly damaging	0.53
R9713:Muc5b	UTSW	7	141,862,941 (GRCm38)	missense	probably benign	0.01
R9789:Muc5b	UTSW	7	141,861,593 (GRCm38)	missense	possibly damaging	0.95
R9800:Muc5b	UTSW	7	141,861,743 (GRCm38)	missense	possibly damaging	0.53
Z1088:Muc5b	UTSW	7	141,862,214 (GRCm38)	missense	probably benign	0.01
Z1176:Muc5b	UTSW	7	141,842,705 (GRCm38)	missense	unknown
Z1177:Muc5b	UTSW	7	141,863,173 (GRCm38)	missense	probably benign	0.04

Predicted Primers

PCR Primer
(F):5'- AGGAACTGTGCTGGACGATG -3'
(R):5'- TGCTCTTGACCACCAACAGG -3'

Sequencing Primer
(F):5'- ATGTCAGACACTTGGGATGCC -3'
(R):5'- CAGGACCCTAGCAGATGTCTATG -3'

Posted On

2014-07-14