Incidental Mutation 'R1919:Parp4'
| ID |
212882 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Parp4
|
| Ensembl Gene |
ENSMUSG00000054509 |
| Gene Name |
poly (ADP-ribose) polymerase family, member 4 |
| Synonyms |
VPARP, Adprtl1, C030027K23Rik, VAULT3, p193, PH5P, E230037B21Rik |
| MMRRC Submission |
039937-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.151)
|
| Stock # |
R1919 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
14 |
| Chromosomal Location |
56813076-56897251 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 56861474 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 936
(S936P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124258
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000161553]
|
| AlphaFold |
E9PYK3 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000160334
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161382
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000161553
AA Change: S936P
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000124258
Gene: ENSMUSG00000054509
AA Change: S936P
| Domain | Start | End | E-Value | Type |
|---|
|
BRCT
|
3 |
84 |
4.32e-9 |
SMART |
|
low complexity region
|
97 |
104 |
N/A |
INTRINSIC |
|
SCOP:d1a26_1
|
252 |
352 |
2e-19 |
SMART |
|
Pfam:PARP
|
371 |
559 |
1.8e-50 |
PFAM |
|
VIT
|
600 |
728 |
1.5e-57 |
SMART |
|
VWA
|
867 |
1030 |
6.08e-13 |
SMART |
|
Blast:14_3_3
|
1149 |
1205 |
5e-10 |
BLAST |
|
low complexity region
|
1255 |
1264 |
N/A |
INTRINSIC |
|
low complexity region
|
1348 |
1362 |
N/A |
INTRINSIC |
|
low complexity region
|
1371 |
1394 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1395 |
1416 |
4.48e-6 |
PROSPERO |
|
Pfam:Drf_FH1
|
1443 |
1542 |
3.3e-15 |
PFAM |
|
low complexity region
|
1553 |
1587 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1588 |
1608 |
2.45e-5 |
PROSPERO |
|
low complexity region
|
1695 |
1708 |
N/A |
INTRINSIC |
|
low complexity region
|
1739 |
1750 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162231
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.7%
- 20x: 93.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants are helathy and fertile. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
A |
G |
3: 137,773,031 (GRCm39) |
E740G |
probably damaging |
Het |
| 4930474N05Rik |
G |
T |
14: 35,817,414 (GRCm39) |
V105F |
possibly damaging |
Het |
| Actr10 |
A |
G |
12: 70,989,104 (GRCm39) |
I74M |
probably benign |
Het |
| Aen |
T |
C |
7: 78,555,660 (GRCm39) |
Y108H |
probably damaging |
Het |
| Afm |
A |
T |
5: 90,672,779 (GRCm39) |
K205* |
probably null |
Het |
| Ankrd27 |
T |
A |
7: 35,332,410 (GRCm39) |
S846T |
probably benign |
Het |
| Ano3 |
A |
G |
2: 110,715,352 (GRCm39) |
S29P |
probably benign |
Het |
| Apaf1 |
C |
T |
10: 90,913,476 (GRCm39) |
W138* |
probably null |
Het |
| Arfgef1 |
C |
T |
1: 10,270,103 (GRCm39) |
A349T |
probably benign |
Het |
| Arhgef4 |
A |
G |
1: 34,850,221 (GRCm39) |
Q1798R |
probably damaging |
Het |
| Astn1 |
G |
A |
1: 158,337,541 (GRCm39) |
V416I |
probably damaging |
Het |
| Atxn2l |
G |
A |
7: 126,092,340 (GRCm39) |
T70I |
probably damaging |
Het |
| Auh |
G |
A |
13: 52,989,532 (GRCm39) |
P308L |
probably benign |
Het |
| Bltp1 |
A |
G |
3: 37,061,132 (GRCm39) |
|
probably null |
Het |
| Bspry |
T |
A |
4: 62,413,034 (GRCm39) |
C256S |
probably damaging |
Het |
| C3 |
C |
A |
17: 57,527,135 (GRCm39) |
W771C |
probably damaging |
Het |
| Camkv |
A |
G |
9: 107,824,287 (GRCm39) |
D233G |
possibly damaging |
Het |
| Catsperd |
T |
A |
17: 56,942,548 (GRCm39) |
V109E |
probably damaging |
Het |
| Cd101 |
A |
G |
3: 100,926,233 (GRCm39) |
L162P |
probably damaging |
Het |
| Cdr2l |
A |
G |
11: 115,283,603 (GRCm39) |
T154A |
probably damaging |
Het |
| Clca3a2 |
G |
C |
3: 144,516,457 (GRCm39) |
Q380E |
probably benign |
Het |
| Col6a3 |
T |
C |
1: 90,750,081 (GRCm39) |
N251S |
possibly damaging |
Het |
| Cttnbp2nl |
A |
G |
3: 104,918,594 (GRCm39) |
V82A |
possibly damaging |
Het |
| Cux1 |
G |
A |
5: 136,392,173 (GRCm39) |
Q194* |
probably null |
Het |
| Daam2 |
T |
C |
17: 49,792,485 (GRCm39) |
E361G |
probably benign |
Het |
| Dcaf17 |
A |
T |
2: 70,908,516 (GRCm39) |
|
probably null |
Het |
| Dnai1 |
T |
C |
4: 41,570,020 (GRCm39) |
|
probably null |
Het |
| Eml5 |
T |
C |
12: 98,765,098 (GRCm39) |
Y1617C |
probably damaging |
Het |
| Epb41l4b |
T |
C |
4: 57,040,993 (GRCm39) |
E490G |
probably damaging |
Het |
| Epha7 |
T |
C |
4: 28,963,969 (GRCm39) |
M988T |
possibly damaging |
Het |
| Fancm |
T |
C |
12: 65,152,294 (GRCm39) |
C917R |
possibly damaging |
Het |
| Fnip1 |
C |
T |
11: 54,371,510 (GRCm39) |
T177I |
probably damaging |
Het |
| Gm3604 |
G |
T |
13: 62,517,756 (GRCm39) |
H201N |
probably benign |
Het |
| Gnpda1 |
T |
C |
18: 38,466,243 (GRCm39) |
|
probably null |
Het |
| Gpatch8 |
A |
G |
11: 102,398,968 (GRCm39) |
|
probably null |
Het |
| H2-M3 |
T |
C |
17: 37,582,080 (GRCm39) |
Y179H |
possibly damaging |
Het |
| H2-Q10 |
C |
A |
17: 35,781,385 (GRCm39) |
S62R |
probably damaging |
Het |
| Hipk2 |
G |
A |
6: 38,795,919 (GRCm39) |
R117* |
probably null |
Het |
| Hrg |
A |
T |
16: 22,773,207 (GRCm39) |
Q113H |
probably damaging |
Het |
| Kcnj16 |
T |
C |
11: 110,915,779 (GRCm39) |
V147A |
possibly damaging |
Het |
| Kif1a |
T |
C |
1: 92,946,753 (GRCm39) |
I1650V |
possibly damaging |
Het |
| Kmt2a |
C |
T |
9: 44,731,642 (GRCm39) |
|
probably benign |
Het |
| Krt90 |
A |
T |
15: 101,465,665 (GRCm39) |
Y319N |
probably damaging |
Het |
| Lipo4 |
T |
C |
19: 33,476,671 (GRCm39) |
N359S |
possibly damaging |
Het |
| Lrp1b |
G |
T |
2: 41,618,741 (GRCm39) |
T225K |
probably benign |
Het |
| Map1a |
C |
T |
2: 121,137,493 (GRCm39) |
P2532S |
probably damaging |
Het |
| Mmrn2 |
A |
G |
14: 34,119,600 (GRCm39) |
D193G |
probably benign |
Het |
| Mpped2 |
T |
A |
2: 106,697,377 (GRCm39) |
I284N |
probably damaging |
Het |
| Msh6 |
A |
G |
17: 88,292,553 (GRCm39) |
H436R |
probably benign |
Het |
| Mterf3 |
A |
T |
13: 67,078,126 (GRCm39) |
S48T |
probably damaging |
Het |
| Muc5b |
T |
C |
7: 141,399,768 (GRCm39) |
F414L |
unknown |
Het |
| Mylk4 |
A |
T |
13: 32,908,836 (GRCm39) |
D90E |
probably benign |
Het |
| Nherf4 |
T |
C |
9: 44,161,600 (GRCm39) |
D93G |
possibly damaging |
Het |
| Nploc4 |
A |
G |
11: 120,295,055 (GRCm39) |
Y420H |
probably damaging |
Het |
| Npr2 |
T |
A |
4: 43,640,578 (GRCm39) |
Y344N |
probably damaging |
Het |
| Nsun5 |
A |
G |
5: 135,404,452 (GRCm39) |
T397A |
probably benign |
Het |
| Ntsr2 |
A |
T |
12: 16,704,111 (GRCm39) |
Q204L |
probably damaging |
Het |
| Nwd2 |
T |
A |
5: 63,963,523 (GRCm39) |
Y1036N |
probably damaging |
Het |
| Oacyl |
T |
C |
18: 65,843,618 (GRCm39) |
V105A |
possibly damaging |
Het |
| Or6c2 |
T |
A |
10: 129,362,918 (GRCm39) |
V274D |
probably damaging |
Het |
| Parp3 |
T |
A |
9: 106,352,316 (GRCm39) |
Q70L |
possibly damaging |
Het |
| Phkb |
A |
G |
8: 86,648,790 (GRCm39) |
E202G |
probably benign |
Het |
| Pink1 |
T |
C |
4: 138,041,331 (GRCm39) |
N530S |
probably benign |
Het |
| Pou3f2 |
T |
C |
4: 22,487,119 (GRCm39) |
D338G |
probably damaging |
Het |
| Prss8 |
G |
T |
7: 127,529,030 (GRCm39) |
L9I |
probably benign |
Het |
| Ptpn22 |
G |
A |
3: 103,784,054 (GRCm39) |
|
probably null |
Het |
| Rad54b |
A |
C |
4: 11,601,693 (GRCm39) |
N416T |
probably damaging |
Het |
| Rasef |
A |
G |
4: 73,662,351 (GRCm39) |
S200P |
possibly damaging |
Het |
| Rb1 |
T |
A |
14: 73,450,430 (GRCm39) |
K645* |
probably null |
Het |
| Robo2 |
C |
T |
16: 73,696,042 (GRCm39) |
G1367D |
probably benign |
Het |
| Rp1 |
A |
G |
1: 4,422,894 (GRCm39) |
V52A |
probably damaging |
Het |
| Samd13 |
T |
C |
3: 146,368,467 (GRCm39) |
T23A |
probably benign |
Het |
| Scn7a |
T |
C |
2: 66,530,317 (GRCm39) |
H676R |
probably damaging |
Het |
| Serpinb6b |
A |
G |
13: 33,162,223 (GRCm39) |
I222V |
probably benign |
Het |
| Slc2a8 |
T |
C |
2: 32,870,091 (GRCm39) |
Y150C |
probably damaging |
Het |
| Slc7a6os |
C |
A |
8: 106,937,196 (GRCm39) |
R88L |
probably damaging |
Het |
| Slc8a2 |
A |
G |
7: 15,886,845 (GRCm39) |
I657V |
probably benign |
Het |
| Slit2 |
C |
A |
5: 48,348,358 (GRCm39) |
|
probably benign |
Het |
| Spire2 |
A |
G |
8: 124,089,810 (GRCm39) |
D447G |
probably benign |
Het |
| Sptlc3 |
A |
G |
2: 139,408,595 (GRCm39) |
N237D |
possibly damaging |
Het |
| Stk3 |
G |
A |
15: 35,073,363 (GRCm39) |
T119I |
probably damaging |
Het |
| Suv39h2 |
G |
A |
2: 3,465,353 (GRCm39) |
T334I |
probably damaging |
Het |
| Syt5 |
G |
T |
7: 4,543,278 (GRCm39) |
T327N |
probably damaging |
Het |
| Tcof1 |
T |
C |
18: 60,949,156 (GRCm39) |
D1253G |
possibly damaging |
Het |
| Timd5 |
A |
G |
11: 46,419,358 (GRCm39) |
D58G |
possibly damaging |
Het |
| Tnks |
A |
T |
8: 35,342,386 (GRCm39) |
V388D |
probably damaging |
Het |
| Ugt2b1 |
T |
C |
5: 87,073,859 (GRCm39) |
T167A |
probably benign |
Het |
| Usp40 |
G |
A |
1: 87,923,564 (GRCm39) |
R236C |
possibly damaging |
Het |
| Utrn |
T |
C |
10: 12,331,224 (GRCm39) |
D2904G |
probably benign |
Het |
| Vmn1r226 |
T |
C |
17: 20,907,842 (GRCm39) |
S25P |
probably damaging |
Het |
| Vmn2r23 |
T |
C |
6: 123,689,969 (GRCm39) |
S282P |
possibly damaging |
Het |
| Vps45 |
T |
C |
3: 95,953,752 (GRCm39) |
E200G |
probably benign |
Het |
| Wnt7b |
T |
A |
15: 85,443,281 (GRCm39) |
I41F |
probably damaging |
Het |
| Zmym6 |
T |
A |
4: 126,997,207 (GRCm39) |
N275K |
probably damaging |
Het |
|
| Other mutations in Parp4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00479:Parp4
|
APN |
14 |
56,853,917 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL00571:Parp4
|
APN |
14 |
56,884,810 (GRCm39) |
missense |
unknown |
|
|
IGL00737:Parp4
|
APN |
14 |
56,821,620 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00793:Parp4
|
APN |
14 |
56,840,334 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL01108:Parp4
|
APN |
14 |
56,844,897 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01131:Parp4
|
APN |
14 |
56,823,217 (GRCm39) |
splice site |
probably benign |
|
|
IGL01485:Parp4
|
APN |
14 |
56,859,661 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL01704:Parp4
|
APN |
14 |
56,839,783 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01993:Parp4
|
APN |
14 |
56,848,245 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02125:Parp4
|
APN |
14 |
56,827,959 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL02851:Parp4
|
APN |
14 |
56,886,326 (GRCm39) |
missense |
unknown |
|
|
IGL02863:Parp4
|
APN |
14 |
56,886,243 (GRCm39) |
missense |
unknown |
|
|
IGL03065:Parp4
|
APN |
14 |
56,875,326 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03117:Parp4
|
APN |
14 |
56,840,313 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL03271:Parp4
|
APN |
14 |
56,823,082 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03309:Parp4
|
APN |
14 |
56,825,265 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03408:Parp4
|
APN |
14 |
56,839,865 (GRCm39) |
missense |
probably damaging |
0.99 |
|
poisonous
|
UTSW |
14 |
56,873,205 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0515_Parp4_195
|
UTSW |
14 |
56,851,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
toxic
|
UTSW |
14 |
56,866,615 (GRCm39) |
missense |
probably benign |
0.28 |
|
venomous
|
UTSW |
14 |
56,827,355 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
virulent
|
UTSW |
14 |
56,825,235 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0278:Parp4
|
UTSW |
14 |
56,844,980 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0320:Parp4
|
UTSW |
14 |
56,825,953 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0445:Parp4
|
UTSW |
14 |
56,840,205 (GRCm39) |
splice site |
probably null |
|
|
R0452:Parp4
|
UTSW |
14 |
56,886,300 (GRCm39) |
missense |
unknown |
|
|
R0511:Parp4
|
UTSW |
14 |
56,873,172 (GRCm39) |
splice site |
probably benign |
|
|
R0515:Parp4
|
UTSW |
14 |
56,851,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0608:Parp4
|
UTSW |
14 |
56,839,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0800:Parp4
|
UTSW |
14 |
56,827,408 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0959:Parp4
|
UTSW |
14 |
56,885,576 (GRCm39) |
missense |
unknown |
|
|
R1207:Parp4
|
UTSW |
14 |
56,885,339 (GRCm39) |
missense |
unknown |
|
|
R1207:Parp4
|
UTSW |
14 |
56,885,339 (GRCm39) |
missense |
unknown |
|
|
R1342:Parp4
|
UTSW |
14 |
56,827,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1520:Parp4
|
UTSW |
14 |
56,835,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1565:Parp4
|
UTSW |
14 |
56,827,329 (GRCm39) |
splice site |
probably benign |
|
|
R1574:Parp4
|
UTSW |
14 |
56,839,752 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1574:Parp4
|
UTSW |
14 |
56,839,752 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1649:Parp4
|
UTSW |
14 |
56,827,885 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1666:Parp4
|
UTSW |
14 |
56,861,620 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1781:Parp4
|
UTSW |
14 |
56,864,838 (GRCm39) |
splice site |
probably null |
|
|
R1799:Parp4
|
UTSW |
14 |
56,885,589 (GRCm39) |
missense |
unknown |
|
|
R1823:Parp4
|
UTSW |
14 |
56,827,329 (GRCm39) |
splice site |
probably benign |
|
|
R1859:Parp4
|
UTSW |
14 |
56,886,372 (GRCm39) |
missense |
unknown |
|
|
R2000:Parp4
|
UTSW |
14 |
56,851,181 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2032:Parp4
|
UTSW |
14 |
56,866,553 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R2034:Parp4
|
UTSW |
14 |
56,871,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2177:Parp4
|
UTSW |
14 |
56,896,746 (GRCm39) |
missense |
unknown |
|
|
R2291:Parp4
|
UTSW |
14 |
56,851,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2865:Parp4
|
UTSW |
14 |
56,851,181 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3012:Parp4
|
UTSW |
14 |
56,832,873 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3841:Parp4
|
UTSW |
14 |
56,825,235 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3913:Parp4
|
UTSW |
14 |
56,857,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4064:Parp4
|
UTSW |
14 |
56,861,597 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4201:Parp4
|
UTSW |
14 |
56,829,848 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4288:Parp4
|
UTSW |
14 |
56,844,951 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4360:Parp4
|
UTSW |
14 |
56,866,661 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4506:Parp4
|
UTSW |
14 |
56,889,761 (GRCm39) |
missense |
unknown |
|
|
R4577:Parp4
|
UTSW |
14 |
56,827,867 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4633:Parp4
|
UTSW |
14 |
56,885,048 (GRCm39) |
missense |
unknown |
|
|
R4762:Parp4
|
UTSW |
14 |
56,848,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4836:Parp4
|
UTSW |
14 |
56,823,195 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4974:Parp4
|
UTSW |
14 |
56,827,355 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5049:Parp4
|
UTSW |
14 |
56,873,188 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5479:Parp4
|
UTSW |
14 |
56,861,552 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5683:Parp4
|
UTSW |
14 |
56,884,886 (GRCm39) |
nonsense |
probably null |
|
|
R5884:Parp4
|
UTSW |
14 |
56,852,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5965:Parp4
|
UTSW |
14 |
56,861,489 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6001:Parp4
|
UTSW |
14 |
56,878,740 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6027:Parp4
|
UTSW |
14 |
56,866,615 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6230:Parp4
|
UTSW |
14 |
56,844,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6242:Parp4
|
UTSW |
14 |
56,832,856 (GRCm39) |
nonsense |
probably null |
|
|
R6355:Parp4
|
UTSW |
14 |
56,839,757 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R6414:Parp4
|
UTSW |
14 |
56,864,838 (GRCm39) |
splice site |
probably null |
|
|
R6418:Parp4
|
UTSW |
14 |
56,858,108 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6477:Parp4
|
UTSW |
14 |
56,884,694 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6542:Parp4
|
UTSW |
14 |
56,885,339 (GRCm39) |
missense |
unknown |
|
|
R6759:Parp4
|
UTSW |
14 |
56,857,947 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6995:Parp4
|
UTSW |
14 |
56,851,196 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7002:Parp4
|
UTSW |
14 |
56,839,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7026:Parp4
|
UTSW |
14 |
56,858,049 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7062:Parp4
|
UTSW |
14 |
56,852,216 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7101:Parp4
|
UTSW |
14 |
56,827,430 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7124:Parp4
|
UTSW |
14 |
56,840,256 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7162:Parp4
|
UTSW |
14 |
56,886,333 (GRCm39) |
missense |
unknown |
|
|
R7293:Parp4
|
UTSW |
14 |
56,885,303 (GRCm39) |
small deletion |
probably benign |
|
|
R7297:Parp4
|
UTSW |
14 |
56,885,138 (GRCm39) |
missense |
not run |
|
|
R7337:Parp4
|
UTSW |
14 |
56,839,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7539:Parp4
|
UTSW |
14 |
56,873,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7575:Parp4
|
UTSW |
14 |
56,875,375 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7808:Parp4
|
UTSW |
14 |
56,873,205 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7854:Parp4
|
UTSW |
14 |
56,896,805 (GRCm39) |
missense |
unknown |
|
|
R7960:Parp4
|
UTSW |
14 |
56,832,708 (GRCm39) |
splice site |
probably null |
|
|
R8152:Parp4
|
UTSW |
14 |
56,884,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8344:Parp4
|
UTSW |
14 |
56,886,186 (GRCm39) |
missense |
unknown |
|
|
R8416:Parp4
|
UTSW |
14 |
56,825,271 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8726:Parp4
|
UTSW |
14 |
56,866,556 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8752:Parp4
|
UTSW |
14 |
56,886,073 (GRCm39) |
missense |
unknown |
|
|
R8804:Parp4
|
UTSW |
14 |
56,853,900 (GRCm39) |
nonsense |
probably null |
|
|
R9046:Parp4
|
UTSW |
14 |
56,864,927 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9176:Parp4
|
UTSW |
14 |
56,873,274 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R9303:Parp4
|
UTSW |
14 |
56,852,224 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9303:Parp4
|
UTSW |
14 |
56,832,790 (GRCm39) |
frame shift |
probably null |
|
|
R9305:Parp4
|
UTSW |
14 |
56,852,224 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9305:Parp4
|
UTSW |
14 |
56,832,790 (GRCm39) |
frame shift |
probably null |
|
|
R9360:Parp4
|
UTSW |
14 |
56,878,775 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9430:Parp4
|
UTSW |
14 |
56,866,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9491:Parp4
|
UTSW |
14 |
56,832,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9729:Parp4
|
UTSW |
14 |
56,885,888 (GRCm39) |
missense |
unknown |
|
|
RF020:Parp4
|
UTSW |
14 |
56,884,806 (GRCm39) |
missense |
unknown |
|
|
Z1177:Parp4
|
UTSW |
14 |
56,829,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTTTGGGCATTTGTCAGACC -3'
(R):5'- ACAATGGTGACCCGATCTCTG -3'
Sequencing Primer
(F):5'- GGGCATTTGTCAGACCAGATCTAC -3'
(R):5'- ATGGTGACCCGATCTCTGAAACTTAC -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation