Mutagenetix > Incidental Mutation

Incidental Mutation 'R1920:Vmn2r61'

212946

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r61

Ensembl Gene

ENSMUSG00000090967

Gene Name

vomeronasal 2, receptor 61

Synonyms

Gprc2a-rs2, Casr-rs2, EG637873

MMRRC Submission

039938-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.101) question?

Stock #

R1920 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

41909477-41950179 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 41949710 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 710 (I710T)

Ref Sequence

ENSEMBL: ENSMUSP00000129576 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166131]

AlphaFold

L7N2B8

Predicted Effect

possibly damaging
Transcript: ENSMUST00000166131
AA Change: I710T

PolyPhen 2 Score 0.728 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000129576
Gene: ENSMUSG00000090967
AA Change: I710T

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	471	4e-42	PFAM
Pfam:NCD3G	514	567	1.9e-21	PFAM
Pfam:7tm_3	600	835	6.2e-52	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000173044

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 97.5%
3x: 97.0%
10x: 95.7%
20x: 93.4%

Validation Efficiency

98% (101/103)

Allele List at MGI

Other mutations in this stock

Total: 98 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700056E22Rik	A	G	1: 183,765,828 (GRCm39)	V77A	probably benign	Het
Actl7a	G	A	4: 56,744,135 (GRCm39)	V221M	probably damaging	Het
Alkbh2	C	T	5: 114,262,287 (GRCm39)	E148K	probably damaging	Het
Arhgef10	C	T	8: 15,006,987 (GRCm39)		probably benign	Het
Asgr2	T	C	11: 69,989,123 (GRCm39)	L86P	possibly damaging	Het
Atp12a	A	G	14: 56,624,308 (GRCm39)	R919G	probably benign	Het
Atrn	A	G	2: 130,836,971 (GRCm39)	Y1145C	probably damaging	Het
B3gnt5	T	G	16: 19,588,294 (GRCm39)	L171R	probably benign	Het
Bbof1	T	A	12: 84,457,859 (GRCm39)	N41K	possibly damaging	Het
Bdp1	A	T	13: 100,235,097 (GRCm39)	W166R	probably benign	Het
Bean1	A	T	8: 104,937,742 (GRCm39)	H107L	possibly damaging	Het
Brd4	T	C	17: 32,417,060 (GRCm39)		probably benign	Het
Cadps	T	C	14: 12,465,859 (GRCm38)	K1017R	possibly damaging	Het
Cep78	G	A	19: 15,951,715 (GRCm39)		probably benign	Het
Cfap70	C	T	14: 20,445,020 (GRCm39)	A1087T	probably damaging	Het
Cideb	A	G	14: 55,992,700 (GRCm39)	V72A	probably benign	Het
Cpz	T	C	5: 35,675,012 (GRCm39)	E79G	probably damaging	Het
Crybg1	A	G	10: 43,873,544 (GRCm39)	L1188P	probably damaging	Het
Cuzd1	G	A	7: 130,911,425 (GRCm39)	P518L	probably benign	Het
Cyp2j5	A	T	4: 96,551,491 (GRCm39)	N77K	probably damaging	Het
Cyp4f39	T	G	17: 32,702,265 (GRCm39)	F254C	probably benign	Het
Dkk1	C	A	19: 30,524,731 (GRCm39)	V225L	probably damaging	Het
Dlg5	T	C	14: 24,226,639 (GRCm39)	Y421C	probably damaging	Het
Dll3	T	C	7: 27,998,348 (GRCm39)	T206A	probably benign	Het
Dnhd1	T	C	7: 105,362,614 (GRCm39)	C3766R	probably benign	Het
Dock9	G	T	14: 121,820,792 (GRCm39)	S1534Y	probably damaging	Het
Dst	T	C	1: 34,200,110 (GRCm39)	V96A	probably damaging	Het
F2r	A	G	13: 95,740,698 (GRCm39)	F279S	probably damaging	Het
Farp1	C	A	14: 121,492,908 (GRCm39)	N503K	probably benign	Het
Fbxw2	G	A	2: 34,712,776 (GRCm39)	T95I	probably damaging	Het
Fis1	A	G	5: 136,994,461 (GRCm39)	T50A	probably benign	Het
Frzb	T	G	2: 80,276,772 (GRCm39)	E138A	probably damaging	Het
Fsip2	A	T	2: 82,817,164 (GRCm39)	D4299V	probably benign	Het
Fyco1	C	T	9: 123,659,478 (GRCm39)	D233N	probably damaging	Het
Gmpr	A	G	13: 45,667,997 (GRCm39)		probably benign	Het
Hc	C	T	2: 34,919,407 (GRCm39)		probably benign	Het
Hnrnpa1	T	C	15: 103,150,699 (GRCm39)	M186T	possibly damaging	Het
Kl	A	G	5: 150,906,132 (GRCm39)	K501E	probably benign	Het
Klhl42	A	G	6: 147,009,427 (GRCm39)	N422S	probably damaging	Het
Kmt2d	C	G	15: 98,753,471 (GRCm39)	K127N	probably damaging	Het
Kmt2d	T	A	15: 98,753,472 (GRCm39)	K127M	probably damaging	Het
Krt39	T	A	11: 99,405,461 (GRCm39)	T480S	probably benign	Het
Lims2	T	A	18: 32,088,395 (GRCm39)	C198*	probably null	Het
Mctp1	A	G	13: 76,532,729 (GRCm39)	N26D	possibly damaging	Het
Mdm4	A	G	1: 132,931,538 (GRCm39)	S168P	probably benign	Het
Myo3a	A	G	2: 22,455,008 (GRCm39)	Y71C	probably benign	Het
Nlrp9c	T	A	7: 26,084,319 (GRCm39)	D420V	probably damaging	Het
Ntf3	A	T	6: 126,079,485 (GRCm39)	I7N	possibly damaging	Het
Or10ag52	G	A	2: 87,043,721 (GRCm39)	G162S	probably benign	Het
Or13c25	G	T	4: 52,910,849 (GRCm39)	T315K	probably benign	Het
Or4c119	A	G	2: 88,986,925 (GRCm39)	V198A	probably benign	Het
Or8b38	T	C	9: 37,972,981 (GRCm39)	Y122H	probably damaging	Het
Papln	C	A	12: 83,836,028 (GRCm39)	Y1222*	probably null	Het
Pgm3	T	G	9: 86,440,531 (GRCm39)	I387L	possibly damaging	Het
Pira12	G	C	7: 3,900,871 (GRCm39)	P20R	probably damaging	Het
Pkd1	C	A	17: 24,814,131 (GRCm39)	P4167Q	probably damaging	Het
Plcb4	T	A	2: 135,854,947 (GRCm39)	V1174E	probably damaging	Het
Polr1b	A	G	2: 128,943,031 (GRCm39)	N9D	probably benign	Het
Prkaa2	G	A	4: 104,893,950 (GRCm39)	Q456*	probably null	Het
Ptch2	G	T	4: 116,965,858 (GRCm39)	V425L	probably benign	Het
Ptprh	A	T	7: 4,552,394 (GRCm39)	S957T	probably benign	Het
Riok1	A	G	13: 38,241,177 (GRCm39)	D444G	probably benign	Het
Rrbp1	A	T	2: 143,830,211 (GRCm39)	V652E	probably benign	Het
Rrp36	C	T	17: 46,983,671 (GRCm39)	R47Q	possibly damaging	Het
Sec24c	T	C	14: 20,736,955 (GRCm39)	S304P	probably damaging	Het
Serpinb6b	A	T	13: 33,158,991 (GRCm39)	D64V	possibly damaging	Het
Serpinb9b	A	T	13: 33,223,531 (GRCm39)		probably null	Het
Six6	T	A	12: 72,988,538 (GRCm39)	I237N	probably damaging	Het
Slc25a36	A	T	9: 96,975,135 (GRCm39)	M127K	probably benign	Het
Slc2a10	A	G	2: 165,356,550 (GRCm39)	D70G	probably damaging	Het
Slc2a3	T	A	6: 122,713,700 (GRCm39)	I171F	probably damaging	Het
Smc4	A	G	3: 68,940,401 (GRCm39)	T1087A	probably damaging	Het
Spg21	A	G	9: 65,391,779 (GRCm39)	Y242C	probably damaging	Het
St14	A	G	9: 31,001,166 (GRCm39)	V855A	possibly damaging	Het
Stx2	G	A	5: 129,065,903 (GRCm39)	T251M	probably damaging	Het
Svs3b	A	T	2: 164,097,848 (GRCm39)	S158T	probably benign	Het
Synpo	C	T	18: 60,736,661 (GRCm39)	M428I	probably benign	Het
Tasor2	A	T	13: 3,626,612 (GRCm39)	Y1113N	possibly damaging	Het
Tbc1d31	G	A	15: 57,775,760 (GRCm39)	R17H	probably damaging	Het
Tbl3	G	A	17: 24,923,477 (GRCm39)	T284I	probably benign	Het
Tcof1	T	C	18: 60,971,927 (GRCm39)	T127A	possibly damaging	Het
Tgoln1	T	C	6: 72,593,084 (GRCm39)	E132G	probably benign	Het
Timeless	T	C	10: 128,077,583 (GRCm39)	I221T	probably damaging	Het
Tmem176b	C	T	6: 48,815,138 (GRCm39)	A52T	possibly damaging	Het
Tmem192	C	T	8: 65,418,235 (GRCm39)	L207F	probably damaging	Het
Trank1	T	C	9: 111,176,996 (GRCm39)		probably null	Het
Ttc7b	C	T	12: 100,381,389 (GRCm39)		probably null	Het
Tubb5	T	C	17: 36,146,190 (GRCm39)	Y340C	probably benign	Het
Ubr1	G	A	2: 120,761,449 (GRCm39)	T576I	probably benign	Het
Vcan	T	C	13: 89,841,134 (GRCm39)	E1470G	probably damaging	Het
Vmn1r200	T	A	13: 22,579,663 (GRCm39)	N146K	probably damaging	Het
Vmn2r120	T	A	17: 57,831,839 (GRCm39)	I317F	probably benign	Het
Wipf1	T	A	2: 73,270,499 (GRCm39)	K61N	probably benign	Het
Zfp112	T	C	7: 23,824,662 (GRCm39)	V210A	probably benign	Het
Zfp612	G	A	8: 110,815,095 (GRCm39)	V101M	probably benign	Het
Zfp637	A	G	6: 117,822,681 (GRCm39)	R270G	probably damaging	Het
Zfp652	A	G	11: 95,654,851 (GRCm39)	E418G	possibly damaging	Het
Zfp97	A	G	17: 17,365,265 (GRCm39)	I255V	probably benign	Het

Other mutations in Vmn2r61

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00158:Vmn2r61	APN	7	41,950,175 (GRCm39)	missense	possibly damaging	0.96
IGL00824:Vmn2r61	APN	7	41,916,438 (GRCm39)	missense	probably benign	0.03
IGL00903:Vmn2r61	APN	7	41,949,935 (GRCm39)	missense	probably damaging	1.00
IGL01125:Vmn2r61	APN	7	41,909,550 (GRCm39)	missense	probably damaging	1.00
IGL01393:Vmn2r61	APN	7	41,916,258 (GRCm39)	missense	probably benign	0.08
IGL01712:Vmn2r61	APN	7	41,909,661 (GRCm39)	missense	probably damaging	0.98
IGL01822:Vmn2r61	APN	7	41,950,130 (GRCm39)	missense	probably benign	0.18
IGL01835:Vmn2r61	APN	7	41,950,015 (GRCm39)	missense	probably benign	0.12
IGL01844:Vmn2r61	APN	7	41,909,639 (GRCm39)	missense	probably benign	0.00
IGL01953:Vmn2r61	APN	7	41,949,613 (GRCm39)	missense	probably damaging	1.00
IGL02032:Vmn2r61	APN	7	41,949,466 (GRCm39)	missense	probably damaging	0.99
IGL02054:Vmn2r61	APN	7	41,926,158 (GRCm39)	critical splice donor site	probably null
IGL02569:Vmn2r61	APN	7	41,926,070 (GRCm39)	missense	probably damaging	1.00
IGL02697:Vmn2r61	APN	7	41,924,892 (GRCm39)	missense	possibly damaging	0.55
IGL02958:Vmn2r61	APN	7	41,949,361 (GRCm39)	missense	probably benign
IGL03290:Vmn2r61	APN	7	41,915,408 (GRCm39)	missense	probably benign	0.00
IGL03337:Vmn2r61	APN	7	41,916,509 (GRCm39)	missense	possibly damaging	0.58
IGL03369:Vmn2r61	APN	7	41,909,517 (GRCm39)	missense	probably benign
IGL03402:Vmn2r61	APN	7	41,909,679 (GRCm39)	missense	probably benign
R0026:Vmn2r61	UTSW	7	41,924,898 (GRCm39)	missense	possibly damaging	0.64
R0319:Vmn2r61	UTSW	7	41,949,941 (GRCm39)	missense	probably damaging	0.99
R0433:Vmn2r61	UTSW	7	41,915,335 (GRCm39)	missense	probably benign	0.02
R0555:Vmn2r61	UTSW	7	41,915,442 (GRCm39)	missense	probably benign	0.02
R0691:Vmn2r61	UTSW	7	41,949,844 (GRCm39)	missense	probably damaging	1.00
R1701:Vmn2r61	UTSW	7	41,949,935 (GRCm39)	missense	probably damaging	1.00
R1718:Vmn2r61	UTSW	7	41,950,121 (GRCm39)	missense	probably benign
R1835:Vmn2r61	UTSW	7	41,916,076 (GRCm39)	nonsense	probably null
R2069:Vmn2r61	UTSW	7	41,949,425 (GRCm39)	missense	probably benign	0.06
R2326:Vmn2r61	UTSW	7	41,916,287 (GRCm39)	missense	probably damaging	1.00
R2402:Vmn2r61	UTSW	7	41,949,529 (GRCm39)	missense	possibly damaging	0.90
R3103:Vmn2r61	UTSW	7	41,916,067 (GRCm39)	missense	possibly damaging	0.73
R3107:Vmn2r61	UTSW	7	41,916,491 (GRCm39)	missense	possibly damaging	0.82
R4426:Vmn2r61	UTSW	7	41,950,159 (GRCm39)	missense	probably benign
R4426:Vmn2r61	UTSW	7	41,950,157 (GRCm39)	missense	probably benign
R4484:Vmn2r61	UTSW	7	41,950,120 (GRCm39)	missense	probably benign
R4748:Vmn2r61	UTSW	7	41,916,565 (GRCm39)	missense	probably damaging	0.96
R4835:Vmn2r61	UTSW	7	41,916,459 (GRCm39)	missense	possibly damaging	0.52
R4863:Vmn2r61	UTSW	7	41,950,132 (GRCm39)	missense	probably benign	0.03
R4923:Vmn2r61	UTSW	7	41,916,520 (GRCm39)	missense	probably damaging	1.00
R4968:Vmn2r61	UTSW	7	41,949,478 (GRCm39)	missense	probably benign	0.14
R5114:Vmn2r61	UTSW	7	41,949,953 (GRCm39)	missense	possibly damaging	0.92
R5297:Vmn2r61	UTSW	7	41,909,646 (GRCm39)	missense	probably benign
R5497:Vmn2r61	UTSW	7	41,924,906 (GRCm39)	missense	possibly damaging	0.95
R5508:Vmn2r61	UTSW	7	41,916,242 (GRCm39)	missense	possibly damaging	0.52
R5587:Vmn2r61	UTSW	7	41,949,911 (GRCm39)	missense	probably damaging	1.00
R5615:Vmn2r61	UTSW	7	41,949,917 (GRCm39)	missense	probably damaging	1.00
R5615:Vmn2r61	UTSW	7	41,916,677 (GRCm39)	missense	probably benign	0.00
R5782:Vmn2r61	UTSW	7	41,949,253 (GRCm39)	missense	probably damaging	1.00
R6136:Vmn2r61	UTSW	7	41,916,455 (GRCm39)	missense	probably damaging	1.00
R6207:Vmn2r61	UTSW	7	41,909,616 (GRCm39)	missense	probably benign	0.01
R6265:Vmn2r61	UTSW	7	41,915,915 (GRCm39)	missense	probably benign	0.01
R6272:Vmn2r61	UTSW	7	41,949,242 (GRCm39)	missense	probably damaging	1.00
R6355:Vmn2r61	UTSW	7	41,916,659 (GRCm39)	missense	probably benign	0.00
R6469:Vmn2r61	UTSW	7	41,915,283 (GRCm39)	nonsense	probably null
R6554:Vmn2r61	UTSW	7	41,926,139 (GRCm39)	missense	probably damaging	1.00
R6699:Vmn2r61	UTSW	7	41,949,580 (GRCm39)	missense	probably benign
R6768:Vmn2r61	UTSW	7	41,949,748 (GRCm39)	missense	probably damaging	1.00
R6824:Vmn2r61	UTSW	7	41,949,403 (GRCm39)	missense	probably benign	0.10
R6930:Vmn2r61	UTSW	7	41,949,364 (GRCm39)	missense	probably benign	0.02
R7053:Vmn2r61	UTSW	7	41,916,557 (GRCm39)	missense	probably damaging	0.96
R7238:Vmn2r61	UTSW	7	41,916,629 (GRCm39)	missense	possibly damaging	0.73
R7332:Vmn2r61	UTSW	7	41,909,534 (GRCm39)	missense	probably benign	0.00
R7359:Vmn2r61	UTSW	7	41,915,407 (GRCm39)	missense	probably benign	0.11
R7553:Vmn2r61	UTSW	7	41,916,205 (GRCm39)	missense	not run
R7710:Vmn2r61	UTSW	7	41,916,472 (GRCm39)	missense	probably damaging	1.00
R7732:Vmn2r61	UTSW	7	41,916,097 (GRCm39)	missense	probably benign
R7839:Vmn2r61	UTSW	7	41,916,032 (GRCm39)	missense	probably damaging	0.97
R7916:Vmn2r61	UTSW	7	41,949,935 (GRCm39)	missense	probably damaging	1.00
R8026:Vmn2r61	UTSW	7	41,916,141 (GRCm39)	missense	probably benign	0.02
R8440:Vmn2r61	UTSW	7	41,916,080 (GRCm39)	missense	probably benign	0.02
R8499:Vmn2r61	UTSW	7	41,949,700 (GRCm39)	missense	probably damaging	0.99
R8771:Vmn2r61	UTSW	7	41,916,194 (GRCm39)	missense	probably damaging	0.99
R8847:Vmn2r61	UTSW	7	41,950,010 (GRCm39)	missense	probably damaging	1.00
R8986:Vmn2r61	UTSW	7	41,915,325 (GRCm39)	nonsense	probably null
R9290:Vmn2r61	UTSW	7	41,915,385 (GRCm39)	missense	probably benign	0.27
R9311:Vmn2r61	UTSW	7	41,950,092 (GRCm39)	missense	possibly damaging	0.92
R9324:Vmn2r61	UTSW	7	41,916,619 (GRCm39)	missense	probably benign	0.00
R9476:Vmn2r61	UTSW	7	41,949,593 (GRCm39)	missense	probably damaging	1.00
R9521:Vmn2r61	UTSW	7	41,916,626 (GRCm39)	missense	probably damaging	0.99
R9619:Vmn2r61	UTSW	7	41,926,136 (GRCm39)	missense	probably damaging	0.98
R9729:Vmn2r61	UTSW	7	41,949,917 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn2r61	UTSW	7	41,949,388 (GRCm39)	missense	possibly damaging	0.93
Z1176:Vmn2r61	UTSW	7	41,916,166 (GRCm39)	missense	probably benign	0.00
Z1176:Vmn2r61	UTSW	7	41,909,585 (GRCm39)	missense	possibly damaging	0.46

Predicted Primers

PCR Primer
(F):5'- TCAGCTACATCCTGCTATTGACAC -3'
(R):5'- ATGGTGTAGCTCCCAAGTGC -3'

Sequencing Primer
(F):5'- GCTGTTTGTTGGCCAGCCC -3'
(R):5'- TGTAGCTCCCAAGTGCTAAGG -3'

Posted On

2014-07-14