Incidental Mutation 'R1920:Serpinb9b'
ID 212976
Institutional Source Beutler Lab
Gene Symbol Serpinb9b
Ensembl Gene ENSMUSG00000021403
Gene Name serine (or cysteine) peptidase inhibitor, clade B, member 9b
Synonyms R86, ovalbumin, Spi10, 1600019A21Rik, SPI-CI
MMRRC Submission 039938-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1920 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 33211397-33224571 bp(+) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) A to T at 33223531 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000006392 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006392]
AlphaFold Q9DAV6
Predicted Effect probably null
Transcript: ENSMUST00000006392
SMART Domains Protein: ENSMUSP00000006392
Gene: ENSMUSG00000021403

DomainStartEndE-ValueType
SERPIN 13 377 7.86e-164 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220566
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221946
Meta Mutation Damage Score 0.9485 question?
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 97.0%
  • 10x: 95.7%
  • 20x: 93.4%
Validation Efficiency 98% (101/103)
Allele List at MGI
Other mutations in this stock
Total: 98 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700056E22Rik A G 1: 183,765,828 (GRCm39) V77A probably benign Het
Actl7a G A 4: 56,744,135 (GRCm39) V221M probably damaging Het
Alkbh2 C T 5: 114,262,287 (GRCm39) E148K probably damaging Het
Arhgef10 C T 8: 15,006,987 (GRCm39) probably benign Het
Asgr2 T C 11: 69,989,123 (GRCm39) L86P possibly damaging Het
Atp12a A G 14: 56,624,308 (GRCm39) R919G probably benign Het
Atrn A G 2: 130,836,971 (GRCm39) Y1145C probably damaging Het
B3gnt5 T G 16: 19,588,294 (GRCm39) L171R probably benign Het
Bbof1 T A 12: 84,457,859 (GRCm39) N41K possibly damaging Het
Bdp1 A T 13: 100,235,097 (GRCm39) W166R probably benign Het
Bean1 A T 8: 104,937,742 (GRCm39) H107L possibly damaging Het
Brd4 T C 17: 32,417,060 (GRCm39) probably benign Het
Cadps T C 14: 12,465,859 (GRCm38) K1017R possibly damaging Het
Cep78 G A 19: 15,951,715 (GRCm39) probably benign Het
Cfap70 C T 14: 20,445,020 (GRCm39) A1087T probably damaging Het
Cideb A G 14: 55,992,700 (GRCm39) V72A probably benign Het
Cpz T C 5: 35,675,012 (GRCm39) E79G probably damaging Het
Crybg1 A G 10: 43,873,544 (GRCm39) L1188P probably damaging Het
Cuzd1 G A 7: 130,911,425 (GRCm39) P518L probably benign Het
Cyp2j5 A T 4: 96,551,491 (GRCm39) N77K probably damaging Het
Cyp4f39 T G 17: 32,702,265 (GRCm39) F254C probably benign Het
Dkk1 C A 19: 30,524,731 (GRCm39) V225L probably damaging Het
Dlg5 T C 14: 24,226,639 (GRCm39) Y421C probably damaging Het
Dll3 T C 7: 27,998,348 (GRCm39) T206A probably benign Het
Dnhd1 T C 7: 105,362,614 (GRCm39) C3766R probably benign Het
Dock9 G T 14: 121,820,792 (GRCm39) S1534Y probably damaging Het
Dst T C 1: 34,200,110 (GRCm39) V96A probably damaging Het
F2r A G 13: 95,740,698 (GRCm39) F279S probably damaging Het
Farp1 C A 14: 121,492,908 (GRCm39) N503K probably benign Het
Fbxw2 G A 2: 34,712,776 (GRCm39) T95I probably damaging Het
Fis1 A G 5: 136,994,461 (GRCm39) T50A probably benign Het
Frzb T G 2: 80,276,772 (GRCm39) E138A probably damaging Het
Fsip2 A T 2: 82,817,164 (GRCm39) D4299V probably benign Het
Fyco1 C T 9: 123,659,478 (GRCm39) D233N probably damaging Het
Gmpr A G 13: 45,667,997 (GRCm39) probably benign Het
Hc C T 2: 34,919,407 (GRCm39) probably benign Het
Hnrnpa1 T C 15: 103,150,699 (GRCm39) M186T possibly damaging Het
Kl A G 5: 150,906,132 (GRCm39) K501E probably benign Het
Klhl42 A G 6: 147,009,427 (GRCm39) N422S probably damaging Het
Kmt2d C G 15: 98,753,471 (GRCm39) K127N probably damaging Het
Kmt2d T A 15: 98,753,472 (GRCm39) K127M probably damaging Het
Krt39 T A 11: 99,405,461 (GRCm39) T480S probably benign Het
Lims2 T A 18: 32,088,395 (GRCm39) C198* probably null Het
Mctp1 A G 13: 76,532,729 (GRCm39) N26D possibly damaging Het
Mdm4 A G 1: 132,931,538 (GRCm39) S168P probably benign Het
Myo3a A G 2: 22,455,008 (GRCm39) Y71C probably benign Het
Nlrp9c T A 7: 26,084,319 (GRCm39) D420V probably damaging Het
Ntf3 A T 6: 126,079,485 (GRCm39) I7N possibly damaging Het
Or10ag52 G A 2: 87,043,721 (GRCm39) G162S probably benign Het
Or13c25 G T 4: 52,910,849 (GRCm39) T315K probably benign Het
Or4c119 A G 2: 88,986,925 (GRCm39) V198A probably benign Het
Or8b38 T C 9: 37,972,981 (GRCm39) Y122H probably damaging Het
Papln C A 12: 83,836,028 (GRCm39) Y1222* probably null Het
Pgm3 T G 9: 86,440,531 (GRCm39) I387L possibly damaging Het
Pira12 G C 7: 3,900,871 (GRCm39) P20R probably damaging Het
Pkd1 C A 17: 24,814,131 (GRCm39) P4167Q probably damaging Het
Plcb4 T A 2: 135,854,947 (GRCm39) V1174E probably damaging Het
Polr1b A G 2: 128,943,031 (GRCm39) N9D probably benign Het
Prkaa2 G A 4: 104,893,950 (GRCm39) Q456* probably null Het
Ptch2 G T 4: 116,965,858 (GRCm39) V425L probably benign Het
Ptprh A T 7: 4,552,394 (GRCm39) S957T probably benign Het
Riok1 A G 13: 38,241,177 (GRCm39) D444G probably benign Het
Rrbp1 A T 2: 143,830,211 (GRCm39) V652E probably benign Het
Rrp36 C T 17: 46,983,671 (GRCm39) R47Q possibly damaging Het
Sec24c T C 14: 20,736,955 (GRCm39) S304P probably damaging Het
Serpinb6b A T 13: 33,158,991 (GRCm39) D64V possibly damaging Het
Six6 T A 12: 72,988,538 (GRCm39) I237N probably damaging Het
Slc25a36 A T 9: 96,975,135 (GRCm39) M127K probably benign Het
Slc2a10 A G 2: 165,356,550 (GRCm39) D70G probably damaging Het
Slc2a3 T A 6: 122,713,700 (GRCm39) I171F probably damaging Het
Smc4 A G 3: 68,940,401 (GRCm39) T1087A probably damaging Het
Spg21 A G 9: 65,391,779 (GRCm39) Y242C probably damaging Het
St14 A G 9: 31,001,166 (GRCm39) V855A possibly damaging Het
Stx2 G A 5: 129,065,903 (GRCm39) T251M probably damaging Het
Svs3b A T 2: 164,097,848 (GRCm39) S158T probably benign Het
Synpo C T 18: 60,736,661 (GRCm39) M428I probably benign Het
Tasor2 A T 13: 3,626,612 (GRCm39) Y1113N possibly damaging Het
Tbc1d31 G A 15: 57,775,760 (GRCm39) R17H probably damaging Het
Tbl3 G A 17: 24,923,477 (GRCm39) T284I probably benign Het
Tcof1 T C 18: 60,971,927 (GRCm39) T127A possibly damaging Het
Tgoln1 T C 6: 72,593,084 (GRCm39) E132G probably benign Het
Timeless T C 10: 128,077,583 (GRCm39) I221T probably damaging Het
Tmem176b C T 6: 48,815,138 (GRCm39) A52T possibly damaging Het
Tmem192 C T 8: 65,418,235 (GRCm39) L207F probably damaging Het
Trank1 T C 9: 111,176,996 (GRCm39) probably null Het
Ttc7b C T 12: 100,381,389 (GRCm39) probably null Het
Tubb5 T C 17: 36,146,190 (GRCm39) Y340C probably benign Het
Ubr1 G A 2: 120,761,449 (GRCm39) T576I probably benign Het
Vcan T C 13: 89,841,134 (GRCm39) E1470G probably damaging Het
Vmn1r200 T A 13: 22,579,663 (GRCm39) N146K probably damaging Het
Vmn2r120 T A 17: 57,831,839 (GRCm39) I317F probably benign Het
Vmn2r61 T C 7: 41,949,710 (GRCm39) I710T possibly damaging Het
Wipf1 T A 2: 73,270,499 (GRCm39) K61N probably benign Het
Zfp112 T C 7: 23,824,662 (GRCm39) V210A probably benign Het
Zfp612 G A 8: 110,815,095 (GRCm39) V101M probably benign Het
Zfp637 A G 6: 117,822,681 (GRCm39) R270G probably damaging Het
Zfp652 A G 11: 95,654,851 (GRCm39) E418G possibly damaging Het
Zfp97 A G 17: 17,365,265 (GRCm39) I255V probably benign Het
Other mutations in Serpinb9b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00157:Serpinb9b APN 13 33,219,608 (GRCm39) missense probably benign 0.00
IGL00518:Serpinb9b APN 13 33,223,553 (GRCm39) missense probably benign 0.17
IGL01939:Serpinb9b APN 13 33,223,648 (GRCm39) missense probably damaging 0.99
IGL02472:Serpinb9b APN 13 33,223,953 (GRCm39) utr 3 prime probably benign
IGL02632:Serpinb9b APN 13 33,223,806 (GRCm39) missense probably benign 0.01
R0255:Serpinb9b UTSW 13 33,222,003 (GRCm39) missense probably benign
R0667:Serpinb9b UTSW 13 33,216,909 (GRCm39) nonsense probably null
R0699:Serpinb9b UTSW 13 33,217,549 (GRCm39) missense probably benign 0.00
R0703:Serpinb9b UTSW 13 33,216,964 (GRCm39) missense probably benign 0.29
R1605:Serpinb9b UTSW 13 33,222,112 (GRCm39) critical splice donor site probably null
R1623:Serpinb9b UTSW 13 33,213,548 (GRCm39) missense possibly damaging 0.61
R1815:Serpinb9b UTSW 13 33,223,887 (GRCm39) missense probably damaging 1.00
R1987:Serpinb9b UTSW 13 33,213,542 (GRCm39) missense probably benign 0.07
R1988:Serpinb9b UTSW 13 33,213,542 (GRCm39) missense probably benign 0.07
R3035:Serpinb9b UTSW 13 33,213,529 (GRCm39) missense possibly damaging 0.81
R3683:Serpinb9b UTSW 13 33,213,581 (GRCm39) missense probably damaging 0.98
R3758:Serpinb9b UTSW 13 33,219,571 (GRCm39) missense probably damaging 1.00
R4677:Serpinb9b UTSW 13 33,223,806 (GRCm39) missense probably damaging 0.97
R5412:Serpinb9b UTSW 13 33,213,496 (GRCm39) missense probably benign 0.00
R5481:Serpinb9b UTSW 13 33,222,076 (GRCm39) missense possibly damaging 0.93
R5672:Serpinb9b UTSW 13 33,223,582 (GRCm39) missense probably benign 0.01
R5957:Serpinb9b UTSW 13 33,223,831 (GRCm39) missense possibly damaging 0.81
R6797:Serpinb9b UTSW 13 33,213,467 (GRCm39) missense possibly damaging 0.60
R7586:Serpinb9b UTSW 13 33,223,743 (GRCm39) missense probably damaging 1.00
R8115:Serpinb9b UTSW 13 33,219,531 (GRCm39) missense probably null 0.94
R8309:Serpinb9b UTSW 13 33,223,554 (GRCm39) missense probably damaging 1.00
R8529:Serpinb9b UTSW 13 33,223,543 (GRCm39) missense probably benign 0.04
R8802:Serpinb9b UTSW 13 33,213,587 (GRCm39) missense probably benign
R8810:Serpinb9b UTSW 13 33,213,452 (GRCm39) missense possibly damaging 0.83
R9020:Serpinb9b UTSW 13 33,223,887 (GRCm39) missense probably damaging 1.00
R9310:Serpinb9b UTSW 13 33,219,523 (GRCm39) missense probably benign
R9424:Serpinb9b UTSW 13 33,213,544 (GRCm39) missense probably damaging 0.99
X0019:Serpinb9b UTSW 13 33,219,514 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GTCGTCTTTGCCCATCAATG -3'
(R):5'- TTGGACAGACATAGGTTTCTCTCTG -3'

Sequencing Primer
(F):5'- GTCTTTGCCCATCAATGAAGCCAC -3'
(R):5'- CAGACATAGGTTTCTCTCTGGAGAC -3'
Posted On 2014-07-14