Incidental Mutation 'R0125:Vps8'
| ID |
21330 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vps8
|
| Ensembl Gene |
ENSMUSG00000033653 |
| Gene Name |
VPS8 CORVET complex subunit |
| Synonyms |
|
| MMRRC Submission |
038410-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0125 (G1)
|
| Quality Score |
159 |
|
Status
|
Validated
(trace)
|
| Chromosome |
16 |
| Chromosomal Location |
21241868-21463430 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 21288904 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 421
(V421E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112636
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096191]
[ENSMUST00000096192]
[ENSMUST00000115397]
[ENSMUST00000117598]
[ENSMUST00000118923]
|
| AlphaFold |
Q0P5W1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000096191
AA Change: V419E
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000093905
Gene: ENSMUSG00000033653
AA Change: V419E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
7e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.7e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
Blast:RING
|
1257 |
1277 |
1e-5 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000096192
AA Change: V421E
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000093906
Gene: ENSMUSG00000033653
AA Change: V421E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
1e-8 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.4e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115397
AA Change: V421E
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000111055
Gene: ENSMUSG00000033653
AA Change: V421E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
8e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
613 |
796 |
1.3e-61 |
PFAM |
|
low complexity region
|
994 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1099 |
N/A |
INTRINSIC |
|
low complexity region
|
1128 |
1139 |
N/A |
INTRINSIC |
|
RING
|
1259 |
1310 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000117598
AA Change: V419E
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000112937
Gene: ENSMUSG00000033653
AA Change: V419E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
8e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.9e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
RING
|
1257 |
1308 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000118923
AA Change: V421E
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000112636
Gene: ENSMUSG00000033653
AA Change: V421E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
9e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.9e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125487
|
| SMART Domains |
Protein: ENSMUSP00000114719
Gene: ENSMUSG00000033653
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Vps8
|
182 |
365 |
8.5e-62 |
PFAM |
|
low complexity region
|
563 |
578 |
N/A |
INTRINSIC |
|
low complexity region
|
656 |
668 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
708 |
N/A |
INTRINSIC |
|
RING
|
828 |
879 |
1.23e-4 |
SMART |
|
| Meta Mutation Damage Score |
0.1187 |
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 97.9%
- 10x: 94.7%
- 20x: 87.1%
|
| Validation Efficiency |
98% (96/98) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9930012K11Rik |
T |
C |
14: 70,394,096 (GRCm39) |
|
probably benign |
Het |
| Adam23 |
T |
C |
1: 63,573,515 (GRCm39) |
L261P |
probably benign |
Het |
| Adgra3 |
G |
A |
5: 50,159,194 (GRCm39) |
|
probably benign |
Het |
| Agtr1b |
A |
G |
3: 20,369,704 (GRCm39) |
F301L |
probably benign |
Het |
| Ahnak2 |
G |
A |
12: 112,748,776 (GRCm39) |
T357I |
probably benign |
Het |
| Aldh1a7 |
T |
C |
19: 20,704,430 (GRCm39) |
|
probably benign |
Het |
| Apoh |
A |
T |
11: 108,302,899 (GRCm39) |
N288I |
probably damaging |
Het |
| Arfgap3 |
A |
G |
15: 83,227,340 (GRCm39) |
V24A |
probably benign |
Het |
| Atp6v0a1 |
A |
G |
11: 100,929,677 (GRCm39) |
|
probably null |
Het |
| Axl |
A |
T |
7: 25,486,368 (GRCm39) |
M112K |
probably benign |
Het |
| Bnc2 |
A |
C |
4: 84,211,169 (GRCm39) |
I425S |
probably damaging |
Het |
| Ccn4 |
T |
C |
15: 66,789,194 (GRCm39) |
S227P |
possibly damaging |
Het |
| Cdc42bpa |
C |
T |
1: 179,788,763 (GRCm39) |
T30M |
probably damaging |
Het |
| Cebpz |
C |
A |
17: 79,227,317 (GRCm39) |
R1051M |
possibly damaging |
Het |
| Ces1d |
A |
C |
8: 93,901,810 (GRCm39) |
|
probably benign |
Het |
| Chd1l |
T |
C |
3: 97,494,465 (GRCm39) |
N405S |
probably benign |
Het |
| Chodl |
G |
T |
16: 78,738,311 (GRCm39) |
G93V |
probably damaging |
Het |
| Cpeb2 |
C |
T |
5: 43,395,743 (GRCm39) |
|
probably benign |
Het |
| Crebbp |
A |
G |
16: 3,935,105 (GRCm39) |
|
probably benign |
Het |
| Crybb3 |
T |
C |
5: 113,227,675 (GRCm39) |
T49A |
possibly damaging |
Het |
| Ctps1 |
A |
G |
4: 120,418,722 (GRCm39) |
|
probably benign |
Het |
| Cyp26b1 |
A |
G |
6: 84,551,497 (GRCm39) |
Y240H |
probably damaging |
Het |
| Cyp2d11 |
A |
C |
15: 82,273,422 (GRCm39) |
V483G |
probably benign |
Het |
| Dennd2b |
T |
C |
7: 109,155,545 (GRCm39) |
K402E |
probably benign |
Het |
| Dnah14 |
A |
T |
1: 181,579,628 (GRCm39) |
N3054Y |
probably damaging |
Het |
| Dspp |
A |
C |
5: 104,325,905 (GRCm39) |
D756A |
unknown |
Het |
| Dst |
T |
C |
1: 34,309,984 (GRCm39) |
S1553P |
probably damaging |
Het |
| Elp4 |
A |
G |
2: 105,622,559 (GRCm39) |
|
probably null |
Het |
| Eml6 |
G |
T |
11: 29,832,088 (GRCm39) |
T194K |
probably benign |
Het |
| Evi5 |
A |
G |
5: 107,943,638 (GRCm39) |
I569T |
probably benign |
Het |
| Fancm |
C |
T |
12: 65,168,730 (GRCm39) |
P1698S |
possibly damaging |
Het |
| Fhdc1 |
T |
C |
3: 84,352,852 (GRCm39) |
D791G |
probably benign |
Het |
| Frem1 |
A |
G |
4: 82,930,188 (GRCm39) |
Y253H |
probably damaging |
Het |
| Gpn3 |
A |
G |
5: 122,519,481 (GRCm39) |
Y196C |
probably benign |
Het |
| Hcls1 |
A |
G |
16: 36,782,525 (GRCm39) |
D398G |
probably benign |
Het |
| Hydin |
T |
C |
8: 111,189,163 (GRCm39) |
V1189A |
probably benign |
Het |
| Itgb3 |
G |
A |
11: 104,534,789 (GRCm39) |
D549N |
probably damaging |
Het |
| Itpr2 |
A |
G |
6: 146,141,951 (GRCm39) |
F1697S |
probably benign |
Het |
| Klk1b11 |
A |
G |
7: 43,648,475 (GRCm39) |
T161A |
probably benign |
Het |
| Kntc1 |
G |
A |
5: 123,903,120 (GRCm39) |
|
probably benign |
Het |
| Map3k19 |
A |
T |
1: 127,750,837 (GRCm39) |
F838Y |
probably benign |
Het |
| Map6 |
T |
A |
7: 98,985,187 (GRCm39) |
|
probably null |
Het |
| Mcrs1 |
A |
G |
15: 99,142,608 (GRCm39) |
|
probably benign |
Het |
| Mdn1 |
A |
T |
4: 32,729,956 (GRCm39) |
Y2766F |
probably damaging |
Het |
| Med23 |
C |
T |
10: 24,776,686 (GRCm39) |
H739Y |
probably damaging |
Het |
| Mmp17 |
T |
A |
5: 129,671,646 (GRCm39) |
D65E |
possibly damaging |
Het |
| Mmp9 |
T |
A |
2: 164,793,177 (GRCm39) |
L442Q |
probably damaging |
Het |
| Myo19 |
T |
C |
11: 84,779,001 (GRCm39) |
|
probably benign |
Het |
| Nedd1 |
A |
C |
10: 92,527,791 (GRCm39) |
S468A |
possibly damaging |
Het |
| Niban2 |
T |
A |
2: 32,813,833 (GRCm39) |
V682D |
probably benign |
Het |
| Nlrp4d |
A |
C |
7: 10,116,316 (GRCm39) |
V152G |
probably damaging |
Het |
| Nxf1 |
T |
A |
19: 8,740,170 (GRCm39) |
D112E |
probably benign |
Het |
| Oas1h |
A |
T |
5: 121,000,626 (GRCm39) |
K79* |
probably null |
Het |
| Omg |
T |
A |
11: 79,393,679 (GRCm39) |
I60F |
possibly damaging |
Het |
| Or5p69 |
A |
G |
7: 107,967,576 (GRCm39) |
Y293C |
probably damaging |
Het |
| Or8b101 |
A |
G |
9: 38,020,815 (GRCm39) |
T278A |
probably benign |
Het |
| Or8b1b |
T |
A |
9: 38,375,757 (GRCm39) |
L140* |
probably null |
Het |
| Pck1 |
G |
A |
2: 172,997,874 (GRCm39) |
W314* |
probably null |
Het |
| Pla2g15 |
T |
C |
8: 106,889,756 (GRCm39) |
Y343H |
probably benign |
Het |
| Plcb3 |
T |
C |
19: 6,936,276 (GRCm39) |
E749G |
probably damaging |
Het |
| Plgrkt |
A |
G |
19: 29,328,442 (GRCm39) |
|
probably null |
Het |
| Pprc1 |
A |
G |
19: 46,057,951 (GRCm39) |
|
probably benign |
Het |
| Prkdc |
A |
T |
16: 15,516,871 (GRCm39) |
I1082F |
probably damaging |
Het |
| Rapgef6 |
T |
A |
11: 54,516,701 (GRCm39) |
Y172* |
probably null |
Het |
| Ros1 |
G |
T |
10: 52,001,885 (GRCm39) |
A1079D |
probably benign |
Het |
| Sap30 |
T |
C |
8: 57,938,545 (GRCm39) |
E147G |
probably null |
Het |
| Sell |
T |
C |
1: 163,899,674 (GRCm39) |
|
probably benign |
Het |
| Senp1 |
A |
T |
15: 97,946,112 (GRCm39) |
D544E |
probably damaging |
Het |
| Shpk |
G |
A |
11: 73,105,048 (GRCm39) |
|
probably benign |
Het |
| Slc35b1 |
A |
T |
11: 95,277,353 (GRCm39) |
T74S |
probably benign |
Het |
| Slc6a3 |
T |
A |
13: 73,718,098 (GRCm39) |
|
probably benign |
Het |
| Slf1 |
T |
C |
13: 77,191,864 (GRCm39) |
N990S |
probably benign |
Het |
| Smgc |
A |
G |
15: 91,738,746 (GRCm39) |
|
probably benign |
Het |
| Snx19 |
T |
A |
9: 30,351,515 (GRCm39) |
V861D |
probably damaging |
Het |
| Sprr2e |
C |
T |
3: 92,260,285 (GRCm39) |
P39S |
unknown |
Het |
| Sstr2 |
T |
A |
11: 113,515,303 (GRCm39) |
M74K |
probably damaging |
Het |
| Svep1 |
T |
C |
4: 58,099,937 (GRCm39) |
|
probably benign |
Het |
| Tas2r143 |
A |
G |
6: 42,377,889 (GRCm39) |
I240V |
probably benign |
Het |
| Tbrg1 |
T |
C |
9: 37,563,937 (GRCm39) |
I233V |
probably benign |
Het |
| Tecpr1 |
G |
T |
5: 144,134,717 (GRCm39) |
D1055E |
probably damaging |
Het |
| Thap2 |
A |
T |
10: 115,212,277 (GRCm39) |
|
probably null |
Het |
| Tinagl1 |
A |
G |
4: 130,060,101 (GRCm39) |
Y388H |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,585,896 (GRCm39) |
Y21945F |
probably damaging |
Het |
| Ugt2b1 |
A |
T |
5: 87,073,961 (GRCm39) |
W133R |
probably benign |
Het |
| Usp24 |
C |
T |
4: 106,254,496 (GRCm39) |
P1491L |
possibly damaging |
Het |
| Utp15 |
A |
G |
13: 98,387,390 (GRCm39) |
S395P |
possibly damaging |
Het |
| Vav1 |
T |
A |
17: 57,606,847 (GRCm39) |
L254Q |
probably damaging |
Het |
| Vmn2r104 |
T |
C |
17: 20,250,069 (GRCm39) |
Y734C |
probably damaging |
Het |
| Xkr7 |
G |
T |
2: 152,874,346 (GRCm39) |
A138S |
probably benign |
Het |
|
| Other mutations in Vps8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00500:Vps8
|
APN |
16 |
21,261,084 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL00596:Vps8
|
APN |
16 |
21,267,162 (GRCm39) |
splice site |
probably benign |
|
|
IGL00985:Vps8
|
APN |
16 |
21,296,334 (GRCm39) |
splice site |
probably benign |
|
|
IGL01356:Vps8
|
APN |
16 |
21,336,107 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01375:Vps8
|
APN |
16 |
21,378,122 (GRCm39) |
nonsense |
probably null |
|
|
IGL01643:Vps8
|
APN |
16 |
21,336,972 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02159:Vps8
|
APN |
16 |
21,285,234 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02214:Vps8
|
APN |
16 |
21,336,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02465:Vps8
|
APN |
16 |
21,340,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02651:Vps8
|
APN |
16 |
21,336,086 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03174:Vps8
|
APN |
16 |
21,285,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03337:Vps8
|
APN |
16 |
21,381,918 (GRCm39) |
missense |
probably benign |
|
|
IGL03383:Vps8
|
APN |
16 |
21,254,573 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03402:Vps8
|
APN |
16 |
21,267,148 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
empires
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
porky
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
realm
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
realms
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
Reich
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
reichen
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
IGL03052:Vps8
|
UTSW |
16 |
21,267,115 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4677001:Vps8
|
UTSW |
16 |
21,319,084 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0137:Vps8
|
UTSW |
16 |
21,323,136 (GRCm39) |
splice site |
probably benign |
|
|
R0362:Vps8
|
UTSW |
16 |
21,426,977 (GRCm39) |
intron |
probably benign |
|
|
R0384:Vps8
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
R0492:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0525:Vps8
|
UTSW |
16 |
21,358,859 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0531:Vps8
|
UTSW |
16 |
21,278,561 (GRCm39) |
intron |
probably benign |
|
|
R0605:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0636:Vps8
|
UTSW |
16 |
21,253,683 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0707:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0840:Vps8
|
UTSW |
16 |
21,275,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1170:Vps8
|
UTSW |
16 |
21,278,570 (GRCm39) |
intron |
probably benign |
|
|
R1203:Vps8
|
UTSW |
16 |
21,330,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1482:Vps8
|
UTSW |
16 |
21,400,348 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1531:Vps8
|
UTSW |
16 |
21,285,226 (GRCm39) |
nonsense |
probably null |
|
|
R1642:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R1956:Vps8
|
UTSW |
16 |
21,279,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2201:Vps8
|
UTSW |
16 |
21,395,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2287:Vps8
|
UTSW |
16 |
21,387,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2423:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3151:Vps8
|
UTSW |
16 |
21,261,123 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3943:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4043:Vps8
|
UTSW |
16 |
21,345,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Vps8
|
UTSW |
16 |
21,314,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4398:Vps8
|
UTSW |
16 |
21,323,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4477:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4478:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4479:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4480:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4571:Vps8
|
UTSW |
16 |
21,254,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4653:Vps8
|
UTSW |
16 |
21,318,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4664:Vps8
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
R4713:Vps8
|
UTSW |
16 |
21,261,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4726:Vps8
|
UTSW |
16 |
21,267,154 (GRCm39) |
splice site |
probably null |
|
|
R4959:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4973:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4975:Vps8
|
UTSW |
16 |
21,285,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vps8
|
UTSW |
16 |
21,280,158 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5144:Vps8
|
UTSW |
16 |
21,378,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5168:Vps8
|
UTSW |
16 |
21,351,849 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5168:Vps8
|
UTSW |
16 |
21,276,195 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5222:Vps8
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
R5231:Vps8
|
UTSW |
16 |
21,395,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5876:Vps8
|
UTSW |
16 |
21,280,189 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5963:Vps8
|
UTSW |
16 |
21,288,871 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6010:Vps8
|
UTSW |
16 |
21,363,955 (GRCm39) |
intron |
probably benign |
|
|
R6023:Vps8
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6173:Vps8
|
UTSW |
16 |
21,314,682 (GRCm39) |
splice site |
probably null |
|
|
R6185:Vps8
|
UTSW |
16 |
21,288,891 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6264:Vps8
|
UTSW |
16 |
21,378,099 (GRCm39) |
nonsense |
probably null |
|
|
R6409:Vps8
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6522:Vps8
|
UTSW |
16 |
21,261,129 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6528:Vps8
|
UTSW |
16 |
21,372,875 (GRCm39) |
nonsense |
probably null |
|
|
R6784:Vps8
|
UTSW |
16 |
21,381,957 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7040:Vps8
|
UTSW |
16 |
21,393,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R7103:Vps8
|
UTSW |
16 |
21,345,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7149:Vps8
|
UTSW |
16 |
21,278,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7195:Vps8
|
UTSW |
16 |
21,275,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7206:Vps8
|
UTSW |
16 |
21,276,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7403:Vps8
|
UTSW |
16 |
21,253,722 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7782:Vps8
|
UTSW |
16 |
21,330,308 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7806:Vps8
|
UTSW |
16 |
21,278,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7846:Vps8
|
UTSW |
16 |
21,351,070 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7943:Vps8
|
UTSW |
16 |
21,296,622 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8075:Vps8
|
UTSW |
16 |
21,340,644 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8190:Vps8
|
UTSW |
16 |
21,393,780 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8307:Vps8
|
UTSW |
16 |
21,314,652 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8483:Vps8
|
UTSW |
16 |
21,393,763 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8814:Vps8
|
UTSW |
16 |
21,395,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9064:Vps8
|
UTSW |
16 |
21,288,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9367:Vps8
|
UTSW |
16 |
21,340,668 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R9404:Vps8
|
UTSW |
16 |
21,426,927 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9544:Vps8
|
UTSW |
16 |
21,336,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9570:Vps8
|
UTSW |
16 |
21,462,953 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9634:Vps8
|
UTSW |
16 |
21,372,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9702:Vps8
|
UTSW |
16 |
21,462,883 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCAAGAGTTGTCCTCTGACCATC -3'
(R):5'- AATGCCACTGTGGGGAGATCAATG -3'
Sequencing Primer
(F):5'- TCCCTTATGCAAGCAGAGTG -3'
(R):5'- TGGGGAGATCAATGCTGGG -3'
|
| Posted On |
2013-04-11 |
Incidental Mutation