Incidental Mutation 'R1937:Tet2'
| ID |
213514 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tet2
|
| Ensembl Gene |
ENSMUSG00000040943 |
| Gene Name |
tet methylcytosine dioxygenase 2 |
| Synonyms |
E130014J05Rik, Ayu17-449 |
| MMRRC Submission |
039955-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1937 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
133169438-133250882 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 133194399 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 12
(T12A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000096203
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000098603]
[ENSMUST00000196398]
[ENSMUST00000197118]
|
| AlphaFold |
Q4JK59 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000098603
AA Change: T12A
PolyPhen 2
Score 0.682 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000096203
Gene: ENSMUSG00000040943
AA Change: T12A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
690 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
862 |
N/A |
INTRINSIC |
|
low complexity region
|
884 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
899 |
921 |
N/A |
INTRINSIC |
|
Tet_JBP
|
1203 |
1819 |
7e-301 |
SMART |
|
low complexity region
|
1832 |
1844 |
N/A |
INTRINSIC |
|
low complexity region
|
1885 |
1897 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000196398
AA Change: T12A
PolyPhen 2
Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000143029
Gene: ENSMUSG00000040943
AA Change: T12A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
690 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
862 |
N/A |
INTRINSIC |
|
low complexity region
|
884 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
899 |
921 |
N/A |
INTRINSIC |
|
Tet_JBP
|
1211 |
1827 |
3.4e-305 |
SMART |
|
low complexity region
|
1840 |
1852 |
N/A |
INTRINSIC |
|
low complexity region
|
1893 |
1905 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000197118
AA Change: T12A
PolyPhen 2
Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.7%
- 20x: 93.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele die shortly after birth and exhibit a loss of acidic granules in the proximal convoluted tubules of the kidneys. Mice homozygous for a conditional allele activated in hematopoeitic compartment exhibit self-renewal and myeloid transforamtion. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(1246) : Targeted(6) Gene trapped(1240)
|
| Other mutations in this stock |
Total: 106 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 5730480H06Rik |
C |
A |
5: 48,531,777 (GRCm39) |
T35K |
probably benign |
Het |
| Abhd14a |
A |
G |
9: 106,317,446 (GRCm39) |
|
probably benign |
Het |
| Abhd8 |
A |
G |
8: 71,914,506 (GRCm39) |
F41L |
possibly damaging |
Het |
| Ace2 |
A |
T |
X: 162,939,524 (GRCm39) |
M123L |
possibly damaging |
Het |
| Actr5 |
T |
C |
2: 158,477,949 (GRCm39) |
Y440H |
possibly damaging |
Het |
| Akr1c6 |
T |
A |
13: 4,496,383 (GRCm39) |
N81K |
probably benign |
Het |
| Aqp11 |
T |
A |
7: 97,386,725 (GRCm39) |
N157I |
possibly damaging |
Het |
| Arhgap10 |
T |
C |
8: 78,071,282 (GRCm39) |
E568G |
probably damaging |
Het |
| Asb7 |
T |
A |
7: 66,329,001 (GRCm39) |
Q13L |
probably benign |
Het |
| Atf7ip |
C |
A |
6: 136,537,778 (GRCm39) |
A345E |
probably benign |
Het |
| Atp8a2 |
T |
C |
14: 60,097,719 (GRCm39) |
K770E |
probably benign |
Het |
| Bpifb4 |
A |
T |
2: 153,785,996 (GRCm39) |
I259F |
probably damaging |
Het |
| Cand1 |
A |
T |
10: 119,038,925 (GRCm39) |
D1218E |
probably damaging |
Het |
| Capg |
A |
G |
6: 72,535,236 (GRCm39) |
|
probably null |
Het |
| Cep290 |
C |
T |
10: 100,333,815 (GRCm39) |
T289M |
possibly damaging |
Het |
| Cfap69 |
T |
C |
5: 5,643,818 (GRCm39) |
Y548C |
probably damaging |
Het |
| Cfap97d1 |
A |
T |
11: 101,877,989 (GRCm39) |
H17L |
probably damaging |
Het |
| Cimip2b |
T |
A |
4: 43,427,586 (GRCm39) |
K220N |
probably damaging |
Het |
| Clock |
A |
G |
5: 76,377,340 (GRCm39) |
L652P |
probably damaging |
Het |
| Col3a1 |
C |
T |
1: 45,373,453 (GRCm39) |
|
probably benign |
Het |
| Coro7 |
T |
C |
16: 4,446,596 (GRCm39) |
E843G |
probably benign |
Het |
| Crebrf |
T |
C |
17: 26,961,442 (GRCm39) |
S188P |
probably damaging |
Het |
| Crppa |
G |
A |
12: 36,440,367 (GRCm39) |
V92I |
probably benign |
Het |
| Cul1 |
T |
C |
6: 47,485,289 (GRCm39) |
F307L |
probably benign |
Het |
| Cyb561d2 |
G |
A |
9: 107,417,515 (GRCm39) |
R79W |
probably damaging |
Het |
| Cyp3a59 |
T |
C |
5: 146,031,187 (GRCm39) |
S117P |
possibly damaging |
Het |
| Ddias |
A |
G |
7: 92,507,830 (GRCm39) |
I695T |
probably benign |
Het |
| Dhx29 |
G |
A |
13: 113,101,864 (GRCm39) |
G1311D |
probably benign |
Het |
| Dync2h1 |
A |
G |
9: 7,139,159 (GRCm39) |
|
probably null |
Het |
| Ece2 |
T |
A |
16: 20,436,616 (GRCm39) |
V146E |
probably damaging |
Het |
| Eml2 |
A |
G |
7: 18,937,889 (GRCm39) |
K586E |
possibly damaging |
Het |
| Eps8l3 |
A |
G |
3: 107,791,708 (GRCm39) |
E316G |
probably benign |
Het |
| Fam135b |
A |
T |
15: 71,493,863 (GRCm39) |
L22H |
probably damaging |
Het |
| Focad |
T |
A |
4: 88,319,318 (GRCm39) |
M1K |
probably null |
Het |
| Fryl |
A |
G |
5: 73,290,710 (GRCm39) |
S65P |
probably damaging |
Het |
| Gm14190 |
C |
T |
11: 99,581,556 (GRCm39) |
C4Y |
unknown |
Het |
| H2-T5 |
T |
A |
17: 36,478,899 (GRCm39) |
T117S |
probably damaging |
Het |
| Ift74 |
T |
A |
4: 94,550,883 (GRCm39) |
M345K |
probably benign |
Het |
| Jag1 |
C |
G |
2: 136,925,393 (GRCm39) |
V1070L |
possibly damaging |
Het |
| Kcng1 |
T |
C |
2: 168,104,941 (GRCm39) |
T302A |
probably benign |
Het |
| Kif20b |
T |
C |
19: 34,930,278 (GRCm39) |
V1221A |
possibly damaging |
Het |
| Kif23 |
A |
T |
9: 61,853,892 (GRCm39) |
|
probably null |
Het |
| Lpxn |
T |
G |
19: 12,802,274 (GRCm39) |
S200A |
probably benign |
Het |
| Meiob |
A |
G |
17: 25,037,305 (GRCm39) |
H61R |
probably benign |
Het |
| Mfhas1 |
C |
T |
8: 36,056,799 (GRCm39) |
L425F |
probably damaging |
Het |
| Myo3a |
A |
T |
2: 22,401,126 (GRCm39) |
S632C |
probably damaging |
Het |
| Naip2 |
T |
C |
13: 100,298,362 (GRCm39) |
E558G |
probably benign |
Het |
| Naip2 |
C |
T |
13: 100,298,368 (GRCm39) |
G556D |
probably benign |
Het |
| Nbeal1 |
T |
A |
1: 60,307,100 (GRCm39) |
Y374* |
probably null |
Het |
| Notch3 |
T |
C |
17: 32,372,826 (GRCm39) |
S582G |
probably benign |
Het |
| Nphs1 |
A |
T |
7: 30,173,798 (GRCm39) |
Q985L |
probably damaging |
Het |
| Oas1c |
T |
A |
5: 120,941,049 (GRCm39) |
H248L |
probably benign |
Het |
| Or5c1 |
A |
T |
2: 37,221,896 (GRCm39) |
N46Y |
probably damaging |
Het |
| Or5g26 |
T |
C |
2: 85,494,341 (GRCm39) |
I146V |
probably benign |
Het |
| Or5h25 |
A |
T |
16: 58,930,157 (GRCm39) |
M272K |
probably benign |
Het |
| Or8g35 |
A |
G |
9: 39,381,333 (GRCm39) |
S230P |
possibly damaging |
Het |
| Pamr1 |
A |
T |
2: 102,472,617 (GRCm39) |
I639F |
possibly damaging |
Het |
| Panx1 |
G |
T |
9: 14,918,980 (GRCm39) |
T293K |
possibly damaging |
Het |
| Papss1 |
G |
T |
3: 131,305,632 (GRCm39) |
V226F |
probably benign |
Het |
| Pax1 |
G |
T |
2: 147,209,809 (GRCm39) |
G301V |
possibly damaging |
Het |
| Pdlim5 |
C |
A |
3: 141,950,742 (GRCm39) |
R557L |
possibly damaging |
Het |
| Pdyn |
C |
A |
2: 129,531,729 (GRCm39) |
M20I |
probably benign |
Het |
| Pelp1 |
G |
A |
11: 70,284,541 (GRCm39) |
|
probably null |
Het |
| Pkd2 |
T |
C |
5: 104,626,790 (GRCm39) |
V324A |
probably damaging |
Het |
| Pkdrej |
A |
G |
15: 85,703,368 (GRCm39) |
I856T |
probably benign |
Het |
| Polr1a |
T |
C |
6: 71,913,536 (GRCm39) |
|
probably null |
Het |
| Pot1a |
A |
T |
6: 25,753,323 (GRCm39) |
D404E |
probably benign |
Het |
| Ppp2r2a |
A |
T |
14: 67,253,878 (GRCm39) |
I430N |
possibly damaging |
Het |
| Prob1 |
C |
T |
18: 35,787,279 (GRCm39) |
R325Q |
possibly damaging |
Het |
| Prrc2a |
T |
C |
17: 35,376,884 (GRCm39) |
D742G |
probably damaging |
Het |
| Psmc1 |
C |
T |
12: 100,081,102 (GRCm39) |
P54S |
probably benign |
Het |
| Rab22a |
A |
G |
2: 173,530,004 (GRCm39) |
T61A |
probably damaging |
Het |
| Rims1 |
T |
A |
1: 22,358,754 (GRCm39) |
K184N |
probably damaging |
Het |
| Rnf213 |
G |
A |
11: 119,322,511 (GRCm39) |
R1376H |
probably damaging |
Het |
| Ryr2 |
T |
C |
13: 11,683,848 (GRCm39) |
E3072G |
probably damaging |
Het |
| Serpina1b |
T |
C |
12: 103,698,420 (GRCm39) |
K143R |
probably benign |
Het |
| Slc22a15 |
T |
G |
3: 101,787,505 (GRCm39) |
|
probably null |
Het |
| Slc25a14 |
G |
A |
X: 47,740,840 (GRCm39) |
V210I |
probably benign |
Het |
| Slc25a48 |
A |
C |
13: 56,596,811 (GRCm39) |
T31P |
probably damaging |
Het |
| Slc9a3 |
C |
T |
13: 74,314,175 (GRCm39) |
|
probably null |
Het |
| Slx4 |
T |
C |
16: 3,805,030 (GRCm39) |
*105W |
probably null |
Het |
| Smc6 |
A |
G |
12: 11,349,399 (GRCm39) |
N794S |
probably benign |
Het |
| Spata18 |
G |
A |
5: 73,834,307 (GRCm39) |
R387Q |
probably damaging |
Het |
| Sphkap |
C |
A |
1: 83,245,162 (GRCm39) |
E1486* |
probably null |
Het |
| Srsf6 |
C |
T |
2: 162,776,403 (GRCm39) |
|
probably benign |
Het |
| St8sia1 |
C |
T |
6: 142,909,398 (GRCm39) |
A33T |
probably damaging |
Het |
| Tmem144 |
G |
T |
3: 79,732,611 (GRCm39) |
S222R |
probably damaging |
Het |
| Tnrc6c |
A |
G |
11: 117,646,849 (GRCm39) |
D1450G |
possibly damaging |
Het |
| Top1 |
A |
T |
2: 160,512,042 (GRCm39) |
K27N |
unknown |
Het |
| Tox2 |
A |
G |
2: 163,067,476 (GRCm39) |
H30R |
probably benign |
Het |
| Tra2b |
T |
C |
16: 22,065,993 (GRCm39) |
|
probably benign |
Het |
| Trio |
A |
T |
15: 27,833,142 (GRCm39) |
V1165E |
probably damaging |
Het |
| Troap |
T |
A |
15: 98,975,269 (GRCm39) |
S145R |
probably damaging |
Het |
| Ttc34 |
G |
A |
4: 154,950,139 (GRCm39) |
A1031T |
possibly damaging |
Het |
| Ttc6 |
C |
T |
12: 57,663,109 (GRCm39) |
P302S |
probably benign |
Het |
| Ubiad1 |
A |
G |
4: 148,528,468 (GRCm39) |
L147P |
probably damaging |
Het |
| Ugt2b35 |
G |
T |
5: 87,149,141 (GRCm39) |
V131F |
probably damaging |
Het |
| Utp25 |
A |
T |
1: 192,804,401 (GRCm39) |
D200E |
probably damaging |
Het |
| Vmn1r167 |
G |
A |
7: 23,204,452 (GRCm39) |
T188I |
probably benign |
Het |
| Vmn1r46 |
G |
T |
6: 89,953,716 (GRCm39) |
M188I |
probably benign |
Het |
| Vmn2r115 |
T |
A |
17: 23,578,388 (GRCm39) |
N620K |
probably damaging |
Het |
| Vmn2r66 |
A |
G |
7: 84,644,344 (GRCm39) |
S689P |
probably damaging |
Het |
| Wipf2 |
C |
T |
11: 98,783,236 (GRCm39) |
R221* |
probably null |
Het |
| Zbtb16 |
T |
C |
9: 48,571,078 (GRCm39) |
S563G |
probably benign |
Het |
| Zfp319 |
T |
C |
8: 96,055,199 (GRCm39) |
T335A |
probably damaging |
Het |
| Zfp418 |
A |
G |
7: 7,185,401 (GRCm39) |
R455G |
possibly damaging |
Het |
|
| Other mutations in Tet2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00341:Tet2
|
APN |
3 |
133,193,846 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL00401:Tet2
|
APN |
3 |
133,172,643 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01528:Tet2
|
APN |
3 |
133,186,059 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02053:Tet2
|
APN |
3 |
133,194,284 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02142:Tet2
|
APN |
3 |
133,185,900 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02512:Tet2
|
APN |
3 |
133,175,069 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03148:Tet2
|
APN |
3 |
133,187,124 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL03182:Tet2
|
APN |
3 |
133,177,159 (GRCm39) |
nonsense |
probably null |
|
|
IGL03371:Tet2
|
APN |
3 |
133,173,312 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
P0022:Tet2
|
UTSW |
3 |
133,192,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
P0023:Tet2
|
UTSW |
3 |
133,192,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
P0031:Tet2
|
UTSW |
3 |
133,185,963 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0012:Tet2
|
UTSW |
3 |
133,182,319 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0012:Tet2
|
UTSW |
3 |
133,182,319 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0463:Tet2
|
UTSW |
3 |
133,192,427 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0522:Tet2
|
UTSW |
3 |
133,172,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0593:Tet2
|
UTSW |
3 |
133,193,870 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0600:Tet2
|
UTSW |
3 |
133,173,486 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0600:Tet2
|
UTSW |
3 |
133,173,363 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0698:Tet2
|
UTSW |
3 |
133,173,145 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0723:Tet2
|
UTSW |
3 |
133,173,045 (GRCm39) |
missense |
probably benign |
|
|
R0726:Tet2
|
UTSW |
3 |
133,173,945 (GRCm39) |
missense |
probably benign |
|
|
R0747:Tet2
|
UTSW |
3 |
133,173,231 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1006:Tet2
|
UTSW |
3 |
133,182,362 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1382:Tet2
|
UTSW |
3 |
133,182,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1455:Tet2
|
UTSW |
3 |
133,179,406 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1550:Tet2
|
UTSW |
3 |
133,175,280 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1647:Tet2
|
UTSW |
3 |
133,191,641 (GRCm39) |
missense |
probably benign |
|
|
R1662:Tet2
|
UTSW |
3 |
133,172,613 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1727:Tet2
|
UTSW |
3 |
133,193,051 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1738:Tet2
|
UTSW |
3 |
133,187,148 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1749:Tet2
|
UTSW |
3 |
133,185,892 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1869:Tet2
|
UTSW |
3 |
133,187,202 (GRCm39) |
splice site |
probably null |
|
|
R1887:Tet2
|
UTSW |
3 |
133,193,094 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1939:Tet2
|
UTSW |
3 |
133,194,399 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1940:Tet2
|
UTSW |
3 |
133,194,399 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1997:Tet2
|
UTSW |
3 |
133,192,350 (GRCm39) |
nonsense |
probably null |
|
|
R2082:Tet2
|
UTSW |
3 |
133,191,488 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2084:Tet2
|
UTSW |
3 |
133,193,528 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R2215:Tet2
|
UTSW |
3 |
133,192,362 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2321:Tet2
|
UTSW |
3 |
133,192,100 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2873:Tet2
|
UTSW |
3 |
133,192,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3439:Tet2
|
UTSW |
3 |
133,172,592 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3783:Tet2
|
UTSW |
3 |
133,185,124 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3894:Tet2
|
UTSW |
3 |
133,175,238 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3916:Tet2
|
UTSW |
3 |
133,191,816 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3966:Tet2
|
UTSW |
3 |
133,193,418 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4457:Tet2
|
UTSW |
3 |
133,191,324 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4633:Tet2
|
UTSW |
3 |
133,191,310 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4646:Tet2
|
UTSW |
3 |
133,193,843 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4647:Tet2
|
UTSW |
3 |
133,193,843 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4648:Tet2
|
UTSW |
3 |
133,193,843 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4691:Tet2
|
UTSW |
3 |
133,191,844 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4805:Tet2
|
UTSW |
3 |
133,173,076 (GRCm39) |
missense |
probably benign |
0.32 |
|
R4829:Tet2
|
UTSW |
3 |
133,182,381 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4901:Tet2
|
UTSW |
3 |
133,172,805 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4975:Tet2
|
UTSW |
3 |
133,192,520 (GRCm39) |
unclassified |
probably benign |
|
|
R5004:Tet2
|
UTSW |
3 |
133,193,140 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5075:Tet2
|
UTSW |
3 |
133,192,667 (GRCm39) |
missense |
probably benign |
|
|
R5137:Tet2
|
UTSW |
3 |
133,182,326 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5324:Tet2
|
UTSW |
3 |
133,191,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5590:Tet2
|
UTSW |
3 |
133,182,241 (GRCm39) |
splice site |
probably null |
|
|
R5854:Tet2
|
UTSW |
3 |
133,193,646 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5856:Tet2
|
UTSW |
3 |
133,192,401 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5865:Tet2
|
UTSW |
3 |
133,192,860 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5879:Tet2
|
UTSW |
3 |
133,193,721 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R5935:Tet2
|
UTSW |
3 |
133,194,296 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6012:Tet2
|
UTSW |
3 |
133,172,542 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6075:Tet2
|
UTSW |
3 |
133,177,196 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R6181:Tet2
|
UTSW |
3 |
133,193,520 (GRCm39) |
nonsense |
probably null |
|
|
R6188:Tet2
|
UTSW |
3 |
133,186,087 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6339:Tet2
|
UTSW |
3 |
133,192,178 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6612:Tet2
|
UTSW |
3 |
133,193,096 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6923:Tet2
|
UTSW |
3 |
133,185,102 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6934:Tet2
|
UTSW |
3 |
133,188,998 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7076:Tet2
|
UTSW |
3 |
133,172,784 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7155:Tet2
|
UTSW |
3 |
133,175,352 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7184:Tet2
|
UTSW |
3 |
133,179,391 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7200:Tet2
|
UTSW |
3 |
133,192,953 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7459:Tet2
|
UTSW |
3 |
133,186,050 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7504:Tet2
|
UTSW |
3 |
133,193,100 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7524:Tet2
|
UTSW |
3 |
133,185,990 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7613:Tet2
|
UTSW |
3 |
133,172,509 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7653:Tet2
|
UTSW |
3 |
133,192,146 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7691:Tet2
|
UTSW |
3 |
133,192,610 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7770:Tet2
|
UTSW |
3 |
133,186,056 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7807:Tet2
|
UTSW |
3 |
133,192,302 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7813:Tet2
|
UTSW |
3 |
133,179,404 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7978:Tet2
|
UTSW |
3 |
133,193,426 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8055:Tet2
|
UTSW |
3 |
133,173,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8164:Tet2
|
UTSW |
3 |
133,172,895 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8236:Tet2
|
UTSW |
3 |
133,193,547 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8755:Tet2
|
UTSW |
3 |
133,194,039 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8962:Tet2
|
UTSW |
3 |
133,193,804 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9009:Tet2
|
UTSW |
3 |
133,193,360 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9014:Tet2
|
UTSW |
3 |
133,172,949 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9128:Tet2
|
UTSW |
3 |
133,175,374 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9166:Tet2
|
UTSW |
3 |
133,173,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9190:Tet2
|
UTSW |
3 |
133,187,147 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9344:Tet2
|
UTSW |
3 |
133,175,115 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9360:Tet2
|
UTSW |
3 |
133,192,903 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9471:Tet2
|
UTSW |
3 |
133,191,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9488:Tet2
|
UTSW |
3 |
133,193,103 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9534:Tet2
|
UTSW |
3 |
133,173,689 (GRCm39) |
nonsense |
probably null |
|
|
R9557:Tet2
|
UTSW |
3 |
133,191,566 (GRCm39) |
missense |
probably benign |
|
|
R9621:Tet2
|
UTSW |
3 |
133,193,767 (GRCm39) |
nonsense |
probably null |
|
|
R9644:Tet2
|
UTSW |
3 |
133,193,064 (GRCm39) |
nonsense |
probably null |
|
|
R9719:Tet2
|
UTSW |
3 |
133,191,803 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
X0021:Tet2
|
UTSW |
3 |
133,192,056 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
X0066:Tet2
|
UTSW |
3 |
133,194,134 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- AATACCCTCTGTCTTCATGTGGAC -3'
(R):5'- CTCCATGCAGGGAAGACAAG -3'
Sequencing Primer
(F):5'- ATGTGGACTCTCATGACTGC -3'
(R):5'- CTCCATGCAGGGAAGACAAGAGTAG -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation