Incidental Mutation 'R1939:Nav1'
| ID |
213775 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nav1
|
| Ensembl Gene |
ENSMUSG00000009418 |
| Gene Name |
neuron navigator 1 |
| Synonyms |
9930003A20Rik, unc53H1, steerin-1, POMFIL3, C230080M11Rik |
| MMRRC Submission |
039957-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.934)
|
| Stock # |
R1939 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
135362318-135615843 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 135393636 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Glutamine
at position 1034
(L1034Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000067241
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040599]
[ENSMUST00000067414]
[ENSMUST00000190298]
|
| AlphaFold |
Q8CH77 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000040599
AA Change: L1034Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000043803
Gene: ENSMUSG00000009418
AA Change: L1034Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1070 |
1105 |
N/A |
INTRINSIC |
|
low complexity region
|
1179 |
1210 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1304 |
N/A |
INTRINSIC |
|
coiled coil region
|
1328 |
1360 |
N/A |
INTRINSIC |
|
AAA
|
1548 |
1702 |
3.16e-5 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000067414
AA Change: L1034Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000067241
Gene: ENSMUSG00000009418
AA Change: L1034Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1070 |
1105 |
N/A |
INTRINSIC |
|
low complexity region
|
1179 |
1210 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1304 |
N/A |
INTRINSIC |
|
coiled coil region
|
1328 |
1360 |
N/A |
INTRINSIC |
|
AAA
|
1548 |
1702 |
3.16e-5 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000189252
AA Change: L48Q
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000189362
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000190130
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190298
|
| SMART Domains |
Protein: ENSMUSP00000140322
Gene: ENSMUSG00000009418
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1013 |
1048 |
N/A |
INTRINSIC |
|
low complexity region
|
1122 |
1153 |
N/A |
INTRINSIC |
|
low complexity region
|
1200 |
1221 |
N/A |
INTRINSIC |
|
low complexity region
|
1236 |
1244 |
N/A |
INTRINSIC |
|
coiled coil region
|
1268 |
1300 |
N/A |
INTRINSIC |
|
AAA
|
1488 |
1642 |
3.16e-5 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000190735
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.6%
- 20x: 93.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700020L24Rik |
T |
A |
11: 83,331,130 (GRCm39) |
W11R |
probably damaging |
Het |
| 2700049A03Rik |
A |
G |
12: 71,207,186 (GRCm39) |
|
probably null |
Het |
| 4933409G03Rik |
T |
C |
2: 68,419,328 (GRCm39) |
S26P |
possibly damaging |
Het |
| Ace2 |
A |
T |
X: 162,939,524 (GRCm39) |
M123L |
possibly damaging |
Het |
| Acot3 |
A |
G |
12: 84,105,325 (GRCm39) |
N264S |
probably benign |
Het |
| Acvr1c |
A |
T |
2: 58,173,517 (GRCm39) |
N248K |
probably damaging |
Het |
| Adam22 |
A |
T |
5: 8,380,015 (GRCm39) |
F94L |
probably damaging |
Het |
| Adarb2 |
T |
C |
13: 8,253,358 (GRCm39) |
|
probably null |
Het |
| Aldh1b1 |
A |
G |
4: 45,802,755 (GRCm39) |
M98V |
possibly damaging |
Het |
| Arfgef2 |
T |
A |
2: 166,715,548 (GRCm39) |
V1331D |
probably damaging |
Het |
| Atf2 |
G |
A |
2: 73,676,563 (GRCm39) |
P184S |
probably damaging |
Het |
| Atp8b3 |
A |
T |
10: 80,361,220 (GRCm39) |
C785* |
probably null |
Het |
| Birc6 |
T |
C |
17: 74,977,332 (GRCm39) |
S4362P |
probably damaging |
Het |
| Brd10 |
A |
G |
19: 29,731,077 (GRCm39) |
F712S |
possibly damaging |
Het |
| Chn1 |
A |
G |
2: 73,455,245 (GRCm39) |
C39R |
probably damaging |
Het |
| Cngb1 |
C |
A |
8: 96,026,320 (GRCm39) |
G154W |
probably damaging |
Het |
| Cntnap5b |
A |
G |
1: 99,895,073 (GRCm39) |
H115R |
probably benign |
Het |
| Col23a1 |
A |
G |
11: 51,442,816 (GRCm39) |
D159G |
unknown |
Het |
| Coro7 |
T |
C |
16: 4,446,596 (GRCm39) |
E843G |
probably benign |
Het |
| Dnase2a |
G |
T |
8: 85,637,524 (GRCm39) |
A309S |
possibly damaging |
Het |
| Dync2h1 |
A |
G |
9: 7,139,159 (GRCm39) |
|
probably null |
Het |
| Engase |
T |
A |
11: 118,370,012 (GRCm39) |
N97K |
probably damaging |
Het |
| Fam83b |
A |
T |
9: 76,400,362 (GRCm39) |
M247K |
probably damaging |
Het |
| Fer |
T |
C |
17: 64,280,123 (GRCm39) |
S65P |
probably damaging |
Het |
| Fgf10 |
A |
G |
13: 118,925,688 (GRCm39) |
R156G |
probably damaging |
Het |
| Gm10608 |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
9: 118,989,784 (GRCm39) |
|
probably null |
Het |
| Gm904 |
T |
C |
13: 50,798,772 (GRCm39) |
|
probably null |
Het |
| Gpat2 |
T |
A |
2: 127,277,879 (GRCm39) |
*802K |
probably null |
Het |
| Hcfc2 |
G |
T |
10: 82,538,284 (GRCm39) |
R107L |
probably damaging |
Het |
| Itga8 |
T |
G |
2: 12,305,657 (GRCm39) |
D111A |
probably damaging |
Het |
| Jag1 |
C |
G |
2: 136,925,393 (GRCm39) |
V1070L |
possibly damaging |
Het |
| Lama5 |
T |
C |
2: 179,832,714 (GRCm39) |
N1646S |
probably benign |
Het |
| Lgals8 |
T |
G |
13: 12,474,069 (GRCm39) |
I10L |
probably benign |
Het |
| Lrp1b |
A |
G |
2: 40,587,601 (GRCm39) |
S116P |
unknown |
Het |
| Mcpt1 |
A |
T |
14: 56,256,546 (GRCm39) |
K94I |
possibly damaging |
Het |
| Mpnd |
T |
C |
17: 56,322,920 (GRCm39) |
F384S |
probably damaging |
Het |
| Mrgprb5 |
A |
T |
7: 47,818,686 (GRCm39) |
N16K |
probably benign |
Het |
| Myo15b |
A |
G |
11: 115,778,529 (GRCm39) |
T1139A |
probably benign |
Het |
| Nat8f5 |
A |
C |
6: 85,794,801 (GRCm39) |
I53R |
possibly damaging |
Het |
| Nudt6 |
T |
C |
3: 37,459,379 (GRCm39) |
Y54C |
probably damaging |
Het |
| Or10j3b |
G |
T |
1: 173,043,499 (GRCm39) |
A94S |
probably benign |
Het |
| Or5p58 |
A |
G |
7: 107,694,348 (GRCm39) |
V143A |
probably benign |
Het |
| Or6c217 |
A |
C |
10: 129,737,970 (GRCm39) |
M203R |
probably damaging |
Het |
| Or8b35 |
A |
G |
9: 37,904,385 (GRCm39) |
N199S |
probably benign |
Het |
| Or8c15 |
T |
A |
9: 38,120,725 (GRCm39) |
Y72* |
probably null |
Het |
| Osbpl8 |
A |
T |
10: 111,125,672 (GRCm39) |
H784L |
probably benign |
Het |
| Osr1 |
T |
G |
12: 9,629,687 (GRCm39) |
S187A |
probably damaging |
Het |
| Pcdhgc5 |
A |
G |
18: 37,955,003 (GRCm39) |
Y759C |
probably damaging |
Het |
| Pkd1l2 |
G |
T |
8: 117,772,921 (GRCm39) |
Y1035* |
probably null |
Het |
| Pla2g15 |
A |
G |
8: 106,889,927 (GRCm39) |
T400A |
probably damaging |
Het |
| Pms1 |
A |
C |
1: 53,236,135 (GRCm39) |
L715R |
probably damaging |
Het |
| Prkd1 |
T |
C |
12: 50,441,777 (GRCm39) |
N254S |
probably benign |
Het |
| Prkdc |
T |
C |
16: 15,653,777 (GRCm39) |
V3868A |
possibly damaging |
Het |
| Ptprt |
T |
C |
2: 161,769,560 (GRCm39) |
N435S |
probably benign |
Het |
| Purb |
T |
C |
11: 6,424,943 (GRCm39) |
E315G |
unknown |
Het |
| Rap1b |
A |
T |
10: 117,654,491 (GRCm39) |
N116K |
probably damaging |
Het |
| Rmc1 |
T |
C |
18: 12,313,562 (GRCm39) |
L15P |
probably damaging |
Het |
| Rp1l1 |
A |
G |
14: 64,267,042 (GRCm39) |
N876S |
probably benign |
Het |
| Rps6ka4 |
T |
A |
19: 6,816,834 (GRCm39) |
I114F |
probably damaging |
Het |
| Semp2l1 |
T |
C |
1: 32,584,627 (GRCm39) |
I428V |
probably damaging |
Het |
| Sh3bp2 |
A |
G |
5: 34,708,963 (GRCm39) |
N19D |
probably damaging |
Het |
| Slc16a4 |
A |
G |
3: 107,208,317 (GRCm39) |
M276V |
probably benign |
Het |
| Slc17a1 |
A |
G |
13: 24,059,864 (GRCm39) |
T172A |
probably benign |
Het |
| Slc4a7 |
C |
T |
14: 14,748,581 (GRCm38) |
A320V |
probably damaging |
Het |
| Slco1a6 |
T |
A |
6: 142,078,956 (GRCm39) |
Y113F |
probably damaging |
Het |
| Srsf6 |
C |
T |
2: 162,776,403 (GRCm39) |
|
probably benign |
Het |
| St3gal6 |
A |
T |
16: 58,293,924 (GRCm39) |
|
probably null |
Het |
| Tdp2 |
A |
G |
13: 25,025,260 (GRCm39) |
D343G |
probably benign |
Het |
| Tecpr2 |
T |
A |
12: 110,899,603 (GRCm39) |
L657Q |
probably damaging |
Het |
| Tet2 |
T |
C |
3: 133,194,399 (GRCm39) |
T12A |
possibly damaging |
Het |
| Trappc6a |
T |
A |
7: 19,248,426 (GRCm39) |
F28I |
probably damaging |
Het |
| Trim32 |
G |
A |
4: 65,532,303 (GRCm39) |
V287I |
probably benign |
Het |
| Trpd52l3 |
T |
C |
19: 29,981,289 (GRCm39) |
S15P |
probably damaging |
Het |
| Tsnaxip1 |
A |
G |
8: 106,566,670 (GRCm39) |
I169V |
probably benign |
Het |
| Ttc34 |
G |
A |
4: 154,950,139 (GRCm39) |
A1031T |
possibly damaging |
Het |
| Ttll11 |
T |
A |
2: 35,830,765 (GRCm39) |
Q18L |
probably null |
Het |
| Ttll8 |
A |
T |
15: 88,799,689 (GRCm39) |
I584N |
probably damaging |
Het |
| Ubiad1 |
A |
G |
4: 148,528,468 (GRCm39) |
L147P |
probably damaging |
Het |
| Ucp3 |
T |
C |
7: 100,129,871 (GRCm39) |
V171A |
probably benign |
Het |
| Vmn1r174 |
T |
A |
7: 23,453,532 (GRCm39) |
I66N |
probably damaging |
Het |
| Vmn2r13 |
T |
C |
5: 109,339,852 (GRCm39) |
D41G |
possibly damaging |
Het |
| Vmn2r4 |
T |
C |
3: 64,305,976 (GRCm39) |
D393G |
probably benign |
Het |
| Wipf2 |
C |
T |
11: 98,783,236 (GRCm39) |
R221* |
probably null |
Het |
| Zfp976 |
C |
A |
7: 42,263,105 (GRCm39) |
C244F |
unknown |
Het |
| Zmym5 |
A |
G |
14: 57,036,577 (GRCm39) |
V190A |
probably damaging |
Het |
|
| Other mutations in Nav1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01061:Nav1
|
APN |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01455:Nav1
|
APN |
1 |
135,397,373 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL01650:Nav1
|
APN |
1 |
135,382,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01872:Nav1
|
APN |
1 |
135,381,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01967:Nav1
|
APN |
1 |
135,464,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02167:Nav1
|
APN |
1 |
135,398,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02278:Nav1
|
APN |
1 |
135,391,452 (GRCm39) |
splice site |
probably benign |
|
|
IGL02343:Nav1
|
APN |
1 |
135,382,490 (GRCm39) |
nonsense |
probably null |
|
|
IGL02378:Nav1
|
APN |
1 |
135,397,716 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02554:Nav1
|
APN |
1 |
135,512,651 (GRCm39) |
synonymous |
silent |
|
|
IGL03148:Nav1
|
APN |
1 |
135,397,762 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03286:Nav1
|
APN |
1 |
135,382,274 (GRCm39) |
missense |
probably benign |
|
|
IGL03372:Nav1
|
APN |
1 |
135,378,641 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4802001:Nav1
|
UTSW |
1 |
135,380,671 (GRCm39) |
missense |
unknown |
|
|
R0388:Nav1
|
UTSW |
1 |
135,376,655 (GRCm39) |
splice site |
probably benign |
|
|
R0390:Nav1
|
UTSW |
1 |
135,377,704 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0395:Nav1
|
UTSW |
1 |
135,460,361 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0395:Nav1
|
UTSW |
1 |
135,460,359 (GRCm39) |
nonsense |
probably null |
|
|
R0416:Nav1
|
UTSW |
1 |
135,398,864 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0463:Nav1
|
UTSW |
1 |
135,379,945 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R0538:Nav1
|
UTSW |
1 |
135,392,430 (GRCm39) |
splice site |
probably benign |
|
|
R0594:Nav1
|
UTSW |
1 |
135,395,381 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R0696:Nav1
|
UTSW |
1 |
135,460,352 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0699:Nav1
|
UTSW |
1 |
135,380,687 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0759:Nav1
|
UTSW |
1 |
135,382,998 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1164:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
|
|
R1169:Nav1
|
UTSW |
1 |
135,382,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1401:Nav1
|
UTSW |
1 |
135,388,163 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1421:Nav1
|
UTSW |
1 |
135,512,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1642:Nav1
|
UTSW |
1 |
135,380,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1705:Nav1
|
UTSW |
1 |
135,512,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1713:Nav1
|
UTSW |
1 |
135,522,972 (GRCm39) |
intron |
probably benign |
|
|
R1728:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1729:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1730:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1739:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1740:Nav1
|
UTSW |
1 |
135,386,127 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1762:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1783:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1784:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1785:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1895:Nav1
|
UTSW |
1 |
135,386,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1896:Nav1
|
UTSW |
1 |
135,388,475 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1901:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1902:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1925:Nav1
|
UTSW |
1 |
135,534,967 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R1971:Nav1
|
UTSW |
1 |
135,460,091 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2063:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2066:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2084:Nav1
|
UTSW |
1 |
135,535,158 (GRCm39) |
unclassified |
probably benign |
|
|
R2090:Nav1
|
UTSW |
1 |
135,534,903 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R2107:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2110:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2111:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2112:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2136:Nav1
|
UTSW |
1 |
135,382,174 (GRCm39) |
missense |
probably null |
0.18 |
|
R2268:Nav1
|
UTSW |
1 |
135,399,974 (GRCm39) |
nonsense |
probably null |
|
|
R2269:Nav1
|
UTSW |
1 |
135,399,974 (GRCm39) |
nonsense |
probably null |
|
|
R2847:Nav1
|
UTSW |
1 |
135,378,382 (GRCm39) |
splice site |
probably null |
|
|
R2869:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2871:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2872:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2904:Nav1
|
UTSW |
1 |
135,512,976 (GRCm39) |
missense |
probably benign |
|
|
R3690:Nav1
|
UTSW |
1 |
135,395,382 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3716:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3717:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3718:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3815:Nav1
|
UTSW |
1 |
135,398,862 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4282:Nav1
|
UTSW |
1 |
135,385,651 (GRCm39) |
intron |
probably benign |
|
|
R4361:Nav1
|
UTSW |
1 |
135,535,175 (GRCm39) |
unclassified |
probably benign |
|
|
R4610:Nav1
|
UTSW |
1 |
135,520,186 (GRCm39) |
intron |
probably benign |
|
|
R4730:Nav1
|
UTSW |
1 |
135,535,049 (GRCm39) |
unclassified |
probably benign |
|
|
R4784:Nav1
|
UTSW |
1 |
135,386,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4788:Nav1
|
UTSW |
1 |
135,397,461 (GRCm39) |
missense |
probably benign |
|
|
R4808:Nav1
|
UTSW |
1 |
135,382,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4996:Nav1
|
UTSW |
1 |
135,393,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5284:Nav1
|
UTSW |
1 |
135,377,701 (GRCm39) |
nonsense |
probably null |
|
|
R5514:Nav1
|
UTSW |
1 |
135,398,299 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5769:Nav1
|
UTSW |
1 |
135,379,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5834:Nav1
|
UTSW |
1 |
135,460,144 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5898:Nav1
|
UTSW |
1 |
135,512,884 (GRCm39) |
missense |
probably benign |
|
|
R6081:Nav1
|
UTSW |
1 |
135,398,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6344:Nav1
|
UTSW |
1 |
135,378,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Nav1
|
UTSW |
1 |
135,382,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7001:Nav1
|
UTSW |
1 |
135,382,349 (GRCm39) |
splice site |
probably null |
|
|
R7185:Nav1
|
UTSW |
1 |
135,398,746 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7291:Nav1
|
UTSW |
1 |
135,393,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Nav1
|
UTSW |
1 |
135,380,591 (GRCm39) |
missense |
unknown |
|
|
R7390:Nav1
|
UTSW |
1 |
135,512,656 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7464:Nav1
|
UTSW |
1 |
135,512,647 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7502:Nav1
|
UTSW |
1 |
135,397,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7601:Nav1
|
UTSW |
1 |
135,388,176 (GRCm39) |
missense |
unknown |
|
|
R7625:Nav1
|
UTSW |
1 |
135,395,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7639:Nav1
|
UTSW |
1 |
135,398,860 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7786:Nav1
|
UTSW |
1 |
135,397,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7808:Nav1
|
UTSW |
1 |
135,379,986 (GRCm39) |
missense |
unknown |
|
|
R7815:Nav1
|
UTSW |
1 |
135,512,377 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7825:Nav1
|
UTSW |
1 |
135,377,782 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8030:Nav1
|
UTSW |
1 |
135,464,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8370:Nav1
|
UTSW |
1 |
135,398,882 (GRCm39) |
nonsense |
probably null |
|
|
R8405:Nav1
|
UTSW |
1 |
135,382,508 (GRCm39) |
missense |
unknown |
|
|
R8720:Nav1
|
UTSW |
1 |
135,388,464 (GRCm39) |
missense |
unknown |
|
|
R8868:Nav1
|
UTSW |
1 |
135,512,943 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8973:Nav1
|
UTSW |
1 |
135,512,463 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9039:Nav1
|
UTSW |
1 |
135,371,487 (GRCm39) |
missense |
unknown |
|
|
R9261:Nav1
|
UTSW |
1 |
135,388,095 (GRCm39) |
missense |
unknown |
|
|
R9523:Nav1
|
UTSW |
1 |
135,379,929 (GRCm39) |
missense |
unknown |
|
|
Z1088:Nav1
|
UTSW |
1 |
135,398,462 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Nav1
|
UTSW |
1 |
135,400,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Nav1
|
UTSW |
1 |
135,380,624 (GRCm39) |
missense |
unknown |
|
|
Z1177:Nav1
|
UTSW |
1 |
135,397,469 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCCAAGTTGATGTCCTGTG -3'
(R):5'- TAACCTCCAGCTGCTTGCAC -3'
Sequencing Primer
(F):5'- GCCCAAGTTGATGTCCTGTGAAATC -3'
(R):5'- ACCAGAGAGCTGATGACCCTG -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation