Incidental Mutation 'R1939:Tet2'
| ID |
213795 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tet2
|
| Ensembl Gene |
ENSMUSG00000040943 |
| Gene Name |
tet methylcytosine dioxygenase 2 |
| Synonyms |
E130014J05Rik, Ayu17-449 |
| MMRRC Submission |
039957-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1939 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
133169438-133250882 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 133194399 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 12
(T12A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000096203
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000098603]
[ENSMUST00000196398]
[ENSMUST00000197118]
|
| AlphaFold |
Q4JK59 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000098603
AA Change: T12A
PolyPhen 2
Score 0.682 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000096203
Gene: ENSMUSG00000040943
AA Change: T12A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
690 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
862 |
N/A |
INTRINSIC |
|
low complexity region
|
884 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
899 |
921 |
N/A |
INTRINSIC |
|
Tet_JBP
|
1203 |
1819 |
7e-301 |
SMART |
|
low complexity region
|
1832 |
1844 |
N/A |
INTRINSIC |
|
low complexity region
|
1885 |
1897 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000196398
AA Change: T12A
PolyPhen 2
Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000143029
Gene: ENSMUSG00000040943
AA Change: T12A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
690 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
862 |
N/A |
INTRINSIC |
|
low complexity region
|
884 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
899 |
921 |
N/A |
INTRINSIC |
|
Tet_JBP
|
1211 |
1827 |
3.4e-305 |
SMART |
|
low complexity region
|
1840 |
1852 |
N/A |
INTRINSIC |
|
low complexity region
|
1893 |
1905 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000197118
AA Change: T12A
PolyPhen 2
Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.6%
- 20x: 93.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele die shortly after birth and exhibit a loss of acidic granules in the proximal convoluted tubules of the kidneys. Mice homozygous for a conditional allele activated in hematopoeitic compartment exhibit self-renewal and myeloid transforamtion. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(1246) : Targeted(6) Gene trapped(1240)
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700020L24Rik |
T |
A |
11: 83,331,130 (GRCm39) |
W11R |
probably damaging |
Het |
| 2700049A03Rik |
A |
G |
12: 71,207,186 (GRCm39) |
|
probably null |
Het |
| 4933409G03Rik |
T |
C |
2: 68,419,328 (GRCm39) |
S26P |
possibly damaging |
Het |
| Ace2 |
A |
T |
X: 162,939,524 (GRCm39) |
M123L |
possibly damaging |
Het |
| Acot3 |
A |
G |
12: 84,105,325 (GRCm39) |
N264S |
probably benign |
Het |
| Acvr1c |
A |
T |
2: 58,173,517 (GRCm39) |
N248K |
probably damaging |
Het |
| Adam22 |
A |
T |
5: 8,380,015 (GRCm39) |
F94L |
probably damaging |
Het |
| Adarb2 |
T |
C |
13: 8,253,358 (GRCm39) |
|
probably null |
Het |
| Aldh1b1 |
A |
G |
4: 45,802,755 (GRCm39) |
M98V |
possibly damaging |
Het |
| Arfgef2 |
T |
A |
2: 166,715,548 (GRCm39) |
V1331D |
probably damaging |
Het |
| Atf2 |
G |
A |
2: 73,676,563 (GRCm39) |
P184S |
probably damaging |
Het |
| Atp8b3 |
A |
T |
10: 80,361,220 (GRCm39) |
C785* |
probably null |
Het |
| Birc6 |
T |
C |
17: 74,977,332 (GRCm39) |
S4362P |
probably damaging |
Het |
| Brd10 |
A |
G |
19: 29,731,077 (GRCm39) |
F712S |
possibly damaging |
Het |
| Chn1 |
A |
G |
2: 73,455,245 (GRCm39) |
C39R |
probably damaging |
Het |
| Cngb1 |
C |
A |
8: 96,026,320 (GRCm39) |
G154W |
probably damaging |
Het |
| Cntnap5b |
A |
G |
1: 99,895,073 (GRCm39) |
H115R |
probably benign |
Het |
| Col23a1 |
A |
G |
11: 51,442,816 (GRCm39) |
D159G |
unknown |
Het |
| Coro7 |
T |
C |
16: 4,446,596 (GRCm39) |
E843G |
probably benign |
Het |
| Dnase2a |
G |
T |
8: 85,637,524 (GRCm39) |
A309S |
possibly damaging |
Het |
| Dync2h1 |
A |
G |
9: 7,139,159 (GRCm39) |
|
probably null |
Het |
| Engase |
T |
A |
11: 118,370,012 (GRCm39) |
N97K |
probably damaging |
Het |
| Fam83b |
A |
T |
9: 76,400,362 (GRCm39) |
M247K |
probably damaging |
Het |
| Fer |
T |
C |
17: 64,280,123 (GRCm39) |
S65P |
probably damaging |
Het |
| Fgf10 |
A |
G |
13: 118,925,688 (GRCm39) |
R156G |
probably damaging |
Het |
| Gm10608 |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
9: 118,989,784 (GRCm39) |
|
probably null |
Het |
| Gm904 |
T |
C |
13: 50,798,772 (GRCm39) |
|
probably null |
Het |
| Gpat2 |
T |
A |
2: 127,277,879 (GRCm39) |
*802K |
probably null |
Het |
| Hcfc2 |
G |
T |
10: 82,538,284 (GRCm39) |
R107L |
probably damaging |
Het |
| Itga8 |
T |
G |
2: 12,305,657 (GRCm39) |
D111A |
probably damaging |
Het |
| Jag1 |
C |
G |
2: 136,925,393 (GRCm39) |
V1070L |
possibly damaging |
Het |
| Lama5 |
T |
C |
2: 179,832,714 (GRCm39) |
N1646S |
probably benign |
Het |
| Lgals8 |
T |
G |
13: 12,474,069 (GRCm39) |
I10L |
probably benign |
Het |
| Lrp1b |
A |
G |
2: 40,587,601 (GRCm39) |
S116P |
unknown |
Het |
| Mcpt1 |
A |
T |
14: 56,256,546 (GRCm39) |
K94I |
possibly damaging |
Het |
| Mpnd |
T |
C |
17: 56,322,920 (GRCm39) |
F384S |
probably damaging |
Het |
| Mrgprb5 |
A |
T |
7: 47,818,686 (GRCm39) |
N16K |
probably benign |
Het |
| Myo15b |
A |
G |
11: 115,778,529 (GRCm39) |
T1139A |
probably benign |
Het |
| Nat8f5 |
A |
C |
6: 85,794,801 (GRCm39) |
I53R |
possibly damaging |
Het |
| Nav1 |
A |
T |
1: 135,393,636 (GRCm39) |
L1034Q |
probably damaging |
Het |
| Nudt6 |
T |
C |
3: 37,459,379 (GRCm39) |
Y54C |
probably damaging |
Het |
| Or10j3b |
G |
T |
1: 173,043,499 (GRCm39) |
A94S |
probably benign |
Het |
| Or5p58 |
A |
G |
7: 107,694,348 (GRCm39) |
V143A |
probably benign |
Het |
| Or6c217 |
A |
C |
10: 129,737,970 (GRCm39) |
M203R |
probably damaging |
Het |
| Or8b35 |
A |
G |
9: 37,904,385 (GRCm39) |
N199S |
probably benign |
Het |
| Or8c15 |
T |
A |
9: 38,120,725 (GRCm39) |
Y72* |
probably null |
Het |
| Osbpl8 |
A |
T |
10: 111,125,672 (GRCm39) |
H784L |
probably benign |
Het |
| Osr1 |
T |
G |
12: 9,629,687 (GRCm39) |
S187A |
probably damaging |
Het |
| Pcdhgc5 |
A |
G |
18: 37,955,003 (GRCm39) |
Y759C |
probably damaging |
Het |
| Pkd1l2 |
G |
T |
8: 117,772,921 (GRCm39) |
Y1035* |
probably null |
Het |
| Pla2g15 |
A |
G |
8: 106,889,927 (GRCm39) |
T400A |
probably damaging |
Het |
| Pms1 |
A |
C |
1: 53,236,135 (GRCm39) |
L715R |
probably damaging |
Het |
| Prkd1 |
T |
C |
12: 50,441,777 (GRCm39) |
N254S |
probably benign |
Het |
| Prkdc |
T |
C |
16: 15,653,777 (GRCm39) |
V3868A |
possibly damaging |
Het |
| Ptprt |
T |
C |
2: 161,769,560 (GRCm39) |
N435S |
probably benign |
Het |
| Purb |
T |
C |
11: 6,424,943 (GRCm39) |
E315G |
unknown |
Het |
| Rap1b |
A |
T |
10: 117,654,491 (GRCm39) |
N116K |
probably damaging |
Het |
| Rmc1 |
T |
C |
18: 12,313,562 (GRCm39) |
L15P |
probably damaging |
Het |
| Rp1l1 |
A |
G |
14: 64,267,042 (GRCm39) |
N876S |
probably benign |
Het |
| Rps6ka4 |
T |
A |
19: 6,816,834 (GRCm39) |
I114F |
probably damaging |
Het |
| Semp2l1 |
T |
C |
1: 32,584,627 (GRCm39) |
I428V |
probably damaging |
Het |
| Sh3bp2 |
A |
G |
5: 34,708,963 (GRCm39) |
N19D |
probably damaging |
Het |
| Slc16a4 |
A |
G |
3: 107,208,317 (GRCm39) |
M276V |
probably benign |
Het |
| Slc17a1 |
A |
G |
13: 24,059,864 (GRCm39) |
T172A |
probably benign |
Het |
| Slc4a7 |
C |
T |
14: 14,748,581 (GRCm38) |
A320V |
probably damaging |
Het |
| Slco1a6 |
T |
A |
6: 142,078,956 (GRCm39) |
Y113F |
probably damaging |
Het |
| Srsf6 |
C |
T |
2: 162,776,403 (GRCm39) |
|
probably benign |
Het |
| St3gal6 |
A |
T |
16: 58,293,924 (GRCm39) |
|
probably null |
Het |
| Tdp2 |
A |
G |
13: 25,025,260 (GRCm39) |
D343G |
probably benign |
Het |
| Tecpr2 |
T |
A |
12: 110,899,603 (GRCm39) |
L657Q |
probably damaging |
Het |
| Trappc6a |
T |
A |
7: 19,248,426 (GRCm39) |
F28I |
probably damaging |
Het |
| Trim32 |
G |
A |
4: 65,532,303 (GRCm39) |
V287I |
probably benign |
Het |
| Trpd52l3 |
T |
C |
19: 29,981,289 (GRCm39) |
S15P |
probably damaging |
Het |
| Tsnaxip1 |
A |
G |
8: 106,566,670 (GRCm39) |
I169V |
probably benign |
Het |
| Ttc34 |
G |
A |
4: 154,950,139 (GRCm39) |
A1031T |
possibly damaging |
Het |
| Ttll11 |
T |
A |
2: 35,830,765 (GRCm39) |
Q18L |
probably null |
Het |
| Ttll8 |
A |
T |
15: 88,799,689 (GRCm39) |
I584N |
probably damaging |
Het |
| Ubiad1 |
A |
G |
4: 148,528,468 (GRCm39) |
L147P |
probably damaging |
Het |
| Ucp3 |
T |
C |
7: 100,129,871 (GRCm39) |
V171A |
probably benign |
Het |
| Vmn1r174 |
T |
A |
7: 23,453,532 (GRCm39) |
I66N |
probably damaging |
Het |
| Vmn2r13 |
T |
C |
5: 109,339,852 (GRCm39) |
D41G |
possibly damaging |
Het |
| Vmn2r4 |
T |
C |
3: 64,305,976 (GRCm39) |
D393G |
probably benign |
Het |
| Wipf2 |
C |
T |
11: 98,783,236 (GRCm39) |
R221* |
probably null |
Het |
| Zfp976 |
C |
A |
7: 42,263,105 (GRCm39) |
C244F |
unknown |
Het |
| Zmym5 |
A |
G |
14: 57,036,577 (GRCm39) |
V190A |
probably damaging |
Het |
|
| Other mutations in Tet2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00341:Tet2
|
APN |
3 |
133,193,846 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL00401:Tet2
|
APN |
3 |
133,172,643 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01528:Tet2
|
APN |
3 |
133,186,059 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02053:Tet2
|
APN |
3 |
133,194,284 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02142:Tet2
|
APN |
3 |
133,185,900 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02512:Tet2
|
APN |
3 |
133,175,069 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03148:Tet2
|
APN |
3 |
133,187,124 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL03182:Tet2
|
APN |
3 |
133,177,159 (GRCm39) |
nonsense |
probably null |
|
|
IGL03371:Tet2
|
APN |
3 |
133,173,312 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
P0022:Tet2
|
UTSW |
3 |
133,192,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
P0023:Tet2
|
UTSW |
3 |
133,192,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
P0031:Tet2
|
UTSW |
3 |
133,185,963 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0012:Tet2
|
UTSW |
3 |
133,182,319 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0012:Tet2
|
UTSW |
3 |
133,182,319 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0463:Tet2
|
UTSW |
3 |
133,192,427 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0522:Tet2
|
UTSW |
3 |
133,172,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0593:Tet2
|
UTSW |
3 |
133,193,870 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0600:Tet2
|
UTSW |
3 |
133,173,486 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0600:Tet2
|
UTSW |
3 |
133,173,363 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0698:Tet2
|
UTSW |
3 |
133,173,145 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0723:Tet2
|
UTSW |
3 |
133,173,045 (GRCm39) |
missense |
probably benign |
|
|
R0726:Tet2
|
UTSW |
3 |
133,173,945 (GRCm39) |
missense |
probably benign |
|
|
R0747:Tet2
|
UTSW |
3 |
133,173,231 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1006:Tet2
|
UTSW |
3 |
133,182,362 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1382:Tet2
|
UTSW |
3 |
133,182,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1455:Tet2
|
UTSW |
3 |
133,179,406 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1550:Tet2
|
UTSW |
3 |
133,175,280 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1647:Tet2
|
UTSW |
3 |
133,191,641 (GRCm39) |
missense |
probably benign |
|
|
R1662:Tet2
|
UTSW |
3 |
133,172,613 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1727:Tet2
|
UTSW |
3 |
133,193,051 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1738:Tet2
|
UTSW |
3 |
133,187,148 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1749:Tet2
|
UTSW |
3 |
133,185,892 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1869:Tet2
|
UTSW |
3 |
133,187,202 (GRCm39) |
splice site |
probably null |
|
|
R1887:Tet2
|
UTSW |
3 |
133,193,094 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1937:Tet2
|
UTSW |
3 |
133,194,399 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1940:Tet2
|
UTSW |
3 |
133,194,399 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1997:Tet2
|
UTSW |
3 |
133,192,350 (GRCm39) |
nonsense |
probably null |
|
|
R2082:Tet2
|
UTSW |
3 |
133,191,488 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2084:Tet2
|
UTSW |
3 |
133,193,528 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R2215:Tet2
|
UTSW |
3 |
133,192,362 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2321:Tet2
|
UTSW |
3 |
133,192,100 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2873:Tet2
|
UTSW |
3 |
133,192,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3439:Tet2
|
UTSW |
3 |
133,172,592 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3783:Tet2
|
UTSW |
3 |
133,185,124 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3894:Tet2
|
UTSW |
3 |
133,175,238 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3916:Tet2
|
UTSW |
3 |
133,191,816 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3966:Tet2
|
UTSW |
3 |
133,193,418 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4457:Tet2
|
UTSW |
3 |
133,191,324 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4633:Tet2
|
UTSW |
3 |
133,191,310 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4646:Tet2
|
UTSW |
3 |
133,193,843 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4647:Tet2
|
UTSW |
3 |
133,193,843 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4648:Tet2
|
UTSW |
3 |
133,193,843 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4691:Tet2
|
UTSW |
3 |
133,191,844 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4805:Tet2
|
UTSW |
3 |
133,173,076 (GRCm39) |
missense |
probably benign |
0.32 |
|
R4829:Tet2
|
UTSW |
3 |
133,182,381 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4901:Tet2
|
UTSW |
3 |
133,172,805 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4975:Tet2
|
UTSW |
3 |
133,192,520 (GRCm39) |
unclassified |
probably benign |
|
|
R5004:Tet2
|
UTSW |
3 |
133,193,140 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5075:Tet2
|
UTSW |
3 |
133,192,667 (GRCm39) |
missense |
probably benign |
|
|
R5137:Tet2
|
UTSW |
3 |
133,182,326 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5324:Tet2
|
UTSW |
3 |
133,191,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5590:Tet2
|
UTSW |
3 |
133,182,241 (GRCm39) |
splice site |
probably null |
|
|
R5854:Tet2
|
UTSW |
3 |
133,193,646 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5856:Tet2
|
UTSW |
3 |
133,192,401 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5865:Tet2
|
UTSW |
3 |
133,192,860 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5879:Tet2
|
UTSW |
3 |
133,193,721 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R5935:Tet2
|
UTSW |
3 |
133,194,296 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6012:Tet2
|
UTSW |
3 |
133,172,542 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6075:Tet2
|
UTSW |
3 |
133,177,196 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R6181:Tet2
|
UTSW |
3 |
133,193,520 (GRCm39) |
nonsense |
probably null |
|
|
R6188:Tet2
|
UTSW |
3 |
133,186,087 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6339:Tet2
|
UTSW |
3 |
133,192,178 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6612:Tet2
|
UTSW |
3 |
133,193,096 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6923:Tet2
|
UTSW |
3 |
133,185,102 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6934:Tet2
|
UTSW |
3 |
133,188,998 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7076:Tet2
|
UTSW |
3 |
133,172,784 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7155:Tet2
|
UTSW |
3 |
133,175,352 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7184:Tet2
|
UTSW |
3 |
133,179,391 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7200:Tet2
|
UTSW |
3 |
133,192,953 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7459:Tet2
|
UTSW |
3 |
133,186,050 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7504:Tet2
|
UTSW |
3 |
133,193,100 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7524:Tet2
|
UTSW |
3 |
133,185,990 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7613:Tet2
|
UTSW |
3 |
133,172,509 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7653:Tet2
|
UTSW |
3 |
133,192,146 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7691:Tet2
|
UTSW |
3 |
133,192,610 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7770:Tet2
|
UTSW |
3 |
133,186,056 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7807:Tet2
|
UTSW |
3 |
133,192,302 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7813:Tet2
|
UTSW |
3 |
133,179,404 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7978:Tet2
|
UTSW |
3 |
133,193,426 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8055:Tet2
|
UTSW |
3 |
133,173,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8164:Tet2
|
UTSW |
3 |
133,172,895 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8236:Tet2
|
UTSW |
3 |
133,193,547 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8755:Tet2
|
UTSW |
3 |
133,194,039 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8962:Tet2
|
UTSW |
3 |
133,193,804 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9009:Tet2
|
UTSW |
3 |
133,193,360 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9014:Tet2
|
UTSW |
3 |
133,172,949 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9128:Tet2
|
UTSW |
3 |
133,175,374 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9166:Tet2
|
UTSW |
3 |
133,173,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9190:Tet2
|
UTSW |
3 |
133,187,147 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9344:Tet2
|
UTSW |
3 |
133,175,115 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9360:Tet2
|
UTSW |
3 |
133,192,903 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9471:Tet2
|
UTSW |
3 |
133,191,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9488:Tet2
|
UTSW |
3 |
133,193,103 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9534:Tet2
|
UTSW |
3 |
133,173,689 (GRCm39) |
nonsense |
probably null |
|
|
R9557:Tet2
|
UTSW |
3 |
133,191,566 (GRCm39) |
missense |
probably benign |
|
|
R9621:Tet2
|
UTSW |
3 |
133,193,767 (GRCm39) |
nonsense |
probably null |
|
|
R9644:Tet2
|
UTSW |
3 |
133,193,064 (GRCm39) |
nonsense |
probably null |
|
|
R9719:Tet2
|
UTSW |
3 |
133,191,803 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
X0021:Tet2
|
UTSW |
3 |
133,192,056 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
X0066:Tet2
|
UTSW |
3 |
133,194,134 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- AATACCCTCTGTCTTCATGTGGAC -3'
(R):5'- CTCCATGCAGGGAAGACAAG -3'
Sequencing Primer
(F):5'- ATGTGGACTCTCATGACTGC -3'
(R):5'- CTCCATGCAGGGAAGACAAGAGTAG -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation