Incidental Mutation 'R1940:Tet2'
| ID |
213906 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tet2
|
| Ensembl Gene |
ENSMUSG00000040943 |
| Gene Name |
tet methylcytosine dioxygenase 2 |
| Synonyms |
E130014J05Rik, Ayu17-449 |
| MMRRC Submission |
039958-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1940 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
133169438-133250882 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 133194399 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 12
(T12A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000096203
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000098603]
[ENSMUST00000196398]
[ENSMUST00000197118]
|
| AlphaFold |
Q4JK59 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000098603
AA Change: T12A
PolyPhen 2
Score 0.682 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000096203
Gene: ENSMUSG00000040943
AA Change: T12A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
690 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
862 |
N/A |
INTRINSIC |
|
low complexity region
|
884 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
899 |
921 |
N/A |
INTRINSIC |
|
Tet_JBP
|
1203 |
1819 |
7e-301 |
SMART |
|
low complexity region
|
1832 |
1844 |
N/A |
INTRINSIC |
|
low complexity region
|
1885 |
1897 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000196398
AA Change: T12A
PolyPhen 2
Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000143029
Gene: ENSMUSG00000040943
AA Change: T12A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
690 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
862 |
N/A |
INTRINSIC |
|
low complexity region
|
884 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
899 |
921 |
N/A |
INTRINSIC |
|
Tet_JBP
|
1211 |
1827 |
3.4e-305 |
SMART |
|
low complexity region
|
1840 |
1852 |
N/A |
INTRINSIC |
|
low complexity region
|
1893 |
1905 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000197118
AA Change: T12A
PolyPhen 2
Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.8%
- 20x: 93.7%
|
| Validation Efficiency |
98% (108/110) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele die shortly after birth and exhibit a loss of acidic granules in the proximal convoluted tubules of the kidneys. Mice homozygous for a conditional allele activated in hematopoeitic compartment exhibit self-renewal and myeloid transforamtion. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(1246) : Targeted(6) Gene trapped(1240)
|
| Other mutations in this stock |
Total: 107 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca16 |
T |
C |
7: 120,032,832 (GRCm39) |
|
probably benign |
Het |
| Ace2 |
A |
T |
X: 162,939,524 (GRCm39) |
M123L |
possibly damaging |
Het |
| Acvr1c |
A |
T |
2: 58,173,517 (GRCm39) |
N248K |
probably damaging |
Het |
| Adam24 |
A |
T |
8: 41,134,400 (GRCm39) |
R623* |
probably null |
Het |
| Agbl2 |
T |
A |
2: 90,641,626 (GRCm39) |
L752Q |
probably damaging |
Het |
| Ankrd26 |
A |
T |
6: 118,488,654 (GRCm39) |
F1335Y |
probably damaging |
Het |
| Ankrd34a |
A |
G |
3: 96,505,992 (GRCm39) |
S399G |
probably benign |
Het |
| Aoc1l3 |
A |
T |
6: 48,967,007 (GRCm39) |
K652* |
probably null |
Het |
| Ap3d1 |
G |
A |
10: 80,545,607 (GRCm39) |
P1041S |
probably benign |
Het |
| Arid3b |
A |
T |
9: 57,703,431 (GRCm39) |
M466K |
possibly damaging |
Het |
| Arsj |
T |
C |
3: 126,231,995 (GRCm39) |
I247T |
probably damaging |
Het |
| AU016765 |
G |
A |
17: 64,826,873 (GRCm39) |
|
noncoding transcript |
Het |
| Azin2 |
C |
T |
4: 128,844,577 (GRCm39) |
|
probably null |
Het |
| Bcat2 |
T |
C |
7: 45,237,792 (GRCm39) |
Y313H |
possibly damaging |
Het |
| Cables2 |
A |
G |
2: 179,901,873 (GRCm39) |
V465A |
probably damaging |
Het |
| Ccdc60 |
G |
A |
5: 116,264,224 (GRCm39) |
H517Y |
probably damaging |
Het |
| Cd55b |
A |
T |
1: 130,345,843 (GRCm39) |
|
probably null |
Het |
| Cdc40 |
G |
A |
10: 40,759,067 (GRCm39) |
|
probably benign |
Het |
| Cdh20 |
G |
A |
1: 109,976,754 (GRCm39) |
V140I |
probably benign |
Het |
| Cdhr18 |
A |
T |
14: 13,828,582 (GRCm38) |
M726K |
probably null |
Het |
| Cfi |
T |
C |
3: 129,652,477 (GRCm39) |
|
probably benign |
Het |
| Chit1 |
G |
A |
1: 134,073,156 (GRCm39) |
|
probably null |
Het |
| Chn1 |
A |
G |
2: 73,455,245 (GRCm39) |
C39R |
probably damaging |
Het |
| Ciao1 |
A |
G |
2: 127,088,380 (GRCm39) |
S148P |
possibly damaging |
Het |
| Clmn |
G |
A |
12: 104,756,361 (GRCm39) |
T163I |
probably damaging |
Het |
| Cngb1 |
C |
A |
8: 96,026,320 (GRCm39) |
G154W |
probably damaging |
Het |
| Col19a1 |
A |
T |
1: 24,303,831 (GRCm39) |
C1117* |
probably null |
Het |
| Cplane1 |
T |
A |
15: 8,263,336 (GRCm39) |
S2496R |
probably damaging |
Het |
| Cyp2d10 |
T |
A |
15: 82,289,495 (GRCm39) |
I206F |
probably benign |
Het |
| Ddrgk1 |
G |
T |
2: 130,505,480 (GRCm39) |
|
probably benign |
Het |
| Ddx18 |
A |
T |
1: 121,482,953 (GRCm39) |
V611D |
probably damaging |
Het |
| Dnah8 |
A |
T |
17: 30,950,181 (GRCm39) |
H2000L |
probably damaging |
Het |
| Duox1 |
T |
C |
2: 122,156,465 (GRCm39) |
V464A |
probably benign |
Het |
| Dync2h1 |
A |
G |
9: 7,139,159 (GRCm39) |
|
probably null |
Het |
| Eif4enif1 |
A |
G |
11: 3,193,279 (GRCm39) |
H857R |
probably damaging |
Het |
| Elmo2 |
A |
G |
2: 165,133,970 (GRCm39) |
|
probably benign |
Het |
| Fam171b |
CCAGCAGCAGCAGCAGCAGCAGC |
CCAGCAGCAGCAGCAGCAGC |
2: 83,643,218 (GRCm39) |
|
probably benign |
Het |
| Glrx |
A |
G |
13: 75,988,256 (GRCm39) |
I57V |
probably benign |
Het |
| Golm1 |
A |
T |
13: 59,790,051 (GRCm39) |
|
probably benign |
Het |
| Grm3 |
G |
A |
5: 9,561,682 (GRCm39) |
R723W |
probably damaging |
Het |
| Gsta3 |
G |
A |
1: 21,327,601 (GRCm39) |
R45Q |
probably benign |
Het |
| Gtf3c3 |
A |
C |
1: 54,468,117 (GRCm39) |
|
probably benign |
Het |
| Hk3 |
C |
T |
13: 55,159,204 (GRCm39) |
V451I |
probably damaging |
Het |
| Hoxa10 |
C |
A |
6: 52,211,350 (GRCm39) |
G189C |
possibly damaging |
Het |
| Hs3st3b1 |
T |
C |
11: 63,780,569 (GRCm39) |
D186G |
probably benign |
Het |
| Hscb |
G |
T |
5: 110,983,926 (GRCm39) |
H63N |
probably benign |
Het |
| Itpr3 |
A |
G |
17: 27,330,191 (GRCm39) |
E1603G |
probably damaging |
Het |
| Ivl |
T |
A |
3: 92,480,056 (GRCm39) |
H3L |
probably benign |
Het |
| Klhl26 |
C |
A |
8: 70,904,911 (GRCm39) |
R252L |
probably damaging |
Het |
| Krt31 |
T |
A |
11: 99,939,069 (GRCm39) |
T251S |
probably benign |
Het |
| Lama5 |
T |
C |
2: 179,832,714 (GRCm39) |
N1646S |
probably benign |
Het |
| Lhx3 |
T |
C |
2: 26,093,974 (GRCm39) |
D83G |
probably benign |
Het |
| Lss |
C |
A |
10: 76,381,296 (GRCm39) |
N427K |
possibly damaging |
Het |
| Mettl24 |
G |
A |
10: 40,613,722 (GRCm39) |
A154T |
probably benign |
Het |
| Mgat4a |
A |
T |
1: 37,575,118 (GRCm39) |
|
probably null |
Het |
| Moxd2 |
C |
T |
6: 40,860,466 (GRCm39) |
R326Q |
probably damaging |
Het |
| Mpdz |
G |
A |
4: 81,279,680 (GRCm39) |
A669V |
probably benign |
Het |
| Msra |
G |
A |
14: 64,522,505 (GRCm39) |
|
probably benign |
Het |
| Muc13 |
A |
T |
16: 33,628,281 (GRCm39) |
T344S |
probably benign |
Het |
| Myo3b |
T |
C |
2: 70,088,419 (GRCm39) |
I866T |
probably benign |
Het |
| Nbea |
T |
C |
3: 55,860,521 (GRCm39) |
S1852G |
possibly damaging |
Het |
| Ncf2 |
A |
G |
1: 152,709,815 (GRCm39) |
|
probably benign |
Het |
| Nfyc |
C |
A |
4: 120,630,861 (GRCm39) |
|
probably benign |
Het |
| Nop2 |
T |
C |
6: 125,111,597 (GRCm39) |
V110A |
probably benign |
Het |
| Nrg2 |
C |
A |
18: 36,329,897 (GRCm39) |
|
probably benign |
Het |
| Nrl |
A |
G |
14: 55,759,892 (GRCm39) |
Y12H |
probably damaging |
Het |
| Nrxn3 |
T |
C |
12: 89,227,151 (GRCm39) |
V635A |
probably damaging |
Het |
| Or4d11 |
A |
C |
19: 12,013,275 (GRCm39) |
V277G |
probably benign |
Het |
| Or6b2b |
T |
A |
1: 92,419,457 (GRCm39) |
T7S |
probably benign |
Het |
| Or8k41 |
T |
A |
2: 86,313,703 (GRCm39) |
K128* |
probably null |
Het |
| Or9g8 |
T |
A |
2: 85,607,515 (GRCm39) |
S196T |
probably benign |
Het |
| Papolg |
A |
T |
11: 23,817,279 (GRCm39) |
N639K |
probably benign |
Het |
| Paqr4 |
T |
C |
17: 23,956,638 (GRCm39) |
I242V |
probably damaging |
Het |
| Pramel6 |
A |
T |
2: 87,339,076 (GRCm39) |
K92M |
probably damaging |
Het |
| Prg4 |
T |
C |
1: 150,331,774 (GRCm39) |
T300A |
possibly damaging |
Het |
| Ptprb |
A |
T |
10: 116,155,515 (GRCm39) |
|
probably benign |
Het |
| Rab28 |
A |
T |
5: 41,783,133 (GRCm39) |
S216T |
probably benign |
Het |
| Rrp1b |
A |
T |
17: 32,275,819 (GRCm39) |
R455S |
possibly damaging |
Het |
| Sash1 |
A |
T |
10: 8,605,696 (GRCm39) |
M898K |
probably benign |
Het |
| Scn8a |
C |
T |
15: 100,868,085 (GRCm39) |
T310I |
probably benign |
Het |
| Secisbp2l |
C |
A |
2: 125,582,259 (GRCm39) |
D1066Y |
probably damaging |
Het |
| Sipa1l2 |
A |
G |
8: 126,206,887 (GRCm39) |
|
probably benign |
Het |
| Slc12a1 |
A |
G |
2: 125,036,113 (GRCm39) |
T662A |
probably benign |
Het |
| Slc12a4 |
T |
C |
8: 106,672,669 (GRCm39) |
I749V |
probably benign |
Het |
| Slc22a27 |
A |
G |
19: 7,887,092 (GRCm39) |
S266P |
probably damaging |
Het |
| Slc25a14 |
G |
A |
X: 47,740,840 (GRCm39) |
V210I |
probably benign |
Het |
| Slit1 |
T |
A |
19: 41,619,215 (GRCm39) |
N762I |
probably damaging |
Het |
| Spata31d1b |
C |
A |
13: 59,865,835 (GRCm39) |
D994E |
possibly damaging |
Het |
| Sphk1 |
A |
G |
11: 116,426,676 (GRCm39) |
I204V |
probably benign |
Het |
| Srsf6 |
C |
T |
2: 162,776,403 (GRCm39) |
|
probably benign |
Het |
| Tgfbi |
A |
T |
13: 56,762,127 (GRCm39) |
Q70L |
possibly damaging |
Het |
| Tlr9 |
T |
C |
9: 106,101,846 (GRCm39) |
L379P |
probably damaging |
Het |
| Tnrc6c |
A |
G |
11: 117,646,849 (GRCm39) |
D1450G |
possibly damaging |
Het |
| Tra2b |
A |
G |
16: 22,073,795 (GRCm39) |
|
probably benign |
Het |
| Trit1 |
T |
C |
4: 122,948,033 (GRCm39) |
I451T |
probably benign |
Het |
| Trnau1ap |
A |
G |
4: 132,049,114 (GRCm39) |
Y30H |
probably damaging |
Het |
| Ttc34 |
G |
A |
4: 154,950,139 (GRCm39) |
A1031T |
possibly damaging |
Het |
| Ubiad1 |
A |
G |
4: 148,528,468 (GRCm39) |
L147P |
probably damaging |
Het |
| Ush2a |
A |
G |
1: 188,683,758 (GRCm39) |
D4979G |
probably null |
Het |
| Usp50 |
C |
T |
2: 126,619,943 (GRCm39) |
R123Q |
probably benign |
Het |
| Vmn2r117 |
A |
T |
17: 23,696,454 (GRCm39) |
Y318N |
probably damaging |
Het |
| Whamm |
C |
T |
7: 81,228,047 (GRCm39) |
T304I |
probably null |
Het |
| Wipf2 |
C |
T |
11: 98,783,236 (GRCm39) |
R221* |
probably null |
Het |
| Ythdf3 |
A |
G |
3: 16,259,256 (GRCm39) |
N468D |
possibly damaging |
Het |
| Zbtb17 |
T |
C |
4: 141,192,859 (GRCm39) |
I486T |
possibly damaging |
Het |
| Zfp3 |
T |
C |
11: 70,662,202 (GRCm39) |
S54P |
probably benign |
Het |
| Zscan10 |
A |
T |
17: 23,828,826 (GRCm39) |
H379L |
probably damaging |
Het |
|
| Other mutations in Tet2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00341:Tet2
|
APN |
3 |
133,193,846 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL00401:Tet2
|
APN |
3 |
133,172,643 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01528:Tet2
|
APN |
3 |
133,186,059 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02053:Tet2
|
APN |
3 |
133,194,284 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02142:Tet2
|
APN |
3 |
133,185,900 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02512:Tet2
|
APN |
3 |
133,175,069 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03148:Tet2
|
APN |
3 |
133,187,124 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL03182:Tet2
|
APN |
3 |
133,177,159 (GRCm39) |
nonsense |
probably null |
|
|
IGL03371:Tet2
|
APN |
3 |
133,173,312 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
P0022:Tet2
|
UTSW |
3 |
133,192,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
P0023:Tet2
|
UTSW |
3 |
133,192,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
P0031:Tet2
|
UTSW |
3 |
133,185,963 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0012:Tet2
|
UTSW |
3 |
133,182,319 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0012:Tet2
|
UTSW |
3 |
133,182,319 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0463:Tet2
|
UTSW |
3 |
133,192,427 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0522:Tet2
|
UTSW |
3 |
133,172,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0593:Tet2
|
UTSW |
3 |
133,193,870 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0600:Tet2
|
UTSW |
3 |
133,173,486 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0600:Tet2
|
UTSW |
3 |
133,173,363 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0698:Tet2
|
UTSW |
3 |
133,173,145 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0723:Tet2
|
UTSW |
3 |
133,173,045 (GRCm39) |
missense |
probably benign |
|
|
R0726:Tet2
|
UTSW |
3 |
133,173,945 (GRCm39) |
missense |
probably benign |
|
|
R0747:Tet2
|
UTSW |
3 |
133,173,231 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1006:Tet2
|
UTSW |
3 |
133,182,362 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1382:Tet2
|
UTSW |
3 |
133,182,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1455:Tet2
|
UTSW |
3 |
133,179,406 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1550:Tet2
|
UTSW |
3 |
133,175,280 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1647:Tet2
|
UTSW |
3 |
133,191,641 (GRCm39) |
missense |
probably benign |
|
|
R1662:Tet2
|
UTSW |
3 |
133,172,613 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1727:Tet2
|
UTSW |
3 |
133,193,051 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1738:Tet2
|
UTSW |
3 |
133,187,148 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1749:Tet2
|
UTSW |
3 |
133,185,892 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1869:Tet2
|
UTSW |
3 |
133,187,202 (GRCm39) |
splice site |
probably null |
|
|
R1887:Tet2
|
UTSW |
3 |
133,193,094 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1937:Tet2
|
UTSW |
3 |
133,194,399 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1939:Tet2
|
UTSW |
3 |
133,194,399 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1997:Tet2
|
UTSW |
3 |
133,192,350 (GRCm39) |
nonsense |
probably null |
|
|
R2082:Tet2
|
UTSW |
3 |
133,191,488 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2084:Tet2
|
UTSW |
3 |
133,193,528 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R2215:Tet2
|
UTSW |
3 |
133,192,362 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2321:Tet2
|
UTSW |
3 |
133,192,100 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2873:Tet2
|
UTSW |
3 |
133,192,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3439:Tet2
|
UTSW |
3 |
133,172,592 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3783:Tet2
|
UTSW |
3 |
133,185,124 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3894:Tet2
|
UTSW |
3 |
133,175,238 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3916:Tet2
|
UTSW |
3 |
133,191,816 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3966:Tet2
|
UTSW |
3 |
133,193,418 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4457:Tet2
|
UTSW |
3 |
133,191,324 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4633:Tet2
|
UTSW |
3 |
133,191,310 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4646:Tet2
|
UTSW |
3 |
133,193,843 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4647:Tet2
|
UTSW |
3 |
133,193,843 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4648:Tet2
|
UTSW |
3 |
133,193,843 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4691:Tet2
|
UTSW |
3 |
133,191,844 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4805:Tet2
|
UTSW |
3 |
133,173,076 (GRCm39) |
missense |
probably benign |
0.32 |
|
R4829:Tet2
|
UTSW |
3 |
133,182,381 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4901:Tet2
|
UTSW |
3 |
133,172,805 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4975:Tet2
|
UTSW |
3 |
133,192,520 (GRCm39) |
unclassified |
probably benign |
|
|
R5004:Tet2
|
UTSW |
3 |
133,193,140 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5075:Tet2
|
UTSW |
3 |
133,192,667 (GRCm39) |
missense |
probably benign |
|
|
R5137:Tet2
|
UTSW |
3 |
133,182,326 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5324:Tet2
|
UTSW |
3 |
133,191,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5590:Tet2
|
UTSW |
3 |
133,182,241 (GRCm39) |
splice site |
probably null |
|
|
R5854:Tet2
|
UTSW |
3 |
133,193,646 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5856:Tet2
|
UTSW |
3 |
133,192,401 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5865:Tet2
|
UTSW |
3 |
133,192,860 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5879:Tet2
|
UTSW |
3 |
133,193,721 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R5935:Tet2
|
UTSW |
3 |
133,194,296 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6012:Tet2
|
UTSW |
3 |
133,172,542 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6075:Tet2
|
UTSW |
3 |
133,177,196 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R6181:Tet2
|
UTSW |
3 |
133,193,520 (GRCm39) |
nonsense |
probably null |
|
|
R6188:Tet2
|
UTSW |
3 |
133,186,087 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6339:Tet2
|
UTSW |
3 |
133,192,178 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6612:Tet2
|
UTSW |
3 |
133,193,096 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6923:Tet2
|
UTSW |
3 |
133,185,102 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6934:Tet2
|
UTSW |
3 |
133,188,998 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7076:Tet2
|
UTSW |
3 |
133,172,784 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7155:Tet2
|
UTSW |
3 |
133,175,352 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7184:Tet2
|
UTSW |
3 |
133,179,391 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7200:Tet2
|
UTSW |
3 |
133,192,953 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7459:Tet2
|
UTSW |
3 |
133,186,050 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7504:Tet2
|
UTSW |
3 |
133,193,100 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7524:Tet2
|
UTSW |
3 |
133,185,990 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7613:Tet2
|
UTSW |
3 |
133,172,509 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7653:Tet2
|
UTSW |
3 |
133,192,146 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7691:Tet2
|
UTSW |
3 |
133,192,610 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7770:Tet2
|
UTSW |
3 |
133,186,056 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7807:Tet2
|
UTSW |
3 |
133,192,302 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7813:Tet2
|
UTSW |
3 |
133,179,404 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7978:Tet2
|
UTSW |
3 |
133,193,426 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8055:Tet2
|
UTSW |
3 |
133,173,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8164:Tet2
|
UTSW |
3 |
133,172,895 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8236:Tet2
|
UTSW |
3 |
133,193,547 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8755:Tet2
|
UTSW |
3 |
133,194,039 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8962:Tet2
|
UTSW |
3 |
133,193,804 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9009:Tet2
|
UTSW |
3 |
133,193,360 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9014:Tet2
|
UTSW |
3 |
133,172,949 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9128:Tet2
|
UTSW |
3 |
133,175,374 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9166:Tet2
|
UTSW |
3 |
133,173,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9190:Tet2
|
UTSW |
3 |
133,187,147 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9344:Tet2
|
UTSW |
3 |
133,175,115 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9360:Tet2
|
UTSW |
3 |
133,192,903 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9471:Tet2
|
UTSW |
3 |
133,191,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9488:Tet2
|
UTSW |
3 |
133,193,103 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9534:Tet2
|
UTSW |
3 |
133,173,689 (GRCm39) |
nonsense |
probably null |
|
|
R9557:Tet2
|
UTSW |
3 |
133,191,566 (GRCm39) |
missense |
probably benign |
|
|
R9621:Tet2
|
UTSW |
3 |
133,193,767 (GRCm39) |
nonsense |
probably null |
|
|
R9644:Tet2
|
UTSW |
3 |
133,193,064 (GRCm39) |
nonsense |
probably null |
|
|
R9719:Tet2
|
UTSW |
3 |
133,191,803 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
X0021:Tet2
|
UTSW |
3 |
133,192,056 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
X0066:Tet2
|
UTSW |
3 |
133,194,134 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCACCTGGAATACCCTCTGTC -3'
(R):5'- CTCCATGCAGGGAAGACAAG -3'
Sequencing Primer
(F):5'- ATGTGGACTCTCATGACTGC -3'
(R):5'- CTCCATGCAGGGAAGACAAGAGTAG -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation