Incidental Mutation 'R1941:Naa15'
ID 213989
Institutional Source Beutler Lab
Gene Symbol Naa15
Ensembl Gene ENSMUSG00000063273
Gene Name N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms Narg1, 5730450D16Rik, ASTBDN, Tbdn-1, tubedown, mNAT1
MMRRC Submission 039959-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.964) question?
Stock # R1941 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 51323437-51383406 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 51363355 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 346 (Y346*)
Ref Sequence ENSEMBL: ENSMUSP00000141433 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029303] [ENSMUST00000193266]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000029303
AA Change: Y396*
SMART Domains Protein: ENSMUSP00000029303
Gene: ENSMUSG00000063273
AA Change: Y396*

DomainStartEndE-ValueType
TPR 46 79 6.24e1 SMART
TPR 80 113 1.01e0 SMART
Blast:TPR 224 257 3e-12 BLAST
TPR 374 407 1.87e1 SMART
TPR 408 441 5.06e1 SMART
low complexity region 603 641 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192523
Predicted Effect probably null
Transcript: ENSMUST00000193266
AA Change: Y346*
SMART Domains Protein: ENSMUSP00000141433
Gene: ENSMUSG00000063273
AA Change: Y346*

DomainStartEndE-ValueType
Blast:TPR 1 29 3e-10 BLAST
TPR 30 63 4.9e-3 SMART
Blast:TPR 174 207 3e-12 BLAST
TPR 324 357 8.9e-2 SMART
TPR 358 391 2.4e-1 SMART
coiled coil region 533 585 N/A INTRINSIC
Blast:TPR 622 655 7e-10 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193694
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194685
Coding Region Coverage
  • 1x: 97.3%
  • 3x: 96.6%
  • 10x: 94.8%
  • 20x: 91.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Art2b A C 7: 101,229,524 (GRCm39) F125C probably damaging Het
Camta1 T C 4: 151,159,612 (GRCm39) Y1616C probably damaging Het
Cep162 T G 9: 87,082,048 (GRCm39) I1286L probably benign Het
Chd9 T A 8: 91,703,697 (GRCm39) probably null Het
Col11a2 T A 17: 34,263,925 (GRCm39) S247T probably benign Het
Col6a4 T G 9: 105,952,209 (GRCm39) D563A probably benign Het
Crebbp C T 16: 3,997,555 (GRCm39) M176I probably benign Het
Cyp4a12b A G 4: 115,295,256 (GRCm39) N454S probably damaging Het
Dhx8 T C 11: 101,643,024 (GRCm39) probably null Het
Dock7 G A 4: 98,872,952 (GRCm39) L1165F probably benign Het
Fam117a A T 11: 95,271,624 (GRCm39) N399Y probably damaging Het
Fmn1 A G 2: 113,195,488 (GRCm39) K396R unknown Het
Foxk1 T A 5: 142,442,429 (GRCm39) V693E possibly damaging Het
Gml A G 15: 74,689,020 (GRCm39) L10P probably damaging Het
Gpx8 A G 13: 113,182,809 (GRCm39) L34P probably damaging Het
Kank2 A G 9: 21,684,162 (GRCm39) L689P possibly damaging Het
Mt4 G A 8: 94,864,874 (GRCm39) C16Y possibly damaging Het
Ntrk3 C T 7: 77,897,010 (GRCm39) V676I probably damaging Het
Oasl2 G A 5: 115,049,423 (GRCm39) probably benign Het
Or1e1c T A 11: 73,266,447 (GRCm39) F294I probably damaging Het
Or6c215 T A 10: 129,638,281 (GRCm39) M38L probably benign Het
Or6c8 T G 10: 128,915,823 (GRCm39) N3T probably damaging Het
Or7e169 G A 9: 19,757,246 (GRCm39) S223F probably damaging Het
Or7g20 A C 9: 18,947,162 (GRCm39) T248P possibly damaging Het
Otud7a C T 7: 63,379,574 (GRCm39) R273* probably null Het
Pcare T G 17: 72,059,063 (GRCm39) T205P probably damaging Het
Pde11a C T 2: 76,121,594 (GRCm39) R329Q probably benign Het
Pga5 G T 19: 10,646,820 (GRCm39) probably null Het
Ppp1r1a A G 15: 103,441,528 (GRCm39) probably null Het
Pus10 A G 11: 23,661,198 (GRCm39) Q262R possibly damaging Het
Rbm17 T C 2: 11,593,885 (GRCm39) K241R possibly damaging Het
Rp1l1 T G 14: 64,259,701 (GRCm39) D114E probably damaging Het
Safb T A 17: 56,905,992 (GRCm39) probably benign Het
Sgpl1 T C 10: 60,939,086 (GRCm39) Y371C probably damaging Het
Siglec1 C A 2: 130,920,051 (GRCm39) A827S possibly damaging Het
Smg5 T A 3: 88,252,687 (GRCm39) S158T possibly damaging Het
Sp2 C T 11: 96,846,762 (GRCm39) C527Y probably damaging Het
Spaca6 A G 17: 18,058,664 (GRCm39) I71V probably benign Het
Spaca6 A G 17: 18,058,692 (GRCm39) E80G probably damaging Het
Steap1 C A 5: 5,790,541 (GRCm39) A136S probably damaging Het
Supv3l1 G C 10: 62,285,391 (GRCm39) P25R probably benign Het
Tex21 T C 12: 76,268,458 (GRCm39) K108R possibly damaging Het
Tnc A G 4: 63,933,201 (GRCm39) Y688H probably damaging Het
Tnr G A 1: 159,677,704 (GRCm39) E30K possibly damaging Het
Tnrc18 G T 5: 142,800,905 (GRCm39) P18T probably damaging Het
Ttk T G 9: 83,735,179 (GRCm39) S422A probably benign Het
Ubap1 A G 4: 41,378,968 (GRCm39) K61E probably damaging Het
Ubr2 C T 17: 47,284,952 (GRCm39) R522H probably damaging Het
Vwf A T 6: 125,616,242 (GRCm39) E1185D possibly damaging Het
Wwp2 A G 8: 108,244,547 (GRCm39) T194A probably benign Het
Zfp36 A G 7: 28,077,071 (GRCm39) V279A probably damaging Het
Zfp870 C A 17: 33,101,778 (GRCm39) R517L possibly damaging Het
Other mutations in Naa15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Naa15 APN 3 51,345,826 (GRCm39) missense probably damaging 1.00
IGL01753:Naa15 APN 3 51,350,274 (GRCm39) missense probably damaging 1.00
IGL01837:Naa15 APN 3 51,351,369 (GRCm39) nonsense probably null
IGL02619:Naa15 APN 3 51,367,552 (GRCm39) missense probably benign 0.03
IGL02691:Naa15 APN 3 51,358,747 (GRCm39) missense probably damaging 0.97
IGL02974:Naa15 APN 3 51,368,628 (GRCm39) missense possibly damaging 0.95
R0009:Naa15 UTSW 3 51,377,640 (GRCm39) missense probably damaging 1.00
R0010:Naa15 UTSW 3 51,343,634 (GRCm39) critical splice acceptor site probably null
R0114:Naa15 UTSW 3 51,355,859 (GRCm39) critical splice donor site probably null
R0411:Naa15 UTSW 3 51,373,060 (GRCm39) missense possibly damaging 0.81
R1348:Naa15 UTSW 3 51,373,091 (GRCm39) missense probably damaging 1.00
R3082:Naa15 UTSW 3 51,367,471 (GRCm39) missense probably damaging 1.00
R4377:Naa15 UTSW 3 51,355,786 (GRCm39) missense possibly damaging 0.91
R4591:Naa15 UTSW 3 51,349,345 (GRCm39) missense probably damaging 1.00
R4980:Naa15 UTSW 3 51,366,173 (GRCm39) critical splice donor site probably null
R5087:Naa15 UTSW 3 51,364,706 (GRCm39) splice site probably null
R5139:Naa15 UTSW 3 51,351,261 (GRCm39) missense probably damaging 1.00
R5289:Naa15 UTSW 3 51,363,315 (GRCm39) missense probably damaging 1.00
R5527:Naa15 UTSW 3 51,349,368 (GRCm39) missense probably damaging 1.00
R5776:Naa15 UTSW 3 51,367,447 (GRCm39) missense probably damaging 0.96
R5909:Naa15 UTSW 3 51,367,485 (GRCm39) missense probably damaging 1.00
R6034:Naa15 UTSW 3 51,350,242 (GRCm39) missense probably damaging 0.98
R6034:Naa15 UTSW 3 51,350,242 (GRCm39) missense probably damaging 0.98
R6194:Naa15 UTSW 3 51,370,721 (GRCm39) missense probably benign 0.00
R6291:Naa15 UTSW 3 51,350,212 (GRCm39) missense probably damaging 1.00
R6522:Naa15 UTSW 3 51,378,935 (GRCm39) missense probably damaging 1.00
R6731:Naa15 UTSW 3 51,363,294 (GRCm39) missense probably damaging 1.00
R6984:Naa15 UTSW 3 51,380,021 (GRCm39) missense probably benign 0.10
R7040:Naa15 UTSW 3 51,380,205 (GRCm39) missense possibly damaging 0.89
R7091:Naa15 UTSW 3 51,366,177 (GRCm39) splice site probably null
R7380:Naa15 UTSW 3 51,367,268 (GRCm39) splice site probably null
R7685:Naa15 UTSW 3 51,377,395 (GRCm39) splice site probably null
R7781:Naa15 UTSW 3 51,378,904 (GRCm39) critical splice acceptor site probably null
R7797:Naa15 UTSW 3 51,356,031 (GRCm39) missense probably damaging 0.99
R7836:Naa15 UTSW 3 51,370,688 (GRCm39) nonsense probably null
R7981:Naa15 UTSW 3 51,366,092 (GRCm39) missense probably damaging 0.96
R8513:Naa15 UTSW 3 51,367,444 (GRCm39) missense probably damaging 0.99
R8923:Naa15 UTSW 3 51,367,443 (GRCm39) missense probably damaging 1.00
R9159:Naa15 UTSW 3 51,358,802 (GRCm39) missense probably benign 0.01
R9701:Naa15 UTSW 3 51,349,370 (GRCm39) nonsense probably null
R9802:Naa15 UTSW 3 51,349,370 (GRCm39) nonsense probably null
X0020:Naa15 UTSW 3 51,377,553 (GRCm39) missense probably benign 0.00
X0061:Naa15 UTSW 3 51,356,022 (GRCm39) missense probably benign 0.11
X0061:Naa15 UTSW 3 51,356,021 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGTCTTAAATGTGCTTAGCTGTAG -3'
(R):5'- AAATGTGGCTATGACAAGTCCAAG -3'

Sequencing Primer
(F):5'- AATGTGCTTAGCTGTAGATTATAGC -3'
(R):5'- CCTTATAAGGAAAGGGGGGT -3'
Posted On 2014-07-14