Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00229:Scara3'

2140

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Scara3

Ensembl Gene

ENSMUSG00000034463

Gene Name

scavenger receptor class A, member 3

Synonyms

C130058N24Rik

Accession Numbers

Genbank: NM_172604; MGI: 2444418

Essential gene?

Probably non essential (E-score: 0.101) question?

Stock #

IGL00229

Quality Score

Status

Chromosome

Chromosomal Location

65919394-65953935 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 65933121 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Alanine at position 103 (E103A)

Ref Sequence

ENSEMBL: ENSMUSP00000046525 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042046]

AlphaFold

Q8C850

Predicted Effect

probably benign
Transcript: ENSMUST00000042046
AA Change: E103A

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000046525
Gene: ENSMUSG00000034463
AA Change: E103A

Domain	Start	End	E-Value	Type
transmembrane domain	55	77	N/A	INTRINSIC
coiled coil region	117	155	N/A	INTRINSIC
low complexity region	300	311	N/A	INTRINSIC
Pfam:Collagen	455	513	3.1e-12	PFAM
Pfam:Collagen	499	558	4.2e-11	PFAM
Pfam:Collagen	544	606	2.9e-12	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a macrophage scavenger receptor-like protein. This protein has been shown to deplete reactive oxygen species, and thus play an important role in protecting cells from oxidative stress. The expression of this gene is induced by oxidative stress. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010111I01Rik	A	G	13: 63,199,500		probably benign	Het
9030624J02Rik	T	A	7: 118,804,191		probably benign	Het
Abca4	A	G	3: 122,170,954	T929A	probably damaging	Het
Adam6b	G	A	12: 113,491,393	R610H	probably damaging	Het
Adamts12	T	A	15: 11,311,599	M1314K	probably benign	Het
Alg6	T	A	4: 99,753,054	F152I	probably damaging	Het
Arid5b	A	G	10: 68,128,975	S289P	probably damaging	Het
Axin1	T	C	17: 26,194,072	F780L	probably damaging	Het
C87499	A	G	4: 88,629,053	I214T	probably damaging	Het
C9	C	T	15: 6,483,231	S278L	possibly damaging	Het
Calr4	A	T	4: 109,244,115	I65F	probably damaging	Het
Cdh23	A	G	10: 60,523,548	V260A	probably benign	Het
Ddx25	T	C	9: 35,543,595		probably benign	Het
Dppa4	A	G	16: 48,291,083	T92A	possibly damaging	Het
Ercc5	T	C	1: 44,163,898	Y232H	probably damaging	Het
Exoc4	A	G	6: 33,918,399		probably null	Het
Fam149a	A	G	8: 45,351,786	V253A	probably damaging	Het
Fam209	C	T	2: 172,474,182	T159I	probably damaging	Het
Gcfc2	A	T	6: 81,936,015	N265I	probably damaging	Het
Glud1	T	C	14: 34,336,130	V366A	probably benign	Het
Hdac10	T	C	15: 89,128,442	T3A	probably damaging	Het
Ifnar1	T	C	16: 91,489,782	S54P	probably damaging	Het
Itpr2	T	C	6: 146,144,185	Y2561C	probably damaging	Het
Klhl30	A	G	1: 91,354,157	E160G	possibly damaging	Het
Kmt2d	A	T	15: 98,862,333	S1015T	unknown	Het
Lactb2	A	G	1: 13,660,374	M26T	probably damaging	Het
Lactbl1	A	T	4: 136,631,051	D111V	probably damaging	Het
Lig4	T	C	8: 9,972,775	Y335C	probably damaging	Het
Lrrc8e	T	A	8: 4,235,921	D715E	probably benign	Het
Med6	A	T	12: 81,579,574	V142D	possibly damaging	Het
Men1	G	A	19: 6,337,207		probably null	Het
Mettl13	A	G	1: 162,535,865	V600A	possibly damaging	Het
Mpdz	A	T	4: 81,310,224	C1314*	probably null	Het
Nbeal2	A	G	9: 110,635,869	V1009A	probably damaging	Het
Nmur2	A	G	11: 56,040,777	L36P	probably damaging	Het
Nudt2	T	A	4: 41,480,474	L119Q	probably damaging	Het
Olfr1472	T	C	19: 13,453,840	M226V	possibly damaging	Het
Osbpl3	C	T	6: 50,323,068	E519K	probably damaging	Het
Pak6	A	T	2: 118,689,845	T106S	possibly damaging	Het
Pggt1b	T	G	18: 46,280,719	Q34P	probably benign	Het
Phactr4	T	C	4: 132,370,992	T322A	possibly damaging	Het
Plekhj1	T	C	10: 80,796,602		probably null	Het
Pnpt1	T	C	11: 29,154,217		probably null	Het
Prr14l	T	C	5: 32,830,676	I492V	probably benign	Het
Ranbp2	C	A	10: 58,477,256	A1266E	probably damaging	Het
Riok3	G	A	18: 12,137,020	D140N	probably damaging	Het
Rsph4a	G	A	10: 33,914,343	E643K	probably damaging	Het
Sgk3	T	C	1: 9,868,384	V33A	probably damaging	Het
Slc38a4	A	G	15: 96,999,494	F480S	probably damaging	Het
Slc44a1	G	A	4: 53,543,571	V372M	probably damaging	Het
Slc9a2	A	G	1: 40,767,737	Y728C	probably benign	Het
Sox4	C	A	13: 28,952,973	G17W	probably damaging	Het
Spidr	A	T	16: 15,895,578	L847Q	probably damaging	Het
Sptb	A	G	12: 76,620,753	S857P	probably benign	Het
Syde1	A	G	10: 78,585,809	V636A	probably damaging	Het
Syna	A	G	5: 134,559,717	L126P	possibly damaging	Het
Taar2	A	G	10: 23,941,368	T269A	possibly damaging	Het
Tapbp	C	T	17: 33,925,704	T258I	probably damaging	Het
Tcf20	T	A	15: 82,857,142	Q36L	possibly damaging	Het
Tmem131l	A	T	3: 83,942,500	M260K	probably damaging	Het
Tnc	T	A	4: 64,016,824		probably benign	Het
Ugp2	T	A	11: 21,354,345	E27D	probably benign	Het
Wdr27	A	T	17: 14,928,310	C140*	probably null	Het
Wnt2b	T	C	3: 104,953,133	T153A	possibly damaging	Het
Xirp2	A	T	2: 67,513,375	T1987S	probably benign	Het
Zfp36l1	C	A	12: 80,110,464	G48C	probably damaging	Het
Zfp474	A	T	18: 52,638,493	I73F	possibly damaging	Het
Zfp790	T	A	7: 29,828,563	F224L	probably benign	Het

Other mutations in Scara3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00646:Scara3	APN	14	65921156	nonsense	probably null
IGL00718:Scara3	APN	14	65931427	missense	possibly damaging	0.67
IGL01948:Scara3	APN	14	65930812	missense	probably damaging	0.99
IGL01979:Scara3	APN	14	65930963	missense	probably benign	0.01
IGL02399:Scara3	APN	14	65933110	nonsense	probably null
IGL02939:Scara3	APN	14	65931656	missense	probably benign	0.00
IGL02945:Scara3	APN	14	65931211	missense	probably damaging	1.00
IGL03075:Scara3	APN	14	65931154	missense	probably damaging	1.00
IGL03100:Scara3	APN	14	65931273	missense	probably damaging	1.00
IGL03156:Scara3	APN	14	65931154	missense	probably damaging	1.00
IGL03179:Scara3	APN	14	65931154	missense	probably damaging	1.00
condor	UTSW	14	65931202	missense	probably damaging	1.00
PIT4362001:Scara3	UTSW	14	65936402	missense	probably benign
R0062:Scara3	UTSW	14	65930968	missense	probably damaging	1.00
R0062:Scara3	UTSW	14	65930968	missense	probably damaging	1.00
R0124:Scara3	UTSW	14	65931221	missense	probably benign	0.01
R0349:Scara3	UTSW	14	65931781	missense	probably damaging	0.98
R1584:Scara3	UTSW	14	65921104	missense	probably damaging	1.00
R4785:Scara3	UTSW	14	65953501	start codon destroyed	probably null	0.06
R5336:Scara3	UTSW	14	65931038	missense	probably damaging	1.00
R6307:Scara3	UTSW	14	65938261	missense	probably benign	0.24
R6420:Scara3	UTSW	14	65938252	missense	possibly damaging	0.92
R6610:Scara3	UTSW	14	65931221	missense	probably damaging	0.97
R7159:Scara3	UTSW	14	65920780	missense	probably damaging	0.98
R7208:Scara3	UTSW	14	65931266	missense	possibly damaging	0.62
R7246:Scara3	UTSW	14	65931644	missense	probably damaging	0.97
R7315:Scara3	UTSW	14	65931440	missense	probably damaging	1.00
R7324:Scara3	UTSW	14	65931416	missense	probably benign	0.03
R7497:Scara3	UTSW	14	65931202	missense	probably damaging	1.00
R7504:Scara3	UTSW	14	65931331	missense	possibly damaging	0.82
R7554:Scara3	UTSW	14	65920850	missense	possibly damaging	0.69
R8143:Scara3	UTSW	14	65931820	missense	probably damaging	0.96
R9043:Scara3	UTSW	14	65931621	missense	probably damaging	1.00
R9226:Scara3	UTSW	14	65931784	missense	possibly damaging	0.69
R9363:Scara3	UTSW	14	65931271	missense	probably benign	0.01
R9730:Scara3	UTSW	14	65930812	missense	probably damaging	0.99
YA93:Scara3	UTSW	14	65930949	missense	probably damaging	0.98

Posted On

2011-12-09