Incidental Mutation 'R1941:Or7g20'
ID 214011
Institutional Source Beutler Lab
Gene Symbol Or7g20
Ensembl Gene ENSMUSG00000045204
Gene Name olfactory receptor family 7 subfamily G member 20
Synonyms MOR150-3, GA_x6K02T2PVTD-12771995-12772930, Olfr835
MMRRC Submission 039959-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.127) question?
Stock # R1941 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 18946421-18947356 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 18947162 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Proline at position 248 (T248P)
Ref Sequence ENSEMBL: ENSMUSP00000148416 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059315] [ENSMUST00000213018]
AlphaFold Q7TRG7
Predicted Effect possibly damaging
Transcript: ENSMUST00000059315
AA Change: T248P

PolyPhen 2 Score 0.932 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000052610
Gene: ENSMUSG00000045204
AA Change: T248P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.8e-47 PFAM
Pfam:7TM_GPCR_Srsx 35 206 2.9e-7 PFAM
Pfam:7tm_1 41 303 1.3e-23 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213018
AA Change: T248P

PolyPhen 2 Score 0.932 (Sensitivity: 0.80; Specificity: 0.94)
Coding Region Coverage
  • 1x: 97.3%
  • 3x: 96.6%
  • 10x: 94.8%
  • 20x: 91.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Art2b A C 7: 101,229,524 (GRCm39) F125C probably damaging Het
Camta1 T C 4: 151,159,612 (GRCm39) Y1616C probably damaging Het
Cep162 T G 9: 87,082,048 (GRCm39) I1286L probably benign Het
Chd9 T A 8: 91,703,697 (GRCm39) probably null Het
Col11a2 T A 17: 34,263,925 (GRCm39) S247T probably benign Het
Col6a4 T G 9: 105,952,209 (GRCm39) D563A probably benign Het
Crebbp C T 16: 3,997,555 (GRCm39) M176I probably benign Het
Cyp4a12b A G 4: 115,295,256 (GRCm39) N454S probably damaging Het
Dhx8 T C 11: 101,643,024 (GRCm39) probably null Het
Dock7 G A 4: 98,872,952 (GRCm39) L1165F probably benign Het
Fam117a A T 11: 95,271,624 (GRCm39) N399Y probably damaging Het
Fmn1 A G 2: 113,195,488 (GRCm39) K396R unknown Het
Foxk1 T A 5: 142,442,429 (GRCm39) V693E possibly damaging Het
Gml A G 15: 74,689,020 (GRCm39) L10P probably damaging Het
Gpx8 A G 13: 113,182,809 (GRCm39) L34P probably damaging Het
Kank2 A G 9: 21,684,162 (GRCm39) L689P possibly damaging Het
Mt4 G A 8: 94,864,874 (GRCm39) C16Y possibly damaging Het
Naa15 C A 3: 51,363,355 (GRCm39) Y346* probably null Het
Ntrk3 C T 7: 77,897,010 (GRCm39) V676I probably damaging Het
Oasl2 G A 5: 115,049,423 (GRCm39) probably benign Het
Or1e1c T A 11: 73,266,447 (GRCm39) F294I probably damaging Het
Or6c215 T A 10: 129,638,281 (GRCm39) M38L probably benign Het
Or6c8 T G 10: 128,915,823 (GRCm39) N3T probably damaging Het
Or7e169 G A 9: 19,757,246 (GRCm39) S223F probably damaging Het
Otud7a C T 7: 63,379,574 (GRCm39) R273* probably null Het
Pcare T G 17: 72,059,063 (GRCm39) T205P probably damaging Het
Pde11a C T 2: 76,121,594 (GRCm39) R329Q probably benign Het
Pga5 G T 19: 10,646,820 (GRCm39) probably null Het
Ppp1r1a A G 15: 103,441,528 (GRCm39) probably null Het
Pus10 A G 11: 23,661,198 (GRCm39) Q262R possibly damaging Het
Rbm17 T C 2: 11,593,885 (GRCm39) K241R possibly damaging Het
Rp1l1 T G 14: 64,259,701 (GRCm39) D114E probably damaging Het
Safb T A 17: 56,905,992 (GRCm39) probably benign Het
Sgpl1 T C 10: 60,939,086 (GRCm39) Y371C probably damaging Het
Siglec1 C A 2: 130,920,051 (GRCm39) A827S possibly damaging Het
Smg5 T A 3: 88,252,687 (GRCm39) S158T possibly damaging Het
Sp2 C T 11: 96,846,762 (GRCm39) C527Y probably damaging Het
Spaca6 A G 17: 18,058,664 (GRCm39) I71V probably benign Het
Spaca6 A G 17: 18,058,692 (GRCm39) E80G probably damaging Het
Steap1 C A 5: 5,790,541 (GRCm39) A136S probably damaging Het
Supv3l1 G C 10: 62,285,391 (GRCm39) P25R probably benign Het
Tex21 T C 12: 76,268,458 (GRCm39) K108R possibly damaging Het
Tnc A G 4: 63,933,201 (GRCm39) Y688H probably damaging Het
Tnr G A 1: 159,677,704 (GRCm39) E30K possibly damaging Het
Tnrc18 G T 5: 142,800,905 (GRCm39) P18T probably damaging Het
Ttk T G 9: 83,735,179 (GRCm39) S422A probably benign Het
Ubap1 A G 4: 41,378,968 (GRCm39) K61E probably damaging Het
Ubr2 C T 17: 47,284,952 (GRCm39) R522H probably damaging Het
Vwf A T 6: 125,616,242 (GRCm39) E1185D possibly damaging Het
Wwp2 A G 8: 108,244,547 (GRCm39) T194A probably benign Het
Zfp36 A G 7: 28,077,071 (GRCm39) V279A probably damaging Het
Zfp870 C A 17: 33,101,778 (GRCm39) R517L possibly damaging Het
Other mutations in Or7g20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01718:Or7g20 APN 9 18,946,584 (GRCm39) nonsense probably null
IGL02546:Or7g20 APN 9 18,946,650 (GRCm39) missense possibly damaging 0.88
R0010:Or7g20 UTSW 9 18,946,618 (GRCm39) missense probably damaging 1.00
R0107:Or7g20 UTSW 9 18,946,629 (GRCm39) missense probably damaging 1.00
R1867:Or7g20 UTSW 9 18,946,562 (GRCm39) missense probably benign 0.36
R1891:Or7g20 UTSW 9 18,947,274 (GRCm39) missense probably damaging 0.99
R4152:Or7g20 UTSW 9 18,946,816 (GRCm39) nonsense probably null
R5451:Or7g20 UTSW 9 18,946,787 (GRCm39) missense probably damaging 1.00
R5677:Or7g20 UTSW 9 18,946,854 (GRCm39) missense possibly damaging 0.93
R5970:Or7g20 UTSW 9 18,946,443 (GRCm39) missense probably benign
R6187:Or7g20 UTSW 9 18,946,689 (GRCm39) missense probably benign 0.12
R6805:Or7g20 UTSW 9 18,946,597 (GRCm39) missense probably damaging 1.00
R7183:Or7g20 UTSW 9 18,946,628 (GRCm39) missense probably damaging 1.00
R8029:Or7g20 UTSW 9 18,947,090 (GRCm39) missense probably damaging 1.00
R8139:Or7g20 UTSW 9 18,946,871 (GRCm39) missense probably benign 0.07
R8736:Or7g20 UTSW 9 18,946,774 (GRCm39) missense probably damaging 1.00
R8868:Or7g20 UTSW 9 18,946,778 (GRCm39) missense probably damaging 1.00
R8909:Or7g20 UTSW 9 18,946,888 (GRCm39) missense probably benign 0.08
R9116:Or7g20 UTSW 9 18,946,773 (GRCm39) missense probably damaging 1.00
R9479:Or7g20 UTSW 9 18,946,730 (GRCm39) missense probably benign 0.30
R9786:Or7g20 UTSW 9 18,947,241 (GRCm39) missense possibly damaging 0.87
Predicted Primers PCR Primer
(F):5'- AACTTTCTCAGGTCATGAAGCTTG -3'
(R):5'- GCATTCCTTTCAAAGAGAAGCTAC -3'

Sequencing Primer
(F):5'- ATGAAGCTTGCATGCTCTGACAC -3'
(R):5'- CCTTTCAAAGAGAAGCTACTTTACTG -3'
Posted On 2014-07-14