Mutagenetix > Incidental Mutation

Incidental Mutation 'R0126:Dnah5'

21405

Institutional Source

Beutler Lab

Gene Symbol

Dnah5

Ensembl Gene

ENSMUSG00000022262

Gene Name

dynein, axonemal, heavy chain 5

Synonyms

b2b1565Clo, b2b1134Clo, Mdnah5, b2b1537Clo, b2b1154Clo, Dnahc5

MMRRC Submission

038411-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.812) question?

Stock #

R0126 (G1)

Quality Score

145

Status

Validated (trace)

Chromosome

Chromosomal Location

28203752-28472052 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 28246319 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 601 (D601G)

Ref Sequence

ENSEMBL: ENSMUSP00000069751 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067048]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000067048
AA Change: D601G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000069751
Gene: ENSMUSG00000022262
AA Change: D601G

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	247	802	2.3e-163	PFAM
low complexity region	1077	1088	N/A	INTRINSIC
low complexity region	1113	1128	N/A	INTRINSIC
Pfam:DHC_N2	1399	1807	2.3e-134	PFAM
AAA	1972	2108	2e-3	SMART
AAA	2251	2424	4.3e-3	SMART
AAA	2579	2777	2.2e-3	SMART
low complexity region	2874	2889	N/A	INTRINSIC
Pfam:AAA_8	2914	3186	3.2e-70	PFAM
Pfam:MT	3198	3546	1e-44	PFAM
Pfam:AAA_9	3567	3792	1.4e-86	PFAM
low complexity region	3889	3899	N/A	INTRINSIC
Pfam:Dynein_heavy	3930	4618	4.4e-246	PFAM

Meta Mutation Damage Score

0.1252

Coding Region Coverage

1x: 98.8%
3x: 97.6%
10x: 93.2%
20x: 81.8%

Validation Efficiency

98% (102/104)

MGI Phenotype

Strain: 2180081
Lethality: D14-D21
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009]
PHENOTYPE: Mice homozygous for a disruption in this gene display postnatal lethality, hydrocephalus, respiratory infections, situs inversus and ciliary immotility. [provided by MGI curators]

Allele List at MGI

All alleles(11) : Targeted(2) Gene trapped(1) Transgenic(1) Chemically induced(7)

Other mutations in this stock

Total: 85 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca2	T	C	2: 25,443,730 (GRCm38)	L1730P	possibly damaging	Het
Adam9	T	C	8: 24,970,737 (GRCm38)	N577S	probably damaging	Het
Add1	T	C	5: 34,613,579 (GRCm38)	Y316H	probably benign	Het
Agpat3	T	C	10: 78,278,056 (GRCm38)	D266G	probably null	Het
Aldh3a2	C	A	11: 61,224,558 (GRCm38)	Q524H	probably benign	Het
Alox12b	A	C	11: 69,167,471 (GRCm38)	S550R	probably benign	Het
Ano4	T	A	10: 88,952,292 (GRCm38)	I753F	possibly damaging	Het
AW011738	T	A	4: 156,203,647 (GRCm38)		probably benign	Het
B4galt3	C	T	1: 171,276,165 (GRCm38)	T103M	probably damaging	Het
Cabs1	C	T	5: 87,980,195 (GRCm38)	T235I	probably damaging	Het
Casq2	A	G	3: 102,133,399 (GRCm38)	H272R	probably damaging	Het
Ccdc180	T	C	4: 45,912,866 (GRCm38)		probably null	Het
Cdh12	A	T	15: 21,583,945 (GRCm38)	M624L	probably benign	Het
Cdh5	A	C	8: 104,140,682 (GRCm38)		probably null	Het
Col7a1	A	G	9: 108,969,583 (GRCm38)		probably benign	Het
Cpne2	A	T	8: 94,554,933 (GRCm38)	I199F	probably damaging	Het
Crebbp	A	T	16: 4,084,063 (GRCm38)	F2399L	possibly damaging	Het
Defb36	T	C	2: 152,612,579 (GRCm38)	C53R	probably damaging	Het
Degs1	T	C	1: 182,279,692 (GRCm38)	M1V	probably null	Het
Disp2	T	A	2: 118,790,338 (GRCm38)	F517Y	probably damaging	Het
Dnpep	G	A	1: 75,312,538 (GRCm38)	Q310*	probably null	Het
Dsg1a	A	G	18: 20,340,878 (GRCm38)	T1003A	probably benign	Het
Fbrsl1	C	G	5: 110,396,040 (GRCm38)		probably benign	Het
Foxh1	A	T	15: 76,669,254 (GRCm38)	L116H	probably damaging	Het
Gigyf2	G	A	1: 87,411,875 (GRCm38)		probably benign	Het
Golm2	T	C	2: 121,906,084 (GRCm38)		probably benign	Het
Gp1ba	A	T	11: 70,641,033 (GRCm38)		probably benign	Het
Gucy1b1	A	G	3: 82,037,911 (GRCm38)		probably benign	Het
Gucy2g	T	G	19: 55,241,166 (GRCm38)	D24A	probably benign	Het
Hirip3	A	G	7: 126,863,442 (GRCm38)	K190R	probably damaging	Het
Hmmr	T	C	11: 40,705,954 (GRCm38)	N717D	probably damaging	Het
Il12b	A	T	11: 44,410,218 (GRCm38)	Y187F	probably damaging	Het
Iqgap1	A	G	7: 80,738,322 (GRCm38)	I859T	probably benign	Het
Jmjd1c	T	C	10: 67,219,326 (GRCm38)	L175P	probably damaging	Het
Klc2	T	C	19: 5,112,746 (GRCm38)	M242V	possibly damaging	Het
Klf3	T	C	5: 64,822,103 (GRCm38)	M96T	probably benign	Het
Lrrc66	G	T	5: 73,607,088 (GRCm38)	H871N	probably benign	Het
Ltn1	A	T	16: 87,425,640 (GRCm38)	D168E	probably benign	Het
Mak	T	C	13: 41,032,596 (GRCm38)	D532G	probably damaging	Het
Marchf6	A	G	15: 31,462,005 (GRCm38)	M859T	probably benign	Het
Meak7	T	C	8: 119,762,350 (GRCm38)	D398G	possibly damaging	Het
Mlxipl	C	A	5: 135,132,323 (GRCm38)	N365K	probably damaging	Het
Mplkip	T	C	13: 17,695,752 (GRCm38)	S90P	possibly damaging	Het
Myo5c	A	T	9: 75,269,525 (GRCm38)	H584L	probably benign	Het
Myt1l	A	G	12: 29,851,720 (GRCm38)	T228A	possibly damaging	Het
Nxpe3	A	T	16: 55,866,229 (GRCm38)	Y139N	possibly damaging	Het
Or2z8	C	T	8: 72,058,400 (GRCm38)	T240M	probably damaging	Het
Or51f2	A	G	7: 102,877,140 (GRCm38)	T7A	probably benign	Het
Or8k40	T	A	2: 86,754,637 (GRCm38)	I34L	probably damaging	Het
Pak6	C	T	2: 118,690,332 (GRCm38)	S268F	possibly damaging	Het
Parp10	G	A	15: 76,243,066 (GRCm38)	A57V	probably damaging	Het
Pik3r3	T	A	4: 116,256,268 (GRCm38)	D69E	probably damaging	Het
Polr2a	T	G	11: 69,747,425 (GRCm38)	K105T	probably damaging	Het
Prdm16	A	T	4: 154,328,838 (GRCm38)		probably benign	Het
Prepl	G	A	17: 85,083,242 (GRCm38)	T96I	probably benign	Het
Ret	C	T	6: 118,165,995 (GRCm38)		probably benign	Het
Rgl3	A	T	9: 21,975,812 (GRCm38)	D541E	probably benign	Het
Rpa1	A	C	11: 75,318,529 (GRCm38)	Y143D	probably benign	Het
Rps16	T	A	7: 28,351,083 (GRCm38)	L47Q	probably damaging	Het
Sbno2	A	T	10: 80,068,853 (GRCm38)		probably null	Het
Scube1	A	T	15: 83,621,063 (GRCm38)	N385K	probably damaging	Het
Shank2	A	G	7: 144,031,355 (GRCm38)	E31G	probably damaging	Het
Slc38a9	G	T	13: 112,729,257 (GRCm38)	C496F	possibly damaging	Het
Snap47	A	G	11: 59,437,987 (GRCm38)	V163A	probably damaging	Het
Sntg2	T	C	12: 30,201,261 (GRCm38)		probably benign	Het
Sp7	C	A	15: 102,358,460 (GRCm38)	V322F	probably damaging	Het
Spic	T	C	10: 88,676,062 (GRCm38)	K111E	probably damaging	Het
Sqor	T	C	2: 122,798,027 (GRCm38)		probably benign	Het
St6galnac1	T	A	11: 116,766,584 (GRCm38)	M385L	probably benign	Het
Synpo2	A	T	3: 123,079,862 (GRCm38)	S1211T	possibly damaging	Het
Sytl2	T	A	7: 90,396,589 (GRCm38)	V638E	probably damaging	Het
Taar1	T	A	10: 23,920,547 (GRCm38)	S48T	probably benign	Het
Tbx18	T	A	9: 87,729,653 (GRCm38)	D108V	possibly damaging	Het
Tdh	C	T	14: 63,497,593 (GRCm38)		probably benign	Het
Tlr9	T	A	9: 106,225,682 (GRCm38)	L724Q	probably benign	Het
Tmem270	T	A	5: 134,902,788 (GRCm38)	Y100F	probably benign	Het
Trim65	G	C	11: 116,124,604 (GRCm38)		probably benign	Het
Trrap	A	T	5: 144,805,750 (GRCm38)	K1393*	probably null	Het
Ttc13	A	G	8: 124,683,291 (GRCm38)	V523A	probably damaging	Het
Utrn	T	A	10: 12,711,475 (GRCm38)	D939V	probably benign	Het
Vmn1r46	G	T	6: 89,976,953 (GRCm38)	M261I	probably benign	Het
Vwa5a	A	G	9: 38,737,807 (GRCm38)		probably null	Het
Zfp108	A	T	7: 24,260,724 (GRCm38)	T247S	probably benign	Het
Zfp366	A	T	13: 99,228,621 (GRCm38)	I97F	probably benign	Het
Zfp986	C	T	4: 145,898,943 (GRCm38)	R58C	probably benign	Het

Other mutations in Dnah5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00226:Dnah5	APN	15	28,272,342 (GRCm38)	missense	probably benign
IGL00331:Dnah5	APN	15	28,421,620 (GRCm38)	missense	probably damaging	1.00
IGL00519:Dnah5	APN	15	28,444,218 (GRCm38)	missense	probably benign	0.10
IGL00537:Dnah5	APN	15	28,458,702 (GRCm38)	critical splice donor site	probably null
IGL01102:Dnah5	APN	15	28,410,003 (GRCm38)	critical splice donor site	probably null
IGL01126:Dnah5	APN	15	28,302,399 (GRCm38)	missense	possibly damaging	0.85
IGL01154:Dnah5	APN	15	28,458,656 (GRCm38)	missense	possibly damaging	0.75
IGL01349:Dnah5	APN	15	28,294,913 (GRCm38)	splice site	probably benign
IGL01353:Dnah5	APN	15	28,233,272 (GRCm38)	missense	probably benign	0.00
IGL01372:Dnah5	APN	15	28,230,490 (GRCm38)	missense	probably benign	0.00
IGL01390:Dnah5	APN	15	28,411,540 (GRCm38)	missense	probably benign	0.00
IGL01446:Dnah5	APN	15	28,326,669 (GRCm38)	missense	probably damaging	1.00
IGL01472:Dnah5	APN	15	28,331,726 (GRCm38)	missense	probably damaging	1.00
IGL01485:Dnah5	APN	15	28,331,726 (GRCm38)	missense	probably damaging	1.00
IGL01568:Dnah5	APN	15	28,229,652 (GRCm38)	missense	probably benign	0.01
IGL01592:Dnah5	APN	15	28,236,637 (GRCm38)	missense	probably benign	0.01
IGL01594:Dnah5	APN	15	28,311,334 (GRCm38)	missense	possibly damaging	0.87
IGL01677:Dnah5	APN	15	28,367,782 (GRCm38)	missense	probably damaging	1.00
IGL01845:Dnah5	APN	15	28,449,169 (GRCm38)	missense	probably benign	0.06
IGL01904:Dnah5	APN	15	28,307,364 (GRCm38)	missense	probably benign	0.09
IGL01913:Dnah5	APN	15	28,313,753 (GRCm38)	missense	possibly damaging	0.50
IGL01950:Dnah5	APN	15	28,290,289 (GRCm38)	missense	probably null	1.00
IGL01963:Dnah5	APN	15	28,370,536 (GRCm38)	missense	probably benign	0.12
IGL02008:Dnah5	APN	15	28,343,552 (GRCm38)	missense	probably damaging	0.98
IGL02088:Dnah5	APN	15	28,459,118 (GRCm38)	critical splice acceptor site	probably null
IGL02090:Dnah5	APN	15	28,240,041 (GRCm38)	splice site	probably benign
IGL02114:Dnah5	APN	15	28,397,124 (GRCm38)	missense	probably damaging	0.97
IGL02135:Dnah5	APN	15	28,247,885 (GRCm38)	missense	possibly damaging	0.50
IGL02232:Dnah5	APN	15	28,299,240 (GRCm38)	missense	probably damaging	1.00
IGL02386:Dnah5	APN	15	28,340,381 (GRCm38)	missense	probably damaging	1.00
IGL02475:Dnah5	APN	15	28,219,150 (GRCm38)	missense	probably benign	0.09
IGL02626:Dnah5	APN	15	28,307,276 (GRCm38)	missense	possibly damaging	0.94
IGL02650:Dnah5	APN	15	28,289,047 (GRCm38)	splice site	probably benign
IGL02651:Dnah5	APN	15	28,350,622 (GRCm38)	missense	probably benign	0.05
IGL02652:Dnah5	APN	15	28,366,187 (GRCm38)	missense	probably damaging	0.99
IGL02670:Dnah5	APN	15	28,409,296 (GRCm38)	missense	probably damaging	1.00
IGL02697:Dnah5	APN	15	28,445,143 (GRCm38)	missense	probably benign	0.00
IGL02721:Dnah5	APN	15	28,234,243 (GRCm38)	critical splice acceptor site	probably null
IGL02858:Dnah5	APN	15	28,453,212 (GRCm38)	missense	possibly damaging	0.65
IGL02859:Dnah5	APN	15	28,383,625 (GRCm38)	missense	probably benign	0.01
IGL02945:Dnah5	APN	15	28,270,426 (GRCm38)	missense	probably benign	0.00
IGL02949:Dnah5	APN	15	28,272,185 (GRCm38)	missense	probably benign	0.32
IGL02971:Dnah5	APN	15	28,384,461 (GRCm38)	missense	probably damaging	1.00
IGL03017:Dnah5	APN	15	28,340,325 (GRCm38)	missense	possibly damaging	0.93
IGL03177:Dnah5	APN	15	28,295,399 (GRCm38)	missense	probably damaging	0.97
IGL03212:Dnah5	APN	15	28,290,163 (GRCm38)	missense	probably benign	0.08
IGL03224:Dnah5	APN	15	28,459,154 (GRCm38)	missense	probably damaging	1.00
IGL03231:Dnah5	APN	15	28,311,148 (GRCm38)	missense	probably damaging	1.00
IGL03273:Dnah5	APN	15	28,458,649 (GRCm38)	missense	probably damaging	0.98
IGL03294:Dnah5	APN	15	28,233,295 (GRCm38)	critical splice donor site	probably null
IGL03331:Dnah5	APN	15	28,419,940 (GRCm38)	missense	probably damaging	1.00
IGL03337:Dnah5	APN	15	28,290,141 (GRCm38)	missense	probably benign	0.10
IGL03367:Dnah5	APN	15	28,234,327 (GRCm38)	missense	possibly damaging	0.95
Firtel	UTSW	15	28,448,367 (GRCm38)	missense	possibly damaging	0.95
lowbar	UTSW	15	28,311,133 (GRCm38)	splice site	probably null
notherone	UTSW	15	28,340,406 (GRCm38)	missense	probably benign	0.13
scheffler	UTSW	15	28,438,091 (GRCm38)	splice site	probably benign
IGL02837:Dnah5	UTSW	15	28,269,400 (GRCm38)	missense	probably benign
P0008:Dnah5	UTSW	15	28,302,387 (GRCm38)	missense	probably damaging	1.00
P0014:Dnah5	UTSW	15	28,403,473 (GRCm38)	missense	probably damaging	1.00
PIT4687001:Dnah5	UTSW	15	28,383,577 (GRCm38)	missense	probably damaging	0.98
R0030:Dnah5	UTSW	15	28,451,517 (GRCm38)	missense	probably benign	0.34
R0087:Dnah5	UTSW	15	28,350,613 (GRCm38)	missense	probably damaging	1.00
R0099:Dnah5	UTSW	15	28,239,934 (GRCm38)	missense	probably damaging	1.00
R0102:Dnah5	UTSW	15	28,245,751 (GRCm38)	splice site	probably benign
R0102:Dnah5	UTSW	15	28,245,751 (GRCm38)	splice site	probably benign
R0104:Dnah5	UTSW	15	28,453,353 (GRCm38)	missense	possibly damaging	0.88
R0112:Dnah5	UTSW	15	28,263,679 (GRCm38)	missense	probably benign	0.00
R0122:Dnah5	UTSW	15	28,378,363 (GRCm38)	missense	probably damaging	1.00
R0127:Dnah5	UTSW	15	28,294,925 (GRCm38)	missense	probably damaging	1.00
R0233:Dnah5	UTSW	15	28,333,070 (GRCm38)	missense	probably damaging	1.00
R0310:Dnah5	UTSW	15	28,299,110 (GRCm38)	missense	probably benign	0.19
R0386:Dnah5	UTSW	15	28,383,581 (GRCm38)	missense	probably damaging	1.00
R0421:Dnah5	UTSW	15	28,229,541 (GRCm38)	missense	possibly damaging	0.79
R0481:Dnah5	UTSW	15	28,383,599 (GRCm38)	missense	probably benign	0.31
R0514:Dnah5	UTSW	15	28,366,321 (GRCm38)	missense	probably damaging	1.00
R0609:Dnah5	UTSW	15	28,327,779 (GRCm38)	missense	probably benign
R0720:Dnah5	UTSW	15	28,313,861 (GRCm38)	missense	probably null	0.98
R0731:Dnah5	UTSW	15	28,311,143 (GRCm38)	missense	possibly damaging	0.78
R0747:Dnah5	UTSW	15	28,444,187 (GRCm38)	missense	possibly damaging	0.64
R0747:Dnah5	UTSW	15	28,444,186 (GRCm38)	missense	probably damaging	0.99
R0766:Dnah5	UTSW	15	28,448,487 (GRCm38)	missense	probably null	0.89
R0849:Dnah5	UTSW	15	28,263,599 (GRCm38)	missense	probably damaging	0.96
R1034:Dnah5	UTSW	15	28,302,471 (GRCm38)	missense	probably damaging	1.00
R1084:Dnah5	UTSW	15	28,343,452 (GRCm38)	missense	probably benign	0.01
R1148:Dnah5	UTSW	15	28,421,690 (GRCm38)	missense	probably damaging	1.00
R1148:Dnah5	UTSW	15	28,421,690 (GRCm38)	missense	probably damaging	1.00
R1200:Dnah5	UTSW	15	28,246,257 (GRCm38)	missense	possibly damaging	0.88
R1208:Dnah5	UTSW	15	28,327,731 (GRCm38)	missense	probably damaging	1.00
R1208:Dnah5	UTSW	15	28,327,731 (GRCm38)	missense	probably damaging	1.00
R1269:Dnah5	UTSW	15	28,238,511 (GRCm38)	missense	probably damaging	1.00
R1373:Dnah5	UTSW	15	28,313,918 (GRCm38)	splice site	probably benign
R1401:Dnah5	UTSW	15	28,401,913 (GRCm38)	missense	probably damaging	1.00
R1413:Dnah5	UTSW	15	28,370,409 (GRCm38)	missense	probably benign
R1430:Dnah5	UTSW	15	28,345,857 (GRCm38)	missense	probably benign	0.37
R1457:Dnah5	UTSW	15	28,403,542 (GRCm38)	critical splice donor site	probably null
R1468:Dnah5	UTSW	15	28,230,463 (GRCm38)	nonsense	probably null
R1468:Dnah5	UTSW	15	28,230,463 (GRCm38)	nonsense	probably null
R1560:Dnah5	UTSW	15	28,420,003 (GRCm38)	missense	probably damaging	1.00
R1568:Dnah5	UTSW	15	28,409,177 (GRCm38)	missense	probably damaging	0.98
R1574:Dnah5	UTSW	15	28,252,423 (GRCm38)	missense	probably benign	0.00
R1574:Dnah5	UTSW	15	28,252,423 (GRCm38)	missense	probably benign	0.00
R1603:Dnah5	UTSW	15	28,449,180 (GRCm38)	missense	probably benign	0.09
R1603:Dnah5	UTSW	15	28,294,985 (GRCm38)	splice site	probably benign
R1673:Dnah5	UTSW	15	28,290,148 (GRCm38)	missense	probably benign
R1755:Dnah5	UTSW	15	28,326,636 (GRCm38)	missense	probably damaging	0.99
R1785:Dnah5	UTSW	15	28,313,786 (GRCm38)	missense	probably damaging	1.00
R1786:Dnah5	UTSW	15	28,313,786 (GRCm38)	missense	probably damaging	1.00
R1789:Dnah5	UTSW	15	28,270,426 (GRCm38)	missense	probably benign	0.00
R1817:Dnah5	UTSW	15	28,246,400 (GRCm38)	nonsense	probably null
R1819:Dnah5	UTSW	15	28,246,400 (GRCm38)	nonsense	probably null
R1834:Dnah5	UTSW	15	28,409,124 (GRCm38)	missense	probably benign	0.00
R1855:Dnah5	UTSW	15	28,411,669 (GRCm38)	missense	possibly damaging	0.88
R1870:Dnah5	UTSW	15	28,331,713 (GRCm38)	nonsense	probably null
R1871:Dnah5	UTSW	15	28,331,713 (GRCm38)	nonsense	probably null
R1987:Dnah5	UTSW	15	28,343,591 (GRCm38)	missense	probably damaging	0.99
R1988:Dnah5	UTSW	15	28,343,591 (GRCm38)	missense	probably damaging	0.99
R1989:Dnah5	UTSW	15	28,343,591 (GRCm38)	missense	probably damaging	0.99
R2062:Dnah5	UTSW	15	28,366,270 (GRCm38)	missense	probably damaging	1.00
R2069:Dnah5	UTSW	15	28,312,388 (GRCm38)	splice site	probably null
R2121:Dnah5	UTSW	15	28,297,005 (GRCm38)	splice site	probably benign
R2128:Dnah5	UTSW	15	28,408,321 (GRCm38)	missense	probably benign	0.00
R2129:Dnah5	UTSW	15	28,408,321 (GRCm38)	missense	probably benign	0.00
R2151:Dnah5	UTSW	15	28,444,091 (GRCm38)	missense	probably damaging	1.00
R2159:Dnah5	UTSW	15	28,252,545 (GRCm38)	missense	probably benign	0.00
R2207:Dnah5	UTSW	15	28,343,671 (GRCm38)	missense	probably benign	0.11
R2231:Dnah5	UTSW	15	28,408,417 (GRCm38)	critical splice donor site	probably null
R2232:Dnah5	UTSW	15	28,408,417 (GRCm38)	critical splice donor site	probably null
R2282:Dnah5	UTSW	15	28,327,302 (GRCm38)	missense	probably damaging	0.99
R2305:Dnah5	UTSW	15	28,387,767 (GRCm38)	missense	probably benign	0.25
R2339:Dnah5	UTSW	15	28,313,882 (GRCm38)	missense	probably benign	0.00
R2437:Dnah5	UTSW	15	28,307,391 (GRCm38)	critical splice donor site	probably null
R2696:Dnah5	UTSW	15	28,278,576 (GRCm38)	missense	probably benign	0.00
R3156:Dnah5	UTSW	15	28,438,091 (GRCm38)	splice site	probably benign
R3431:Dnah5	UTSW	15	28,295,267 (GRCm38)	missense	probably benign	0.20
R3700:Dnah5	UTSW	15	28,387,791 (GRCm38)	missense	possibly damaging	0.72
R3724:Dnah5	UTSW	15	28,270,420 (GRCm38)	missense	probably benign	0.08
R3732:Dnah5	UTSW	15	28,409,122 (GRCm38)	missense	possibly damaging	0.64
R3872:Dnah5	UTSW	15	28,411,510 (GRCm38)	missense	possibly damaging	0.50
R4063:Dnah5	UTSW	15	28,420,998 (GRCm38)	missense	probably damaging	0.98
R4072:Dnah5	UTSW	15	28,340,298 (GRCm38)	nonsense	probably null
R4075:Dnah5	UTSW	15	28,293,791 (GRCm38)	missense	probably benign
R4245:Dnah5	UTSW	15	28,219,189 (GRCm38)	missense	probably benign
R4254:Dnah5	UTSW	15	28,438,102 (GRCm38)	missense	probably benign	0.07
R4255:Dnah5	UTSW	15	28,438,102 (GRCm38)	missense	probably benign	0.07
R4392:Dnah5	UTSW	15	28,289,229 (GRCm38)	missense	probably benign	0.19
R4552:Dnah5	UTSW	15	28,397,154 (GRCm38)	missense	probably benign	0.19
R4574:Dnah5	UTSW	15	28,367,763 (GRCm38)	missense	probably benign	0.05
R4577:Dnah5	UTSW	15	28,289,250 (GRCm38)	missense	probably benign	0.06
R4587:Dnah5	UTSW	15	28,304,599 (GRCm38)	missense	probably damaging	1.00
R4631:Dnah5	UTSW	15	28,419,994 (GRCm38)	missense	probably damaging	1.00
R4631:Dnah5	UTSW	15	28,401,953 (GRCm38)	missense	probably damaging	1.00
R4676:Dnah5	UTSW	15	28,295,260 (GRCm38)	missense	possibly damaging	0.65
R4707:Dnah5	UTSW	15	28,372,375 (GRCm38)	missense	probably damaging	0.97
R4754:Dnah5	UTSW	15	28,420,955 (GRCm38)	splice site	probably null
R4767:Dnah5	UTSW	15	28,270,474 (GRCm38)	missense	probably benign	0.02
R4857:Dnah5	UTSW	15	28,345,807 (GRCm38)	missense	probably benign	0.00
R4883:Dnah5	UTSW	15	28,343,638 (GRCm38)	missense	probably benign	0.00
R4889:Dnah5	UTSW	15	28,235,792 (GRCm38)	missense	probably benign	0.01
R4946:Dnah5	UTSW	15	28,387,904 (GRCm38)	missense	probably damaging	1.00
R4946:Dnah5	UTSW	15	28,326,557 (GRCm38)	missense	probably damaging	0.96
R4947:Dnah5	UTSW	15	28,272,372 (GRCm38)	missense	probably benign
R5033:Dnah5	UTSW	15	28,421,678 (GRCm38)	missense	probably damaging	0.96
R5164:Dnah5	UTSW	15	28,408,292 (GRCm38)	missense	probably benign	0.00
R5175:Dnah5	UTSW	15	28,448,404 (GRCm38)	missense	probably damaging	1.00
R5182:Dnah5	UTSW	15	28,311,278 (GRCm38)	missense	probably damaging	0.99
R5187:Dnah5	UTSW	15	28,272,172 (GRCm38)	missense	probably benign	0.41
R5272:Dnah5	UTSW	15	28,350,665 (GRCm38)	missense	probably benign
R5308:Dnah5	UTSW	15	28,229,651 (GRCm38)	missense	possibly damaging	0.80
R5310:Dnah5	UTSW	15	28,311,328 (GRCm38)	missense	probably damaging	1.00
R5322:Dnah5	UTSW	15	28,384,244 (GRCm38)	missense	probably benign	0.41
R5398:Dnah5	UTSW	15	28,293,726 (GRCm38)	missense	probably benign
R5596:Dnah5	UTSW	15	28,343,608 (GRCm38)	missense	probably damaging	1.00
R5603:Dnah5	UTSW	15	28,419,932 (GRCm38)	missense	probably damaging	1.00
R5619:Dnah5	UTSW	15	28,302,435 (GRCm38)	missense	probably damaging	1.00
R5656:Dnah5	UTSW	15	28,421,064 (GRCm38)	missense	probably benign	0.03
R5741:Dnah5	UTSW	15	28,246,367 (GRCm38)	missense	probably benign	0.11
R5754:Dnah5	UTSW	15	28,401,868 (GRCm38)	missense	probably benign	0.01
R5763:Dnah5	UTSW	15	28,311,152 (GRCm38)	missense	probably damaging	1.00
R5824:Dnah5	UTSW	15	28,313,821 (GRCm38)	missense	probably benign	0.00
R5836:Dnah5	UTSW	15	28,383,592 (GRCm38)	missense	probably damaging	1.00
R5838:Dnah5	UTSW	15	28,290,195 (GRCm38)	missense	probably benign	0.00
R5864:Dnah5	UTSW	15	28,297,013 (GRCm38)	missense	possibly damaging	0.83
R5895:Dnah5	UTSW	15	28,234,453 (GRCm38)	splice site	probably null
R5896:Dnah5	UTSW	15	28,272,060 (GRCm38)	missense	probably benign
R5899:Dnah5	UTSW	15	28,448,367 (GRCm38)	missense	possibly damaging	0.95
R5905:Dnah5	UTSW	15	28,387,833 (GRCm38)	missense	probably damaging	1.00
R5924:Dnah5	UTSW	15	28,307,327 (GRCm38)	missense	probably benign	0.41
R5927:Dnah5	UTSW	15	28,335,718 (GRCm38)	missense	probably benign	0.00
R5929:Dnah5	UTSW	15	28,311,208 (GRCm38)	missense	probably damaging	1.00
R5929:Dnah5	UTSW	15	28,311,207 (GRCm38)	missense	probably benign	0.01
R5931:Dnah5	UTSW	15	28,453,279 (GRCm38)	missense	probably damaging	0.99
R5964:Dnah5	UTSW	15	28,458,584 (GRCm38)	missense	possibly damaging	0.49
R5975:Dnah5	UTSW	15	28,234,282 (GRCm38)	missense	probably damaging	1.00
R5993:Dnah5	UTSW	15	28,299,226 (GRCm38)	missense	probably benign	0.09
R6016:Dnah5	UTSW	15	28,327,884 (GRCm38)	missense	probably damaging	1.00
R6028:Dnah5	UTSW	15	28,387,833 (GRCm38)	missense	probably damaging	1.00
R6065:Dnah5	UTSW	15	28,230,468 (GRCm38)	missense	possibly damaging	0.47
R6117:Dnah5	UTSW	15	28,270,420 (GRCm38)	missense	probably damaging	0.99
R6143:Dnah5	UTSW	15	28,233,231 (GRCm38)	missense	probably benign	0.05
R6146:Dnah5	UTSW	15	28,459,185 (GRCm38)	missense	probably benign
R6154:Dnah5	UTSW	15	28,204,031 (GRCm38)	missense	probably benign	0.15
R6164:Dnah5	UTSW	15	28,378,343 (GRCm38)	missense	probably benign	0.08
R6266:Dnah5	UTSW	15	28,335,627 (GRCm38)	missense	possibly damaging	0.67
R6321:Dnah5	UTSW	15	28,372,411 (GRCm38)	missense	probably damaging	0.99
R6349:Dnah5	UTSW	15	28,238,511 (GRCm38)	missense	probably damaging	1.00
R6431:Dnah5	UTSW	15	28,349,824 (GRCm38)	missense	possibly damaging	0.52
R6467:Dnah5	UTSW	15	28,438,183 (GRCm38)	missense	probably benign	0.10
R6564:Dnah5	UTSW	15	28,367,745 (GRCm38)	missense	probably benign
R6607:Dnah5	UTSW	15	28,445,200 (GRCm38)	missense	possibly damaging	0.95
R6619:Dnah5	UTSW	15	28,409,120 (GRCm38)	missense	probably benign	0.03
R6633:Dnah5	UTSW	15	28,293,787 (GRCm38)	missense	probably benign	0.27
R6647:Dnah5	UTSW	15	28,403,487 (GRCm38)	missense	probably benign	0.02
R6782:Dnah5	UTSW	15	28,449,156 (GRCm38)	missense	possibly damaging	0.89
R6797:Dnah5	UTSW	15	28,233,238 (GRCm38)	nonsense	probably null
R6797:Dnah5	UTSW	15	28,451,463 (GRCm38)	missense	probably damaging	1.00
R6831:Dnah5	UTSW	15	28,411,515 (GRCm38)	missense	possibly damaging	0.88
R6849:Dnah5	UTSW	15	28,278,624 (GRCm38)	missense	probably benign	0.14
R6871:Dnah5	UTSW	15	28,229,640 (GRCm38)	missense	probably benign	0.32
R6936:Dnah5	UTSW	15	28,409,268 (GRCm38)	missense	probably damaging	1.00
R6943:Dnah5	UTSW	15	28,235,720 (GRCm38)	missense	probably damaging	1.00
R7030:Dnah5	UTSW	15	28,333,062 (GRCm38)	missense	probably benign	0.00
R7030:Dnah5	UTSW	15	28,238,592 (GRCm38)	missense	probably benign
R7032:Dnah5	UTSW	15	28,326,650 (GRCm38)	missense	probably damaging	1.00
R7063:Dnah5	UTSW	15	28,233,248 (GRCm38)	missense	probably benign	0.00
R7094:Dnah5	UTSW	15	28,453,336 (GRCm38)	missense	probably damaging	0.98
R7097:Dnah5	UTSW	15	28,453,264 (GRCm38)	missense	probably benign	0.00
R7126:Dnah5	UTSW	15	28,349,837 (GRCm38)	missense	probably benign	0.03
R7153:Dnah5	UTSW	15	28,365,522 (GRCm38)	splice site	probably null
R7209:Dnah5	UTSW	15	28,459,225 (GRCm38)	missense	possibly damaging	0.71
R7276:Dnah5	UTSW	15	28,367,838 (GRCm38)	missense	probably damaging	1.00
R7320:Dnah5	UTSW	15	28,270,470 (GRCm38)	missense	probably null	0.33
R7350:Dnah5	UTSW	15	28,235,819 (GRCm38)	critical splice donor site	probably null
R7380:Dnah5	UTSW	15	28,370,378 (GRCm38)	missense	probably damaging	1.00
R7438:Dnah5	UTSW	15	28,346,952 (GRCm38)	missense	probably damaging	0.99
R7499:Dnah5	UTSW	15	28,302,450 (GRCm38)	missense	probably damaging	1.00
R7513:Dnah5	UTSW	15	28,370,415 (GRCm38)	missense	probably benign
R7519:Dnah5	UTSW	15	28,390,483 (GRCm38)	missense	probably damaging	0.98
R7524:Dnah5	UTSW	15	28,297,066 (GRCm38)	missense	possibly damaging	0.50
R7556:Dnah5	UTSW	15	28,290,243 (GRCm38)	missense	probably null	0.43
R7570:Dnah5	UTSW	15	28,346,952 (GRCm38)	missense	probably damaging	1.00
R7585:Dnah5	UTSW	15	28,401,868 (GRCm38)	missense	probably benign	0.09
R7642:Dnah5	UTSW	15	28,247,979 (GRCm38)	critical splice donor site	probably null
R7670:Dnah5	UTSW	15	28,246,232 (GRCm38)	splice site	probably null
R7763:Dnah5	UTSW	15	28,313,855 (GRCm38)	missense	probably damaging	1.00
R7821:Dnah5	UTSW	15	28,411,532 (GRCm38)	missense	possibly damaging	0.89
R7826:Dnah5	UTSW	15	28,367,812 (GRCm38)	missense	probably damaging	1.00
R7872:Dnah5	UTSW	15	28,245,684 (GRCm38)	missense	probably damaging	0.99
R7889:Dnah5	UTSW	15	28,448,414 (GRCm38)	nonsense	probably null
R7919:Dnah5	UTSW	15	28,350,596 (GRCm38)	missense	probably damaging	1.00
R7920:Dnah5	UTSW	15	28,453,222 (GRCm38)	missense	probably benign	0.00
R7936:Dnah5	UTSW	15	28,345,837 (GRCm38)	missense	possibly damaging	0.64
R7996:Dnah5	UTSW	15	28,409,177 (GRCm38)	missense	probably damaging	0.98
R8063:Dnah5	UTSW	15	28,230,583 (GRCm38)	missense	probably benign
R8084:Dnah5	UTSW	15	28,387,953 (GRCm38)	missense	probably damaging	1.00
R8105:Dnah5	UTSW	15	28,372,402 (GRCm38)	missense	probably benign
R8114:Dnah5	UTSW	15	28,239,976 (GRCm38)	missense	probably benign	0.01
R8142:Dnah5	UTSW	15	28,384,373 (GRCm38)	missense	probably benign	0.36
R8153:Dnah5	UTSW	15	28,384,430 (GRCm38)	missense	probably damaging	1.00
R8161:Dnah5	UTSW	15	28,350,704 (GRCm38)	missense	possibly damaging	0.79
R8174:Dnah5	UTSW	15	28,311,133 (GRCm38)	splice site	probably null
R8187:Dnah5	UTSW	15	28,384,209 (GRCm38)	missense	probably damaging	1.00
R8194:Dnah5	UTSW	15	28,453,268 (GRCm38)	missense	probably damaging	0.99
R8280:Dnah5	UTSW	15	28,408,392 (GRCm38)	missense	probably benign	0.01
R8291:Dnah5	UTSW	15	28,263,597 (GRCm38)	missense	probably benign	0.03
R8324:Dnah5	UTSW	15	28,346,865 (GRCm38)	missense	probably damaging	1.00
R8347:Dnah5	UTSW	15	28,236,666 (GRCm38)	missense	possibly damaging	0.90
R8356:Dnah5	UTSW	15	28,444,167 (GRCm38)	missense	probably benign	0.03
R8356:Dnah5	UTSW	15	28,444,323 (GRCm38)	missense	probably null	0.02
R8361:Dnah5	UTSW	15	28,331,810 (GRCm38)	missense	probably damaging	0.98
R8375:Dnah5	UTSW	15	28,327,343 (GRCm38)	missense	probably benign	0.00
R8474:Dnah5	UTSW	15	28,247,832 (GRCm38)	missense	probably benign	0.00
R8481:Dnah5	UTSW	15	28,419,795 (GRCm38)	missense	probably benign	0.00
R8494:Dnah5	UTSW	15	28,345,831 (GRCm38)	missense	probably benign	0.32
R8495:Dnah5	UTSW	15	28,409,268 (GRCm38)	missense	probably damaging	0.97
R8519:Dnah5	UTSW	15	28,299,099 (GRCm38)	missense	probably benign	0.07
R8683:Dnah5	UTSW	15	28,289,221 (GRCm38)	missense	probably benign	0.00
R8739:Dnah5	UTSW	15	28,345,860 (GRCm38)	missense	probably benign	0.01
R8752:Dnah5	UTSW	15	28,290,219 (GRCm38)	missense	probably benign	0.00
R8784:Dnah5	UTSW	15	28,387,951 (GRCm38)	missense	probably benign	0.16
R8813:Dnah5	UTSW	15	28,229,573 (GRCm38)	missense	probably damaging	1.00
R8862:Dnah5	UTSW	15	28,459,356 (GRCm38)	splice site	probably benign
R8873:Dnah5	UTSW	15	28,219,188 (GRCm38)	missense	probably benign
R8885:Dnah5	UTSW	15	28,327,740 (GRCm38)	missense	probably damaging	1.00
R8901:Dnah5	UTSW	15	28,365,569 (GRCm38)	missense	possibly damaging	0.76
R9025:Dnah5	UTSW	15	28,409,266 (GRCm38)	missense	probably damaging	1.00
R9037:Dnah5	UTSW	15	28,247,958 (GRCm38)	missense	probably benign	0.05
R9057:Dnah5	UTSW	15	28,390,868 (GRCm38)	missense	probably damaging	1.00
R9059:Dnah5	UTSW	15	28,245,666 (GRCm38)	missense	probably benign
R9065:Dnah5	UTSW	15	28,293,790 (GRCm38)	missense	probably benign	0.09
R9098:Dnah5	UTSW	15	28,419,961 (GRCm38)	missense
R9118:Dnah5	UTSW	15	28,401,848 (GRCm38)	frame shift	probably null
R9149:Dnah5	UTSW	15	28,387,768 (GRCm38)	missense	probably benign	0.00
R9184:Dnah5	UTSW	15	28,340,406 (GRCm38)	missense	probably benign	0.13
R9205:Dnah5	UTSW	15	28,448,334 (GRCm38)	missense	possibly damaging	0.88
R9297:Dnah5	UTSW	15	28,203,908 (GRCm38)	start gained	probably benign
R9302:Dnah5	UTSW	15	28,239,886 (GRCm38)	missense	probably benign	0.03
R9310:Dnah5	UTSW	15	28,448,433 (GRCm38)	missense	probably damaging	1.00
R9318:Dnah5	UTSW	15	28,203,908 (GRCm38)	start gained	probably benign
R9405:Dnah5	UTSW	15	28,272,160 (GRCm38)	missense	probably benign
R9424:Dnah5	UTSW	15	28,272,140 (GRCm38)	missense	probably benign	0.01
R9467:Dnah5	UTSW	15	28,366,147 (GRCm38)	missense	possibly damaging	0.94
R9469:Dnah5	UTSW	15	28,421,000 (GRCm38)	missense	probably benign	0.06
R9548:Dnah5	UTSW	15	28,327,879 (GRCm38)	missense	possibly damaging	0.79
R9564:Dnah5	UTSW	15	28,290,276 (GRCm38)	missense	probably benign	0.04
R9576:Dnah5	UTSW	15	28,272,140 (GRCm38)	missense	probably benign	0.01
R9593:Dnah5	UTSW	15	28,236,628 (GRCm38)	missense	probably benign
R9644:Dnah5	UTSW	15	28,230,504 (GRCm38)	missense	probably damaging	0.98
R9655:Dnah5	UTSW	15	28,242,754 (GRCm38)	missense	probably benign
R9657:Dnah5	UTSW	15	28,409,943 (GRCm38)	missense	probably damaging	1.00
R9704:Dnah5	UTSW	15	28,247,819 (GRCm38)	missense	probably benign	0.00
R9797:Dnah5	UTSW	15	28,233,170 (GRCm38)	missense	probably benign	0.34
RF009:Dnah5	UTSW	15	28,204,019 (GRCm38)	missense	probably benign	0.00
X0011:Dnah5	UTSW	15	28,408,381 (GRCm38)	missense	probably benign	0.16
X0018:Dnah5	UTSW	15	28,269,354 (GRCm38)	missense	probably benign	0.00
X0022:Dnah5	UTSW	15	28,270,411 (GRCm38)	missense	probably benign	0.01
X0023:Dnah5	UTSW	15	28,384,308 (GRCm38)	missense	probably damaging	0.99
X0028:Dnah5	UTSW	15	28,470,477 (GRCm38)	missense	probably damaging	1.00
Z1088:Dnah5	UTSW	15	28,366,357 (GRCm38)	missense	probably null	0.10
Z1088:Dnah5	UTSW	15	28,384,230 (GRCm38)	missense	probably damaging	1.00
Z1177:Dnah5	UTSW	15	28,295,311 (GRCm38)	missense	probably damaging	0.98
Z1177:Dnah5	UTSW	15	28,270,403 (GRCm38)	missense	probably benign	0.00
Z1177:Dnah5	UTSW	15	28,270,354 (GRCm38)	missense	probably benign	0.32
Z1177:Dnah5	UTSW	15	28,387,763 (GRCm38)	missense	possibly damaging	0.72

Predicted Primers

PCR Primer
(F):5'- GTGAAGAAAAGCCTCTCTCCACGG -3'
(R):5'- TCCAAGAGGACCTTGGCTATCCTG -3'

Sequencing Primer
(F):5'- GCCCGTAGTAATACTGCCTAATG -3'
(R):5'- TTATAGCTGCGGATCACAGG -3'

Posted On

2013-04-11